Conserved Protein Domain Family
DUF4589

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pfam15252: DUF4589 
Domain of unknown function (DUF4589)
This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.
Statistics
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PSSM-Id: 464592
Aligned: 17 rows
Threshold Bit Score: 143.021
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004758430  52 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSdkagvggpfdLGHLDFMTADILSDSW-----------EFCSFLDA 118
3_pfamImport   1 EVVHDIDTLTGDLQLEEDglTDSSKTDTLNSSSSS----------LEKMKLFPEDFIFRPPalvdpvhvnplGVLTVLKK 70 
XP_001928647  52 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSdkagaggpfdLGHLDFMTADILSDSW-----------EFCSFLDV 118
XP_014589486  55 KVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSdkagvggpfdLGHLDFMTADILSDSW-----------EFCSFLDV 121
XP_004855554  52 EVVTQIDKLTSDFDFELE--PDDWTTATVSSTSSSdkagvggpfdLGHLDFMTADILSDSW-----------EFCSFLDV 118
XP_003755027  60 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSekgggsgpfdLTHLDFMTSDILSDSW-----------EFCSFLDI 126
XP_028921664  52 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSdkggg-glfdLGHLDFMTSDILSDSW-----------EFCSFLDV 117
XP_005857150  53 EVVDQIDTLTSDLQLEDEm-TDSSKTDTLNSSSSStta-----ssLEKIKVQANAPLIKPPah-------psAILTVLRK 119
XP_003227760  12 QVVSQIDKLTSDFEFELE--PDDWTTATVSSTSSSdkga--gmfdLGNLDFMTSDILSDSW-----------EFCSFLEA 76 
XP_014744768  63 EVVSQIDRLTSDFALDLE--PDAWTPATASSTSSSdrgg--asleLGPLDFAASDVLSDSW-----------EFCSFLDT 127 Common starling
XP_004758430 119 S---TPSDSVDGPELTRP----------------GAGPDYRLMN-GGTPi-----PNGPR-------VETPDSSSEEAFG 166
3_pfamImport  71 PhppLPPPRLTPPRAEDHniknlphptfvlsgniSKGAGSLMRNgGAFPm----kPNRDLfstmpcfISSDGGIPESGLV 146
XP_001928647 119 S---TPSDSVDGPESVRP----------------GTGTDYRLMN-GGMPi-----PNGPR-------VETPDSSSEEAFA 166
XP_014589486 122 S---TPSDSVDGPESARP----------------GAGPDYRLMN-GGLPi-----PNGPR-------VETPDSSSEEAFS 169
XP_004855554 119 S---TPSDSVDGPESSRP----------------GVGPDYRLMN-GGTPi-----PNGPR-------VETPDSSSEEAFS 166
XP_003755027 127 S---TPSDSGEGPEPARQ----------------PPTPDYRLMN-GGVLi-----PNGPR-------VETPDSSSEEAFS 174
XP_028921664 118 S---TPSDSGDGSEQPGG-----------------RQPDYRLMN-GGVLi-----PNGPR-------GETPDSSSEEAFS 164
XP_005857150 120 PnppPPPPRLTPVKSEDPqrvap-------avnpVKTNGTLLRNg-GLPgapnkiPNGDIc-------cTPGSNSDKASV 184
XP_003227760  77 S---TPSDSGDGSEQQQPq---------------GRQPDYRLMN-GGVLi-----PNGPR-------IGTPDSSSEEAFS 125
XP_014744768 128 S---TPSDPGDCPEPPRP----------------P---PARLMN-GGVPv-----ANGPRg-----gGGTPDSSSEECFG 174 Common starling
XP_004758430 167 -----A---GPV-KGQLPQRTPG-------TRERVRFSDKVLYHALCCDDEEEDGEE-------VVAEEev------gLS 217
3_pfamImport 147 ptlprP---MPL-LRHEKNKCPKargresrERERVRFSETVQYHGYCPDCDLQYDVDdtelhlqAELNN---------LR 213
XP_001928647 167 -----A---GPV-KGQLPQRTPG-------TRERVRFSDKVLYHALCCDDEEGDGEEet----aAAAEEev------gLS 220
XP_014589486 170 -----A---GPA-KGQLPQRTPG-------TRERVRFSDKVLYHALCCDDE-GDGEE-------EAAEEea------dLS 219
XP_004855554 167 -----A---GPT-KG---QRTPG-------TRERVRFSDKVLYHALCCDDE--------------TEEEag------sLP 207
XP_003755027 175 -----ScppDPP-KGQQAHRTPG-------TRERVRFSDKVLYHALCCDDEEGEGEE-------EQEEDga------aPS 228
XP_028921664 165 -----S---APApAKGQPQRTPG-------TRERVRFSDKVLYHALCCDDDEEGEQGee----dGEEEGggdcgggggPP 225
XP_005857150 185 -----Q---PLM-HRPEKDRCPQa-----gPRERVRFNEKVQYHGYCPDCETRYNIKnrevhlhSEPVQ---------PP 241
XP_003227760 126 -----S---APS-HKAQHQRTAG-------TRERVRFSDKVLYHALCCDDD--------------EEADss------pLP 169
XP_014744768 175 -----S---AAV-PKMPSQRPAG-------TRERVRFSDKVLYHALCCDDD-------------GDADAga------dIP 219 Common starling
XP_004758430 218 PEPPRPEAHVGPLKPS-----------------------PAPYKPRRSPLTGrrpsstlape----qtrrvtrnssTQTV 270
3_pfamImport 214 LSPVHCCFSSSPPPFPhqlmlengglssshsfpptaktpPPCVPPHPPTAKP------------------------QKTI 269
XP_001928647 221 PEPPHAEAHAGPVKPS-----------------------PAPYKPRRSPLTGrrsgpttape----qtrrvtrnssTQTV 273
XP_014589486 220 PEPPRTEAPAGPPKPA-----------------------PAPYKPRRSPLTShrsgptvape----qtrrvtrnssTQTV 272
XP_004855554 208 PELPHTEPHEGALKPS-----------------------APLYKTRRSPLTSrrsgptlape----qtrrvtknssTQTV 260
XP_003755027 229 PNPPQTEPHVAPLKPL-----------------------LATCKPRRSPLTSrngghiptltpgsgqtrrvtrntsTQTV 285
XP_028921664 226 PEAPQTE-TEATLKPAlppptckp-------rrsplpsrHVHLAPTLTV--Ggqprkv-------------trnssTQTV 282
XP_005857150 242 GKLPPQGPP-RPPPPHlppfplenggp-gishsnsypplRPATVPPPTAPKP------------------------QKTI 295
XP_003227760 170 EDPPEEASDPAHKAGQ-----------------------VTKTLPRRSPqqqkl-----------------trnssTQTV 209
XP_014744768 220 DDPARKG-------------------------------------PREQLLRNpgtipir----------ratrnssTQTV 252 Common starling
XP_004758430 271 SDKSTQTLL 279
3_pfamImport 270 LRKSTTTTV 278
XP_001928647 274 SDKSTQTVL 282
XP_014589486 273 SDKSTQTAL 281
XP_004855554 261 SDKSTQTVL 269
XP_003755027 286 SDKSTQTVL 294
XP_028921664 283 SDKSTQTAL 291
XP_005857150 296 LRKSTTTTV 304
XP_003227760 210 SDKSTQTVL 218
XP_014744768 253 ADKSTQTLL 261 Common starling
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