Conserved Protein Domain Family
Phospholip_B

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pfam04916: Phospholip_B (this model, PSSM-Id:428195 is obsolete and has been replaced by 461479)
Phospholipase B
Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.
Statistics
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PSSM-Id: 428195
Aligned: 17 rows
Threshold Bit Score: 508.033
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011270802  60 AYGTFEDGLMTTGW---------GVFEVKT---NSAFKDAEQLYAAGFLEGALTYNRIYDHYQNMFTYFFPN---ASDPS 124 Capsaspora owcz...
2_pfamImport   1 VRACFRDSILTNGW---------SQLELES---QSTYTDTVQAYAAGIMEGALTWHNIYMHWSNTIDAVCSKdeeSEEFC 68 
EDQ87028      54 ARASYFPGVNETGW---------ADLTVEAl--TGVCNSSEAAYAMGLLEGALSQPLIYDAFLNFEASNGYL---DKGHL 119 Monosiga brevic...
Q57ZQ0        68 AIVNVSNTFNKTGWdvvtavandGFMHLPGeaePSAERVLLAYKAVGFGEGYATYESMKASINNTFEGPEGL---SALLS 144 Trypanosoma brucei
Q9XWV2        53 ATAYFHDEVNQTGW---------AFLEVDVi--SPKIPHYLQGYAAGFAEGRATRHLIDLHIINTVNGYCDG---AKHFC 118 Caenorhabditis ...
EFX77541      57 AGAQFTNAINQTGW---------ANFEVWT---NGNFPDSVQSKAAGFLEGYLTHELIYFSYLNTLQDYCKG---RDGYC 121 common water flea
O62146        82 AVARWQNAVNTTGW---------TFLEVET---KENYCPQLQAYSAGYLEGLLSKTVLTYHLKNAQEDYCKN---FTGYC 146 Caenorhabditis ...
Q9BL07        73 ALGKYSNQVNTTGW---------GILEIET---FASHSYDVQAYGAGVAEGELTRLQIYYHYRNTIETMCNN---HTLFC 137 Caenorhabditis ...
EFA78500      63 AWCLYGNEMMTTGW---------GYISIQT---NGAYNDTQQASAAGYLEGYVSAEMIYQNWYNMYVNEYKK---S---V 124 Heterostelium a...
Q54ZI6        55 AWGYFKDEMNKDGW---------GKLSIET---VSTVSDNIAFKAAGYLEGYLTWEYIYKFSGNYFNSFFNT---SNIKE 119 Dictyostelium d...
XP_011270802 125 VQl-YRNWFNQQDAWTRRNVQL----NPqvsFWVQTGSILAQFDGLVAGYNAV-AASSRK--L--DVFAFQVLNGNGDIL 194 Capsaspora owcz...
2_pfamImport  69 DW--LRGLITTNVDTVKKMADMkgkhDY---YWYQIALFYDQLDGLEIGFRKGvKRSRMDyeI--PKQDFLLMNAAVDIR 141
EDQ87028     120 PSk-LQAFVDAQLKYISDQWSRnp-aDP---FWRQAGHLLAQARGVQDGYm---LTAPQQqqL--QPDQILILTLAGDLE 189 Monosiga brevic...
Q57ZQ0       145 DApqAQHWIEEHVRYMDAAKFEss------aFYTQLRNMLALIDGMVAGYNAR-APADER--L--DRMKLLMYNMQAEIG 213 Trypanosoma brucei
Q9XWV2       119 DE--LGEFMVDNLKWMEQEIREnp-eDE---YWQQVNLTVNQLFGLIHGYENQlGAEIDFkqI--AVHPIFMIQIAGDLE 190 Caenorhabditis ...
EFX77541     122 SK--LRTFLATNTKWVNKMYTKlrntSP---FWHQVGLFYEQMEGLAAGW--EkAAVNTGhsM--GTYGFMWFNIFGDME 192 common water flea
O62146       147 SR--LSDFLTENQKWIQSSLETvapdDL---YWGAVNRTYHQVSGLIDAY----EGREFKprItyELHPILYLNLNGDFY 217 Caenorhabditis ...
Q9BL07       138 KR--LYIYLQQNLDWMRSQVQAnpptDP---FWRQVNLTFAQLTGIYDAY----SKRNLTpeIgfDLHPIYMMQLAGDMF 208 Caenorhabditis ...
EFA78500     125 NDk-AIAWIDSNNRYMQQQVAEnl-dDP---YWQQVGLVMTQVASLFQGYND--ATTDPSqsL--EFYDILLMNMDGDMI 195 Heterostelium a...
Q54ZI6       120 IPteTLTFVSDNWEYMMERVNSssttDP---YWIQIRNAMSQQIGLYEGYNAA-AGEDYQ--K--TFIEIYMINLYGDMG 191 Dictyostelium d...
