1XCR


Conserved Protein Domain Family
DUF1907
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cd17298: DUF1907 
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proteins similar to putative ester hydrolase C11orf54/PTD012
The structure of this domain displays an alpha-beta-beta-alpha four layer topology, with an HxHxxxxxxxxxH motif (x could be any residue) that coordinates a zinc ion, and an acetate anion at a site that may support the enzymatic activity of a ester. In vitro hydrolytic activity towards para-nitrophenylacetate for the human enzyme was reported. The proteins are homologous to bacterial alpha-acetolactate decarboxylase (AldB, E.C. 4.1.1.5), which converts acetolactate into acetoin.
Links
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Statistics
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PSSM-Id: 341210
Aligned: 86 rows
Threshold Bit Score: 324.058
Created: 20-Mar-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteputative active
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H HClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1XCR_A        15 EELAGVMQKGLKDNFADVQVSVVDCPDLTKEPFTFpvkGICGKTRIAEVGGVPYLLPLv-nQKKVYDLNKIAKEIk--lP 91  human
XP_018393423  28 SEIAAVLQNGMEPLFDFLKVDVASCPCLTREPYNLvgvGLCGNTAIVEFPGSTENIPW---NERTRDIKSVLSASc---Q 101 Cyphomyrmex cos...
XP_016657413  28 DRIIEALLPELSNNFETVSVDAVQCPNLTCSPFNLaaeGLNGDEMVIDIGSPSFLLPLv-nLNKVYDIRDFAKVTg--tD 104 pea aphid
AAX27376      11 HEVSAALESHLKDCFESVKCSITDCPDLSDTPFCLtlkGLCGKGTICDVGSFDYLLPVp-kTDRHYDLLDVFKSAg--iT 87  Schistosoma jap...
NP_001232953  30 RCIIEAILPELLDNFENASVEVVQCPDLTQPPFNLtseGLCGDENVFDIGDVTNLLPSl-kREKLYNVKDLKQITg--sD 106 pea aphid
XP_009170222 157 CPGLGNLTGFMSGCFSKVACQVVDCPNLKDPAYALnsaGLCGSETLCDIGSFDYLLPVp-nKEKRYDLLDAFSLSh--vG 233 Opisthorchis vi...
EUB61511      49 EELAEVLREGLKDCFRSVKVNVVPCPDLTASPFGLlrpGLAGKSVVCDVGSMTYLLPVa-nTSKRYSFGQVIESSg--vC 125 Echinococcus gr...
EFN73155      10 EKLAEYLQVEFNKFYNEATVKVVNCPDLRKAPFHLvapGLCGNTALLEVGSLSNLFPFp-rMEKKYDFISFLETSgrsnD 88  Florida carpent...
KYN38686      16 TELAIVLQNELSTDFEEVKVEWVDCPDLTQEPFNLaapGLCGDTALLDIGGIWNLFPFp-iKDKIIYFQSILEKLdrtqS 94  Trachymyrmex se...
XP_011695697  20 SQIAQVLQDGMAKKFREVKVDIAACPCLTRQPYNLagvGLSGNPSLLEIGGHANFVSNydyDTPTWKVQNMLASGf---F 96  little fire ant

Feature 1                                                                                        
1XCR_A        92 GAFILGAGAGPfqtlGFNSEFMPVIQteseh---kppvNGSYFAHVNPa--dGGCLLEKYsekchdfqCALLANLFASEG 166 human
XP_018393423 102 DSFIIGSSYATkpqmPYFGHLIMNAKyrap----enftNASRIIFTRTd--nGQRRIETLihpn-qmtYANHGSFFLSEG 174 Cyphomyrmex cos...
XP_016657413 105 PLFVIGAGAGPwphvGVNCEFIGNVRltsdd--svnnnNSSHLYKVDPq--tGSQVHHRLpqd--etrFALLANFYTSRG 178 pea aphid
AAX27376      88 VGAVIGAGAGPffltGSNSEMVINISseng----kvskNSSLLGSYDKe--nNKPLITKAdn----tkFALLGQMYMCEG 157 Schistosoma jap...
NP_001232953 107 PLFIIGACAGPypffGADSECVENVKmtgd-----rveNGTHVHMTKSdd-vPECFHKSLpdd--emrFSMMANFFTSNG 178 pea aphid
XP_009170222 234 SGFIMGAAAGPhfvaGINSELVANLSatdg----kvlqNGSYCGSYDAk---NNLPVSTLset---slFAMVGQMFLCEG 303 Opisthorchis vi...
EUB61511     126 GGQLLGAGGGPffthGKSCEMAASLQfang----kiasNSTLHGVYDEq--tGTPQVINAtd----nnFGLVGQLLSSEG 195 Echinococcus gr...
EFN73155      89 DNFIIGASLYPss-nGHMGELIMNASfspldeegmrvkNRSYVAFLAQdhtgENVKLDILndyn-rvkCFLHGNFFISEG 166 Florida carpent...
KYN38686      95 DNLIIGGGLRTerptNLLGELIMNVLispaanetmtvkNKSRFALIKLiqnrKHFSLKFVtdp--npyCNIYGNFFISKG 172 Trachymyrmex se...
XP_011695697  97 DSFIFGSGYAAkpnmPYNGHLIINATyrap----snftNASRIVFAEAs--nGQKRIEMLtdpn-qmlCSYMGSFFISDG 169 little fire ant

