Conserved Protein Domain Family
EMP24_GP25L
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pfam01105: EMP24_GP25L 
emp24/gp25L/p24 family/GOLD
Members of this family are implicated in bringing cargo forward from the ER and binding to coat proteins by their cytoplasmic domains. This domain corresponds closely to the beta-strand rich GOLD domain described in. The GOLD domain is always found combined with lipid- or membrane-association domains.
Links
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Statistics
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PSSM-Id: 426051
Aligned: 208 rows
Threshold Bit Score: 39.9772
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CAM43991  40 ALTFHFVDsKPLCF--SETIenVKESQITGVYDWKasatsPASq-----------------------------VQLRLSV 88  Leishmania brazilie...
Q1EQ41    21 EIYFKIIGkTPKCFsiDEPV----GTLVHAHYKITtlnagKYGkvh-------------------------enIDLHYAL 71  Entamoeba histolytica
EDO07065  20 GFFFNIEYnDRRCF--YENV--PQMAMISVNYEML-----NQEa-----------------------------RACVVRI 61  Babesia bovis
Q4N8G5    19 SLYFLVPQnGERCF--FENV--PEKALLSVSYDLI-----SEEg-----------------------------KDCVLSI 60  Theileria parva
EDL43960  26 AAYFYVKEgVDKCF--VESV--ASNVVITSSYDNF-----GLKgkdafahnastriealrlkkkylpffliaeLKCHINI 96  malaria parasite P....
EAZ51577  17 AIYFYVQEgTEKCF--IQEV--PKSVPIHVKYENV-----NNLg-----------------------------IDCTVIF 58  Cryptosporidium par...
A0DPK0    17 ALTFYLTEgKQRCF--LDEY--TANTVVIGAHQLLdkvqpNGG-------------------------------GVELSV 61  Paramecium tetraurelia
A0BWM4    16 CISFYAKEgVEKCF--SDEI--PSQTIVVIYHELM-----SEGvaknekr----------------dipkmikDGITLNV 70  Paramecium tetraurelia
Q8IDZ5    22 EIYIKMKGkKLKCI--KERI--NKDTLVISKFKTN-----HKN------------------------------ALVSLYI 62  Plasmodium falcipar...
EDL44393  25 EVYVTVRPnKIKCL--KERI--NKDTLVVGKFKTD-----SKN------------------------------SPISIFI 65  malaria parasite P....

CAM43991  89 K-----DSTGN-----VYYDKAMMEgeh-----------sfAVQLNPnVLNGEQLICFTASSNfvas-ekdpVKVRIELD 146 Leishmania brazilie...
Q1EQ41    72 H-----FPQE------LHREDEDAQide-----------dgVVMFTT-KEVGEYQICFYVSNApr-----ydIEYKFTLN 123 Entamoeba histolytica
EDO07065  62 S-----DEEKK-----VLQNTNLKEatt-----------rgRVTYVA-KNEGTYYICIDCPGQlwyt--aqmAKIALSIE 117 Babesia bovis
Q4N8G5    61 S-----DNERR-----VLKNMKLDQdqahsmlyscllhcleRLSFVS-PSTGNYNICVHCPGRlwym--sqmCKISLNFE 127 Theileria parva
EDL43960  97 Kd---qQG--------RVVYSHDTSais-----------kgKVSYLT-KKNGLYYICISCPSSnwfk--staIKWSLSIE 151 malaria parasite P....
EAZ51577  59 Kn---tE--NI-----EVFSRHVNEndh-----------kgSVAYLP-EVDGDHKVCIRCDSSnwfk--seqMKWILSID 114 Cryptosporidium par...
A0DPK0    62 L-----DPDNQ-----VILTKMTNSde-------------gKFTFTT-KKQGRYQVCLKMSNSkgwfgdkkqPLYFLRIK 117 Paramecium tetraurelia
A0BWM4    71 Y-----GPDGN-----IVKTAKTVEgk-------------nKLSFTA-KTMGRYKFCVIKSKQfws---vneYKYSIKIQ 123 Paramecium tetraurelia
Q8IDZ5    63 YdvdvnEKNFHtqpklPIFETVNKHd--------------iKTAFTT-FYSSSYSFCAYNNSDk-------lIEVYFEIK 120 Plasmodium falcipar...
EDL44393  66 YdadvnERTFNfqkklPIFETINEHd--------------iKTAFTT-FYSTSYSFCAYNSTNk-------iLDVFFEIK 123 malaria parasite P....

