4G36,2D1Q,2D1S,4M46,5KYT


Conserved Protein Domain Family
Firefly_Luc

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cd17642: Firefly_Luc 
Click on image for an interactive view with Cn3D
insect luciferase, similar to plant 4-coumarate: CoA ligases
This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.
Statistics
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PSSM-Id: 341297
Aligned: 7 rows
Threshold Bit Score: 896.887
Created: 27-Jan-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
AMP bindingacyl-activating
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:AMP binding site [chemical binding site]
Evidence:
  • Structure:2D1Q; Luciola cruciata luciferase binds AMP, contacts at 4A.
    View structure with Cn3D
  • Citation:PMID 8805533
  • Structure:2D1S; Luciola cruciata luciferase binds 50-O-[N-(dehydroluciferyl)-sulfamoyl adenosine (DLSA), contacts at 4A.
    View structure with Cn3D
  • Comment:luciferyl adenylate releases AMP
  • Comment:Luciferase produces light in the presence of MgATP, molecular oxygen and luciferin

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
4G36_A     12 IKKGPAPfYPLEDgtAGEQLHKAMKRYAlvpgtIAFTDAhieVNITYAEYFEMSVRLAEAMKryglntnHRIVVCSENSL 91  common eastern fir...
2D1Q_A     10 IVVGPKPfYPIEEgsAGTQLRKYMERYAkl-gaIAFTNAvtgVDYSYAEYLEKSXXLGKALQnyglvvdGRIALCSENCE 88  Japanese firefly
2D1S_A     10 IVVGPKPfYPIEEgsAGTQLRKYMERYAkl-gaIAFTNAvtgVDYSYAEYLEKSCXLGKALQnyglvvdGRIALCSENCE 88  Japanese firefly
Q27757      6 ILYGPEPfHPLADgtAGEQMFYALSRYAdisgcIALTNAhtkENVLYEEFLKLSCRLAESFKkyglkqnDTIAVCSENGL 85  Pennsylania firefly
NP_651221   9 NIVYGGPvTERQAqdSRSLGQYILDKYKsfgdrTVLVDAvngVEYSASFMHKSIVRLAYILQklgvkqnDVVGLSSENSV 88  fruit fly
4M46_A     41 IMHGPPPfYPLEDgtAGEQLHKAMKRYAqvpgtIAFTDAhaeVNITYSEYFEMACRLAETMKryglglqHHIAVCSENSL 120 Iranian firefly
5KYT_A      7 IKKGPAPfYPLEDgtAGEQLHKAMKRYAlvpgtIAFTDAhieVNITYAEYFEMSVRLAEAMKryglntnHRIVVCSENSL 86  common eastern fir...
Feature 1                                                                                     
4G36_A     92 QFFMPVLGALFIGVAVAPANDIYneRELLNSMNISQPTVVFVSKkgLQKILNVQKklpiiqKIIIMDs-------kTDYQ 164 common eastern fir...
2D1Q_A     89 EFFIPVIAGLFIGVGVAPTNEIYtlRELVHSLGISKPTIVFSSKkgLDKVITVQKtvttikTIVILDs-------kVDYR 161 Japanese firefly
2D1S_A     89 EFFIPVIAGLFIGVGVAPTNEIYtlRELVHSLGISKPTIVFSSKkgLDKVITVQKtvttikTIVILDs-------kVDYR 161 Japanese firefly
Q27757     86 QFFLPLIASLYLGIIAAPVSDKYieRELIHSLGIVKPRIIFCSKntFQKVLNVKSklkyveTIIILDl-------nEDLG 158 Pennsylania firefly
NP_651221  89 NFALAMFAGLAVGATVAPLNVTYsdREVDHAINLSKPKIIFASKitIDRVAKVASknkfvkGIIALSgtskkfkniYDLK 168 fruit fly
4M46_A    121 QFFMPVCGALFIGVGVAPTNDIYneRELYNSLSISQPTIVFCSKraLQKILGVQKklpiiqKIVILDs-------rEDYM 193 Iranian firefly
5KYT_A     87 QFFMPVLGALFIGVAVAPANDIYneRELLNSMNISQPTVVFVSKkgLQKILNVQKklpiiqKIIIMDs-------kTDYQ 159 common eastern fir...
