Conserved Protein Domain Family
SGL

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pfam08450: SGL 
SMP-30/Gluconolactonase/LRE-like region
This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.
Statistics
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PSSM-Id: 462480
Aligned: 39 rows
Threshold Bit Score: 182.462
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6FRB0        20 LSEGLTYIKETDTLLWV------DIYRGEIHRLDSVSASGTAnhkvfnvsqstyssgaaIKYPKtptp---lreSVGCIF 90  [Candida] glabrata
P56553        19 LTEGVTYDERNNTLLWV------DIIQGEVHRVFLDNTNINTntssss------hetlkWDSSNe---------SIGAIC 77  Candida albican...
Q7UTE9        24 LPEGPMAMVADGKLSWVgiqhgaDVLHGSINVLDLATQTNQS-----------------HDLPG----------RPGFAF 76  Pirellula sp.
vbi:Avi_0916  17 LGEGPTYDVARDTAWWF------DILGKGLIEHRFATGETIR-----------------HDLPM----------MASALA 63 
Q5YUA4        31 WPECPRWH--EGTFWFS------DMYTGTLKTLDADGNATVV-----------------IDATGrgantdvpivLGGFGW 85  Nocardia farcinica
Q73TY7        30 FGEGPRWF--EGLLWFS------DMLGEAVHTTTMGGALTT------------------LPLPGh--------cPSGLGF 75  Mycobacterium a...
Q6N3R9        13 FPEGPVVMP-DGSVVLV------EIRAQQLTRVWPDGRKEVV-----------------AKVPGg---------PNGAAL 59  Rhodopseudomona...
Q8P3F8        62 WSEGPTWVRQGGYLLFT------DVPENKLYRWSDDSGLSVF-----------------LSPSGyagtdvaalrEAGANG 118 Xanthomonas cam...
Q89RF5        48 WAEGPVWFGDGRYLLCS------DIPNQRIIKWEEETGAVSV-----------------FRKPSn--------fANGNTR 96  Bradyrhizobium ...
Q89PW1        29 FTEGPIWHPIDHYLLFS------DMPGDVRRRWDARRGMAEV------------------KRPSn--------kCNGMTY 76  Bradyrhizobium ...
Q6FRB0        91 PviTDGqvDTVLFGSKFGV----------------------GRC--QFSSGeweyltlyshcpelasgDRWLDLRSNDGN 146 [Candida] glabrata
P56553        78 L---TNdpNKLIICSKYGL----------------------AYG--DFSSstieyffk---yphttnpDEKLRLRSNDGI 127 Candida albican...
Q7UTE9        77 Q---CRtaGKFVAGVERSL----------------------GIF--DINSGewtpf-------fdgvdSDVTNTIINDGL 122 Pirellula sp.
vbi:Avi_0916  64 T--IDA--ERQMLATEQGI----------------------FIR--AIASGeltll-------talepER-PGNRSNDGR 107
Q5YUA4        86 L---PD--GRLIVVSMHEK----------------------LVLvhG---Ggapddl-----svyadiSPYCSAAANDMV 130 Nocardia farcinica
Q73TY7        76 R---PD--GSLLIASTRDR----------------------RVLryD---Getvvtv--------aeladiAPADLGDMV 117 Mycobacterium a...
Q6N3R9        60 G---PD--GKMYICNNGGFgwfpsrgtmmpgapapheyiggSIQrvDLQSGevetl--------fdkcGEHPLKGPNDLV 126 Rhodopseudomona...
Q8P3F8       119 L--FAEpgGTVLLADSGTR----------------------IVArlDPATRtktpl-------atsfdGK-RFNSPNDVV 166 Xanthomonas cam...
Q89RF5        97 D---RQ--GRLVTCEHGGR----------------------RVTrtE-YDGsitvl-------mdsfgGK-RLNSPNDVV 140 Bradyrhizobium ...
Q89PW1        77 D---AE--LNLIVCEHATS----------------------SLIreR-PDGrrevl-------ashfgGQ-ELNSPNDVC 120 Bradyrhizobium ...
Q6FRB0       147 VSPDGKsLYVGVMCDFHVPMQDI--------GAIVRVDLVg-SAalplpVHLVIDRVKIPNAIHWNSAGTKMYW---TDS 214 [Candida] glabrata
P56553       128 IDPWGN-LWIGVMNDFPIGAKEGiq----peGKLYRIGFS--KEsnkltCDVMIENSLISNGLCFNNQGDEFYW---TDS 197 Candida albican...
Q7UTE9       123 AIDDN--LIFGTKDLEFAEKK----------AGLYLYRGSd-KK-----LIRLRDDQICSNGKMIRRDDSGKLFlldIDS 184 Pirellula sp.
vbi:Avi_0916 108 VHPCGA-LWIGTMGKTAADGA----------GAIYHVAGD---K-----VTRLYDSISIPNAICFSPDGSLGYY---VDT 165
Q5YUA4       131 VDADGR-AYITQLGFDIFKGDEPt------tSPLIVVEPD--GTv---gTPEKVGPLNCANGIAISADGTKLYT---AEV 195 Nocardia farcinica
Q73TY7       118 VDRAGR-AYIGCQAFTG--------------GAIIRLDPD--DR-----ATVVADDLDFPNGMAITPDGATLIV---AES 172 Mycobacterium a...
