1QWJ,1QWJ,1EZI


Conserved Protein Domain Family
CMP-NeuAc_Synthase
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cd02513: CMP-NeuAc_Synthase 
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CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety.
CMP-N-acetylneuraminic acid synthetase (CMP-NeuAc synthetase) or acylneuraminate cytidylyltransferase catalyzes the transfer the CMP moiety of CTP to the anomeric hydroxyl group of NeuAc in the presence of Mg++. It is the second to last step in the sialylation of the oligosaccharide component of glycoconjugates by providing the activated sugar-nucleotide cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), the substrate for sialyltransferases. Eukaryotic CMP-NeuAc synthetases are predominantly located in the nucleus. The activated CMP-Neu5Ac diffuses from the nucleus into the cytoplasm.
Links
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Statistics
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PSSM-Id: 133006
Aligned: 113 rows
Threshold Bit Score: 157.7
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ligand bindingtetramer
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ###   #     #                                                       #   # 
1QWJ_D         3 HLAALVLARGGSKGIPLKNIKRLA-GVPLIGWVLRAALDAgvfQSVWVSTDHDEIENVAKQFGa------QVHRRSSETS 75  house mouse
YP_411107      2 RWVAFAPLHGNFGPVSRSSARSMA-GRPLFSWSLEQAVISgcfDTIYVTADPPVIRKRIVEEFsradtiiEILDCSGATR 80  Nitrosospira mu...
ZP_00950410    3 KSVGFIPLRKGSKGIPGKNKKDLA-GKPLYQWVLDEAIQSn-lDEVFVFTDDEGIFNDVSQNYast--kvKALPRSQKSA 78  Croceibacter at...
EAT34937      37 SVIALILARGGSRGIPLKNLAKLDdRQTLLSRALHTALSTdgfHSVWVSTEDDRIAQAVERDFphd--lvRVHLRPPEVA 114 yellow fever mo...
CAK18995      13 HFACLILARGGSKGIKLKNIKALA-GQPLIAWVLRAAIDSgefDSVWVSTDHADIARISKEWGa------QVHMRSPHTA 85  purple urchin
YP_101321      3 RTFCFVPVRKGSRGIPGKNLRLLG-DKPLVCWIIDTVLASgiaDEICVATNCDEMESLIRGRYke---ivQIFRRSEWSA 78  Bacteroides fra...
CAK18994      10 HLAALILARGGSKGIPMKNIVNVG-GLPLICWVLRAAVDSnafDSIWVSTDSDEVAEVASSYEv-----vKIHRRSDEVS 83  Ciona intestinalis
NP_001025322  30 HISALILARGGSKGIPLKNIKMLA-GVPLIGWVIRAAVDSnvfNSVWVSTDHEEIAKVALAWGa------KVHKRSPEVS 102 zebrafish
XP_416429     11 HLAALVLARGGSKGIPLKNIKLLA-GVPLIGWVLRAAIDAgvfHSVWVSTDHDEIEKVAKQFGa------QVHRRSPEVS 83  chicken
NP_001090750   9 HLCALVLARGGSKGIPLKNIKDLA-GRPLIGWVLRAARDCggfDSVWVSTDSDDIEKVAREYGa------QVHRRSPEVS 81  western clawed ...

Feature 1                #                      # #                                              
1QWJ_D        76 KDss---tSLDAIVEFLNYHne--vdIVGNIQATSPCLHPTDLQKVAEMIReegyDSVFSVVRRHqfrwseiqkgvre-v 149 house mouse
YP_411107     81 TGvenwtsLLHTFQQKIPFD------VVCSIQAASPLTRAEDFRAAKRKFLsenlDSLLTAAPSRrflwtrmgepv---- 150 Nitrosospira mu...
ZP_00950410   79 SDta---sTEFAMIEFAKQIeyd-fdIICLLQATSPLTTTKDINAALVKMEnveiDSLVSVVRTHrfiwnedgtp----- 149 Croceibacter at...
EAT34937     115 QDht---sSIESVREFLDHHpr--vqNVALVQCTSPFLGVRYLDEALQRFQslrvDCVFSVTRSFklrwrkekdgrv--- 186 yellow fever mo...
CAK18995      86 RDqa---tSIEAMQEFLKEHpe--vkFVANVQCTSPCLHPSHLQRTCHMIRnlgyDSVFAVNRRHlfrwtetpidqav-s 159 purple urchin
YP_101321     79 RDea---sSLEVVQEYLNYRkpdrndDFILLQATSPFTTAQELRGLVEEMKrgeaDSYVACCRLKkfrwsdegrp----- 150 Bacteroides fra...
CAK18994      84 KDnt---sSMESTQEFLNYHpe--idAIGLLQATTPCIQPSQLLSAAEMIKfggfDSVFSVVRRHffrwkevkqgkdgdv 158 Ciona intestinalis
NP_001025322 103 QDss---sSLDTIREFSRQHre--vdVICNIQATSPCLHPKHLTEAVELITkqgyDSVFSVVRRHnfrwkevekggdc-s 176 zebrafish
XP_416429     84 QDss---tSLETIREFLNHHhe--vdIVGNIQATSPCLHPSDLIKVANLIQkegfDSVFSVVRRHqfrwsevkkgenk-m 157 chicken
NP_001090750  82 KDtt---sSLDTVMEFMEHHpe--vdIVANIQATSPCLHPETLKKVIEMMCrdgyDSVFSVVRHHlfrwtdvskaggl-- 154 western clawed ...

Feature 1                              #    #                               #            
1QWJ_D       150 teplnlnpakrpRRQDWDGELYENgSFYFAKRH-LIEMGylqgGKMAYYEMRaeHSVDIDvdIDWPIAEQRV 220 house mouse
YP_411107    151 -ghdplksrascDASNPEGYLLENgAFYLTHEKlLRDNDhylgGRMGIHEMApeTAIEITgeAGWNIVERLL 221 Nitrosospira multiformi...
ZP_00950410  150 ---qnydiynrpRRQDFNGLLIENgAIYCTTQStLKSFSnrlgGNIELLEMKeeSLMEIDsiTDWKIIEQLL 218 Croceibacter atlanticus...
EAT34937     187 -nalnfdprkrpRRQDWDGELVEAgMFYFARRKlLLEGRfq-nNNCEVVVIDerDSLEIDslYDLELARKII 256 yellow fever mosquito
CAK18995     160 tkaenldpakrpRRQDWAGELYENgSFYFATRE-LLMAGlfqgGKVGYCEMQpeYSVDIDtdIDWPIAEQRV 230 purple urchin
YP_101321    151 ---ldysfetkpRRQEYKGFLIESgAFYASTVGrILDSGqllsGVVKVVEVGpaGMIDIDeeADWGLAEHYI 219 Bacteroides fragilis YCH46
CAK18994     159 thplnfdpshrpRRQDWAGELCENgGFYFAKTS-VVRQGlfqgGRTGYQEMPheHSVDIDtpFDLVVADYVI 229 Ciona intestinalis
NP_001025322 177 tepmnlnpacrpRRQDWSGELCENgSFYFAKKE-LIEQGllqgGKKTYYEMKpeYSVDIDvdIDWPVAEQRV 247 zebrafish
XP_416429    158 tepqnlnpakryRRQDWPGELYENgSFYFAKRH-LIEKGylqgGKMAYYEMRaeHSVDIDidIDWPIAEQRV 228 chicken
NP_001090750 155 tkplnfnpdrrpRRQDWDGELYENgSFYFATKE-LLSQGklqgGKIAYYEMKpeHSVDIDvdIDWPIAEQRV 225 western clawed frog

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