7APK


Conserved Protein Domain Family
FmiP_Thoc5

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pfam09766: FmiP_Thoc5 
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Fms-interacting protein/Thoc5
This entry carries part of the crucial 144 N-terminal residues of the FmiP (Fms interacting protein). A member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex which is a subcomplex of the transcription/export (TREX) complex. It is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. Fmip is also known as THOC5 (THO complex subunit 5) a 683 amino acids long protein which contains a nuclear localization sequence (NLS), a leucine zipper and a PEST like sequence (aa. 303-319) that carries three ataxia-telangiectasia mutated (ATM) kinase specific phosphorylation sites. The C-terminus contains a THOC1 binding site. The level of FMIP/Thoc5 expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.
Statistics
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PSSM-Id: 462889
Aligned: 55 rows
Threshold Bit Score: 189.06
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7APK_E       103 RLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEIT--KCLEFK-------SKHEEidlvslEEFYK-EAPPD 172 human
EEY60744      59 RDTFLEADARRTRVQEQKDVAEAHQLQLQNLLYEKDHLLREIR--RCRGFS-------TKEMDk-----IEFADgPLPIK 124
Q55GJ8        56 KLEQLIEDQHWRPIKEIIENINQSNNKLESFKYEKIMLESEINdlRKLQFD-------LSDPSlgitplEKFLSfQSPQY 128 Dictyostelium d...
XP_006676418  73 RASFIHSKTRKEQSTSHKQAMDQTQLTLQNLNYERMHYLREIA--KCESFE-------TTYQDipllseKEFIK-LAPSE 142
XP_001744967  60 RQAGKQLVTGAEANAQMKADIDSVHLRLQNVLYEKLHLLKETA--ACNQFR-------AKTDDmalisaAELSP-ELQTD 129
EGC30418      98 RDTYLDSEYNKAKTNEEKVKLEALNLTYQNILYEKYHLEKEIN--SLKDFN-------IDQFKpel-lpIETYN-SKVQD 166
Q1ZXD7       134 HKTHIDSETKKTKKNEEKEKFEKLNLVYQNYLYEKNHLEKEIN--SYKDFK-------IDDQKpkllslEDFEN-----K 199 Dictyostelium d...
XP_004351476  95 RSIVFDMETWKTQVDKDKQKLDHLNLFYENFIYEKNHLLKEIH--STSDFD-------ISAFEpil-vdEMYYNdKKQQD 164
EFA84452      88 RFYQFQAENSKLDVEKERQKFDSLNLLYQNYLYEKNHLLKEIH--SLSEFN-------ISQYEpnl-veQLYYEsESIDI 157
CBN79838      75 RKIHSAIETIRNKVATAKQTMDVNHLQLENLLYERDYLSRETQ--LCRDFTmtelnkmEEDEE------QGFLEdvdt-- 144
7APK_E       173 Iskae----------vtmgDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLN---SIMQA 239 human
EEY60744     125 Vd----------------pDVHRQHLDQLTQELHARKSLQTELKELKLKITKVEDATETKQAFLNALPDHLA---GIEAA 185
Q55GJ8       129 Iesfn------------skpKEKQSIERLEWEIYQRKLKLIELEKLKKLKIKLKQDDEKANNELKQFEDKLKenlNVKKA 196 Dictyostelium d...
XP_006676418 143 Yttes-----------alqDAHTLMLNHLWFELKQRKDMQDVLAAHNAQKVKVEAENKVLSESLDQLDLEID---TLLKS 208
XP_001744967 130 -------------------DPHQQMLNRIEAERRERERLVDQLEELSQRQSAMKALNKQKASKLKQLPRAIN---RLAEV 187
EGC30418     167 IsynttfksepidtndielNEHNKLVNRLNFEIYERNRMIEQFNKIQRDKKLLLGLNNTKQEFLSSLSKNLS---VISTK 243
Q1ZXD7       200 IkdctsiklesvdtgneelNQHNLLLNRLNFELYERNRTIEQLNKIQRDKRLHLGLNTTKQEFLSSLLTNVT---ALASN 276 Dictyostelium d...
