1O7I,1WJJ


Conserved Protein Domain Family
SoSSB_OBF
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cd04491: SoSSB_OBF 
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SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB can substitute for the basal transcription factor TBP, stimulating transcription from promoters under conditions in which TBP is limiting, and supporting transcription when TBP is absent. SSoSSB selectively melts the duplex DNA of promoter sequences. It also relieves transcriptional repression by the chromatin Alba. In addition, SSoSSB activates reverse gyrase activity, which involves DNA binding, DNA cleavage, strand passage and ligation. SSoSSB stimulates all these steps in the presence of the chromatin protein, Sul7d. SSoSSB antagonizes the inhibitory effect of Sul7d on reverse gyrase supercoiling activity. It also physically and functionally interacts with Mini-chromosome Maintenance (MCM), stimulating the DNA helicase activity of MCM.
Links
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Statistics
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PSSM-Id: 239937
Aligned: 92 rows
Threshold Bit Score: 56.8625
Created: 11-Jul-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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generic bindinggeneric binding
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:generic binding surface I
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            ###                  #### #     ### #             #       ###           ###
1O7I_B       16 NVTVRVLEASEarqiq-tkngvRTISEAIVGDEtgRVKLTLWgkh---agsIKEGQVVKIEnAWTTAFk-----gQVQLN 86  Sulfolobus solfa...
YP_503960   184 SVEGEVTTIFPpr-------spSIAQSGIFADNsgTIRFTVWasan--aplLEQGHWYRLDlVESDEFn-----gQLSIK 249 Methanospirillum...
AAB85862     80 PVTGRVMKISSprtfttrkgreGKLANVIIADDtgELRAVFWtenikllkkFREGDVIRIKdVNIRGGfg----gRKEAH 155 Methanothermobac...
NP_248153   292 SVKGRVIAISNkksvd-ldgeiAKVQDIILDNGtgRVRVSFWrgktallenIKEGDLVRITnCRVKTFydregnkRTDLV 370 Methanocaldococc...
ZP_00609008 136 AVTGKISNMSGkeynk--agktFTIYNGFIEDDtsRVRISSFgk------pLENGKVYRIVgARVSEFn-----kQLEIS 202 Ferroplasma acid...
YP_024197   119 TVSGKVTNVTKren-----dktGTIYSGYIEDDtgRVRFSSFgv------pLENNRFYRIEgARVSMYs-----nRIEIT 182 Picrophilus torr...
NP_393867   121 SVIGKITGIHKkeyes--dgttKSVYQGYIEDDtaRIRISSFgk------qLQDSDVVRIDnARVAQFn-----gYLSLS 187 Thermoplasma aci...
NP_111704   121 SVIGRISGIKEknyds--drgsKIVYQGFIEDEtaKVRISSFgk------pLKDGEIVRVEnARVSQYn-----gYMGIS 187 Thermoplasma vol...
YP_503960   281 LVEGKVVAIEKqy-------sdQILQRGVFADDsgAVRFIIRnspg--aepLMENQWYAIKgAVVDRYrg---alSMQIN 348 Methanospirillum...
NP_069218    70 AVEGVVLRVFPvrhfs-kngrsGKVGSVVIQDDc-TVRVNFWnea---aeiIEAGDIVEGArIKVRGYa-----rGEEIH 139 Archaeoglobus fu...

Feature 1                 
1O7I_B       87 AGskTKIAEA 96  Sulfolobus solfataricus
YP_503960   250 IHsgTKITPI 259 Methanospirillum hungatei JF-1
AAB85862    156 LMprSTVEVL 165 Methanothermobacter thermautotrophicus str. Delta H
NP_248153   371 ATleTEVIKD 380 Methanocaldococcus jannaschii DSM 2661
ZP_00609008 203 IGdkTEVFIE 212 Ferroplasma acidarmanus Fer1
YP_024197   183 VSnkSVVKEI 192 Picrophilus torridus DSM 9790
NP_393867   188 VGdsSRIESV 197 Thermoplasma acidophilum DSM 1728
NP_111704   188 IGenSSIDNV 197 Thermoplasma volcanium GSS1
YP_503960   349 PGtaTPLLED 358 Methanospirillum hungatei JF-1
NP_069218   140 VNslSEVEVF 149 Archaeoglobus fulgidus DSM 4304

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