Conserved Protein Domain Family
FhaC

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COG2831: FhaC 
Hemolysin activation/secretion protein [Intracellular trafficking, secretion, and vesicular transport]
Statistics
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PSSM-Id: 442079
Aligned: 467 rows
Threshold Bit Score: 219.054
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_082121492   1 MNKMkkrisvflaMLTVLAsfnf----afaqSVLppGEH-------ErqqilQ---QQEQekq---ykENIrNil--etQ 61 
YP_002348601   1 --MIrk-----rtALWLVLstga-----qaeT-P--LAIetpssinEsrqslQnnaKEINqlveekrhQQItQhntgqsE 65 
YP_001006626   2 NLMIkc-----kyIIILLFsnvv-----watQ-Pd-----------EskrplSngtTQQSdis--eyhQQFyKsdkyffR 57 
WP_015870382   1 ---Mkk-----ktPFYLLWvtlwgi-scgasAVP----VwdntptdEsrralQnsaREVNslleqqsfQRLeKq-----r 62 
WP_012368231   1 ---Mkk-----kvVLLTLLscf------stsGLSa-NETgnlgsisEsrralQdsqREINqlieqnryQQLqEk----aV 61 
WP_011144712   1 --MIkr------iSILILGcisf-----qiiASP--AEIndnlpmtEarrtlQdssREINqlieqrryQQLkQq----aN 61 
WP_004237648   5 LTLLrr-----ilLSGLFFcptl-----yaaPFP---AAaenpgadAsrramQdagQQVSdlleqqtyRQLsKp----qT 67 
WP_025304472   1 --MIkk-----itALTLLVstal-----saeTLPd-AHMmrdmsmgEsrralQdstREVNqlieqrryQQLkQq----rL 63 
WP_013185719   1 --MIkr------tAIFILLctsf-----qvcALS--EVPgmtfptdEtrrtlQdssREIDllieerrhQGLiNr----sH 61 
WP_106911115   1 MTACry-----fvAATLLVssglfcqglhaqGLPga---------dVprqaiQdssRQLNrwleeqryRQLeQg-----S 61 
WP_082121492  62 RvrdsrVKEGivLPEGggAAEDimqsdaDTIYKFDKIVVIGNKIfsGKTLHKAvlkQFLNKPINKYNVSLLQSMLLKYYI 141
YP_002348601  66 Ls---rPAPP--APV---LPED------TQCLPINGVYIQGITLl-TEDDLSEl-sAIPEQCIHPDNINLLTRELTHIYM 129
YP_001006626  58 Lv-----AKE--TDDR--DFPE------KNCLPITAIFLQGHTLl-TTRELDKl-nDLINYCISSNDLNTLAKKITRLYL 120
WP_015870382  63 Ra---rPTGA--APAQ--LRED------TACLPISGVYLTGITLl-SLRDLRAl-dALPAHCIRSRDINHLAKQLTALYL 127
WP_012368231  62 Ni---sP-----TPTL--ITES------EHCLPIKGVYIQGITLl-TEKDLNSl-sPLPDQCIKSADINRLVKELTQRYL 123
WP_011144712  62 Tv---pESTP--APV---LPES------KQCLPLTGVYLKGISLl-SVRDLSTl-sALSPACISSHDINRLSHELTHLYI 125
WP_004237648  68 Ti---tPTEP--LLR---AAEN------EHCLPVSGVYLSGITLl-SQDDLRSl-sPLPADCIRSRDINVLVAELMERYL 131
WP_025304472  64 La---ePEPA--APA---LPQS------AQCLPIAGVYLQGVTLl-SPSDLSAl-sALPEQCISSNDINRLTRELTRLYV 127
WP_013185719  62 Ni---sPQTV--SPA---LEEA------PPCLAITGVYLQGITLl-SIRDLNTl-sALPDSCITSNNINELSAEITNLYI 125
WP_106911115  62 Sa---pLSAP--AAV---LPES------EQCLPLSAVYLRGVTLl-DKQSLRAl-pQVSPQCITTAALNALIRQLTEAYL 125
WP_082121492 142 SRGYITTKVYFDPEqiNiidnketgqtETTFIVIVEEGktgkiSLEQVTkDNASktvskigkfrnNARLFFAFPFAVNKP 221