XP_004351476 165 Itaeqqssss-speldeetQKHNQKMARLQFELDERIKKLDQLNKLNQKKKLHTEINISKQNFLSTLPKSLS---SLSNK 240
EFA84452     158 Ptmpidi-------dteeeIKHSKIIHRLNFELKERIRVLKQLTQLQEQKKNEIHLNQSKQNYISSLPKMVS---DLSKK 227
CBN79838     145 ---------------lqtaEEHAGNLAILKDQKEQRINAQLALKATQIRVKAASSTVKESRDYLDRLPENLK---DVERA 206
7APK_E       240 SLPVQEYL---------FM----PFD-QAHKQYETARHL--PPPLYVLFVQATAYGQACD----KT-LS-----VAIEGS 293 human
EEY60744     186 TTGLQKYM---------GE----PVTaQRNRHHAAGTEL--STPLYALYCELEAYQTASGd--aGKrLQ-----LEIVDS 243
Q55GJ8       197 VEPFQKFI---------GIlpvsKNNnNNNIIGNHPLLLesPQPLYILYHELVYFKEFFFnenlTV-EL-----IKIENS 261 Dictyostelium d...
XP_006676418 209 TIPLQKKF---------KL----NTT-RERNLSEKSLYL--ASPMFVLYKHFAGYCSMYE----EQgLF-----VDIIGD 263
XP_001744967 188 ASDVSNVF---------SRhqdnALP--AGSNDPRAAAL--PLPLFVFYETTTAFIQLETe--pSG-LH-----VSIEGE 246
EGC30418     244 IAPVQNSLiksitsinnPPlmskRTAsFNSTFEQTVFNL--PKPLYVLYYTVNSFLQSNKt--tNN-NGakspsLRIKGD 318
Q1ZXD7       277 ISNIQPS--------------------STSNYEQSIFNL--PKPLYVLYYSVNSYLQSNT----KStMNsdnllLKIKGD 330 Dictyostelium d...
XP_004351476 241 Ls---------------------QIGsSTSNYNPTAFYL--SKPLYYMYSSILSYQSSCK----KPdFN-----IKIIGD 288
EFA84452     228 LLTIQPNL--------------------NSSYNQNIFHL--PKPLYIIYSSVTSYQSSTKk---SN-LT-----LKIVGD 276
CBN79838     207 LAPLKKNMpwr--------------pgSRRGRHERSSEL--PGPLFTLYCQLEAYCDSV---------------LAATGG 255
7APK_E       294 V--------------------DEAKALF------------------------------KPPEDSQDD------------- 310 human
EEY60744     244 IgvkhtgayrkrgfptalerqEHASTKRlkaps---------------------rspsASLNGATPPhsrapsrspsvkr 302
Q55GJ8       262 D--------------------ENNESVE------------------------------NNTISNNNDnnnnnnnnnnnnn 291 Dictyostelium d...
XP_006676418 264 T--------------------SKAGKRRlitns----------------------------------------------k 277
XP_001744967 247 A--------------------SAVPNFD------------------------------EAVAGLISVktsvqsghqrdde 276
EGC30418     319 M--------------------EKAIKFN------------------------------KEYVe----------------- 331
Q1ZXD7       331 M--------------------DKATIFN------------------------------SDFMIYSQQtqhqhhqqqqqqq 360 Dictyostelium d...
XP_004351476 289 I--------------------DKASTFNqqqqq----------------------------------------------q 302
EFA84452     277 I--------------------EKAIDFN------------------------------TKSNVAVVDndv---------- 296
CBN79838     256 M--------------------DESGAFSplatfggdggdvggdrhppglaasvtiepaKACVSASAKaaaagpkdasdsa 315
7APK_E       311 ---ESDSDAEE---------EQ---TTKRRRP-------TLGVQLDDKRKEMLKR-----------HPLSVMLDLKCK-- 355 human
EEY60744     303 vadSSSQEPESgeivaahtaEKllqLRPHEEEtkeetkdQDENSEAATSQKLWNP-----------HARALQLTISVTvp 371
Q55GJ8       292 nnnNNNNNNKLn-------eNSmnvDNNDDYDdddddgnNYNNYNNNKSTKLISQ-----------SEVYISLKIKILle 353 Dictyostelium d...
XP_006676418 278 qaeSGVDEMEEt-------------SGKRQNN-------------VENIDQIYEH-----------HPMGIVLSFTDS-- 318
XP_001744967 277 ednSSDSPAAVq---------------------------------------ANTP-----------HPLTLKLSVKTA-- 304
EGC30418     332 ---KQTPDNETn------------------------------EEQPNEEDQYYYI-----------HPLSVLLDYTIL-- 365
Q1ZXD7       361 qqqQQQQQQQQq---------------------------QQQQQQQQQQQQSQEEitlrnnnnsdyHPLSVILDYLIF-- 411 Dictyostelium d...
