6JIG,1VRD,1EEP,3KHJ


Conserved Protein Domain Family
IMPDH

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pfam00478: IMPDH 
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IMP dehydrogenase / GMP reductase domain
This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.
Statistics
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PSSM-Id: 459826
Aligned: 439 rows
Threshold Bit Score: 382.507
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6JIG_A                  12 GLTYDDVLIIPQHS--RVTSRkEVNTTTRLS----RN-----VKLSIPIVASNMDTVCEQRMAVAMAREGGIGILHRFCS 80  Trypa...
Q8EW89                  10 TLTFDDVLLRPQYS--EVLPK-ETDVRTTLS----SR-----FQMKIPIMSASMDTVTEIEMAYNMSLNGGIGVIHKNLS 77  Mycop...
jgi:Caka_1876           27 GLTYDDVSLATLYS--EVLPR-QTSLTTKLS----KS-----LELQIPIISSDMDTVTESKMAIQMALNGGMGLIHYNMS 94 
WP_012375621            31 GLTFDDVSLATLYS--EILPK-DAETSTALS----DA-----LRLQIPIISSDMDTVTESRMAIAMALNGGLGLIHYNMP 98  Opitu...
PRJNA63271:OPIT5_29135 104 GLTFDDVSLATLYS--DILPK-DADTSTSLS----EA-----LRLSVPIISSDMDTVTEERMAIAMALNGGLGLIHYNMP 171
WP_013702273             9 SHTFGEYLLIPGYTsaECIPE-NVSLKTPVVrfnkKSgekpsLSMNIPLVSAVMQSVSDDKMAIALAKEGGISFIFGSQT 87  Trepo...
WP_013758950             9 SHTFGEYLLVPGYSsaDCIPA-NVNLKTPVVk--fRRgeespLSMNIPMVSAVMQSVSNDTMAIALAKEGGISFIYGSQT 85  Trepo...
WP_014354544             9 SHTFGEYLLMPGYSstDCIPD-NVSLKTPLVk--fRKgeqsaISLNIPTVSAIMQSVSDDTMAIALAKEGGLSFIYGSQP 85  Aceto...
jgi:Selsp_0725           9 SHTFGEYLLVPGYSseQCVPA-NVSLQTPLVk--fRRgeepkIKMNIPMTSAIMQAVSNDTMAIALAREGGVSFIYGSQT 85 
CDE02777                 9 SHTFSEYLLIPGYTspECIPT-NVSLRTPLVk--fRRgetsdINLNIPLVSAVMQSVSDDRMAIALAREGGISFIYGSQS 85 
6JIG_A                  81 IEEQCAMLREVKRAQSFLIESPRIILPHETAREAWEG--LNWKGRVGGVGCl------Lvvnc---kneRkLLGIITRHD 149 Trypa...
Q8EW89                  78 HSQQSNMIKQIKHIKNGLYYNIMAFESSNKISMIKEK------------VFd-----eYlddcifvtvnGsIVNIVSKED 140 Mycop...
jgi:Caka_1876           95 DEKQIKEVARVKNHIHGFIQEPIKASPDQKIGEVIDYisDRGFGFSTFPVVd-----eD----------DkLLGLLPGRV 159
WP_012375621            99 PKEQIKEVARVKRHIHGLIQDPITVTPDQLIGDVLAMieSKRFAFSTFPVLd-----aE----------GhLVGLLSGNV 163 Opitu...
PRJNA63271:OPIT5_29135 172 ARDQVKAVARVKRHIHGLIQDPITVTPSQHVGDVLALieAKRYEFRTFPVVd-----tQ----------GkLVGLLSGST 236
WP_013702273            88 IENQAAMVARVKSYKAGFVTSDSNIRPDQTLEEVVSL--IEQTGHSTIAVTddgtahgK------------LEGIITERD 153 Trepo...
WP_013758950            86 IERQADMIRRVKSYKAGFVTSDSNIKPDQSLQDVVDL--KARTGHSTVAVTadgspngK------------LLGIITSRD 151 Trepo...
WP_014354544            86 IESQAKMVARVKSYRAGFVVSDSNISPEGTLEEILVL--KKKTGHSTVAVTtdgtedgK------------LVGIVTSRD 151 Aceto...
jgi:Selsp_0725          86 PEQEAAMISRVKNYKSGFVSSDSNIKPTTTLGEVLAL--KDATGHSTMAVTedgtpngK------------LVGIVTSRD 151
CDE02777                86 IEDEAAMVARVKSYKAGFVVSDSNLTPDNTLADVLEL--VERNGHGTIAITddgthngH------------LLGIVTGRD 151
6JIG_A                 150 LKLadesttV-------ESLMTPvDkMVVStn--tsI--SLEEVTHLMRKG-RTANVPIVGQNGQLLYLVTLSDVVK-LR 216 Trypa...
