Conserved Protein Domain Family
SAM1

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COG0499: SAM1 
S-adenosylhomocysteine hydrolase [Coenzyme transport and metabolism]
Statistics
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PSSM-Id: 440265
Aligned: 409 rows
Threshold Bit Score: 416.371
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_108717939  13 SGTLDVRVRDLALADSGRHQIRLAEHEMPGLMALRAELAESQPLAGARIAGSLHMTVQTAVLIETLTALGAQVRWASCNI 92 
EHR77168      13 DATETYTVRDMKLAEEGALRVDWARARMPVLAKLKEEAERTKPLAGMRVAGCLHVTKETAVLVEAIGAAGAEISWSGCNP 92 
BAJ50365       1 -MTEPFHVKDLSLAEKGASRIMLAESMMPVLSLLRRKYADEKPFEGYRVSMCLHVTKETAVLCRVLREGGAKVALCASNP 79 
ALI36439       1 ---MEYRIKDISLADKGKKKIEWAEANMPVLLSLKNKFKESKPLKDLVVGGCLHVTKETAVLTKTLAAAGATIAWSGCNP 77 
WP_012845168   3 YKEGAYKVRDLSLAEAGRKRIEWAESRMPVLMHLRERYSKTQPFKGYKIAGCLHVTKETAVLIETFKACGAEVAWSGCNP 82 
WP_013061672   3 HKEGHYKVRDLGLADEGRKRIEWAESRMPVLMELREEFADEKPFEGYKISGCLHVTKETAVLVETLQACGAEVAWSGCNP 82 
WP_013336214   1 ---MTYKVKDISLAEKGRLLIEWAERHMPVLMKIRERFTREKPLDGIRISASLHVTKETAVLVRTLVAGGATVTLVPSNP 77 
WP_014856049   3 FKEGKYKVRDIKLAAEGRKKIEWAESRMPVMMELREKYSKTKPLKGFKIAGCLHVTKETAVLVETLKAAGAKVSWSGCNP 82 
WP_020962545   1 ---MEYKVKDISLAPKGKLMVEWAEQHMPVLRHIRQKYSEEKPLKGIKIAACMHVTKETAVLMLTLRDAGAEVALSASNP 77 
WP_075056007   1 ---MEYRVKDLALAEEGKRRIDWAEAHMPVLVALRKKYSETKPLKGIRVAGCLHVTKETGVLVRTLKAAGAELSWCGCNP 77 
WP_108717939  93 FSTQDEAAAAVAVgrpedggtaeapRGVPVFAWKGESLAEYWACTDEILTwidpatgedVGPTLILDDGGDATMLVHEgv 172
EHR77168      93 LSTQDSVAAYLAR------------EGYSVHAWHGQSNEDFYWCIDRTLE---------FKPTLTLDDGADLIVRVHG-- 149
BAJ50365      80 LSTQDDVAAALAV------------EGFNVYAFRGMSTQEYYGALGKVLS---------HGPHLLVDDGADLITSLHR-- 136
ALI36439      78 LSTSDDIAASLVKd-----------EELSVFASRGVSTSEYYEDIYSVLK---------FNPDITIDDGADLTIEFHK-- 135
WP_012845168  83 LSTQDDIAAALAV------------AGVEIYAWHGQTVEEFYWSIERTLD---------RPPHLTLDDGADLIFTVHH-- 139
WP_013061672  83 LSTQDDIAAALAN------------GGTEIYAWHGLDTEDFYWCIERTID---------TPPHLTLDDGADLIFTVHS-- 139
WP_013336214  78 LSTQDEVAAALAE------------DGIYVYAWKGMNEREYYNAIGFAIS---------QEPVVTMDDGADLTVTLHKla 136
WP_014856049  83 LSTQDEIAAALAK------------SGIEIYAWHGQNVKEFYWSIEQTLK---------MKPNLTLDDGADLIFTVHN-- 139
WP_020962545  78 LSTQDPVAAYLAT------------EGISIFAWRGMKEDEYFEAIARAAS---------IGPNITMDDGGDLTVMIHKla 136
WP_075056007  78 LSTQDDVAASLVKh-----------DGVSVFASRGVSTKEYYDDIHSSMK---------LNPHITIDDGADLTVEMHK-- 135
WP_108717939 173 aaerrgavesdpqpgergysaerivfletlrrslaadpgRFTR-----IA----------------AGLRGVSEETTTGV 231
