Conserved Protein Domain Family
HAP1_N

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pfam04849: HAP1_N 
HAP1 N-terminal conserved region
This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologs. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34.
Statistics
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PSSM-Id: 461455
Aligned: 22 rows
Threshold Bit Score: 350.865
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P54257       107 FVFQGPFGSRATGRGtGKAAGIWkTPAAYvgRRPGVSGPERAAFIRELEE--ALCPNLPPPVKKiTQEDVKVMLYLLEEl 184  human
ELW58267      33 EEQLPHYKLRADTIY-GYDHDDW-LHTPL--ISPDANIDLTTEQIEETLKyfLLCAERVGQMTK-TYNDIDAVTRLLEE- 106 
XP_015217853 207 QERLPLYTLRADCLF-GYDHDDW-LHTPL--LPPEAALQLTPQQIEETLKyfLLCSERVGQVTK-TYHDIEAVTQLLEE- 280 
XP_023190295 113 SEGQPKYTLRADTVF-GYDNDDW-LHTPL--VPPVVVLGLTYEQIEETFKyfLLCSDRVGQVTK-TYHDIKAVTHLLEE- 186 
XP_003642869 121 GEQLPRYTLRADTVF-GYDHEDW-LHAPP---ASQPTAPLTPQQIEETLWyfLLCAERAVRITK-TYHDIDAVTNLLDE- 193 
XP_013836418 108 FIFRGPFGSQASGLGtGKAAGIWkTPAACisRRPEVSGPERTAFIRELEE--ALCPDQPLPVKKiTQEDVKVMMNLLEE- 184 
XP_005624546 108 FIFQGPLGPRAAGLGtGKAAGIWkTPAARmgRRPGVSGPDHAAFIRELEE--ALCPDRPLPVKI-TQEDVKVMLNLLEE- 183  dog
XP_026368636 108 FMFQGPFGPRATGLGtGKAAGIWkTPAAYigRRPGVSGPEHAAFIREMEE--ALCPDRPPPVKI-TQEDVKLMLKLLEE- 183  Ursus arctos h...
TMS23070      69 SEGQPNYTLRADSVF-GYDNDDW-LHTPL--LPPTVVLGLTHEQIEETLKyfLLCSDRVGQVTK-TYHDIKAVTHLLEE- 142  large yellow c...
XP_006004743   1 --------------------meiwssgvihdecngnvgldnnsdlivceleeVLCSERVGRVTK-TYHDIEAVSHLLEE- 58   coelacanth
P54257       185 lppvwesvtygmvlqRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSdeede 264  human
ELW58267     107 ---------------KERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSA----- 166 
XP_015217853 281 ---------------KERDLELAARIGQSLLKQNRSLTERNELLDEQLEAAREEIAQLRHELTMRDDLLQLYASS----- 340 
XP_023190295 187 ---------------KERDLELAARIGQSLLKQNQELTSRNETLDEQLEIATEEIAQLRHELSMRDDLLQFYAST----- 246 
XP_003642869 194 ---------------KERDLELAARIGQSLLKQNRSLTERNELLEEQLELAKEEIAQLRHEVSMRDDLLHFYTTN----- 253 
XP_013836418 185 ---------------RERDLNTAARIGRSLVKQNSVLTEENSKLEAMLGSAREEILHLRHQVSLRDDLLQLYSDS----- 244 
XP_005624546 184 ---------------RERDLNTAARIGQSLVKQNSVLMAENSKLEAMLGSAREEILHLRHQVSLRDDLLRLYSDS----- 243  dog
XP_026368636 184 ---------------RERDLHTAARIGQSLAKRNSVLMEENSKLEAMLGSAREEILHLRHQVSLRDDLLQLYSDS----- 243  Ursus arctos h...
TMS23070     143 ---------------KERDLELAARIGQSLLKQNQELTARNEMLDEQLEIAKEEIAQLRHELTMRDDLLQFYAST----- 202  large yellow c...
XP_006004743  59 ---------------KERDLELAARIGQSLLKQNQSLTEKDEYLEEQLQLAKEEIAQLRHEIAMRDDLLHVYTNT----- 118  coelacanth
P54257       265 deeEEEEEKEAEEEQEeEEAEEDLqcahpcdap--------------------klisqealLHQHHCPQLEALQEKLRLL 324  human
ELW58267     167 ---AEESEPESVCSTP-LKRNESS-------------------------------------SSVQNYFHLDSLQKKLKDL 205 
XP_015217853 341 ---AEDSEPPSACSTP-MKHSGSS-------------------------------------ASLGSYFHYDFLQQKLKGL 379 
XP_023190295 247 ----EETENAQGLS-P-IKRNESS-------------------------------------SSLSNFVHYDFLHQKLKGL 283 
XP_003642869 254 ---TEENEPTSAPITP-LRRNESS-------------------------------------LSLQQYFQYDALQQKLRCL 292 
XP_013836418 245 ---DEEEEEEEEGEEE-EEEEEEEeeeedgeee-------------------eeqrtplaeSELHCCPQLEALQEQLRLL 301 
XP_005624546 244 ---EEEEEEEEEEGEE-EEEEEEEeeteeeeeeeeeeeqh------dhpygaseltslgepESLHFCPQLEALQEQLRLL 313  dog
XP_026368636 244 ---DEEEEEEEVEEEE-EEEEEEEeeeekeeeeeeeeeeedgeeewqrdhlygaseptsvwESRHQCLQLETLQEQLRRL 319  Ursus arctos h...
