Conserved Protein Domain Family
DPG_synthase
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cd04188: DPG_synthase 
DPG_synthase is involved in protein N-linked glycosylation.
UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.
Links
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Statistics
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PSSM-Id: 133031
Aligned: 43 rows
Threshold Bit Score: 205.879
Created: 4-Jun-2008
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Ligand bindingDXD motifPutative
Feature 1:Ligand binding site
Evidence:
  • Comment:Predicted ligand binding site based on similar proteins.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           # #                                                                          
XP_001639099  47 VVVPSYNEEERLPIMMDETLeyllekkksnpsftsEIIVVDDGSkDKTTEVGLryakqcgvss--------vrvltlakn 118 starlet sea ane...
NP_069415     58 IVLPAYNEAKRLRGAVEEVIkaaek-----tgydfEIIIAEDGSkDGTDRIAAelaasnpri----------khlhsder 122 Archaeoglobus f...
ZP_01052241  159 VVIPCYNEEDRLLSKEFLNFiekh--------sgyHLCFVNDGSkDKTLEVLHkiqkgredf---------itvydcekn 221 Tenacibaculum s...
YP_001181393   5 IVIPAYNEYARMNSQIEKYLels---------kqyDMILVDDGSgDDTYRIGEslgwhv---------------vrlskn 60  Caldicellulosir...
CAC32362      28 VVVPVYNEEKDLGPCVRRLHehldrt----fpyafRITVADNAStDGTPQVAArlaadlaa-----------vrsvrler 92  Streptomyces co...
ZP_01852011    6 IVIPCFNEEKRLEVLQFRKYalsh--------pehQFLFVNDGSsDRTALILDdlkesvpes---------fdvlhlsqn 68  Planctomyces ma...
ZP_01061046    5 IIIPCYNEEKRIDQAAFKAFitqs--------enhHLCFVNDGSkDQTLNVLKsiqhanpek---------vtvidmkrn 67  Flavobacterium ...
YP_633485      8 VVIPAYNEGQRLPRFVAELTrvfler----sappvEFVVVDDGSaPEHAELQRasveaaqarlategarhqftyvaaprn 83  Myxococcus xant...
AAM07219       6 LVLPAYNEVTRIEKTVNQTAetlrd-----itssfEIIIAEDGSiDGTDRIAGklaqehnci----------shlhsdsr 70  Methanosarcina ...
YP_001546749  10 IVIPVLNEEQQLEQSVVALRdflqas----cpyrwRIVVADNGStDRTPQICHdlrsrfpge----------vdferleq 75  Herpetosiphon a...

Feature 1                                     #                                                  
XP_001639099 119 RGKGGAVRMGVFSSrg-----rkILMADADGATKFSDLdrldtalndvtaakgvkpAIVCGSRahlqeeavatrsafRNF 193 starlet sea ane...
NP_069415    123 LGRGRALMNAFSKAsg-----dvVVYMDVDLATDLSHLkelvda------iivegyDFSTGSRlmkesq--tdrpakREI 189 Archaeoglobus f...
ZP_01052241  222 GGKAEAVRLGMLHMakks-dldyIGFLDADLSTDLTDFddlvst------iensdyKIVSGSRisrmgad-itkesaRKI 293 Tenacibaculum s...
YP_001181393  61 MGKGYAVRAGILRAlaltpepsfIGFSDADLSVSPEQWeklis--------kldeyDIVIGSRsmpdsi--vkrsipRKL 130 Caldicellulosir...
CAC32362      93 KGRGRALRTVWSASda-----pvLAYMDVDLSTDLNALlplvap------lisghsDLAIGSRlarssr--vvrgakREF 159 Streptomyces co...
ZP_01852011   69 QGKAEAVRQGMLRAfetd--vdyAGYWDADLATPLDMIpefteql-----dqttqlTLVIGARvkllgrq-ierkklRHY 140 Planctomyces ma...
ZP_01061046   68 SGKAAAVRAGARYLysqe-nvqhIGFMDADLSTDFEDFmaldqtl-----ktnknlKMVFGSRakddsg--iekdplRAF 139 Flavobacterium ...
YP_633485     84 QGKGSAIRLGWRHAsag---vtwLAFLDADGAINAEEFhrlvalsa---semarnvDLLAGSRilmagrr-vvrnlhRHL 156 Myxococcus xant...
AAM07219      71 QGRGRALNRAFKSAsg-----dvLCYIDVDLATDMSHLkelies------isiegyDFATGSRmmpqsn--vkrplkRGI 137 Methanosarcina ...
YP_001546749  76 RGRGRALRTAWLKSsa-----diLCYMDVDLSTNLRALppllaa------lihsdySLGTGSRlmhgai--vtrqwkREM 142 Herpetosiphon a...