Feature 1                                                                                     
4G36_A    165 GfQSMYTFVTSHlppgfneydFVPESFDrdkTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDpifgnqiipdTAILS 244 common eastern fir...
2D1Q_A    162 GyQCLDTFIKRNtppgfqassFKTVEVDrkeQVALIMNSSGSTGLPKGVQLTHENIVTRFSHARDpiygnqvspgTAVLT 241 Japanese firefly
2D1S_A    162 GyQCLDTFIKRNtppgfqassFKTVEVDrkeQVALIMNSSGSTGLPKGVQLTHENIVTRFSHARDpiygnqvspgTAVLT 241 Japanese firefly
Q27757    159 GyQCLNNFISQNsdinldvkkFKPNSFNrddQVALVMFSSGTTGVSKGVMLTHKNIVARFSHCKDptfgnainptTAILT 238 Pennsylania firefly
NP_651221 169 ElMEDEKFKTQPd--------FTSPAANkdeDVSLIVCSSGTTGLPKGVQLTQMNLLATLDSQIQptvi--pmeeVTLLT 238 fruit fly
4M46_A    194 GkQSMYSFIESHlpagfneydYIPDSFDretATALIMNSSGSTGLPKGVELTHKNICVRFSHCRDpvfgnqiipdTAILT 273 Iranian firefly
5KYT_A    160 GfQSMYTFVTSHlppgfneydFVPESFDrdkTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDpifgnqiipdTAILS 239 common eastern fir...
Feature 1          #                                                                      ### 
4G36_A    245 VVPFHHGFGMFTTLGYLICGFRVVLMYRFeeelFLRSLQDYKIQSALLVPTLFSFFAKSTLidkyDLSNLHEIASGGAPL 324 common eastern fir...
2D1Q_A    242 VVPFHHGFGMFTTLGYLICGFRVVMLTKFdeetFLKTLQDYKCTSVILVPTLFAILNKSELlnkyDLSNLVEIASGGAPL 321 Japanese firefly
2D1S_A    242 VVPFHHGFGMFTTLGYLICGFRVVMLTKFdeetFLKTLQDYKCTSVILVPTLFAILNKSELlnkyDLSNLVEIASGGAPL 321 Japanese firefly
Q27757    239 VIPFHHGFGMTTTLGYFTCGFRVALMHTFeeklFLQSLQDYKVESTLLVPTLMAFFPKSALvekyDLSHLKEIASGGAPL 318 Pennsylania firefly
NP_651221 239 VIPWFHAFGCLTLITTACVGARLVYLPKFeeklFLSAIEKYRVMMAFMVPPLMVFLAKHPIvdkyDLSSLMVLLCGAAPL 318 fruit fly
4M46_A    274 VIPFHHGFGMFTTLGYLTCGFRIVLMYRFeeelFLRSLQDYKIQSALLVPTLFSFFAKSTLvdkyDLSNLHEIASGGAPL 353 Iranian firefly
5KYT_A    240 VVPFHHGFGMFTTLGYLICGFRVVLMYRFeeelFLRSLQDYKIQTALLVPTLFSFFAKSTLidkyDLSNLHEIASGGAPL 319 common eastern fir...
Feature 1                        #####                                                        
4G36_A    325 SKEVGEAVAkrfhlpGIRQGYGLTETTSaILITPEGddkpgAVGKVVPfFEAKVVDldtgktlgvnqRGELCVRGPMIMS 404 common eastern fir...