XP_004351476 303 qqqQQQQQQQQq---------------------------QQQQQQQQIDQQPLTV-----------HPLSLEFEYRISke 344
EFA84452     297 -ddGGVVDGEIn------------------------------------NDQLIAVaqy------iiHPLSLIIEFQCE-- 331
CBN79838     316 eapAASTDSTSgss---epdSKrprLDREQEDgeggvagGGEGRARLKRTISRREagkatlealrpSPLEVQLTINFGdr 392
7APK_E       356 -------------DDSV----------LHLTFYYLMNLNIMTVKAKVTtamelitpiSAGDLLSPDSV--LSCLYP-GDH 409 human
EEY60744     372 -----------mdTDKNgtttktvsgsFTVMFQYFPVAKMVTAEVVKT---------APAGFYPGSQRcmLTNLFP-GDD 430
Q55GJ8       354 n-----------------------kkdLSIQFYYYPNLKIVTVLPSLD-----------GDFEMGQKL--LESLDN-SDT 396 Dictyostelium d...
XP_006676418 319 ---------------------------IKMVFNYIPVLNIVIVSAQLG---------SDTGNLPANYL--LHGLVP-QDD 359
XP_001744967 305 --------------KVQ----------VAWTLRWYPVVDMVTVEQD-----------PAPGLLEDA----LSHLYV-NDT 344
EGC30418     366 --------------DTK----------TTLQFRWNWSKNVV----------------LCKTLGHSDYY--LFNIFP-NDN 402
Q1ZXD7       412 --------------DTK----------VSLEFTWDWFRNIV----------------LCKPIDHSDFY--LYNIFP-NDT 448 Dictyostelium d...
XP_004351476 345 --------------------------lVSIQFYFLADENII----------------VCSINTDNQSY--LSNLFP-NDI 379
EFA84452     332 --------------NQT----------TQLQFHSVVNLNLVS---------------LVTTDAQDDCF--LSNLYCgNNV 370
CBN79838     393 ksdagaaaappkaSGSTsta-----etFKVRFSFFPSLGVVAVRPAAHdgg-----------------alLANLFP-ADT 449
7APK_E       410 G-KKT----------------------PNPANQYQFDkvgilt---------lsdyvLE---LG----------HPYLWV 444 human
EEY60744     431 G-LTV----------------------PQVAVNYTFQ--------------------EDsdeRTevefpasaacRPYYWT 467
Q55GJ8       397 G-LMT----------------------PNLSNHFIFEsfgkd-----------lfklDEhnlKG----------RPYKWV 432 Dictyostelium d...
XP_006676418 360 G-LTS----------------------PNPANQFLMQgsf---------------tfDVvkaGG----------MALQWA 391
XP_001744967 345 G-TEI------------------------VNTRIALQeavarsa-------tvddllSE---RQ----------RAYRWL 379
EGC30418     403 G-FSNytngidipplsissqfaspftsPTPLSPKPINnnstskrnnf-lapsplpplSPpssLG----------KPYKWV 470
Q1ZXD7       449 GlLASftgdvei--------ppisitsPTPLSPKPINnqqpsqqqshqnninvniidSYnsgFG----------RPYKWT 510 Dictyostelium d...
XP_004351476 380 Gddfiq-----------------sfttTNTNGPKQSN--------------------STlniVG----------KVFRWA 412
EFA84452     371 Gcgg---------------------veLHPSIPIPLNsnnnnnsssnsnssnsnsniNNqsrSG----------KFYDWV 419
CBN79838     450 G-KDT----------------------PNPANHHNKA--------------------AQaspLGvfeypadvpcRPYRWA 486
7APK_E       445 QKLGGLHF 452 human
EEY60744     468 QWICGLNP 475
Q55GJ8       433 QFITGLSF 440 Dictyostelium discoideum AX4
XP_006676418 392 QAISGASF 399
XP_001744967 380 QICSGLve 387
EGC30418     471 QVLCGLLP 478
Q1ZXD7       511 QVLCGLLP 518 Dictyostelium discoideum AX4
XP_004351476 413 QLLGGLmv 420
EFA84452     420 QMLSGLvh 427
CBN79838     487 QRLAGLRF 494
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