TMS23070     203 ----EEIENAESHSp--IKRNESC-------------------------------------SSLSNFVHYDFLQQKLKGL 239  large yellow c...
XP_006004743 119 ---AEESESSSTVSTP-LRRNESS-------------------------------------ASLQHYIHLDFLQEKLRGL 157  coelacanth
P54257       325 EEENHQLREEASQL----DTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCRM 400  human
ELW58267     206 EEENVVLRSEACQLktetITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA 285 
XP_015217853 380 EEENLKLRTEARDLttetTNYEEQEQQLMMDCVQELASVNKQVAQLSEELARKVEDTMRQQEEISHLLAQIVDLQHRSKA 459 
XP_023190295 284 EEENRKLRLEATELstetTNYEEQEQELMMVCVEELSSANKQVVDLSEELARKVEDTVRQQEEISSLLAQLVDLQARCKG 363 
XP_003642869 293 EEENQKLRLEATTIvtetSRYEDQEQQLMIDCVEQFSAASQQVVCLSEELARKAEDTARQQEEISQLLAQVVELQQKCRT 372 
XP_013836418 302 EEENEQLREEASQL----DDLEEEEQMLILDCVEQFSEASQQMAELSEVLALRMENFEQQQREVAQLRAQVVKLQQCCRS 377 
XP_005624546 314 EVENEQLREEASQL----DALEEEEQMLILDCVEQFSEASQQMAELSEVLALRMESHDQQRREVTQLRTQVLKLQRRCQS 389  dog
XP_026368636 320 QAENEQLREEASHL----DALEEEEQMLILDCVEQFSEASQQMAELSEVLALRMETHDQQRREVTQLRTQVLTLQRCCQT 395  Ursus arctos h...
TMS23070     240 EDENRKLRLEANELttetSHYEEQEQELMMVCVEELSSVNKQVVDLSEELARKVEDSLRQQEEISSLLAQIVDLQARCKG 319  large yellow c...
XP_006004743 158 EEENQKLRSEATDMvtetVDFEEQEQQLMIDCVQELAEANREVGMLSEELARKTEDILRQQEEISQLLAQIVDLQQKCKS 237  coelacanth
P54257       401 -------------------------YGA--ETEKLQKQLASEKEIQMQLQEEsvwvgsqLQDLREKYMDCGGMLIEMQEE 453  human
ELW58267     286 -------------------------CAV--ENEELVQHLGAAKDAQRQLTAE-------LRELEDKYAECMEMLHEAQEE 331 
XP_015217853 460 -------------------------LSS--ENDELNQHLAASREVQAQLRSE-------LSDLQDRYSECEDMLQEARED 505 
XP_023190295 364 -------------------------LGH--ENEALNHQLSASREKEAKFTSE-------LKDLQDKYSECEDMLHEAQKD 409 
XP_003642869 373 -------------------------YGT--EVEELQQHLAAAKEVQQQLRTE-------LQDLQDKYVECGGMLQEAQEE 418 
XP_013836418 378 -------------------------YGV--ETEKLQQQLASEKEIQMQLQDE-------LQDLREKYSECGGMLIEAQDE 423 
XP_005624546 390 -------------------------YGV--ETEKLQQQLVLEKEIQMRLQDEd-----aLPGFQETLAEELRMSIRRIIS 437  dog
XP_026368636 396 ygaeteklqqqlasekeiqirlqdeEALpgFQETLAEELRMSMRRIISDPVF-------FMERNHRTTTEEMSHLGYKLC 468  Ursus arctos h...
TMS23070     320 -------------------------LTh--ENEELNHNLSASRESQLKLKSE-------LKDLQDKYSQCEDMLCEARED 365  large yellow c...
XP_006004743 238 -------------------------ITT--ESEELSQHLALSRERQEQLRLE-------LKDLQEKHAEYKELLQETREE 283  coelacanth
P54257       454 VKTLRQQ 460  human
ELW58267     332 LKNLRNK 338 
XP_015217853 506 IKNLRNK 512 
XP_023190295 410 IKNLRNK 416 
XP_003642869 419 VKSLRSR 425 
XP_013836418 424 VRTLRQQ 430 
XP_005624546 438 DPVFFME 444  dog
XP_026368636 469 CNEAREQ 475  Ursus arctos horribilis
TMS23070     366 IKNLRNK 372  large yellow croaker
XP_006004743 284 NKNLRNK 290  coelacanth
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