XP_011270802 195 DLMNVLqpstrpswnd--mtpqqaqleAS--------RRGHCSGFIKMLP---GFEDILISHSSWFTFTATNRIYKHYNF 261 Capsaspora owcz...
2_pfamImport 142 DLKIYYt-------------------nFLmensglkpEPAKGIMLLKLLQqpnGQSKVLLGHTSDGSYSSMLRMVKKYTL 202
EDQ87028     190 DLASALvd-----------------yvAPlhnefpdyEHMHCSGLVKLTI---SRDDLFTGHTTFNAYWCMLRIYKHYIV 249 Monosiga brevic...
Q57ZQ0       214 DIVRATspaevlddm--------------rqmmprwfVDTHCSAFVKVVK-----DDIYFGHATWSSFNTMLRQYKTYAF 274 Trypanosoma brucei
Q9XWV2       191 DLAMKFkkpen------------pkkvFS--------GPGHCSALVKLLP---KNEDILFSHVTWSSYGTMLRINKKYSF 247 Caenorhabditis ...
EFX77541     193 EFEQMFapqk-------------agkdWRlnkvgrrhMFASCSALIKVLP---DASDIYTSHVTWNGYESMIRILKKYNF 256 common water flea
O62146       218 DLEKKL---------------------NKtrdpafeqTGGKCSGLIKVAP---GNADLFISQVTMSGFQNMLRVIKLYKF 273 Caenorhabditis ...
Q9BL07       209 DLNKLL---------------------NKtadpmeypEGGRCSGFVKLAP---GNKDMFMAHVSMSSLSWMQRVLKIYKF 264 Caenorhabditis ...
EFA78500     196 DLAPALnisfdaataaalppkqhlenfMR--------KTGHCSSLIKLTD---DLTELYAGHTTWSSFYEMVRMFKIYTF 264 Heterostelium a...
Q54ZI6       192 DIVtltttpnnefi---pmdrkeveqlMA--------TTGHCTSIIKLTN---NCSDLMSAHTSWADFSVMIRIYKRINI 257 Dictyostelium d...
XP_011270802 262 Q-----------------L-NDQATA-AKRTSFSSYPAYLSSLDDFY-IMDSG---LVMIQTTNNVFNMSLY--DLVRPE 316 Capsaspora owcz...
2_pfamImport 203 RyhlsaetartvvsaqaaEdEDRAVVpGTNIVFTGYPGVLASLDDFYvISGRRqhrLVAAGVKMENEHVDLW--RKIDLV 280
EDQ87028     250 P-----------------------GVpGNVVSFSSRPGDLHSKDDYF-QTSAN---LTVIETSLTVFNKSLY--NTLQPN 300 Monosiga brevic...
Q57ZQ0       275 G--------------------------GRFVTMSSYPGLAHSVDDWY-MTHKR---LAVMETTNVIHNATLL--RNHVGS 322 Trypanosoma brucei
Q9XWV2       248 K----------------------TGDpGQIYSFSSYPASITSTDDFV-LTSAK---LAILETTIGNYNEKSL--DLITPN 299 Caenorhabditis ...
EFX77541     257 Evhr------------taA-EDSAVIpGHSMSFSSYPGLLYSGDDFS-VISSG---LVSMETTIGNNNVELF--KYIKPT 317 common water flea
O62146       274 G-------------------YDRQFYpGYASSFSSYPGLLYSSDDFA-LQTSG---LAVIETTISVFNTSLF--ENTKPV 328 Caenorhabditis ...
Q9BL07       265 G-------------------YDVNEVpGHIVTFSGYPGVLISTDDYT-ITSAG---LTSIETTIAIFNQTLYtdKFMKPE 321 Caenorhabditis ...
EFA78500     265 A-----------------F-SSSSLSrSATTMFSSYPASLSSIDDFY-LLDTG---LVVVETTNGMMNNNLY--YLVTPS 320 Heterostelium a...
Q54ZI6       258 P-----------------V-ASTPY--GSETLFSSYPGLLVSIDDFYqIRPSK---LHLTETLNTILNQTLY--QQINAQ 312 Dictyostelium d...
XP_011270802 317 -SLLAWQRV-------------RLANTMAHDG-REWSHIVAQfNSGTYNNQYMVVTLDQIKL-GQ--------------- 365 Capsaspora owcz...
2_pfamImport 281 rSVSLAPRV-------------MAANRLGHSG-RSWARYFAR-NPSTGVKQWLVIDMSRFVG-SNetevellatspasva 344
EDQ87028     301 -SVPCWMRSqlsltsstfgglpQIANRLATSS-DTWMEFFAReNSGTHNNQWIVSNYNLFTP-GT--------------- 362 Monosiga brevic...
