Conserved Protein Domain Family
REJ
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pfam02010: REJ 
REJ domain
The REJ (Receptor for Egg Jelly) domain is found in PKD1 and the sperm receptor for egg jelly. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.
Links
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Statistics
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PSSM-Id: 366875
Aligned: 23 rows
Threshold Bit Score: 235.088
Created: 19-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001075438 1506 TTLSIN--CTS-SNLVYYMWQVfflWDNGTLEEVALPSFVASE-GATLSKivi-parTLTPGNHVISVTVSIQDEPg-LA 1579 purple sea ur...
Q4T3T9        639 ASVVSN--CS--AYNIRYQWEVltlSATYPEIMLSDNKARLGG-QEAASLlllipkhSLSVGQYCLLFTVSLQGTP--LQ 711  spotted green...
XP_001627539 2101 AKAVLSp-CLD-PSVAASVLFSweiDAVGIDLGVTDKPRLRIK-QATLEGg----------KTYTLTVTAAMASDQt-LS 2166 starlet sea a...
Q8MVW7       1353 TPVISFpsCYS------------------------------GS-G---------------ATTYTFALDGSVSK------ 1380 Naegleria gru...
ABM98427     2017 ADIKYYseCVA-AGETVIEWSVndtSVALNLFTMYTRALR-VD-EGSLPGg----------ATILFTVRVYKSSTPs-QV 2082 purple sea ur...
NP_001075437 2353 AAVRFYeaCGG-AEQMEYAWSVdddSIALNLQTINKPLLDVAA-G-SLPGd----------SQVTFTLEVNRESDPs-TV 2418 purple sea ur...
Q54XQ9       1128 SSCSVDgaSQN-TNTIKYKWSI------VPEIQLASSKDYTGP-TLNIPSs-----kWVYDTTYVITLTATSGKETn--- 1191 Dictyostelium...
Q229K3        637 ETCELGqiTFF-NEPVDLQLTSnqlQKQSLSQYIQSSFQYDIP-PYSLASn----------QTFNISLTLNLSSDSn-IA 703  Tetrahymena t...
A0FEM4       1482 STVRLR--CYGlEETPQFQWSTkmiDDLNGTFTDLDNEA--LP-DYTFPPl------TFAVALYNLTMTVTVTETSppLS 1550 purple sea ur...
XP_001621745 1141 SKINAS--CSS-ANKVDYRWSFfhvEGNSTMKSMELPKDLQGSkELTLPRy------FMTSGLYKIDLEVVASPLG--IS 1209 starlet sea a...

NP_001075438 1580 TIATTNASIAASDLVAKINGGDQRIVSYQvddpvtqalttQSFYVDGSL--SSDP-D--------KDPQDh--LGWTFTW 1646 purple sea ur...
Q4T3T9        712 VQQNTTITVVNAPLVAVIKGGSKRLWPHL-----------SDLTLDGSE--SQDL-D--------REQGEe--DMLKYDW 767  spotted green...
XP_001627539 2167 STKSITLNVESSPLVARIRGGATKVVGAT-----------STMTMDASP--SIDP-D--------KTSE----TAW-YRW 2219 starlet sea a...
Q8MVW7       1381 --------VSSLSVVTK-----------------------DNLMVLGSGytNFNQ-E--------GD----------YYF 1410 Naegleria gru...
ABM98427     2083 TETSILVTTHQSDLFAKIDGATEFTVGRDs----------GTITLVGTN--SIDP-D--------EQA-----RDWEYVW 2136 purple sea ur...
NP_001075437 2419 TTQTVTITTVYTDLDALIDGGSERTIGVDs----------ESFTLDGSS--SFDP-D--------REN-----EEMTYLW 2472 purple sea ur...
Q54XQ9       1192 -YDNVTVIISKKPITAVIDG-ADKEFPLN-----------TLITLDASK--SFDPtTtstvskelDDSTStqqQSFTYAW 1256 Dictyostelium...
Q229K3        704 AIQNISVNIQITDLYLQIIGGSSLVQGYQ-----------NQMILNTDSr-DYEI----------QDPNSa--SNINFSW 759  Tetrahymena t...
A0FEM4       1551 GIDYVYMRIDSTPLIVVISGGTARTVNGK-----------LDIQFNATE--SQDP-D--------EELGDqdlSKWNFTW 1608 purple sea ur...
XP_001621745 1210 ASGSGFLKVRVPGLEAKIDCGSFRKMSRR-----------EEVHINAGE--SYDP-G--------SPSSRt--ASFDFEW 1265 starlet sea a...