Q8EW89                 141 LEN------KkidsnstLESIG--RkKIIFak--dsS--SLEEILKIMDEN-KLDFMPIVSETTN--GIIAVAKRKW-LV 204 Mycop...
jgi:Caka_1876          160 VKPrya--------drlVSEAMTpRdQVYTlneseiTqdPIKTADQFFTEHlGIHKLLVVNDKDQLRGLFTLSDIERiEA 231
WP_012375621           164 VKEryk--------akpVTDVMTpRaQLITeneaavAkdPIKAADSFFSTHvGVNKMLVVDGADRLRGLVTISDVEKiTS 235 Opitu...
PRJNA63271:OPIT5_29135 237 VREryk--------srtVADAMVpRhEIQTiherqlQpdPITAADAFFTENiGIHKMLVVDDDDRLRGLVTFSDIESiLQ 308
WP_013702273           154 FRIdhvp------anskVNEYMTpFaKLVTgk--dgI--TLSAANDLIWAH-KVNQLPIIDDKNHLVSIVFRKDFDN-HE 221 Trepo...
WP_013758950           152 FRInkvd------paakVRDYMTrFdDLIVgq--dgI--TLSEANELIWAH-KLNSLPIIGKSGNLVSMVFRKDYAS-HE 219 Trepo...
WP_014354544           152 YRIsrmd------lktkVKEFMTpFeNLVWap--dnT--TLKEANDIIWEH-KLNCLPLIDSKQKLVFMVFRKDYDS-HK 219 Aceto...
jgi:Selsp_0725         152 YRVtrms------fdtpVKDFMTpFeRLIYad--anL--TLPQANDLIWEH-KLNMLPLIDENQRLRYMVFRKDYTD-NK 219
CDE02777               152 YRVsrms------pdlkISEFMTpRaHLVTap--anT--TLKEANDIIWDN-KLNALPIVDDEDRLCYFVFRKDYSE-HK 219
6JIG_A                 217 KNKQASL---DSRGRLLVGAAV-------GVKK--DDMNRAIRLVEAGADVLVVDIAHGHSDLCINMVKRLKGDPrtAsV 284 Trypa...
Q8EW89                 205 PYLNSDDpliDSKERPKVCGAI-------GVTE--DSIERAKLLIAAGVDAIIIDCAHGHSKKVIELTREIKKLFp-K-L 273 Mycop...
jgi:Caka_1876          232 EQQQSVKparDDHFRLRCGAAIsahrtpdGELDkqRIIGHVTRLVEEGVDAVAVSTAHGFSKGVGDCIRMLRAEFs-D-L 309
WP_012375621           236 ETKSRRKparDASFRLVVGAALspvrksdGSLDreKILNHVGHLVDEHVDAIAVSTAHGHTAGVGDVVKLVHGAFp-Q-V 313 Opitu...
PRJNA63271:OPIT5_29135 309 ESRSRRKparDHAFRLVVGAAIapvrlpdGSLDrdKIISHVGHLVDEAIDAVAVSTAHGHTAGVGDMVKLVRDAFp-D-L 386
WP_013702273           222 THPNELM---DTNHRYIVGAGI-------NTR---DYMERVPALLKAGVDILCLDSSEGYSEWQAKALHDIHEKFg-KdV 287 Trepo...
WP_013758950           220 EHPLELL---DSRQRYVVGAGI-------NTR---DYMERVPALIEAGADVFCLDSSEGFSEWQKRALHDIHKNFg-DkV 285 Trepo...
WP_014354544           220 ENENELI---DDFKRFVVGAGV-------NTR---DYAERIPALIAAGADVLCIDSSEGFTEWQKIVIQYVRSNYg-DkV 285 Aceto...
jgi:Selsp_0725         220 ENELELI---DERKRYIVGAGI-------NTR---DYAERVPALLEAGADVLCIDSSEGYSEWQKKTLEYIHKEFg-EdV 285
CDE02777               220 ENPQELL---DKQKRFMVGAGI-------NTR---DYAERVPALVDAGVDVLCIDASEGYTCWQKQTLDFIRGRYg-DsV 285
6JIG_A                 285 DII-AGNIASAEAAEALIDAGADGLKIGVGPGSIAITRLVAGAGVPQLSAVLACTR-VARRR-G----VPCIADGGLRTS 357 Trypa...
Q8EW89                 274 FLI-VGNVVTANGVNDLYKAGADAVKIGVGPGAICTTRTVSGVGIPQFSAILECYE-EAKKL-N----IPIIADGGIKNS 346 Mycop...
jgi:Caka_1876          310 TLI-AGNVTSADGVNYLADAGADVIKIGQGPGSICTTRIVAGVGIPQMTALYVAAV-AAKAK-G----VTILADGGITKS 382
WP_012375621           314 TLI-AGNVTSGNGVTYLAECGAHAIKIGQGPGSICTTRMVAGVGIPQLTALYVASL-AAKTA-G----VKLIADGGIVKS 386 Opitu...
PRJNA63271:OPIT5_29135 387 TII-AGNVTSGAGVEYLAGCGADAIKVGQGPGSICTTRVVAGVGIPQLTALYVAARgAAAAA-GrgknIKIIADGGITKS 464
WP_013702273           288 -KVgAGNVVDREGFMFLAENGADFVKIGIGGGSICITREQKGIGRGQATATIEVAKaRDEYYsKtgiyVPICSDGGIVHD 366 Trepo...
