Conserved Protein Domain Family
ESM4

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pfam15952: ESM4 
Enhancer of split M4 family
This family of proteins includes enhancer of split M4, enhancer of split M2 and enhancer of split MAlpha. These proteins are part of the Notch signaling pathway.
Statistics
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PSSM-Id: 464953
Aligned: 13 rows
Threshold Bit Score: 116.216
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001999739          1 MYLDTKNLiag-----------nsnSNSSTTAAATAALAAP----KAGRRMRKVWQPLRRLLTVGGKGRPS----CQPHP 61 
EDW34003              1 MYLDTKNLtasstntntnsssssihTSASMTATAATPLGVP----KTVRRMRKVWQPLRRLLTVGGKGRPAp--lTLAHP 74 
O97177                1 MYLDTKNLta-------------ssTSALTAATASN----S----KSTRRMRNVWKPLSRLLKVGGKGRTAq--aTLAHP 57  fruit fly
XP_001954334          1 MYLDTKNLt---------------aSGNTSTV--TVADSTS----KSVRRMRKVWQPLRRLLAVGGKGRPTh--lTLAHP 57 
XP_002074084          1 MR-----------------------------------------------RMRKVWQPLKRLLTVGGKGRPTq--lTLVHP 31 
XP_002016901          1 MCQNK--------------------TNDSNTMS---IKSNK----KLSYSVKKLLQKIFK--QQQQQLVEEeqnlKNTLK 51 
WGS:AAQB:GK14456-PA   1 MCQQVIVAat--------------nNSTTNKM-------------KTSYSIKQVLKTLFKKQQKQQQQQQQfq------- 46 
XP_001990618          1 MCQQVAII-----------------NNNNNKM-------------KTSYSIKQVLKTFFKKQQKQQQNKQCq-------- 42 
OWR46582              1 MSYYANNEy---------------iISTNNSINENKYNSEK----MKNSGLKALLKPLMRIIKKTTKRSP---------- 51 
EDS38481              1 MC-----------------------KSIITTINENKYNNEKlmksSPVYKLKKILKPIAALLKSKKQSKKQe-------- 49 
WGS:AAQB:GK10544-PA   1 MSFKTQEY-----------------KFDCSQMMQHKSGQHT----MAMRSLKKLVKPLLRLVKKKELLRKTlaevQTQNN 59 
EDV97553              1 MSFITREY-----------------KFESSIMMQRKSDQHT----MAMLSLKKLVKPLLRLIKKKQLIRKTldevQSQNE 59 
XP_002053476          1 MYLDTKNLtag-----------csnNNTTATTAST----AP----KTGRRMRKVWQPLRRLLTVGGKGRPA----SQPHP 57 
XP_001999739         62 NNVDLNN-TQ--LLPQlepl---qadNSDSSKttpde-siskfAELSLQQ----VHEEltqtppppn------------- 117
EDW34003             75 NNVDLNN-TQqqQQQQqqqi---eliLEDESKstpeesiykygAELRQLP----VEDEvsltqppnt------------- 133
O97177               58 NNVDLNN-TQqqQQQQqqe-----llIEDDTKstpeesihkygLELRQLP----EEEQvsltqppnt------------- 114 fruit fly
XP_001954334         58 NNVDLNN-TQsqQQPQqp------apEEPESKstpeelvhkygLELRTQP----LEEEvslmqppnt------------- 113
XP_002074084         32 NNVDLNN-TQqqQPQQqqhhlqleefTDDESK-----------TTLELDA----SSISlsplllsspsdkiveqvvdltp 95 
XP_002016901         52 -ANSLESlESi----------------ENSRN-----------ADLES-AsvcaSMES---------------------- 80 
WGS:AAQB:GK14456-PA  47 rQHSLESlESv----------------ENLRN-----------AQVEEAY----YAEI---------------------- 73 
XP_001990618         43 -NNSLESlESv----------------DNLRN-----------TEVEEVY----YAEI---------------------- 68 
OWR46582             52 -AKTMDTcYEd---------------eQNACN-----------EALERKI----YDEM---------------------- 78 
EDS38481             50 -----------qSYYIpepsfvpdyeYDNSEN-----------ERLESQL----LAEI---------------------- 81 
