Conserved Protein Domain Family
hlyII

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TIGR01002: hlyII 
beta-channel forming cytolysin
This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance]
Statistics
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PSSM-Id: 273388
Aligned: 6 rows
Threshold Bit Score: 369.504
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAB51536   3 KAKGIAKSVAVASVIMSGSLGLQATSAFadskGTVENLQNGGKVYNSFKTTYDMKQNIKNSIKVSFIEDPYADKKIAIVT 82  Bacillus cereus
CAA55783   5 KVIKAATATSVALMLFSNPVYAANQITP----VSEKKVDDKITLYKTTATADSDNLNISQLLTFNFIKDKSYDKDTLVLK 80  Staphylococcus inte...
CAA51252   3 KIVKSREVTSIALLLLSNTLDAAQHITP----VSEKKVDDKITLYKTTATSDSDKLKISQILTFNFIKDKSYDKDTLILK 78  Staphylococcus aureus
BAA07715   4 RKLLVTTLSLGLIVPIATPFQGSKATT------NAEDIGDDAEVIKRTEDVSSRKWGVTQNVQFDFVKDKKYNKDALIIK 77  Staphylococcus aureus
AAA23284  17 GCLLSPTLVYANDIGKTTTITRNKTSDGy---TIITQNDKQIISYQSVDSSSKNEDGFTASIDARFIDDKYSSEMTTLIN 93  Clostridium perfrin...
P09616     4 RIVSSVTTTLLLGSILMNPVAGAADSDIni-kTGTTDIGSNTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIR 82  Staphylococcus aureus
AAB51536  83 TDGsNIDAK----YTING---GYYNAGLKWPSAYHTEAEITSGDS-AQFHKAAPVNTMTSAKVTSEVGYTLGGSVKVGVN 154 Bacillus cereus
CAA55783  81 AAG-NINSG----YKSPNp-nDYIYSSFYWGAKYNVSISAESKGA-VNVVDYAPKNQNEEFQVQNTLGYSFGGDISISKG 153 Staphylococcus inte...
CAA51252  79 AAG-NIYSG----YTKPNp-kDTISSQFYWGSKYNISINSDSNDS-VNVVDYAPKNQNEEFQVQQTVGYSYGGDINISNG 151 Staphylococcus aureus
BAA07715  78 MQG-FINSR----TTFNDvkqNRANKRMVWPFQYNIGLTSKDQN--TSLINYLPKNKIETVDVGQTLGYNIGGKFQSVPS 150 Staphylococcus aureus
AAA23284  94 LTG-FMSSKkedvIKKYNlhdVTNSTAINFPVRYSISILNESINEnVKIVDSIPKNTISQKTVSNTMGYKIGGSIEIEEN 172 Clostridium perfrin...
P09616    83 TKG-TIAGQ----YRVYSe-eGANKSGLAWPSAFKVQLQLPDNEV-AQISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDT 155 Staphylococcus aureus
AAB51536 155 dkgpnADASITGSFAWKESVSYDQVDYKTVLETHTD-KKLNWKVGFQSFNFPEWGIYNRDSFNTFYGNQLFMKSRSYN-E 232 Bacillus cereus
CAA55783 154 -----LSGGLNGSESFSETINYKQESYRTTIDKHTDnKTIGWGVEAHKIMNAGWGPYGRDSFHDLYGNELFLGGRQSKlN 228 Staphylococcus inte...
CAA51252 152 -----LSGGGNGSKSFSETINYKQESYRTSLDKRTNfKKIGWDVEAHKIMNNGWGPYGRDSYHSTYGNEMFLGSRQSNlN 226 Staphylococcus aureus
BAA07715 151 -----IGG--NGSFNYSKSIKYSQKSYVSEVEQQSS-KTIKWGVKANSFVIAGHR-------WSAYDELLFIRNTTRGpN 215 Staphylococcus aureus
AAA23284 173 k----PKASIESEYAESSTIEYVQPDFSTIQTDHST-SKASWDTKFTETTRGNYN---LKSNNPVYGNEMFMYGRYTNvP 244 Clostridium perfrin...
P09616   156 g---kIGGLIGANVSIGHTLKYVQPDFKTILESPTD-KKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSmK 231 Staphylococcus aureus
AAB51536 233 GTNNFVSKDTVPALTGYGFSPNVVAVITADKTESTS--DLKITNRRISDQ-YNIEWVSSKWWG-TNNKDTYNEFFTN--- 305 Bacillus cereus
CAA55783 229 AGQNFLPTRQMPLLARGNFNPEFLSVLSHKPNGAKTs-KIKVTYQREMDE-YTNYWNGFHWMG-TNYKNQNNATFTS--- 302 Staphylococcus inte...
CAA51252 227 AGQNFLEYHKMPVLSRGNFNPEFIGVLSRKQNAAKKs-KITVTYQSEMDR-YTNFWINFNWIG-NNYKDHIRATHTS--- 300 Staphylococcus aureus
BAA07715 216 ARDYFVDDNELPPLITSGFNPSFIATVSHEKDSGDTs-EFEITYGRNMDVtYATYLPKLGLYPeRKHNEFVNRNLVV--- 291 Staphylococcus aureus
AAA23284 245 ATENIIPDYQMSKLITGGLNPNMSVVLTAPNGTEES--IIKVKMERERNC-YYLNWNGANWVGqVYSRLAFDTPNVDshi 321 Clostridium perfrin...
P09616   232 AADNFLDPNKASSLLSSGFSPDFATVITMDRKASKQqtNIDVIYERVRDD-YQLHWTSTNWKG-TNTKDKWTDRSSE--- 306 Staphylococcus aureus
AAB51536 306 -NYKLDWKNHQVTL 318 Bacillus cereus
CAA55783 303 -FYEIDWDQHTVKL 315 Staphylococcus intermedius
CAA51252 301 -IYEVDWENHTVKL 313 Staphylococcus aureus
BAA07715 292 -KYEVNWKTSELKV 304 Staphylococcus aureus
AAA23284 322 fTFKINWLTHKVTA 335 Clostridium perfringens
P09616   307 -RYKIDWEKEEMTN 319 Staphylococcus aureus
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