YP_002348601 130 DKGYITARIQFIPPd-A----------DGKLGLDITEG-----FVEAID-STDT-----------GLDGETVFPNMIGKP 181
YP_001006626 121 DKGYLAARVSFIPLn-T----------AGQLGINITEG-----IVEKIE-GGDR-----------QANPYFLFPNMLDKP 172
WP_015870382 128 EKGYITARVQFLRPn-A----------RGELGVRVTEG-----FIERIE-GSDR-----------GVNRRWLFPGAIGKP 179
WP_012368231 124 QHGYITARIQFLRPn-Q----------HGELGLYAIEG-----FVERIE-GGDR-----------GVNTTLLFPRIKGQP 175
WP_011144712 126 SKGYITARVQFIAPn-T----------DGELGLNVIEG-----FVEKIE-GGDR-----------WVNSSMLFPGLEKQP 177
WP_004237648 132 DKGYITARIRFLPVn-D----------YHELGIGVTEG-----TVERID-STDR-----------GVNTALLFPALTGKP 183
WP_025304472 128 QKGYITARVQIVRPn-S----------QGELGLSVTEG-----FIEKIE-GGDR-----------WVNNRLLFPGLEGKP 179
WP_013185719 126 AKGYITARVQFIPPn-S----------NGELGLNVVEG-----FIEAIE-GGDR-----------WVNSRTLFPNLTNKP 177
WP_106911115 126 QRGYIAARVILLPVd-A----------EGALTLQVIEG-----HLEAIE-GDST-----------LVNSATLLPGKTGQP 177
WP_082121492 222 VNMNVFEQGLDQMNRLQSNNVTMEIAPAAdkralEQAYSNIVIINNQnplaggvasgARTTFLNLNYNNGGSKSTGEQVL 301
YP_002348601 182 LNITRLDQGLDQANRLPSNKVTVDILPGT-----LPGGSILKLHNTP----------STPWHLTTSMDNYGNKNTGKWLS 246
YP_001006626 173 LNISELDQGIDQANRLRSNKVRVDVLPGT-----LTGMSTIRINNNN----------AKPWSLWASIDNYGYKNSDEWQA 237
WP_015870382 180 LRLAALDQGLDQANRLRSNHVSMDILPGE-----HVGGSVIRLYNRR----------GRPWQVSGSLDNYGQQSTGEWVA 244
WP_012368231 176 LKLATLDQGLDQANRLQSNKVTVDILPGT-----ELGGSVIKLSNQR----------KSPWHLNIASDNYGQKNSGRWLI 240
WP_011144712 178 LNITQLDQGLDQANRLQSNKTTLDILPGT-----VNGGSVIKLHNQR----------SKPWLLNIKTDNYGQKSTGKWRV 242
WP_004237648 184 LKITELEQGLDQANRLKSNHVTMDILPGS-----APGGSVIRLVNQR----------GTPAGFSISADNYGQKSTGRNVI 248
WP_025304472 180 LKLTELDQGLDQANRLQSNTTKLDILPGH-----QVGGSVIRLRNQH----------AKPWLITAGTDNYGQKSTGQWLA 244
WP_013185719 178 LNLNQLDQGLDQANRLRSNKTTLDILPGT-----VNGGSIIKLYNQH----------TSPWRITTTTDNYGQKNTGKWIN 242
WP_106911115 178 LNIHDLDQALDQANRLAANHVQADILPGR-----TPGGSVIRLLNTP----------DKRWHLTASTDNEGQKSTGRWQT 242
WP_082121492 302 NLSVSQDNLLSINDNIYISYTENsdslfnldkkdssvdygqshayktldmfnnddEKkkfSKALQGAVSFPFGYWTLNAS 381
YP_002348601 247 RNALSFDNPLGLSDSVSINISNTvdr--------------------------pqhNY---SRAYSMFYSVPYGALTFSGF 297
YP_001006626 238 KTVLTLDSPLGISDLVNINFNKTlen--------------------------gkrRY---KHSAGIYYSVPYGALTLSAL 288
WP_015870382 245 RGSATLDSPLGLSDFVSLSASTTlaa--------------------------psaRY---SRAYMLFYSLPYGDLTFSGF 295
WP_012368231 241 RTNASLDSPLGLSDFVSLNANITtdn--------------------------pntRF---NRAYTLLYSIPYGGFTFSSF 291