Feature 1                                                                                        
XP_001639099 194 LMYGFHflvwflcvkgiKDTQCGFKLFTRSAalltf-salhvERWAFDVELLYIAqqlqi----------piaevAVNWT 262 starlet sea ane...
NP_069415    190 ASRGYNflvrlflgsklHDHQCGFKAFRRDLildlg-kevkdNHWFWDTEVLVLAqkrgy----------rvkeiPVRWK 258 Archaeoglobus f...
ZP_01052241  294 ISLTINfiirkilkmdfKDTQCGAKIFHKDVigisf-nekfvTQWIFDVEIFKRIthhyglera---reilceqpLKRWI 369 Tenacibaculum s...
YP_001181393 131 ISKIFNhlvhevlqlsvHDTQCGLKFFRPQAaralfsepltaNRYAFDIEILLRArimgl----------sfketGVNWV 200 Caldicellulosir...
CAC32362     160 ISRTYNlilrgslqarfSDAQCGFKAIRRDVaqvll-plvedTGWFFDTEMLVLAeragc----------rihevPVDWV 228 Streptomyces co...
ZP_01852011  141 LGRIFAtaastvlqlpiYDTQCGAKLFRVSQesrtlfskrflTNWIFDVELLARArqlekfyqcdsleatvyelpLKRWQ 220 Planctomyces ma...
ZP_01061046  140 FSKVIKfcvflilglpiQDTQCGAKVFSRDLvpviy-gnqflSKWLFDVEMFIRLkhhmggkea--vmnaiheqaLQRWV 216 Flavobacterium ...
YP_633485    157 QGRIFAtltdanfklhfYDTQCGVKFVRADIlrpll-dvlqeQRWLLDVELLVLLkrqga----------rflevPIDWE 225 Myxococcus xant...
AAM07219     138 ASKGFNflvhtvlhsklYDHQCGFKAFKKAPlfeli-ddvedEHWFWDTELMVLAqaref----------kvkefPVIWR 206 Methanosarcina ...
YP_001546749 143 ISRAYNllirvlfwhrfRDAQCGFKAITRQAaqeli-pmvrdNEWFFDTELLLKAerrgy----------rifevPVEWI 211 Herpetosiphon a...

Feature 1              
XP_001639099 263 EIDGMG 268 starlet sea anemone
NP_069415    259 HGGETK 264 Archaeoglobus fulgidus DSM 4304
ZP_01052241  370 HADGSK 375 Tenacibaculum sp. MED152
YP_001181393 201 ARDGSK 206 Caldicellulosiruptor saccharolyticus DSM 8903
CAC32362     229 DDPDST 234 Streptomyces coelicolor A3(2)
ZP_01852011  221 DVAGSK 226 Planctomyces maris DSM 8797
ZP_01061046  217 HVEDSK 222 Flavobacterium sp. MED217
YP_633485    226 DFGGSK 231 Myxococcus xanthus DK 1622
AAM07219     207 HGGTTK 212 Methanosarcina acetivorans C2A
YP_001546749 212 EDLGTT 217 Herpetosiphon aurantiacus ATCC 23779

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