2D1Q_A    322 SKEVGEAVArrfnlpGVRQGYGLTETTSaIIITPEGddkpgASGKVVPlFKAKVIDldtkkslgpnrRGEVCVKGPMLMK 401 Japanese firefly
2D1S_A    322 SKEVGEAVArrfnlpGVRQGYGLTETTSaIIITPEGddkpgASGKVVPlFKAKVIDldtkkslgpnrRGEVCVKGPMLMK 401 Japanese firefly
Q27757    319 SKEIGEMVKkrfklnFVRQGYGLTETTSaVLITPDTdvrpgSTGKIVPfHAVKVVDpttgkilgpneTGELYFKGDMIMK 398 Pennsylania firefly
NP_651221 319 SRETEDQIKerigvpFIRQGYGLSESTLsVLVQNDEfckpgSVGVLKVgIYAKVIDpdtgkllganeRGELCFKGDGIMK 398 fruit fly
4M46_A    354 AKEVGEAVAkrfklpGIRQGYGLTETTSaIIITPEGddkpgACGKVVPfFSAKIVDldtgktlgvnqRGELCVKGPMIMK 433 Iranian firefly
5KYT_A    320 SKEVGEAVAkrfhlpGIRQGYGLTETTSaILITPEGddkpgAVGKVVPfFEAKVVDldtgktlgvnqRGELCVRGPMIMS 399 common eastern fir...
Feature 1                           #           #  # # # #    #                               
4G36_A    405 GYVNNPEAtnalidkdGWLHSGDIAYWdedEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPniFDAGVAGLPdddagE 484 common eastern fir...
2D1Q_A    402 GYVNNPEAtkelideeGWLHTGDIGYYdeeKHFFIVDRLKSLIKYKGYQVPPAELESVLLQHPsiFDAGVAGVPdpvagE 481 Japanese firefly
2D1S_A    402 GYVNNPEAtkelideeGWLHTGDIGYYdeeKHFFIVDRLKSLIKYKGYQVPPAELESVLLQHPsiFDAGVAGVPdpvagE 481 Japanese firefly
Q27757    399 SYYNNEEAtkaiinkdGWLRSGDIAYYdndGHFYIVDRLKSLIKYKGYQVAPAEIEGILLQHPyiVDAGVTGIPdeaagE 478 Pennsylania firefly
NP_651221 399 GYIGDTKStqta-ikdGWLHTGDIGYYdddFEFFIVDRIKELIKYKGYQVPPAEIEALLLTNDkiKDAAVIGKPdeeagE 477 fruit fly
4M46_A    434 GYVNNPEAtsalidkdGWLHSGDIAYYdkdGHFFIVDRLKSLIKYKGYQVPPAELESILLQHPfiFDAGVAGIPdpdagE 513 Iranian firefly
5KYT_A    400 GYVNNPEAtnalidkdGWLHSGDIAYWdedEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPniFDAGVAGLPdddagE 479 common eastern fir...
Feature 1                                                                
4G36_A    485 LPAAVVVLehgktmTEKEIVDYVASQVttAKKLRGGVVFVDEVPKGLTGKLDaRKIREI 543 common eastern firefly
2D1Q_A    482 LPGAVVVLesgknmTEKEVMDYVASQVsnAKRLRGGVRFVDEVPKGLTGKIDgRAIREI 540 Japanese firefly
2D1S_A    482 LPGAVVVLesgknmTEKEVMDYVASQVsnAKRLRGGVRFVDEVPKGLTGKIDgRAIREI 540 Japanese firefly
Q27757    479 LPAAGVVVqtgkylNEQIVQNFVSSQVstAKWLRGGVKFLDEIPKGSTGKIDrKVLRQM 537 Pennsylania firefly
NP_651221 478 LPLAFVVKqanvqlTENEVIQFVNDNAspAKRLRGGVIFVDEIPKNPSGKILrRILREM 536 fruit fly
4M46_A    514 LPAAVVVLeegktmTEQEVMDYVAGQVtaSKRLRGGVKFVDEVPKGLTGKIDaRKIREI 572 Iranian firefly
5KYT_A    480 LPAAVVVLehgktmTEKEIVDYVASQVttAKKLRGGVVFVDEVPKGLTGKLDaRKIREI 538 common eastern firefly

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