Conserved Protein Domain Family
SOCS
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pfam12610: SOCS 
Suppressor of cytokine signalling
This domain family is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam07525, pfam00017. The suppressors of cytokine signaling (SOCS) family play important roles in regulating a variety of signal transduction pathways that are involved in immunity, growth and development of organisms.
Links
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Statistics
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PSSM-Id: 432667
Aligned: 10 rows
Threshold Bit Score: 52.0874
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_013132427  58 SSCSRRRRERKCSCSALGDTLTSGDiDVMcRKALSRRSLRQKFQDAVGQCFPLRSHHHH 116 Nile tilapia
XP_011608037  55 TSCPRRRRERMCSCTTLGDGPASADnDVVcRKALSRRSLRQKFQDAMGQCLPLRSHHHI 113 torafugu
ABQ28696      57 PSCPRRRRDRTCSCAALGDLPSAADtDAVcHKASSRRSLRQKFQDAVGQCLPLRSHHHA 115 spotted green pufferfish
XP_015206178  56 ASCPRRHRETRCSCSPAGDGDCERP---ScRKALSRRSLRQKFQDAVGQCFPIRSHHHH 111 spotted gar
XP_008570919  58 TEVPLRNQERKHSCSSI-----ELDlDHScGHRFLGRSLKQKLQDAVGQCFPLKNCSSR 111 Sunda flying lemur
XP_007231032 140 TERRSGRSRRRHGTSGISREELEPG---------APRSLRQQFHDTMGLCLPLRSSSRN 189 Mexican tetra
CBY83941     132 SRGSTARRERRYAVSSIQEINDSVEvGSS-GRSLSSRSLRQRLRDTVGLCLPLPTHRRS 189 zebrafish
XP_007255839 136 SRGGTSRRERCYGTSSIQEMSDSAG-GVG-GRSLSVRSVRQRLKDTVGLCLPLPTPRRS 192 Mexican tetra
NP_001116396 141 LRGSGNRRDRRYGISSIQEINDSVG---G-GRSLNTRSLRQRLSDTVGLCLPLPARRCS 195 Japanese medaka
CAG10175     139 VRGSGNRRDRRCGVGSFQEMSDGVC---G-GRGLSARSLRQRLSDTVGLCLPLPAHRRS 193 spotted green pufferfish
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