EHR77168     150 ---------------------------------------DKSE-----YA----------------EGVIGGTEETTTGV 169
BAJ50365     137 ---------------------------------------LIHG-----LPdvhledvrrgmdgadvPRVWGATEETTTGV 172
ALI36439     136 ---------------------------------------TFDK-----YG----------------KNIIGGTEETTTGV 155
WP_012845168 140 ---------------------------------------KRPD-----LA----------------QHIIGGSEETTTGV 159
WP_013061672 140 ---------------------------------------DHPE-----MA----------------DHIIGGSEETTTGV 159
WP_013336214 137 lgvksnev---------------------nyaletagdrDFAK-----LI----------------SSVYGGTEETTTGV 174
WP_014856049 140 ---------------------------------------KYPE-----LA----------------KNIVGGTEETTTGV 159
WP_020962545 137 hgitegi------------------------dyrigkefLSSD-----IA----------------KGIYGGTEETTTGV 171
WP_075056007 136 ---------------------------------------ALEQgrnggLA----------------GPLYGGTEETTTGV 160
WP_108717939 232 HRLAQLAERGELLFPAVNVNDSVTKSKFDNRYGIRHSLPDGLNRATDVLIGGKTAFVVGYGDVGKGAAEALRGQGA-RVI 310
EHR77168     170 HRLRAMGAAGDLRYPVIAVNDAVTKWDFDNVYGTGQSTIDGILRATSVLLAGKTFVVAGFGHCGSGVAMRARGMGA-NVI 248
BAJ50365     173 TRLRALDGEGLLAFPVIAVNDALSKSLFDNPLGTGQSALDGVLRATNLLLAGKTVVVAGYGRVGAGIAERAKGMGA-RVV 251
ALI36439     156 LRLKALEKTSKLSYPIVAVNDAETKHDFDNVYGTGQSALDGIIRATNVLIAGKSVVVAGYGHVGKGIASRARGLGA-SVI 234
WP_012845168 160 KRLRAMAADGKLLYPVFAVNDAETKWDFDNVYGTGQSTIDGILRATSVLLAGKNFVVAGYGHCGRGVAMRARGMGA-NVI 238
WP_013061672 160 HRLRAMDNDGELQYPVYAVNDAETKWDFDNVYGTGQSTIDGILRATSTMIAGKNFVIAGYGHCGRGVATRAKGMGA-NTI 238
WP_013336214 175 IRLRAMAREGTLRYPIIAVNDSYTKYLFDNRYGTGQSTWDGILRATNILVAGKVVVVAGYGWVGRGIAMRAKGLGArRVI 254
WP_014856049 160 HRLRAMAAAKKLLYPVIAVNDAETKWDFDNVYGTGQSSIDGILRATSVLLAGKNFVVAGYGHCGRGVAMRAAGMGA-NVI 238
WP_020962545 172 IRLKALEKDGKLLYPVIAVNDSKTKYMFDNRYGTGQSSLDGILRATNILFAGKNVVVAGYGWVGRGIAWRAKGLGA-RVL 250
WP_075056007 161 VRLRALQKSGRLLYPVIAVNDAETKHDFDNIYGTGQSALDGIIRATNVLLSGKNIVVAGYGHVGKGVAKRASGLGA-NVI 239
WP_108717939 311 VSEIDPICALQAAMDGFQVARLEEVVDRVDFVITTTGNVGVVTVDHIRAMKDKAVLGNIGHFDNEIDMAGLEAVPGvVRT 390
EHR77168     249 ITEVDPLPALRAVMEGYRVMTMDEAAKVGDIFCTATGMEDVIVGRHFESMKDGAIIANTGHYDCEIKITDLEELSS-SVR 327
BAJ50365     252 VVEPDPIKALQAYMNGFTVTSMSKASEIGDVFITATGNIDVIRGEHFEKMKDGVFLANAGHMDVEINKQDLKQLAV-SVE 330
ALI36439     235 VTEIDPINALKARMDGFIVATMDEAALIGDLFITSTGCKDVIVGSHIEKMKNGVILANAGHFNVEISIEEINGMAK-SSK 313
WP_012845168 239 VTEVKPTAALKAVLDGFRVMPMDEAAEIGDIFVTATGMKDVIRSRHFRKMKDGAIVCNTGHYDVELNLKELAELAV-RVR 317
WP_013061672 239 VTEVKPAKALKATLDGHQVMSMDEAAEKGDIFVTATGMKDVIRGRHFLKMKEGAIVANTGHYDVELNLEELAELST-DAR 317