Q6N3R9       127 FDKHGG-LWFTDLGKRRARDMDV--------GAAYYIKPGm-TE-----ITEQVFGTLPLNGIGLSPDEATMYA---AET 188 Rhodopseudomona...
Q8P3F8       167 RRKDGV-VFFTDPPYGLKGMNDSpvke-lrfNGVYRLDTD--GS-----VHLLDDSLSFPNGIALSPDQRTLYV---ANS 234 Xanthomonas cam...
Q89RF5       141 VKSDGS-VWFTDPTFGLLGNYEGykaepeiePNVYRLDPAt-GK-----ANIVAEGVLGPNGLCFSPDEKILYVvesRGV 213 Bradyrhizobium ...
Q89PW1       121 VHSSGA-IYFSDPWYGRMPVYGVerprqlgfQGVYRVMPGgePK-----LVVDRNLFDQPNGLCFSPDERLLYV---NDT 191 Bradyrhizobium ...
Q6FRB0       215 LHFC--LWEQDGDdSST----KKKL-IDVQRHNpefespE---PDGSATDLvNNVVYVCVW-----STH----KVQKYSL 275 [Candida] glabrata
P56553       198 LTFK--IWKYDYDkTTNkltnKSVF-IDLKQFYpdveqpE---PDGLVMTN-NGEIYTCVF-----STG----TILHVDN 261 Candida albican...
Q7UTE9       185 PTRK--VVEYPLDiEAGtigeARVV-LDLTDDP------Gv--PDGAILTPdGKGIIVAIFhpgvaEHG----ETRLYDL 249 Pirellula sp.
vbi:Avi_0916 166 RVNT--LMKVSLDpATGlptgTPSVhIDGRGKD------Gg--IDGAVCDA-EGGLWNARW-----GVG----AVDHYDR 225
Q5YUA4       196 MAFK--ITVIDRAaDGSls-nPRDF-ATCPFM-----------PDGIGLDD-EGGVWAAMP-----GGG----YVARFTE 250 Nocardia farcinica
Q73TY7       173 TGRR--LSAFAIDdDGAls-gRRVF-ADGLDGP----------PDGIALDA-DGGVWAAMT-----LAH----QFERIVA 228 Mycobacterium a...
Q6N3R9       189 PTGR--LWAFDLSgPGEvk-pRDVI-YRGEKGKpicglgGyqmFDSLAVEA-SGNVCVATL-----VSG----CISVIAP 254 Rhodopseudomona...
Q8P3F8       235 DPARpiWMAYALDaQGAvt-gKRVF-ADATDLVnkdtpgL---PDGMAVSA-DGRLFAT-------GPG----GVIVFDP 297 Xanthomonas cam...
Q89RF5       214 PNRK--ILAYDVSaDGTtisnKRVH-IDAGPGT----------PDGMRCDI-DGNLWCGWG-----MGDpeldGVVVFAP 274 Bradyrhizobium ...
Q89PW1       192 VQAL--IRVFDVNaDGTls-nARVFaSSIKSELe----pGl--PDGMKCDQ-HGNVWVTAP-------G----GVWVYSP 250 Bradyrhizobium ...
Q6FRB0       276 EdGTLLHEYVLPqSTpRISSCCFvG----RDLCITTAN 309 [Candida] glabrata
P56553       262 Q-GKEIERIKIA-AK-RPTCVTIgSgiknNEMFVTTGH 296 Candida albicans SC5314
Q7UTE9       250 AtGELRTIWQTP-GSpQNTCPALvPhegkLKLVITTAI 286 Pirellula sp.
vbi:Avi_0916 226 T-GQHLARYRLP-AA-QTTCPAF-IgakaDRLLVTSAT 259
Q5YUA4       251 Q-G-ITDAVPMPlENgIASACLL-GgpdrNRLYMTVGF 285 Nocardia farcinica
Q73TY7       229 G-GAVSDRIDIG--DrVAIACAL-GgpqrRTLFLLSST 262 Mycobacterium avium subsp. paratuberculosis
Q6N3R9       255 D-GTLVE--QVPtGDrVTTNIAF-GgpdlKTAYITLSG 288 Rhodopseudomonas palustris
Q8P3F8       298 D-GRRLGRIETGa---AISNCAFgn--dgHTLYMTSHA 329 Xanthomonas campestris pv. campestris
Q89RF5       275 D-GVMIGRIALPe---RCANLCF-GgvkrNRLFMAASQ 307 Bradyrhizobium japonicum
Q89PW1       251 R-GELLGKVRVPe---LVANLAW-GgpdfRTLYLTSTH 283 Bradyrhizobium japonicum
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