3VPD,4IWX


Conserved Protein Domain Family
rimK_fam

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TIGR00768: rimK_fam 
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alpha-L-glutamate ligase, RimK family
This family, related to bacterial glutathione synthetases, contains at least three different alpha-L-glutamate ligases. One is RimK, as in E. coli, which adds additional Glu residues to the native Glu-Glu C-terminus of ribosomal protein S6, but not to Lys-Glu mutants. Most species with a member of this subfamily lack an S6 homolog ending in Glu-Glu, however. Members in Methanococcus jannaschii act instead as a tetrahydromethanopterin:alpha-l-glutamate ligase (MJ0620) and a gamma-F420-2:alpha-l-glutamate ligase (MJ1001).
Statistics
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PSSM-Id: 273261
Aligned: 12 rows
Threshold Bit Score: 321.218
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3VPD_A         1 MLAILYDR------IRP-DERMLFERAEALGLPYKKVYVPALPMVLGe----------RPEa-----LEGVTVALERC-- 56  Thermus thermop...
P17116         2 KIAILSRD------GTLySCKRLREAAIQRGHLVEILDPLSCYMNINpaass--ihykGRK------LPHFDAVIPRIg- 66  Escherichia coli
P45241         2 KLLMLCRE------PRLySCQRLKEAAKHQGHEMDILDPNHCFLKLSqnpphfqifyqENSeskpylLSDYDAVLPRFg- 74  Haemophilus inf...
BAA74766       1 MLAILYDR------IRP-DERMLFERAEALGLPYKKVYVPALPMVLGe----------RPEa-----LEGVTVALERC-- 56  Thermus thermop...
CAB57657       2 KIALVVDI------IRQ-EEKLIIKALNERQIDYDVINVGQEPIPFN-------------Ka-----LSKYDVGIIRP-- 54  Sulfolobus solf...
Q58037         2 KLGIITIE------RDA-VVNDLIKSCEKYEVDYKVITPSNIVAGFNl---------dFKLkyyksfLDELDCCFVRNl- 64  Methanocaldococ...
P47258         3 KINVVYNPafnpisSKLnQTQLLKNASEELDIELKFFTSFDINTTKA--------------------KANLPFISNKI-- 60  Mycoplasma geni...
BAA86552      30 KLWFLTDRriredyPQKeILRALKAKCCEEELDFRAVVMDEVVLTIEqg-------nlGLRingeliTAYPQVVVVRVpt 102 human
WP_010888824  10 DLAVLYDR------VRP-DEKMLFGALDELGVPYDKVYTPQLTVTFDd----------EGRa-----RVPWKVAIERC-- 65  Deinococcus rad...
WP_010885785   2 KIGITYTI------LRK-EELMIRENAERFG---ETVMLHEDNVRFPy-------------------KYDLDVVIIRN-- 50  Pyrococcus hori...
WP_010866389   6 SILFLYDI------ARL-DEKMLLEELRKRAR-VRVIHTAARALPLGe----------PPRe-----AEEADLAVARG-- 60  Aeropyrum pernix
4IWX_A        22 KIAILSRD------GTLySCKRLREAAIQRGHLVEILDPLSCYMNINpaas---sihyKGRk-----LPHFDAVIPRIg- 86  Escherichia col...
3VPD_A        57 --VSQSRGLAAARYLTALGIPVVNRPEVIEACGDKWATSVALAKAGLPQPKTALAT--------DREEALRLMEAF-G-- 123 Thermus thermop...
P17116        67 -tAITFYGTAALRQFEMLGSYPLNESVAIARARDKLRSMQLLARQGIDLPVTGIAH--------SPDDTSDLIDMV-Gg- 135 Escherichia coli
P45241        75 -tTSTQMGCSVLQHFEGKGTFCLNSSQAFLNARDKWKSLQLLLKAGIPVPNSLLSG--------GEVQAQATIPHI-S-- 142 Haemophilus inf...