CAM43991 147 QalkNefKARKEliktiqkrrqvdgldvytyqevggelkdilqpRAYLETIERELNAMEELLDQLVMGLTTSVTREFRMR 226 Leishmania brazilie...
Q1EQ41   124 L---EigIEAIDyen--------------------------lakTEQLNSIEIQFTQQIDLVKALQDEIKFQQEKHDEFE 174 Entamoeba histolytica
EDO07065 118 I------ADGNDiygrntqyd---------------vdrettakKDEMKNLSEEMRKFSINIINIKNHQRLENNTAKELH 176 Babesia bovis
Q4N8G5   128 I---AdvSSGGDssqydvn-------------------yettakKQQVESLTSHLHHFIASANVIQEYQISENRNSTKLY 185 Theileria parva
EDL43960 152 V---G--GSDVDien--------------------------vakKSELSETLSILLNLKKKFTSMKLQQIYQKQMATNLY 200 malaria parasite P....
EAZ51577 115 T---GniSEHLDvds--------------------------iasKDEANYVEEFINSLISKVNNQVSEGEYEFEKQEMFL 165 Cryptosporidium par...
A0DPK0   118 Q---GenQEFQSaa-----------------------------kESQITGLKQKIKSLQKQEDDFIKLQLMNRENEDKLS 165 Paramecium tetraurelia
A0BWM4   124 Q---GvdHNLQDaa-----------------------------nKTHVESIKDRISALKNRTDDFISLQQLNREQEDKLT 171 Paramecium tetraurelia
Q8IDZ5   121 Y---G--TEARDyaq--------------------------vakTEHLNQGTLYLKQILDQMNIFHVNLKRIRSDEDKEK 169 Plasmodium falcipar...
EDL44393 124 H---G--TEARDyaq--------------------------iakSEHLNEATMYLNQILDQMNNFHLNLKRIKASEENEK 172 malaria parasite P....

CAM43991 227 ETSESTFTRVWVCALLLIGIISGVLWMQFRFLKSTLR 263 Leishmania braziliensis MHOM/BR/75/M2904
Q1EQ41   175 AVTASTIFRVKLFAFIQIIIFALLAWWQYKNLKSFFR 211 Entamoeba histolytica
EDO07065 177 DTYKSMYNYLLYFYLLQLFIIAATALFSVYHITRFFK 213 Babesia bovis
Q4N8G5   186 DHYKSMNNWILVFYLLEILVVVLTSAFSVYHITRFFK 222 Theileria parva
EDL43960 201 EHNKSVHNKMFYCYILEIIILVAITVYSIVHLKNYFR 237 malaria parasite P. vivax
EAZ51577 166 KQALSVNKRIVIYSIIQLTLVSVISYFSIIHMRNFLR 202 Cryptosporidium parvum Iowa II
A0DPK0   166 IENIKINDNVFNATLIQIVVIIGAGVFQIYSLRKFFA 202 Paramecium tetraurelia
A0BWM4   172 TQSIDISRRVTQTTILQIVVLLASGVYQIWSLKKFFK 208 Paramecium tetraurelia
Q8IDZ5   170 KAHDKLNDTLMWFSFLNIIIIVIAAIVQDFYFKKFFT 206 Plasmodium falciparum 3D7
EDL44393 173 KSSDKLNDTLMWFSLMNILIIIVAAIIQDFYFKRFFT 209 malaria parasite P. vivax
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