1I6P,2W3Q,1YM3,3EYX,3LAS,1G5C


Conserved Protein Domain Family
Pro_CA
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smart00947: Pro_CA 
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Carbonic anhydrase
Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.
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Statistics
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PSSM-Id: 214929
Aligned: 320 rows
Threshold Bit Score: 65.6042
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1I6P_A        30 AQAQKPRFLWIGCSDSRVPAERLTG--LEPGELFVHRNVANLVIHTDLNCLSVVQYAVDVLEVEH----------IIICG 97  Shigella flexneri
YP_290188     25 qpvaargLALVTCMDSRIEPLEMLG--LKPGDAKILRNAGARV---TDDTLRTLVLAVYLLGVNR----------VIVLP 89  Thermobifida fu...
YP_001360779  27 pgiagsgLAVLTCMDSRISPLEVLG--LEKGDAKILRNAGARV---TDDVLRTLVLAHHLLGVQR----------VLVLA 91  Kineococcus rad...
YP_873430     38 lgiaARQLAVLTCMDCRIDPLRVLG--LAPGDAKILRNAGARVTP---DVLATLAVAVHLLNVRR----------IMVMA 102 Acidothermus ce...
YP_924141     26 dgvaragVAIVTCMDSRIDPLGMVG--LQPGDAKIFRNPGGRV---TDQALEALVLGVHLLNVDR----------ILVIP 90  Nocardioides sp...
YP_001111819  40 kKYDHAEILIGMCMDNRKRLNIPEK--F----AYVIRTGAGNLRTSEFKVS----YAIAVGGVRA----------IALIG 99  Desulfotomaculu...
YP_001390829  36 eKYDNAELLVGMCMDNRKQLNIPNN--F----AYILRTGGGNLRYSEFKIS----YAIAVGGVKA----------LALIG 95  Clostridium bot...
YP_713017     24 SISPSGNLMVVCCVDPRV--DPTRVlgLEQGEAAVIRNv---gGRITPATLRTMALLGEVGQADRdgrpa-gdwnLVILH 97  Frankia alni AC...
YP_591842     23 QSLQTLKAVIIGCADMRV--DPAHVlgIKPGEAVVIRNi---gGRVTPGLLEEFGLLGRIGEVAGaipggggefhLIVLH 97  Acidobacteria b...
YP_590677     24 SPHPRMALAVLTCMDTRI--SLP-AlgLKVGDAHMIRNa---gGIATDDAIRSLVVSHYLLGTNE----------IMVIN 87  Acidobacteria b...

1I6P_A        98 HYGCGGVQAAVEnPELGLINNWLLHIRDIWFKHSSLLGEMpqerrlDTL-CELNVMEQVYN-----LGHST-I-MQSAWK 169 Shigella flexneri
YP_290188     90 HTGCKMASVSGD-EEVH------------DTIAARYGVDT------RSL-EFHTDSDQIGA-----LHRDV-ErIRHHPL 143 Thermobifida fu...
YP_001360779  92 HTDCGMTKNTD---------------ADVHAKVLAQGVDS------RSI-EFRTIADQRAT-----LVHDVqR-IRSWPF 143 Kineococcus rad...
YP_873430    103 HTRCRMASGTED-DLHQAIAH-------------AGGPDT------RSL-AFLTTTDQTAA-----VQRDVqR-IQSWPY 155 Acidothermus ce...
YP_924141     91 HTRCAMASSTLD-Q--------------VREKVGASAGQD------VSWqTFSMVSDQRAA-----LADDVhK-VVSHPL 143 Nocardioides sp...
YP_001111819 100 HNNCGMANLKSK-KQK-FIDGLVE-VGWNRRAAEDHFENL------APM-FE--IGNEMDF-----LITET-N--RLRLR 159 Desulfotomaculu...
YP_001390829  96 HNRCGMVN-LMN-KKERFIQGLVDNAGWDRNQAEEHFMSF------APM-FE------IENetsflLSETK-R-LREKY- 157 Clostridium bot...
YP_713017     98 HTDCGMTDLAAF-P---ALLADYFEIPARD------------------L-DAKAVGDPVAS-----VRVDV-GiIEREIR 148 Frankia alni AC...
YP_591842     98 HTDCGSTRLVGD-P---AMLAHYFQIPERE------------------V-EAKSVRDPRKS-----VAVDV-AaLRAIPA 148 Acidobacteria b...
YP_590677     88 HTDCGLMKAS-E-S---DLHHKISTEAGKPANA--------------SV-KFHAFHDVNAN-----VREQI-EqLYAHTW 141 Acidobacteria b...

1I6P_A       170 R-Gq-K-VTIHGWAYGIHDGLLRDL 191 Shigella flexneri
YP_290188    144 LpP--D-LPVMGAIYDVDTGRVTPV 165 Thermobifida fusca YX
YP_001360779 144 LpP--T-MPVAGGVYDVRTGAIEMV 165 Kineococcus radiotolerans SRS30216
YP_873430    156 L-QgsG-VAVGGFLYDVDTGDVHVV 178 Acidothermus cellulolyticus 11B
YP_924141    144 V-P--DaVKVGGFIYDVDTGLLEQL 165 Nocardioides sp. JS614
YP_001111819 160 Y-P--K-ILVAPMMYQLEDNRLYLL 180 Desulfotomaculum reducens MI-1
YP_001390829 158 --P--K-ILIAPLFYNVDDNLLYLV 177 Clostridium botulinum F str. Langeland
YP_713017    149 A-R--G-FLVSGLVYDVATGLVDTV 169 Frankia alni ACN14a
YP_591842    149 L-Pd-D-WLISGLVYDVATGLVEVV 170 Acidobacteria bacterium Ellin345
YP_590677    142 L-Kg-R-VKIRGFVFEVETGRLREV 163 Acidobacteria bacterium Ellin345
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