WGS:AAQB:GK10544-PA  60 INASLEDmRKdpAASC-----------DNMAN-----------EQLEQRL----YNEL---------------------- 91 
EDV97553             60 INSSLEDmRKdsVASC-----------DNMAN-----------EQLEQRL----INDL---------------------- 91 
XP_002053476         58 NNVDLNN-TQ--MLPPlell---htdDNDSKAtpdes--inkfAELRLQQ----VHEEltqtppppn------------- 112
XP_001999739        118 ---tptlissvyVEKaT-AQSCNACHHGRNCQHTHH---SSNISDRtahslnvsavstptptpthtssvtpaatlwdLPL 190
EDW34003            134 ----ptlissvyVEKaS-AQSCGACPHGRNCQHTHH---NSNSNRNtttttatssat----------aaqlpsnlwdLQL 195
O97177              115 ----ptlissvhVDKvS-AQSCGNCQHGRNCQHRHH---SSSNINSsssssnmnsss----------atqlpsnlwdLQL 176 fruit fly
XP_001954334        114 ----ptlissvfVEKvS-AQGCRNCQHGRNCQHTHHnhsSSSSSSSsinnnintnnsnss----atsatqlpsafwdLQL 184
XP_002074084         96 ppntptlissvyVEKvSiNQGCGSCQHGRNCQHTHHqtqSQPHPQQsngqs---------------------sawdhLPL 154
XP_002016901         81 ------------YEN-EaNERLSA-----SCDMEDY-----ELEQL-------------------------------PSV 106
WGS:AAQB:GK14456-PA  74 ------------DEN-AaNEKIAQYELENHIEQ--------DEDED-------------------------------VYV 101
XP_001990618         69 ------------DEN-AaNEKLAQLVQEQEL----------DAEED-------------------------------IYV 94 
OWR46582             79 -------------------DNCQSTAFLVNNQDNTFdlvPISRED--------------------------------FYI 107
EDS38481             82 -------------------SECHTNAAIYVYEDQQVqilPVQPEE--------------------------------QFV 110
WGS:AAQB:GK10544-PA  92 -------------------RQCSSNMAMIVRQGQQQqvvPIHPEH--------------------------------TFI 120
EDV97553             92 -------------------RQCPNNAAIIVQQSEQQlivPVHPDQ--------------------------------TFI 120
XP_002053476        113 ---tptlissvyVEKaS-TQSCNACQHGRNCQHTHHtttSSNSSSNnnshnltenvaaq-----stptptstptlwdLQL 183
XP_001999739        191 PLQYISTDNGTFFWANTQERV---DDDLLHAWLCQSFSQLPGT----------LC 232
EDW34003            196 PLQYISTDNGTFFWANTQERV---DDDLLHALLCQSFSQLPGT----------LC 237
O97177              177 PLQYISTDNGTFFWANTQDRV---DDDLLHALLCQSFSQLPGT----------LC 218 fruit fly
XP_001954334        185 PLQYLSTDNGTFFWANSQERV---DDDLLHAWLCQSFSQLPGT----------LC 226
XP_002074084        155 PLQYISTDNGTFFWANTQERV---DDDLLHAWLCQSFSQLPGT----------LC 196
XP_002016901        107 PVHFVRTAHGTFFWTAASDLPa--DNDLIEPLYCSTANEIAVSqfqd---rwvQA 156
WGS:AAQB:GK14456-PA 102 PVRFARTQAGTFFWTTNLQPVas-----iEPAHCYS------Mqyqd---rwaQA 142
XP_001990618         95 PVRFARTQAGTFFWTTNLQPVasvDADLLQPAYCYSSQQHPFMqyqd---rwaQA 146
OWR46582            108 PVHFARTDAGTFFWTTVSK-----PEADFADAQCYTECQTAEQqypvlqdrwvQA 157
EDS38481            111 PVHFARTEAGTFFWTTVSREA---DSDLVQPCQCYSDHQLPQQefcd---rwaQA 159
WGS:AAQB:GK10544-PA 121 PVHFARTTSGTFFWTTAHQ----------------QEQKLRQQydr-----wvQA 154
EDV97553            121 PVHFARTSSGTFFWTSAEG----------------ARQQLKENtmherydrwvQA 159
XP_002053476        184 PLQYISTDNGTFFWANTQERV---DDDLLHAWLCQSFSQLPGT----------LC 225
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