Q57ZQ0       323 sSVATFLRA-------------MIANFIAVDA-PSWVSNFSReSSGAYNNQWMVLNMGAVESeAMf-------------- 374 Trypanosoma brucei
Q9XWV2       300 -TVLTWIRA-------------EIAHRTASSG-LQWAEAFGRhNSGTYNNEWVVVDYKQFHRgKE--------------- 349 Caenorhabditis ...
EFX77541     318 gQVLEGVRS-------------MVANRLASSGiKKWTEVFSRhNSGTYNNQWMIVDYKLFKP-FK--------------- 368 common water flea
O62146       329 gQLPTWIRA-------------IVSNQLARDA-REWCKLYSLyNSGTYNNQWAVLDYKKFKP-NQ--------------- 378 Caenorhabditis ...
Q9BL07       322 gQVHCWIRS-------------MISNLLSRTG-KQWVDMFGRyNSGTYNNQWTVLDWKQFTP-EK--------------- 371 Caenorhabditis ...
EFA78500     321 -SVLSWIRV-------------IIANRMASNG-ANWCTTFGReNSGTYNNQWIIVDYNKFES-GV--------------- 369 Heterostelium a...
Q54ZI6       313 -SFMYWVRN-------------LVANRLANNG-FQWVSIFVEnNSGTNNIQFVVLDYKLFTPyST--------------- 362 Dictyostelium d...
XP_011270802 366 ---------------------------------------------------------------------------AVLD- 369 Capsaspora owcz...
2_pfamImport 345 vdqsvedndiaaeggqdvvadgehqrivtkrmedyvdddfkehlsairqvrmvtipkapepvageelvvepsvghTFGS- 423
EDQ87028     363 ---------------------------------------------------------------------------DLPA- 366 Monosiga brevic...
Q57ZQ0       375 --------------------------------------------------------------------------kNMAP- 379 Trypanosoma brucei
Q9XWV2       350 ---------------------------------------------------------------------------VQPEt 354 Caenorhabditis ...
EFX77541     369 ---------------------------------------------------------------------------PLRD- 372 common water flea
O62146       379 ---------------------------------------------------------------------------PLPKn 383 Caenorhabditis ...
Q9BL07       372 ---------------------------------------------------------------------------ELPDk 376 Caenorhabditis ...
EFA78500     370 ---------------------------------------------------------------------------DAHD- 373 Heterostelium a...
Q54ZI6       363 ---------------------------------------------------------------------------ELQS- 366 Dictyostelium d...
XP_011270802 370 GALWVVEQIPGY-----VESADVTPIL-RAGYFSSFNVPFFERVFDMSGYPAMVAkygvsfthDLAPRAEIFRRDSNTVV 443 Capsaspora owcz...
2_pfamImport 424 GMFWVVDQLPGR-----LHAEDITDKIvSDGYWLTNGVPYFKEALDIGQATANAT--------NTTAPSSTMEKILQNIT 490
EDQ87028     367 HAVSMLEQMVAV-----IETSDLSAVInQEGYIASYNIPRSPVIFEISGYAAQgy------syENDTRARIFRRDQHTVT 435 Monosiga brevic...
Q57ZQ0       380 NTFWVLEQLPGTapplgITSKDMTSVLnTTGYWASYNRPYFPNVYNLSGTLKMQEeygdfysyKNYSRARIFERDQGSVV 459 Trypanosoma brucei
Q9XWV2       355 GIIHVVEQMPGH-----IVHSDKTAHLfRETYWPGYNQPYYKQIIRFSDTDKMVEkfgdwysyDKTPRALIFKRDHNTVT 429 Caenorhabditis ...
EFX77541     373 GLFWVLEQLPTL-----IESRDATDVLrSQSFWPSYNSPYFPTIFNLSGVPALVEeygdwftyDKTPRALIFNRDQSKIT 447 common water flea
O62146       384 GLFYVLEQMPGK-----IVYSDLTWFVeKYSYFPSYNIPFFKEITEISGFIGQAAkmgdwfkwGASPRAKIFERDHGNVH 458 Caenorhabditis ...
Q9BL07       377 DVLWISEQTPGY-----YETRDMTWYLkKYTYFASYNIPFLPKVSEISGFDNKARqfaw-fdwGGSPRARIFDRDHSKVT 450 Caenorhabditis ...
EFA78500     374 GMVYVLEQIPGY-----VEYDDVTNIV-RTGYWPSYNVPYFEYIYNVSGFNNT-QsygnffsySGNPRAMIFRRDANNVY 446 Heterostelium a...
Q54ZI6       367 DLLWIVEQYPGG-----YQAADVTLTLwEQGYWPSYNRPYFEEVFDILGYPYYVEkfgdlftyEYNPRANIFRRDHSKLE 441 Dictyostelium d...
XP_011270802 444 DFSSLKQLMRSNSYktdpysgg-----------------------spanavcsRYDLI----Angg-------------s 483 Capsaspora owcz...
2_pfamImport 491 DLETLARFFRQSAY---------------------------------------RGDLDqdepAa---------------- 515
EDQ87028     436 SLNSMSALLNANDYendplarg-----------------------dpcnqisaRCDLPkagnAsgn------------py 480 Monosiga brevic...
Q57ZQ0       460 DIESMKRLMRYNNYtkdpfslipnctgavgmdddgnvtnvckppysamlsiaaRGDLN----Ppgnateygplvrsvghv 535 Trypanosoma brucei
Q9XWV2       430 DMSSMIALMRSNNYtkdplskcdcn-----------------ppysaenaiacRSDLN----Plngtypf----kslgfr 484 Caenorhabditis ...
EFX77541     448 DMDSMIRMMRYNDYrndplsrcekce----------------pkysgenaisaRNDLN----Pangtypf----halshr 503 common water flea
O62146       459 DLDSLTALMRYNDYkndefskckcn-----------------ppysaeagisaRGDLN----Pangtyef----pgqghv 513 Caenorhabditis ...
Q9BL07       451 DIDSLTKLMRYNDYtheefarckctp----------------npytgeggisaRGDLN----Tpggtyev----esmgfr 506 Caenorhabditis ...
EFA78500     447 TFEQYQAELRYNNWehdplsag-----------------------nsgnaissRFDLV----Tksdpnnp-----ylnkd 494 Heterostelium a...
Q54ZI6       442 TLQDMMNIIDYNQYktdpfsmg-----------------------ypgnsinaRFDIKggslPsgnpiys-----wfyhg 493 Dictyostelium d...
XP_011270802 484 pDGCYDTKATNYARA----RLLQADALNGPTTA---------------------------------------NStlPAY- 519 Capsaspora owcz...
2_pfamImport 516 -FGNIDLKMYTETAD----GTVHFRAYSGPLYDparstpgqaakrsivkseqlhqstatdqksapashgdsaTVasHPF- 589
EDQ87028     481 aFGGIDCKVTGRAQV----LQQEARVAGAPSHA---------------------------------------IQ--PVFa 515 Monosiga brevic...
Q57ZQ0       536 nSGAIDAKIATWTGMvknpESYTAHVVCGPTTD---------------------------------------NQ--PPF- 573 Trypanosoma brucei
Q9XWV2       485 dHGAIDVKVTNSKLI----NSLQFTAVSGPPGGv--------------------------------------TKdvPIF- 521 Caenorhabditis ...
EFX77541     504 sHGATDCKVTSHQLM----TSLDFIAVGGPTFD---------------------------------------SL--PAF- 537 common water flea
O62146       514 nHGALDYKGTNVELM----KKLQFVAQGGPTWG---------------------------------------KV--PSF- 547 Caenorhabditis ...
Q9BL07       507 dHAGLDFKGTNYEMF----KKMRFRAWGGPPYD---------------------------------------PL--PVF- 540 Caenorhabditis ...
EFA78500     495 aFGGIDSKAVNHAMV----RNMQVAAQSGPTYD---------------------------------------QQ--PPF- 528 Heterostelium a...
Q54ZI6       494 tHGGIDGKAINYDMV----NSFTAVARNGPTVT---------------------------------------SDc-PPF- 528 Dictyostelium d...
XP_011270802 520 ---SWSA---FANlPHVGLPETYNFDFITV 543 Capsaspora owczarzaki ATCC 30864
2_pfamImport 590 ---DWSRilpFEV-RHQGHPDVWDFEHITP 615
EDQ87028     516 ftpEWSSv------AHAGMPTQLNFTFRQV 539 Monosiga brevicollis MX1
Q57ZQ0       574 ---QWVDgmfDPMpPTYGLLKLYNFSFVVM 600 Trypanosoma brucei
Q9XWV2       522 ---DWKTsplREKvPHFGQPDRWNFAPVTY 548 Caenorhabditis elegans
EFX77541     538 ---RWSEsdfVNL-SHIGHPDLWKFEPVQT 563 common water flea
O62146       548 ---KWSEfdfKDKvNHVGHPDEWKFNTLVH 574 Caenorhabditis elegans
Q9BL07       541 ---DWNHtnlTNV-RHFGQPDVWNFTYVDL 566 Caenorhabditis elegans
EFA78500     529 ---NWKQgd--wTyTHVGMPEIWQFPWMIM 553 Heterostelium album PN500
Q54ZI6       529 ---NWND---WSLiSHQYMPQIYNFTWISI 552 Dictyostelium discoideum
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