NP_001075438 1647 QCrrkrytlangt------iidnletfqqwNEDFSMLRSDSVVNPdfekeasdvggcfgrnggpsnaslpggllsvrSGI 1720 purple sea ur...
Q4T3T9        768 SF--------------------------------VALSVTPSQSS----------------------------------S 781  spotted green...
XP_001627539 2220 ECfd--------------------------ssENPCFRPDPVNAGrqirvt---------------------fpttaQVS 2252 starlet sea a...
Q8MVW7       1411 IItasaasaqavsvtvkvtavaqpisvsfsVPDMTQSKDDPVAFSinvkdpsstsdsltl--sstcvdstgtacssnPGS 1488 Naegleria gru...
ABM98427     2137 LCeqtdd------------------nsacwSYDP---DALGTLIInds--------------------------nsgMGE 2169 purple sea ur...
NP_001075437 2473 TCrksn--------------------tetgSYEPCVSSETREVFPaea--------------------------dskTST 2506 purple sea ur...
Q54XQ9       1257 RCin----------------------------------ksGKDCGlnl---------------------------esEPI 1275 Dictyostelium...
Q229K3        760 KC-------------------------------NSLYSNDHICYDyqnnqi---------------------qlqqgVSS 787  Tetrahymena t...
A0FEM4       1609 SCyr------------------------edNGVTPVPTVDPTNESiceyskad----------------ehtvtgetKSL 1648 purple sea ur...
XP_001621745 1266 SCky----------------------------------dnVTDCSitnv-------------------------tmkKAI 1286 starlet sea a...

NP_001075438 1721 FTVDTHYLYPNMEYEFKLYVSDGS-----R-SATALQTLYVVDGFIPDVYLKCKANCRDKVNPQNR--WVIGVVlSPAAD 1792 purple sea ur...
Q4T3T9        782 VDSVNNVTVKRRTLTVKNLMREDAasqwlMnKSQTELRAVVQHGNPQEIIPYAIALTSRLNQAVPS------ELtCEDCQ 855  spotted green...
XP_001627539 2253 FSV-ADYLSSNQQYKFKMTFNKGS-----R-SDSTEMTVIVKAGDPPRVTIRPQTNSKENPSDVVK---------IKALA 2316 starlet sea a...
Q8MVW7       1489 TSSFSSSFTAG-TYIFTTTATKGS-----RtASSTLKVTVIDTSKDKIVRVSITSNADLTTVDPTR--DLYLTYnSLDA- 1559 Naegleria gru...
ABM98427     2170 LEFDAQALEADKTYQFSLTVRKET-----R-TAQTFVTILAVNGNPPKIILTTNDEDGVINDDVPLelTAYIFH------ 2237 purple sea ur...
NP_001075437 2507 LTLTSNNLYSDSTYLFTLEINKLS-----R-TASTSVTILSKSGNPPTISLDESLPEKIKSSSSHT--LRVLIShTSDIT 2578 purple sea ur...
Q54XQ9       1276 ITFNSSRLNVGV-FHFSVDVTPNGd---aTrSGSASATVTIVNTPVIDVIISPLPT---TIDPTQK--LVLYTVvSGNDA 1346 Dictyostelium...
Q229K3        788 IKFPAKTFQPYTAIQITVVGQKDS-----RqSNFTTICIFTELDIPPLNILLTATSINRKINLNDD--LNFQINyGENVS 860  Tetrahymena t...
A0FEM4       1649 FTIGAPRLALDATYTIKVTANHAD-----GrLGSYEQAITTVPGYPVQAKIDCIQNCLKKVNPTSL--VAYQAS-CLNCA 1720 purple sea ur...
XP_001621745 1287 LVIPKDSLKAG-NYTFVVKVSQGS-----R-AATAQQKIEIVEEELPDFCLRCVNNCDSKTRHAAP--LIFASSiCN--- 1354 starlet sea a...