BAA74766      57 --VSQSRGLAAARYLTALGIPVVNRPEVIEACGDKWATSVALAKAGLPQPKTALAT--------DREEALRLMEAF-G-- 123 Thermus thermop...
CAB57657      55 --VSMYRALYSSAILEAAGVHTINSTDAIGTCGDKILTYSKLFKHGIPIPDSIIAA--------SPDAAMKAYEQM-G-- 121 Sulfolobus solf...
Q58037        65 -gWDSFFRFDVLKYLN-HYIPVINPPDGIDRASNKFLTSVFLELNNLPQPKTVVTE--------SINEAIVWIDKF-E-- 131 Methanocaldococ...
P47258        61 --LFMDKNIALARWLESNGFEVINSSIGINNADNKGLSHAIIAQYPFIKQIKTLLGpqnfdrewNPVMLDVFINQI-Kqs 137 Mycoplasma geni...
BAA86552     103 pwVQSDSDITVLRHLEKMGCRLMNRPQAILNCVNKFWTFQELAGHGVPLPDTFSYG--------GHENFAKMIDEA-Evl 173 human
WP_010888824  66 --VSQSRGHAVTRALEGFGVKVINPSHVIELCGDKLATNARLAAAGLPTPRTGVAF--------DGESALGLIEEM-G-- 132 Deinococcus rad...
WP_010885785  51 --VSYFKALYLAKLFEEHGVPTVNPFSIMLEAGDKVFSTLKLSKK-VPVPRWGVSF--------SENSAKKIAEEL-G-- 116 Pyrococcus hori...
WP_010866389  61 --VSGRRLLYSALAAESWGLETVNSSHAIMASQDKVWSHMLLSRRGVPTPRSYTIL--------DPQAVPYAAEAI-G-- 127 Aeropyrum pernix
4IWX_A        87 -tAITFYGTAALRQFEMLGSYPLNESVAIARARDKLRSMQLLARQGIDLPVTGIAH--------SPDDTSDLIDMVgG-- 155 Escherichia col...
3VPD_A       124 --YPVVLKPVIGSWGRLLAKVTDRAAAEALLEHKEVLGgfqhqlFYIQEYVE--KPG-RDIRVFVVGERAIAAIY-R--R 195 Thermus thermop...
P17116       136 --APLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNa----hILVQEYIK--EAQgCDIRCLVVGDEVVAAIE-RraK 206 Escherichia coli
P45241       143 --SPTILKTLNGSQGIGVILAEKPQSAVSIMEAFKQTNi----sMLQQDFIE--EAGnADIRCFVIGDQVVATMQ-RigQ 213 Haemophilus inf...
BAA74766     124 --YPVVLKPVIGSWGRLLAKVTDRAAAEALLEHKEVLGgfqhqlFYIQEYVE--KPG-RDIRVFVVGERAIAAIY-R--R 195 Thermus thermop...
CAB57657     122 --FPLIDKPPIGSWGRMVSLIRDVYEGKTIIEHREMLNnsalkvHIIQEYIK--YKE-RDIRCIVIGDELLGCYA-RniP 195 Sulfolobus solf...
Q58037       132 ---EAVLKPIFGCGGEGIVRVKKELPISTKLKILNEFKeky-ntFYIQEFIKpvRNEhRDIRAFVVDDEVVAAMY-Ri-G 205 Methanocaldococ...
P47258       138 meFPVIVKSVFGSFGDYVFLCLDEQKLRKTLMSFNQQA-------IVQKYIT--CSKgESVRVIVVNNKVIGALH-Tt-N 206 Mycoplasma geni...
BAA86552     174 -eFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAp-----YLFQKYVK--ESHgRDVRVIVVGGRVVGTML-RcsT 244 human
WP_010888824 133 --YPVVLKPTVGSWGRMVSRLNDRDAAEAVIEHKEVLGgpqhgvFYVQELIN--KPG-RDIRAFVVGGQGIGAIY-R--T 204 Deinococcus rad...
WP_010885785 117 --YPIVSKPVFGSWGRLLAKINDKDSLEGLLEHKKWMKnplyniHYFQEFIQ--KPG-RDIRSYVIGGEFITAIY-R--Y 188 Pyrococcus hori...