WP_011144712 243 RTNTSFDSPFGLSDFISLNASSTlds--------------------------psnRY---SRAYTLLYSMPYGAATFSGF 293
WP_004237648 249 RAAVTADSPAGLSDFVSLSGSATtdn--------------------------paaRY---SRSGMLFYSVPYGALTISTY 299
WP_025304472 245 RATATLDSPFGLSDFVSLNANSTlen--------------------------pahRY---NRAYTLLYSLPYGAFTFSGF 295
WP_013185719 243 RLSASIDSPLGLSDFISLSGSSTidk--------------------------pntQY---NRAYTLLYSIPYGSLTFSGF 293
WP_106911115 243 RLSAALDSPLGLSDSLNMSAATTltd--------------------------dteRY---NRSYTLLYSVPYGYATFSGF 293
WP_082121492 382 LNYSNYKSTVEGQYTRfHIT-GQSLSQAYTLDRVIYRTQIYKLNFGSGVEIKDTESYIRDVRSEtGSGRRSNVSVYFNNV 460
YP_002348601 298 GSYAEYRYPMKLQFNT-AKLhGETQQHGLRADYVFYRDQSQINGLSAQLTYKRASNYLNEEKIAiSSPTLTIFELGLNHL 376
YP_001006626 289 AHHTEYRRYEKLTYRV-VNFnGYSQQYNFRADYTFHRNQKTINSISGQLEHKQINNYVYDTKINiNSHRLSAIELGINQY 367
WP_015870382 296 ASFSDYQMHQSLPHTR-ILLdGQASQYGLRGDAVLQRSQRQINTLGVQLTYKRIRSYLQDDLLRvSSPTLSVAELGFSHL 374
WP_012368231 292 GSYSEYQFHQKLQTRT-VSLyGDTTQVGIRGDYAFSRSQKQIDTLNIQVTHKRIRNYFSQIRLDlSSPKLTTIELGINHL 370
WP_011144712 294 GSYSQYASRPHLQMRT-IKIyGDTQQIGMRSDFAFYRNQSQINSVSGQLTYKNYNNYIDNAKIGvSSQTLSVFELGVNHL 372
WP_004237648 300 GSLSRYRITQALRYNH-VILsGDSAQAALRADYVIFRNRSRIDSLMAQMTYKRSRNYLNDTLIGvSSPSLSIAEAGYTGL 378
WP_025304472 296 ASFSSYENHQQLPHNV-VKLhGQTQQYGLRSDYVFYRDHDQIDSLSGQLTYKRIDNYFESVRLEvSSPTLTLAELSASHL 374
WP_013185719 294 NSYSQYTSHPHLNLNR-VELhGNSQQTGIRTDWVFHRSQSQISTLNTQLIYKDYNNYFNESRIGvSSQTLSIFELGISHL 372
WP_106911115 294 ASHSDYLNTQPLQIYS-VQLsGHTDQAGLRADYVVARDQRSINTLSVQLTRKQSRNYFADALLGiSSPTLSVLSLSAARM 372
WP_082121492 461 IYtslGTIILKPSYQRGVSWFGSKt-dADTymnyemlsSDPRLEYNLLKLYLYFNTGFSiplltknknsgvrnrLPLSYT 539
YP_002348601 377 HVlpmGLFNINVSLEQGLPWLGAEr-sNGPl------aNYQDSQFTKAKTSITSNHYFAlf------------dDTYLFS 437
YP_001006626 368 RVipnGSMNVNVKVKRGLPWFAADkinASKr------iHYADGQFTTANAMVNFNRNFVlf------------nSVYQLN 429
WP_015870382 375 HIlpgGVATGNLSVERGLSILGADr---GRl------rTGAEAQYTKLKLSAGLNQRVTla------------dDVYLFS 433
WP_012368231 371 QIipnGVLSTNLSVEKAVGWFGAEetpYITn------gNGNDYRFTKVKLFANWYQRFSlw------------rSTFLFN 432
WP_011144712 373 HIiptGLITLNLSVEQGLPWFGAQtg-----------tAYLDKQFTKGKLMVNLHQRFMlf------------nSPYQLN 429
WP_004237648 379 ILvpgGVISTSLSAEKGTTLFGAAt---RNt------mPGSDPQYTKGKFSLSYIQQFSls------------eDAYLFS 437
WP_025304472 375 QIlpnGVFSANLSVEQGLPWLGADr---HPs------sVHLDSQFTKGKLFANLSQRLKlg------------dATYQLN 433
WP_013185719 373 QLipaGIISLDIGIAQGMPWFSN-----QTa------tSHLNTTFTKGKFSANWQQRFKfl------------dTSYQFN 429