WP_013758950           286 -KVgAGNVVDKEGFLFLAENGADFVKVGIGGGSICITREQKGIGRGQATATIEVAKaRDEYYeKtgvyIPVCSDGGIVHD 364 Trepo...
WP_014354544           286 -KIgAGNIVDKEGFLFLAEAGADFIKIGIGGGAICITREQKGIGRGQATAVIEVAKaRDDYFeEtgiyIPLCSDGGTVHD 364 Aceto...
jgi:Selsp_0725         286 -KVgAGNVVDGEGFRFLADAGADFVKVGIGGGSICITRETKGIGRGQATAVIDVCRaRDEYFkEkgvyIPVCSDGGIVHD 364
CDE02777               286 -KVgAGNVVDRDGFRFLAGAGADFVKVGIGGGSICITREQKGIGRGQATALIEVAAaRDEYFeEtgiyVPICSDGGIVHD 364
6JIG_A                 358 GDISKAIGAGADTVMLGNMLAGTDEAPGRVLVkDGQKVKIIRGMAGFGANlskAereRTQDedVF--S------SLVPEG 429 Trypa...
Q8EW89                 347 GDMVKALAAGADAVMLGSLLAGCDESPSVKVMhNNKMYKQYRGMGSIAAMk--A---GSSD--RY--Gqdg-ikKLVAEG 416 Mycop...
jgi:Caka_1876          383 GDMVKALTL-ADGVMCGSLLAGCNEAPGQLLEiNGKLYKQYRGMGSSAAMk--D---GSAA--RYghdrkdvatKAAAEG 454
WP_012375621           387 GDIVKALTL-ADAVICGGLLAGCREAPGEIMEiSGKVYKQYRGMGSLSAMk--A---GSAA--RYghdrndntrKVAAEG 458 Opitu...
PRJNA63271:OPIT5_29135 465 GDIVKALTL-ADAVILGGLLAGCREAPGEIIEiNGKLYKQYRGMGSVSAMk--A---GSAA--RYghdkndttrKLTAEG 536
WP_013702273           367 YHITLALAMGADFVMLGRYFARFDESPTNKLIiNGNYVKEYWGEGSNRAR--------NWQ--RYdlGgk--kgMAFEEG 434 Trepo...
WP_013758950           365 YHVTLALAMGADFVMLGRYFARFDESPTNKLIvNGSYVKEYWGEGSNRAR--------NWQ--RYdlGga--kkMAFEEG 432 Trepo...
WP_014354544           365 YHMTLALAMGADFIMMGRYFARFDESPTNKVNiKGNYMKEYWGEGSERAK--------NWQ--RYdlGgs--skLSFEEG 432 Aceto...
jgi:Selsp_0725         365 YHMTLALAMGADFMMLGRYFSRFDESPTDKVKvNGTYYKEYWGEGSNRAR--------NWQ--RYdlGgd--rkLSFEEG 432
CDE02777               365 YHMTLALAMGADFIMLGRYFARFDESPTNRLFvNGQYVKEYWGEGSNRAR--------NWQ--RYdlGgk--ggLNFEEG 432
6JIG_A                 430 VEGSVACKGPVGPIVRQLVGGLRSGMSYSGAKSIEEMQRRTRFVRMTGAGLRESGSH 486 Trypanosoma brucei brucei
Q8EW89                 417 VEGLMPYIGPVKESLYQLVGGLKSGMGYVGAKTLTDLKNKAEFVEQTGIGLKESSTH 473 Mycoplasma penetrans
jgi:Caka_1876          455 IEALKESVGPLSGVLRELVGGIQSGMGYLGAANLEELRGNARYIRVSPAGQKESAPH 511
WP_012375621           459 IEALKEVSGSVDDVLGNLIGGVQSGMGYLGAKNLPALRANARYVRVTSAGRKEAEPH 515 Opitutus terrae
PRJNA63271:OPIT5_29135 537 IEALKEVSGSVDDVLATLVGGVQSGMGYLGSKDLSTLRKKARYIRVSPAGLKEAAPH 593
WP_013702273           435 VDSYVPYAGRLHDNVSLSMSKVIHTMCNCGALSIPELQQKAKLTLVSSTTISEGSAH 491 Treponema succinifaciens
WP_013758950           433 VDSYVPYAGSLHDNVGMTLSKIRHTMCNCGVLSIAELQKNAKITLVSQASIAEGSSH 489 Treponema brennaborense
WP_014354544           433 VDSYVPYAGSLKDNLSLSLSKIRSTMCNCGVLTIPKLHKHAKITLISETSIIEGGSH 489 Acetobacterium woodii
jgi:Selsp_0725         433 VDSYVPYAGSLRDNIHISLSKIRSTMCNCGALNLSELRDKAKITLVSSTSIVEGGSH 489
CDE02777               433 VDSYVVYAGPLHDNVAKSLYKVKSTMCNCGVNNIPDLQKNARITLVSSTSIVEGGYH 489
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