NP_001075438 1793 IVvNQTVY-YKWdl-------sVYQNNMKQLLSPDAWLPYTSLSNQTTTsadhlLAIES---GFLEEGKQYEISL---MA 1858 purple sea ur...
Q4T3T9        856 KKvLETAG-----------------------KLIHVLEEQASPGVL--------SAVKT---GVALSAVDLAGILmrsVM 901  spotted green...
XP_001627539 2317 SStLPSTN-VTWesveedgfayLDLSTAGTILTPLQFTFEKASGRAKATrg-caLVIAK---DKLSGGVQYKFRL----T 2387 starlet sea a...
Q8MVW7       1560 ---LSSPT-FTW-------------------------TSESGDTSSSSL-----LVISK---SNLVPGASYAVTL----S 1598 Naegleria gru...
ABM98427     2238 ---SSDLSnVDWatvdttsgysYIDLTDSDNLLGD--AQLLETGDGlsi---atITIDR---DIVQRGASYAFSLn--VT 2304 purple sea ur...
NP_001075437 2579 ---------IDWat------fdIDLGYGYVDFSQLNSQSFLIQGDTSPFityafVTIPT---GTLEEDVAYSFSVt--VT 2638 purple sea ur...
Q54XQ9       1347 S--SSNLT-YEWn---------MLEGTLE--LPLKQAYSTPMNSRN--------LVLKA---GALGSKVVYRFSVd--VK 1399 Dictyostelium...
Q229K3        861 SDyLSYAGaILY-------------------------NNNPVAAIKFDY-----FQVRFrvwNYFQKILPSNPTLqirFS 910  Tetrahymena t...
A0FEM4       1721 ---TQNAT-FRWem-------kIGMETRE----EEDLAAKADTDLTKSG-----LVIRA---NVLESGKFYYVRV---YV 1774 purple sea ur...
XP_001621745 1355 ---VANVT-CVWs---------LRHGSPVHHVTRRAVQENLVSGE---------FVVDK---TSLNPDTDYNIVL---VV 1406 starlet sea a...

NP_001075438 1859 SYSPTFNikaDMSMTLDINAPPYGGTCSI----TPLEGTVAVTKYSF---AC-QDWmvTDQDcL----PLLYAVrakvrg 1926 purple sea ur...
Q4T3T9        902 RLRGPQQapvLLSAPHINTVGFRGDPAHL----LCTNH--LQSSTSV---PC---------------------------- 944  spotted green...
XP_001627539 2388 AKHRDSDa--YGDAVIRTNAAPSQGALTV----SPSNGTSMETVFTV---TArEGWsdDADD-L----PLNYQFg----- 2448 starlet sea a...
Q8MVW7       1599 VVDGAKSg--SASVSFTVNSPPTKGTFEA----YPTSGVALSDLFDL---KCgNGW--SDPQ-T----PLKFQF------ 1656 Naegleria gru...
ABM98427     2305 DIDDQYS---TVKSYVVVRSGPTSCEFSV----PSYEELDEVTFTTE---NCv-----TSADaY----PLNYQL------ 2359 purple sea ur...
NP_001075437 2639 DTEGQVS---ASKLTTSTYGGVSSCTFSLgdgsTSYQELDEITLLTQ---NCv-----TDEEaY----PLSYQV------ 2697 purple sea ur...
Q54XQ9       1400 NKKTGATg--KAMVTFTTEAIPQGGDITC----LTTSG-DVTDTYSI---TMgDQW--TDNSgI-----KSYNF------ 1456 Dictyostelium...
Q229K3        911 VYNPLYImpsLSTISIQINIPPQNCVLSI----NPKEGIALETIFQIqllNC------TDED-L----PLTYQFfyy--- 972  Tetrahymena t...
A0FEM4       1775 EEPGLLEg--FTEVYFYTNLPPFGGNCNI----EPRTGTALNTDFTA---TC-KDWkdEGDEaEftddPLPYVPllr--- 1841 purple sea ur...
XP_001621745 1407 TGNETTT---FAMYGIKTDNLPSGGTCDV----LPSVGKVIETSFQI---TC-TRW--ADED-S----PLWYEF------ 1462 starlet sea a...