Feature 1                                                                                        
1XCR_A       167 qpGKVIEVKAKRRTGp-lNFVTCMRETLEKHYgn---kPIGMGGTFIIQKGKVKSHIMPAEfssc---plnSDEEVNKWL 239 human
XP_018393423 175 rtGNVIRMRARGRRMtnmDIITLMQKILSEYTgr--ntTEFFGGVLRMRYGQVACNVMCDEypgr--ilsfNNFFLQQQC 250 Cyphomyrmex cos...
XP_016657413 179 mtGEVLKIVCETRNGp-lDFVTSIRKALAKYFgd---kPVGLGGVILIETSKVKVHVMPDFski----pldSEADLNNWL 250 pea aphid
AAX27376     158 ksGPVIELCVSGRIRd-gKLDAMIREALHKKYghl-ssSVGLGGVIIQEKGKSLYHVLPEFsqe----pidSNEKLRNWI 231 Schistosoma jap...
NP_001232953 179 fkGEVLKIVCEVRKGp-lSYSTCIKEALVKHFgn---eIIALGGVILIENGKVKVHVIKPSltki---pikSEKELGNLL 251 pea aphid
XP_009170222 304 kpGKVIQLTVSGRTRe-gKFDALLREALASKYgal-drPVGVGGVVVQETGKCLFHVLPEFcee----pldTPEKLKQWL 377 Opisthorchis vi...
EUB61511     196 lpGSVVEVDVAGRLKe-gSVYVFLREVLTAAYgkl-dkPVALGGVFVLTDSKARFHVLPNFppy----pvdTPARRAEFI 269 Echinococcus gr...
EFN73155     167 kpGRVLEIHAKARREd-kELTKVIQHTLQKYYeat-stLVGLGGTFVVHNGLVRHHLMPDIgqisl-encsDESRIRNWV 243 Florida carpent...
KYN38686     173 lrEQVLKIHVKHRTGr--DFIVSLQHAIKRFSkc--sqLMGFGGTFIIKNGKTIQHIIRNYwev----pirKKKDIHNCI 244 Trachymyrmex se...
XP_011695697 170 rpGLVLRVRAKDRIStdlDIITIMQNSLYEHFgvnekhPIVLGGVLRMWNGRAVYSLMSEEypqrnnqiheFSDFNNKWF 249 little fire ant

Feature 1                                                 # #          #                         
1XCR_A       240 HFYEMKa--PLVCLPVFVSRDpg------------fDLRLEHTHFFSRh-GEGGHYHYDTTPd--iVEYLGYFLPAEFLY 302 human
XP_018393423 251 IEITLEs--DLIAVGVIFNNIplpladq-eqryginLYNRSEFHCFSNy-GAGGQFISDTTPn--tTEYEGYFNVAKKLI 324 Cyphomyrmex cos...
XP_016657413 251 KFFEVSt--PLVALGYLVSHDpg------------lDLRPQHFHLFGNh-GEGGHYHHDTEPt--tVKYTAYLNVAKKLI 313 pea aphid
AAX27376     232 KMFEMEs--PVISVGIVVSHDph-----------hlGLRLEHFHCFNQdhTNCGHCHFDTHGp--sVSYRAYFALAEHLV 296 Schistosoma jap...
NP_001232953 252 HFIELSp--PLVGVGCIVSHDpg------------lNLRLQHFHLYTDh-NQGGHYYNDTEPe--tIKYTGYFGVSKQFT 314 pea aphid
XP_009170222 378 KFFEMEa--PVVAVGTALSHDpq-----------kwKIRLEHFHCFNRdrTKSGHCHFDSDGp--tASYTAYLVPGKRLL 442 Opisthorchis vi...
EUB61511     270 KIFEMDp--PVLGMGTLVSHDpy-----------giDLKLEHFHCYNEakTLAGHFYWDTDPe--kAHYRLYLTVAKSLL 334 Echinococcus gr...
EFN73155     244 KTRILTt--PLVAVGTIVNKSsfpvvltnsklqtdlQLTTNHFHSFSFepLVGGHYYTNVEYgn-sAEYLGYFCPAKKLY 320 Florida carpent...
KYN38686     245 KYLKIQn-sPIVAFATFVSSDrhkvms----lkkfqDVYLNQWHVHANs-NDSGGYYHETVPnntnTEYLGYFSPATKLY 318 Trachymyrmex se...
XP_011695697 250 QYHEMKlktEVAAVGILTNRKpdlmyte-qryslplWKRRNQFHFISDy-AASGEFIGDTTPd--eTEYEGYFNLAKKYI 325 little fire ant

Feature 1           
1XCR_A       303 RID 305 human
XP_018393423 325 DVK 327 Cyphomyrmex costatus
XP_016657413 314 RVD 316 pea aphid
AAX27376     297 RID 299 Schistosoma japonicum
NP_001232953 315 KID 317 pea aphid
XP_009170222 443 RVD 445 Opisthorchis viverrini
EUB61511     335 RID 337 Echinococcus granulosus
EFN73155     321 RLD 323 Florida carpenter ant
KYN38686     319 RIN 321 Trachymyrmex septentrionalis
XP_011695697 326 IAD 328 little fire ant

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