Conserved Protein Domain Family
Rhomboid

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cl21536: Rhomboid Superfamily 
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Rhomboid family
This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.
Statistics
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Accession: cl21536
PSSM Id: 451297
Name: Rhomboid
Created: 5-Sep-2014
Updated: 4-Oct-2023
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