WP_010866389 128 --FPAVFKPARGSWGKLVSLLRDKSEASLLSEALEYVQgdl-klGLVQEYVD--KPG-RDIRSFCIGDTVPAAIY-R--Y 198 Aeropyrum pernix
4IWX_A       156 --APLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNa----hILVQEYIK--EAQgCDIRCLVVGDEVVAAIErRa-K 226 Escherichia col...
3VPD_A       196 SAHWITNTARGGQAENCPLTEEIARLSVGAAEAVGGGVVAVDLFESE-R------GLLVNEVNHTMEFKNSVHTTGVDIP 268 Thermus thermop...
P17116       207 EGDFRSNLHRGGAASVASITPQEREIAIKAARTMALDVAGVDILRAN-R------GPLVMEVNASPGLEGIEKTTGIDIA 279 Escherichia coli
P45241       214 NGEFRANCHRGGKTEKITLSDEEKQIAIQATKAIGLDVAGVDLIRSK-K------GLLVLEVNASPGLEMIEKTSGIDIA 286 Haemophilus inf...
BAA74766     196 SAHWITNTARGGQAENCPLTEEIARLSVGAAEAVGGGVVAVDLFESE-R------GLLVNEVNHTMEFKNSVHTTGVDIP 268 Thermus thermop...
CAB57657     196 PNEWRANVALGGNPTPIQLDDNIRELAVKSVKLVKGEFVSIDILEHK-Sk-----GYVINELNDVPEFKGFMLATGINVA 269 Sulfolobus solf...
Q58037       206 GENWKNNVSQGGRVEKCEITEEIEKLALKAKNALGLFYAGVDLIESE-D------GLKVLEVNSTPSWIGLSKVSEVNIA 278 Methanocaldococ...
P47258       207 NSDFRSNLNKGAKAERFFLNKEQENLAVKISKVMQLFYCGIDFLFDQ-Dr-----SLIFCEVNPNVQLTRSSMYLNTNLA 280 Mycoplasma geni...
BAA86552     245 DGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKD-Dg-----SFCVCEANANVGFIAFDKACNLDVA 318 human
WP_010888824 205 SEHWITNTARGAKASNCEVTPAIADLAQRAAAAVDGQIVAIDLVEDP-ArqndwdGLVIIEINHTMEFKNSVSTTGVNIP 283 Deinococcus rad...
WP_010885785 189 SDHWITNTARGGRAEPCDNS-EVEEISIKAWEAFGDGALAIDIFESP-N------GLLVNEVNPNMEFKNATRVTGVNIA 260 Pyrococcus hori...
WP_010866389 199 GSGFATNLAAGGRAAPAPVTGDVEDLTLRACEALGVEVGGVDIVESTrDg-----GLLVLEVNPSTEFKNTVRVTGVNVA 273 Aeropyrum pernix
4IWX_A       227 EGDFRSNLHRGGAASVASITPQEREIAIKAARTMALDVAGVDILRAN-R------GPLVMEVNASPGLEGIEKTTGIDIA 299 Escherichia col...
3VPD_A       269 GEILRYA 275 Thermus thermophilus
P17116       280 GKMIRWI 286 Escherichia coli
P45241       287 AEIIDYI 293 Haemophilus influenzae Rd KW20
BAA74766     269 GEILRYA 275 Thermus thermophilus HB27
CAB57657     270 EKLVDHI 276 Sulfolobus solfataricus P2
Q58037       279 DKLLEKI 285 Methanocaldococcus jannaschii DSM 2661
P47258       281 IELLKAI 287 Mycoplasma genitalium G37
BAA86552     319 GIIADYA 325 human
WP_010888824 284 RLMGEYA 290 Deinococcus radiodurans
WP_010885785 261 EKLVEYA 267 Pyrococcus horikoshii
WP_010866389 274 ALIADYV 280 Aeropyrum pernix
4IWX_A       300 GKMIRWI 306 Escherichia coli K-12
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