WP_106911115 373 QIldhGLVSLNASVDQGTPWLGADsppPSGl------sGLPDSHFTKFTVNADLYRYFQpa------------gLNLQWH 434
WP_082121492 540 LTIDSQYSFNSLYGANQFSVGGEYSTRGFKESSISGDNGFYARNDfkvnalqlmpnvLTGSAAMKyktvfllgdslnsll 619
YP_002348601 438 NQFYGQYTRDRLPGVEWLSITDSSAIRGFSRNTLSADQGWYLQNT------------LSRRFTLGd-------------- 491
YP_001006626 430 HVFVGQYSKNKSPGAEWINLTERNAIRGFSRSSQSANNGWYVKNT------------LSRDLSVDn-------------- 483
WP_015870382 434 SQWYGQYSRDPLPGVEWVSLTERSAVRGFKRGTLSADNGWYWQNT------------LSRPLGWRa-------------- 487
WP_012368231 433 STFLGQYSHDTLPGVEWLSLTDKNAIRGFDQSTLSGDNGGYLRNT------------LSYPYRLNh-------------- 486
WP_011144712 430 NLFYGQYNRHGLPGVEWLNITDRNAVRGFSKNTLSGDNGWYLQNT------------LSRTFPLAn-------------- 483
WP_004237648 438 SHLAGQYTQDHLPGGEWLTLSDNSAIRGFHDGSLSADKGWYWQNT------------LSRRFVRQg-------------- 491
WP_025304472 434 NLFYGQYSRDPLPGVEWLSLTDRSAVRGFSRSTQSGDNGWYLQNT------------LSRSFNLGa-------------- 487
WP_013185719 430 SQFHTQYSRDGLPGVEWLTVTDRNAVRGFSKNVLSGDNGWYLRNT------------FSHSIPISn-------------- 483
WP_106911115 435 SQLAAQYSADPLPGIEWFTVSDTYAVRGFSSSNVAADSGAFWRND------------LTYRRPLLg-------------- 488
WP_082121492 620 aKTHLSVFYDFGYVEDKYEdiydKEYNsksGYMMGAGASLNYYGQYINMSLVYAKG-----LHSPKYlqtrdnmSKEEEa 694
YP_002348601 492 aTLTPRVGLDTGRLQ--QK----PQGW---VSAMGLSAGVSLNYQNATLDIEASRGrl---lSGPSK-------INDPTq 552
YP_001006626 484 vLLTPRVGIDAGQVLKHEN----KQGW---QSNSGISTGITVRYQKILFDLEASRGww---iSDSNK-------QNEPIq 546
WP_015870382 488 fTVTPRIGLDVGRVLSNAG----NQGW---QSGVGAVVGVTLSTASAQLDIEVGRAra---iSNNNF-------PGQSTq 550
WP_012368231 487 fSITPRIGVDIGQVKQHGN----YKGW---QGGYGLSSGLNIQYQQAQLDLEVAKGellyhQTNSNK-------TKDPTq 552
WP_011144712 484 sTLSMRIGIDTGRVQGYRS----PQGW---QSSAGISSGTTLRYQRMVFDIETSRGkl---lSNRQA-------SDEPIq 546
WP_004237648 492 iTVTPRAGADYGRVMAQTG----QAGW---QSAAGIAAGVNVSYGGAQLDAQISRArt---sVAAL--------PAQDTl 553
WP_025304472 488 aTLTPRLGADVGRILPRQD----NSGW---RSSAGLSSGATLRYRQALVDLEVSRGwi---lSNHAT-------PEDPVq 550
WP_013185719 484 aSLSLRAGMDIGQTKGYRS----QYGK---RSSAGLSAGLTLRYQNLFADIEVSRGkl---lSHQQPr-----dSDEPTq 548
WP_106911115 489 gELRLLTGADIGQTLRGAT----HNPT---FYAGGLTVGSDYQYQAVQAGIRVSRGrm---wSAGRH-------TTEPLr 551
WP_082121492 695 VYWKVGVSW 703
YP_002348601 553 ILARFSYRF 561
YP_001006626 547 LLGRISYTF 555
WP_015870382 551 LLTRFSYSF 559
WP_012368231 553 LLVKFSYLF 561
WP_011144712 547 VLVRFSYTF 555
WP_004237648 554 FSLRLGYQF 562
WP_025304472 551 VLARFSYTF 559
WP_013185719 549 LLTRFSYTF 557
WP_106911115 552 VLARFSVSF 560
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