NP_001075438 1927 vaetvSLSTQDTSDVWPLIYSGTSPa----SSDLFFSTGLSGY-DYIV-DVKVQISDIYGTYAlDSNMEIRVHPFNEALS 2000 purple sea ur...
Q4T3T9        945 --------------------------------QFYIPPYFTAHlKSQKsEVVQVLLDTDSKLV-SNPLATAADPPISTTL 991  spotted green...
XP_001627539 2449 -----YIDPRTNKEELQGMFGGSNQ------REIKFPPGDENN-ARSL-TVFVNVKDQLGAVT-RQTATITVMPVAVTTA 2514 starlet sea a...
Q8MVW7       1657 ------FFYDSANVKWNPLTEKTEQq----SAKVLLPQPAS---GSVL-MVKAVVYDSLGAST-ETQTNITITKPSVAAA 1721 Naegleria gru...
ABM98427     2360 -------SVVKADGELEIITERNSE-------PSFTGVGKPKLeGSDNrTYIITVCDKNEMCA-TWIAGTNVSLKLSFSA 2424 purple sea ur...
NP_001075437 2698 --------FREKVESSVTRYNAMTGa---lAEASSTILGLPSFsDNQN-TFVVKVCNDFGSCS-SYSLTLDVTPIASFSQ 2764 purple sea ur...
Q54XQ9       1457 -------RYRVGSGPAIALSESSSDn----SISTILPPGQI--------TIIGYVTSNDGITA-SKSCKIQVKEASNIEE 1516 Dictyostelium...
Q229K3        973 --nsaDDALQELISPWNILRRQIQDqtinnSIQTVLPQGNL--------VFMVQVMDSYLGVY-NTSSTIQVQAQNKSAD 1041 Tetrahymena t...
A0FEM4       1842 --yriQYRPQGEEAYSQLVPAGETGi----IKQLKFSIGPEAF-NYTF-EILFTVLDKFGGMD-QANTTIQVIPGVATKE 1912 purple sea ur...
XP_001621745 1463 -------FFDHAQSGPMLLSYGWQEq----SSLLYLPPGDPAN-DFKL-DLHVEITDVLGSKR-IVGLTVKVLGFTAEDG 1528 starlet sea a...

NP_001075438 2001 g---dLANTLTDLTNSMVSEASTGYSDYATSYARV 2032 purple sea urchin
Q4T3T9        992 ------VAMELSTPQGKPIAVQHLDPEQAIRVTLP 1020 spotted green pufferfish
XP_001627539 2515 --------FLDNAKDDILKSFESADWNSALGNMGA 2541 starlet sea anemone
Q8MVW7       1722 -------------TSALSAIASGKDTVTLAAASSA 1743 Naegleria gruberi
ABM98427     2425 ------ADINSFKADFVNAKTFGGDHIGALANRNM 2453 purple sea urchin
NP_001075437 2765 ------EQFDESITNLVEPQKLSGNFLDALVNFNT 2793 purple sea urchin
Q54XQ9       1517 ------------AINFLSTTITNPDV-SLYQLSVA 1538 Dictyostelium discoideum AX4
Q229K3       1042 -------EYYKLVNQHTLQALQSSNMQISNQLVTl 1069 Tetrahymena thermophila SB210
A0FEM4       1913 -----GLVDLFGTGGDIDTFLQSKDPEAGMRYLSA 1942 purple sea urchin
XP_001621745 1529 pvstlLKGFVQGPSSKLGKILARGDAQQGVQLMTT 1563 starlet sea anemone
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