7CLV,7CGP


Conserved Protein Domain Family
Tim17

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pfam02466: Tim17 
Tim17/Tim22/Tim23/Pmp24 family
The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).
Statistics
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PSSM-Id: 460567
Aligned: 387 rows
Threshold Bit Score: 39.8485
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7CLV_A        98 CYGTgavyLLGLGIGGFSGMMQGLQNIPPnSPGKLQ--------LNTVLNHITKRGPFLGNNAGILALSYNIINSTIDA- 168
XP_011271689  13 AYRE----LFQIIKSMRNGAVYGGRLRFA-HSLVIQllfrrtvpLDKRLKLVFKQSKDHGLILASFALVYKVLMIALKQi 87 
EEQ37040     190 AYRP----ILEALRSSRNGVVYGGKIRFS--HALVInllyrsgpMGPRLKQVLKATKEHSLVLAAFAIVYKTVLNILRQe 263
Q6BNB7         8 LYRP----LLEVLRSSRNGIVYGGKIRFS--HALVInllyrsgpLKPRLQQVLKATKNHAEVLAGFAIIYKFAVNVLVSe 81  Debaryomyces ha...
XP_006685249   8 LYRP----LLEVARTARNGVVYGGKIRFS--HALVInllyrsgsLRPRMIEVLKATKNHAEVLASFAVIYKMVLGVLVNe 81 
XP_001485061   8 LYRP----LLEALRSARNGVVYGGKLRFS--HALVInllyrlgpLKPRLTQVLQATKSHAEVLAAFATIYQLAVKVLLHd 81 
CCE86625       8 LYRP----VLEAIRSSRNGIVYGGKLRFS--HALVMnilyrsgpPGPRLKSVLRATKDHAEVLAAFAFLYKVIVSVLRHe 81 
CCE45396       8 LYRP----LLEIIRSARNGVVYGGKLRFS--HALVInllyrsgpLGPRMKSVLEASKDHAEVLASFAIIYKLAVKILQSd 81 
EMG47697       8 LYRP----LFEILKSARNGIVYGGKLRFS--HALVInllyrsgpMLPRLKSVLEATKNHAEVLAAFAIIYKTCILILRQd 81 
Q38FX7       115 KYKI----LFDALKSFRNGFVYGARIRAP--HALVLnlvwssapYSVIARRVFDATRQHALRLGATAFTFSLLRSLMALv 188 Trypanosoma brucei
7CLV_A       169 ---LrGKHDTAGSIGAGALTGAL-FkSskG----LKPMGYSSAMVAA 207
XP_011271689  88 --nG-GAP--INEFISGFISAMLvY-G--NrttvFNHSIAHQITLYC 126
EEQ37040     264 kllG-S-KQGFSKLIAGAVGGWIvY-S--QhfsaFNPGITHQITLYC 305
Q6BNB7        82 kimG-TDKLGLVKFLAGCFGSWVvY-S--QhfnyFNPGITHQVTLYC 124 Debaryomyces hansenii
XP_006685249  82 qvlG-SNSKALSKFVAGCFGSWIvY-S--QhfgyFHPGITHQITLYC 124
XP_001485061  82 qvlG-G-SKGLVKFLAGSFGAWIvY-S--QhfpyFHPGITHQITLYC 123
CCE86625      82 klmG-PRRLALIKFIAGSFSSWIvY-S--QhfnvFHPGITHQVTLYC 124
CCE45396      82 aflG-PKNTQLPKFIAGCLGSWIvY-S--GhfnlFHGGITHQITLYC 124
EMG47697      82 nflG-EKNIGLIKFISGCFGSWIvY-S--QhfpiFHSGITHQITLYC 124
Q38FX7       189 ----eGRQRPWHSVVAGFIIGCLyWg--------EQGAVTVQMSMYI 223 Trypanosoma brucei
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