WP_013336214 255 VTEVNPVRALEAVFDGFEVMPMSEAAEIGDIFITATGDINAITLDHILKMKDGAVLANAGHFNVEIDVAGLERVAA-EKR 333
WP_014856049 239 VTEVKPTAALKAALEGFRVMPMDEAAKIGDIFITATGVKDVIVSKHFKSMKDGAIVCNTGHYDCEINIPHLEKLKK-SKR 317
WP_020962545 251 VVEPDPIKALEAYYDGFYVSDMSTAAELGDVFITATGNRDVIRTEHFLKMKSGAILANAGHFNVEISVADLEKIAV-SKR 329
WP_075056007 240 VTEVDPIAALKAKLDGFAVATMNKAAEVGDVFITTTGCKDVIVADDIAKMKDGAILANAGHFNVEISIPDLEKQST-GTK 318
WP_108717939 391 EIKPQVHEWTLPAedeeigpdGvvrparpeRSVIVLSEGRLLNLGNATGHPSFVMSASFTNQVLAQLDLHAGAaylrprv 470
EHR77168     328 TIRPDNEEFLMPD--------G--------RRVFLLARGRLVNLAAAEGHPSEVMDMSFANQFLSLCRLAREG------- 384
BAJ50365     331 TIRENVTLYRLRN--------G--------RKLFLLADGRLVNLVCAEGHPSEVMDLSFSLQAESLRYLIKNV------- 387
ALI36439     314 HVNENVEQFVLKN--------D--------AKVNVIGEGRLVNLVAAEGHPSEVMDMSFANQFLSVINLVNNK------- 370
WP_012845168 318 EVRPNNKEYLLEN--------G--------RRIYVLADGRLVNLAAAEGHPSEVMDMSFANQFMAHLMLVEKHka----- 376
WP_013061672 318 EVRENNREYTMEN--------G--------KRVYVLGDGRLVNLAAAEGHPSEVMDMSFANQFRAHLDLVQRHes----- 376
WP_013336214 334 KIRDYVVEYRLPN--------G--------KRVYLLAEGRLVNLVAAEGHPSEVMDMSFSNQALAVEYIVKNR------- 390
WP_014856049 318 TVRPNNEEYTLKN--------G--------RRIYLLAQGRLVNLAAAEGHPSEVMDMSFANQFMSQLRLAEVKmk----- 376
WP_020962545 330 KINENVEEYLLPN--------N--------RRLYLIAEGRLVNLAAAEGHPSEVMDLSFGNQALAVKTLLKKH------- 386
WP_075056007 319 EINQHTMQYSLKN--------G--------SRVYLIGEGRLVNLAAAEGHPSEVMDMSFANQFLSVLKLAQSK------- 375
WP_108717939 471 adaeqdqegahdgelasngevrqegarEGTGFDVHRLPKALDEKVARLHLEALGVDLTELTKEQAEYLGVDVAGP 545
EHR77168     385 ---------------------------ASMDNAVYDITTEQDQDLATTKLETLGFSIDVLTDAQLAYLDDYTVGT 432
BAJ50365     388 ---------------------------EKLGKHVYTVPREIDEAVAALKLAAFGVELEKLTPRQLDYMRSWMAGT 435
ALI36439     371 ---------------------------GKFENKIYEIDRDQDLLIAGLKLEAMGIKIDKLSEVQNKYLSEYGEGT 418
WP_012845168 377 --------------------------gEKLPPQVIDLPEELDQEIARIKLETMGIRIDTLTDEQRAYATDYTAGT 425
WP_013061672 377 --------------------------dAMLEDKVYDIPQDMDDEIAEVKLRTMGIQIDALSEEQEHYATDYSAGT 425
WP_013336214 391 ---------------------------GKLQLGVHKLPDELDMEVARLKLETMGIRIDQLTEEQRRYISSWGLGT 438
WP_014856049 377 --------------------------gIKLEPDVIDIPEEQDQEIAMIKLKTMGYKIDKLTREQVKYINDYSAGT 425
WP_020962545 387 ---------------------------VSLRPKVYRLPGSIDRKIAYIKLKALGVKIEKLTPEQKKYLESWSS-- 432
WP_075056007 376 ---------------------------GTMKPIVYNIDKQQDQEIALAKLQSMGVDIDVLTPEQKAYLDGFAEGT 423
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