Conserved Protein Domain Family
AFD_class_I

?
cl17068: AFD_class_I Superfamily 
Adenylate forming domain, Class I superfamily
This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Statistics
?
Accession: cl17068
PSSM Id: 473059
Name: AFD_class_I
Created: 13-Sep-2012
Updated: 4-Oct-2023
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap