Conserved Protein Domain Family
Es2

?
pfam09751: Es2 
Nuclear protein Es2
This entry is of a family of proteins of approximately 500 residues with alternating regions of low complexity and conservation where the domain similarities are strong. Apart from a predicted coiled-coil domain, no other known functional domains have been characterized. The protein appears to be expressed in the nucleus and particularly highly in the pons sub-region of the brain. The protein is clearly necessary for normal development of the nervous system.
Statistics
?
PSSM-Id: 430802
Aligned: 57 rows
Threshold Bit Score: 194.97
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
KIS72291      47 KQAILTEEEYTCALSSIIKRDFFPDLDRITAENEYLAAVEAEEPARIRIALDRLLRLDgrtnASpapQRa------SKRs 120
XP_002954839  37 QPIVLDEDTYTQQLEAIIERDYFPELPKMVNQLEWLRAVNSGDIREMQRAQRNIARRRaaaaAAvaaAAgatpapgSIGg 116
Q656K0        54 RPEVLDEDTYVAAVERIIERDFFPDLPRLRDRLDWLQALRSRDPLVLRDAQLKILERRrraqRQrqgGPv---------- 123 Japanese rice
XP_002272703  42 EVTVLDEDTYVAAIEKIVERDFFPDIPKLRDRLEWLEAVRSGDPLRIRDVQLKIRDRRgrkaLNcaeTErn--------- 112
XP_002301584  44 HPTVLDEDTYVATIEKIIERDFFPDISKLRDRLDWLEAMKSGDPIQIRDAQLKIMERRgk-kVNnpsSDgsfrsrnR--- 119
XP_002533868  45 RARVLDEDTYVAAIEKIIERDFFPDISKLRDRLDWLEAVKTGDPIQIRDAQLKIIERRgk-rVNssnSDgstqtrnRSQ- 122
Q9S7V6        44 RMRVLDEDAYVEAIEKIIERDYFPDITKLRDRLDWIQAVKTRDPIQIRDAQLKIIERRgk-kANhhvGDte--------- 113 thale cress
XP_003544200  38 HPAVLDEDTYVEALEKIIERDYFPDISKLRDRLDWLEAIKTGDPVVIREAQLKILERRagtaKVtnhNDtsr-------- 109
EDQ57272      52 SQIPLDEDTYVAAIEQIIERDFFPDIPKLRNRLEWLEAVRSGDPVIIRDAQMNIIRRRrekaREdgeRDgtps------- 124
XP_001742346  43 PKTVLEEDDYVAALEKIIERDFYPQLPQLRAQEEYLQALEANDFERLRDISRRYGTPGvgstASsrrTTpsra------- 115
KIS72291     121 rnhlsrasaaarndsgewDNTPIA-----F---GSssevfdptfTP-AESTiwldhqgEPQHEAEAeaa--------pas 183
XP_002954839 117 dtpg----------llppFHTPGNgagwaTatpgt-----allrTPaMTPAvggggtgTEAAAAAAaanvaav-aggats 180
Q656K0       124 -----------------pTPTPATstalrSpsf---------laTPsVAPSvagdegaDV-------------------- 157 Japanese rice
XP_002272703 113 -----------------rSRTPGStf-trTftpFEld------kTPdVSNRessvageSAD------------------- 149
XP_002301584 120 ------------------TQTPGStf-mrSltpFDefds--riqTPgVVMDrglssnaESNEN----------------- 161
XP_002533868 123 ------------------TQTPGStf-mrNlnpFDefdiinsnkTPrMDMFgdkeksdNNDEA----------------- 166
Q9S7V6       114 ----------------gkTQTPGStf-lrNftpLDefd----gkTPrTPGVsgrefhgVEVDAGDG-------------- 158 thale cress
XP_003544200 110 ----------------ttSHTPGStf-vrNftpLDefdg-kpsqTPrAPAPeakegenN--------------------- 150
EDQ57272     125 ---------------tniPDTPASmis--------------glaSPaVSLRsaaspsvSGLFPPTGsard-------vdn 168
XP_001742346 116 ---------------ggsFETPLPgarqdAaspw------sragTPgMRSGsdlhlpgAEGGTDGAdsvsaagsnrkadd 174
KIS72291     184 GIHPDLDLSLAHFQSRYTSEDNASFSQLLDRDNELRK-RKHAHLFAHE-AASGKRRQQLIDaerRDAERGkrLMlEASPD 261
XP_002954839 181 ATATPDDLSLDAFLSRYTSEDNASFQAILQEDNRRKRaKVRHHLERPDpRDPETR---------QLLLEGpkDR-PSDEY 250
Q656K0       158 DDDVEAALSLDDFFRRFTSEDNESFSRILEKVNHRRR-ERYAHLLEPGeVAKA-----------PQLEDAkrDR-ITDGY 224 Japanese rice
XP_002272703 150 DDSEALPLSLDQFFRRYTSEDNESFSKILEKANRKRK-ERYEFLTEGEk-EDV-----------KLIEDVkrDR-ITDGY 215
XP_002301584 162 EVAVDKNLSLDEFFRRYTSEDNDSFSKILEKVNRKRK-ERYEHLLEGEk-EDV-----------KFIGDAkrDR-ITDGF 227
XP_002533868 167 DDAVDEFLSLDEFFRRYTSEDNESFSKILEKVNRKRK-ETYGHLLEGEk-EDV-----------KLIEDVkrDR-ITDGY 232
Q9S7V6       159 DEDIDLNLSLDEFFRRYTSEDNESFSKILEKVNRKKK-EKYGFLLEGEk-EDG-----------KSIEDVkrDR-ITDGY 224 thale cress
XP_003544200 151 DGGVDTSLGLDQFMRRYTSEDNHSFSKILEKVNKKRK-ERFGYLNE-----DV-----------QGIEDVkrDR-ITDGY 212
EDQ57272     169 GPSVDVNMKLDDFLRKYTSEDNASFSKILEKVNKQRK-QKYEFLNEKGlVD-------------PNLRIEnaNDrVTDGF 234
XP_001742346 175 KPSADTTLSLDRFLDKYTSEDNDSFDQIIEQTNLRLR-AQFESLFGRAeEQAQRLALTDGD------------------- 234
KIS72291     262 DSNmseeatemlliegsdakveeksataaavtvtgqrpetssekdpmddlvlvceprqDDRRTASglHRWKYTARNALMF 341
XP_002954839 251 GTS-------------------------------------------------------GQMPMTLlpAP--EPVVNALFY 273
Q656K0       225 GTS-------------------------------------------------------GQPLSTL--EGAKFTAKNLLMY 247 Japanese rice
XP_002272703 216 GTS-------------------------------------------------------DQPPSTL--DGWKYTAKNLLMY 238
XP_002301584 228 GTS-------------------------------------------------------DQPPSTL--EGWKYTAKNLLMY 250
XP_002533868 233 GTS-------------------------------------------------------DQPVSTL--EGWNYTAKNLLMY 255
Q9S7V6       225 GTS-------------------------------------------------------DQPPSTL--EGWKYTAKNLLMY 247 thale cress
XP_003544200 213 GTS-------------------------------------------------------YQPPSTL--EGWNYTAKNLLMY 235
EDQ57272     235 GTS-------------------------------------------------------NQPFATL--DTWKYRAKNLLMY 257
XP_001742346 235 ----------------------------------------------------------KDAYKSYflDHWRHTPRNQLMW 256
KIS72291     342 GADANES-----YLHARPLGVTADHEAsRPQTNFTALRLgEQSNShtavrhv--dapqseaGWCASTSRLDAAIQr--GR 412
XP_002954839 274 DSSQRPE-----VPFSAKELADRALGP-PKEINRAGTRLkappeap---------pltvaaPVAAAAAAAAAALAngeDA 338
Q656K0       248 YPADRGE-----APLTDEERAERLKGM-TKEIDRSNTRF-HGKSSvddgakeeeaaailyaPVAGSTP---GGMAyhdPD 317 Japanese rice
XP_002272703 239 HPADRGE-----APLTEEERAERLNGL-TKEVNLTNTRF-HGKLMdsrpkded-tvavlytPIPGATP-VPLSLSereGD 309
XP_002301584 251 HPADRGE-----APLTEEEQAVRLKGL-TKEINRSSTRF-HGKMLdtrprddg-vvevlytPVAGATP-LP--MYdrdGD 319
XP_002533868 256 HPADRGE-----VALTEEERAVRLKGL-TKEINRSNTRF-HGKMLdsrpkddg-svevlytPVVGGTP-LP--VSgrhGD 324
Q9S7V6       248 HPADRGE-----APLTEAERAVRLLGL-TKEIVKGNTRF-HGKTMdsrpredg-sveilytPIAGSSP-MH--ISgrdRD 316 thale cress
XP_003544200 236 HPADRGE-----VPLTEEERAHRIKAA-TKEINRGNTRF-HGKMMdsrpkddg-tvevlytPVGGATP-AP--MSlreGD 304
EDQ57272     258 DSAERED-----VPLTQAEKEELVEGP-PKSIEMKNTRF-HGKMFdskvreed-tvailytPVAGGTPQAWPFAQrdaER 329
XP_001742346 257 APSEKTPtakelIALSKRKQ---------NVIQHANTRF-----Trapfpttg-ssngtktGTKTGASQHGVVILrddGN 321
KIS72291     413 AGSFTS-------PVaSASGDETPK--------VN--GYGFVTpysTPQsgnsqsvdgemhlRVYNAIKRSRQHHVTAst 475
XP_002954839 339 AAAAAA-------AAaAAAAAGAPAgapmpgglIGtvGYAPMA---TPAle----------dVMASPLMTWGDIESTPlr 398
Q656K0       318 KAKKYDledlrktPNpFYVESGKNA--------NN--GYSFVR---TPSpa---------pgVDESPFMTWGEIDGTPlr 375 Japanese rice
XP_002272703 310 KSKKYDledlrktPNpFYVESRKRA--------DN--GYSYVK---TPSpa---------pgVDESPFITWGEIEGTPlr 367
XP_002301584 320 KAKKYDledlrrtPDrFYVESGKKA--------DD--GYSFVR---TPSpa---------pgVDESPFITWGEIEGTPmr 377
XP_002533868 325 KAKKYDledlrrtPNnFYMESGKKA--------EN--GYAFVR---TPSpa---------pgVDESPFITWGEIEGTPlr 382
Q9S7V6       317 KSKRYDlddlrktPNpFYVESDKRA--------DN--GYSFVR---TPSpa---------pgLDESPFITWGEIDGTPmr 374 thale cress
XP_003544200 305 KLKKYDledlrktPNpFYLESGKKA--------EN--GYSFVK---TPSpa---------pgVDESPFITWGEIEGTPlr 362
EDQ57272     330 ARKRYDledlrktPQaLDSQSKGVG--------HPgaGYSYVA---TPSpa---------pgVDESPFMTWGEIEGTPlr 389
XP_001742346 322 KPSVHAr------HTpSSSTDGTPA--------VN--GYKFVA---TPSpv---------pgQDLDPDLTWGEIDGTPfr 373
KIS72291     476 sidd--------iaaraCGFQLPRLDKREQLAEKLTSTPklkrAAE---------------------------------- 513
XP_002954839 399 lgaddmpvdleamvgggPSFRVQGMSEREQAAHRLAAAKagsgTAAgraitargstplltalrraatgtgggagatarag 478
Q656K0       376 ldpeetp--ggsggsdrAHFKIPPPPARDVKAHLLSRDA----ARKikertkmfhk-----------------pplpspv 432 Japanese rice
XP_002272703 368 lepedtp-igiggsgdgPHFKIPCPPSRDLKAHSLSREA----ARKlrerskmfqk-----------------pplpspv 425
XP_002301584 378 lepedtp-idiggsgngPHFKIPNPPARDVKAHSLSREA----SRRlrekskmfqk-----------------pplpsps 435
XP_002533868 383 lesedtp-idiggsgdgPHFKILNPPARDVKAHTLSREA----ARKlrerskmfqk-----------------pplpspg 440
Q9S7V6       375 ldledtp-idiggsadgPHYNIPSAPPRDVRAHSLSRDA----SRKlrersnsmfk----------------kpplpsph 433 thale cress
XP_003544200 363 ldledtp-ldiggsadgPHYKIPSAPARDSKAHSLSREA----ARKirerskmfhk-----------------pplaspv 420
EDQ57272     390 leiedtp-vgiggngdgPHFKIPAPPTRDARAHALSRDA----ARSlrekakfrss----------------rfspspgr 448
XP_001742346 374 ldagd------vplqsgPAFNIPEPSARDQLGRRLAEDT----AAKrrkmqhaaqa----------------rtragsve 427
KIS72291     514 --RASTPygqarytgltrlrtsafgrspqkMRDKVGGLTPAAKAL 556
XP_002954839 479 atGGKTP--------------------------LAVPLSPAARQL 497
Q656K0       433 rgGSASP----------------------------RTFSPAAQKF 449 Japanese rice
XP_002272703 426 rgGSASP--------------------------SVRTLSHAAQKF 444
XP_002301584 436 rgGSASP--------------------------SVRTLSPAAQKF 454
XP_002533868 441 rgGSASP--------------------------NVRTLSPAAQKF 459
Q9S7V6       434 rsGSASP--------------------------NVRTLSPAAQKF 452 thale cress
XP_003544200 421 rgGSASP--------------------------SMRTLSPAAQKF 439
EDQ57272     449 gpGQASP---------------------------APGFSAAAQKF 466
XP_001742346 428 hsSRHTP-----------------------AARRLASMSPAAQQL 449
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap