5DMN


Conserved Protein Domain Family
S-methyl_trans

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pfam02574: S-methyl_trans 
Homocysteine S-methyltransferase
This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5; and Homocysteine S-methyltransferase, EC:2.1.1.10,.
Statistics
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PSSM-Id: 460598
Aligned: 664 rows
Threshold Bit Score: 97.6107
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5DMN_B               17 LL---------------------LDGAMATEL-E----ARgcnladsl-wsakvlveNP--------------E---L-- 50  Escheric...
WP_014857151         16 LI---------------------LDGAVGSLLqQygaaNDkylwss------lanlrNP--------------D---I-- 49  Meliorib...
EKV04507              1 -----mgalsktlpqlassklfitEGGIETSL---------------------------------------------Iyr 30 
WP_011767539         16 FV---------------------SDGGMETTL---------------------------------------------Iyh 29  Azoarcus...
jgi:Cyan7425_0064    16 FI---------------------TDGGIETTL---------------------------------------------Ifr 29 
tgen:AM1_0903         1 ------mpqyrqnlpqlssdvflTDGGLETTL---------------------------------------------Ifh 29 
ACO48026              1 ----------mkgplpqltrrvltDGGLETDL---------------------------------------------Lfn 25 
P74718               29 IIandklavkmtnlphqceqiflLDGGLETEM---------------------------------------------Ifn 63  Synechoc...
jgi:HIMB59_00011980  17 IL---------------------IDGGTGTEV------ERrgvpqlknawnaggaltHP--------------D---I-- 50 
XP_001032383          8 KI---------------------LDGAVGSLLqQ----K------------------YPefyeqrtwmnrilkEkpeK-- 42  Tetrahym...
5DMN_B               51 ----------------------IREVHLDYYR-AGAQ----CAITASYQATPagfaARG---L-DeaQSK-ALIGKSVEL 98  Escheric...
WP_014857151         50 ----------------------VQKIHRDYID-AGAD----IITTNTFRTNp------AaveMsGhsLSIeEFVKKSVNL 96  Meliorib...
EKV04507             31 knidipgfstlpllgteegrktILSIYQDYVKiALAHstgiVLETRTWRGSp-----aWsstIgLsvTQIvDLNRIAVRI 105
WP_011767539         30 hgrelphfaaftlmddaegrrlLTDYYRRYIDiALRHrrglLLETPTWRASa-----dWgarLgYdaAALaRVNRDSVAL 104 Azoarcus...
jgi:Cyan7425_0064    30 eglelpefaafdlfksasgyqaLQKYFRTYARmASTYavgcILESATWRANp-----dWgtkLgYdrDALtAVNGQAIAL 104
tgen:AM1_0903        30 egidlpdfaafdllkdnqgyeaLYEYFQTYAQlAQTYevglILESATWRANp-----dWgtkLgYdaAELaAVNRNAIAL 104
ACO48026             26 rgidlplfssvvllatlegreaLETYYRPYLElAHRHsagfILESATWRASp-----dWaapLgLhqCGLdQLNVAAVEL 100
P74718               64 rgfdlpafaahtllsdplgreaLKNYFHGFLDlAKEKqfgfLIDAPTWRAQp-----fFaeeLgVslEEIrQANFRAVEF 138 Synechoc...
jgi:HIMB59_00011980  51 ----------------------IKGIHTDFIK-EGAE----IIISNTFATYk------HlmkDaDclNDFeLVNKRSVEL 97 
XP_001032383         43 ----------------------LYDLHLEYCK-QGAD----IITSFTFKTNP----IAC-----QslEESkKLVQIAVKE 86  Tetrahym...
5DMN_B               99 ARKAR----EAYlaenpqagtllVAGSVGPYGAYLADgseyrgdyH---CSVEAFQAFHRPRVE-AlLDAGADLLACETL 170 Escheric...
WP_014857151         97 AIEAR----EERni--------iIAGSNAPAEDCYQKer---------tLSKNELEYNHKKHIElL-WESGVDVIWNETQ 154 Meliorib...
EKV04507            106 LRDLR----HKAetps---tpivISGALGPLQDAYQD--------StgrFTFSQAREHYGAQIRvF-AEEGVDMSSIMTV 169
WP_011767539        105 LDALR----ATHqrag---tpmvISGAIGPRGDGYVAda---------gMSATEAADYHGEQIAtL-ASTRCDLVTAFTL 167 Azoarcus...
jgi:Cyan7425_0064   105 LHEIR----HEFeteq---srlvISGCLGPRGDGYIPad---------aMSETEAEFYHRPQIEtF-RQAGADLVTAITM 167
tgen:AM1_0903       105 LHTIR----QQYetea---srmvISGCIGPRGDGYQVdt---------aMTPAEAQVYHLPQIEaF-KEAEADMVSAVTM 167
ACO48026            101 LHRLR----SKSatdp---leivVSGCVGPRGDGYDPgq---------iMNVAEAANYHGHQVRvL-ASAGVDMLSALTM 163
P74718              139 ARALK----QAYvnei---qpllINGLIGPCGDAYGGeh---------fSNAEAAQVYHRQQISwL-AEAGVDLLGAFTL 201 Synechoc...
jgi:HIMB59_00011980  98 AVESR----NDLkkd-----evlVAGGISHWSFTNKL------------PSLKDLEEGASEQAIiM-KDAGADLILLEMM 155
XP_001032383         87 CQKLKeiykDIQ-----------IFGSNSPAEDCYQKer---------tLTKDELIYNHKNHIQfL-YDCQVDCIFNETM 145 Tetrahym...
5DMN_B              171 PNFSEIEALa--eLLtaypraRAWFSFTLr---------------------DSe-hLsDGTPLRD-VVALLAGyPqVVA- 224 Escheric...
WP_014857151        155 SHLDEIEIIcgfcNSqk---lPYVINLFF----------------------DGkmnLlSGESLWEaVGIAAAF-N-PIA- 206 Meliorib...
EKV04507            170 TNLDEATAAvsvaREyn---lPILVSFSIetd----------------------grLrGGRTLEDaIREVDRVtD-NYTt 223
WP_011767539        168 NYVDEAIGIvraaQHet---mPVVISFTLetd----------------------grLpSGQALGDaIRETDAAtA-AGAt 221 Azoarcus...
jgi:Cyan7425_0064   168 NYVEEAIGIargaKTvg---iPVVISFTVetd----------------------gkLpTGQPLKEaIAQVDKAtD-AAPa 221
tgen:AM1_0903       168 TYTEEAIGItraaHLvg---mPVVISFTVetd----------------------gkLpTGQGLKDaIAQVDAAtG-NGPi 221
ACO48026            164 TNINEATGItlaaAEvg---lPVSVSFTVetd----------------------grLpTGDSLMDaVTAVDEAtN-DYAa 217
P74718              202 TSVNEAIGIvrasQEfs---lPVSISFTVetd----------------------grLpTGTALSEaIAIVDEAtN-QGAa 255 Synechoc...
jgi:HIMB59_00011980 156 IDIPRMSSVlkgvRNsd---lPVWVGLSCepddkgvmrllsgqkdlvdsspN----SrVGETLEEaILSLKDQ-N-I--- 223
XP_001032383        146 SQLDELIIVcqicQDmn---iPYIISIYF----------------------DNnlkIlSGESVDDcVDTLLNKyK-FKPi 199 Tetrahym...
5DMN_B              225 -LGINCIA-LEN--TTAALQHLhgltvlpLv----------------VYPN-------------S---GEh-------YD 261 Escheric...
WP_014857151        207 -VGFNCIK-PEY--FLNKIKQDlsvk------------------ewgFYLNcg--------------gGDf-------TD 243 Meliorib...
EKV04507            224 yFGVNCAH-PRH--VMIALRGMsedvm---------------srigsIRGNsslkchdeldnsgVldrGD---------- 275
WP_011767539        222 yYMINCAH-PTH--FDHVLDGAgdwrh----------------rirgLRANascrshaeldaatEldaGD---------- 272 Azoarcus...
jgi:Cyan7425_0064   222 yYMLNCAH-PTH--FMDELRTGetwve----------------rirgIRANastkshaelneseTldeGN---------- 272
tgen:AM1_0903       222 yYMINCAH-PSH--FEQIFATNepwlt----------------rihgLRANastkshaeldeavDlddGN---------- 272
ACO48026            218 yFMVNCAH-PDH--FAAVLDEPaawtr----------------rirgVRANasrcshkeldamtEldaGD---------- 268
P74718              256 yFMVNCAH-PDH--FRAVIREEawls-----------------rlggFRCNpsrrshaqldqanFldiGN---------- 305 Synechoc...
jgi:HIMB59_00011980 224 -PLINIMH-TDVgyIDECLDIVknnwd----------------glvgVYAHs----------------GDdi-----qME 264
XP_001032383        200 cLSFNCVQkKDL--LNLFLQSKk------IfqqksskninsenikygFYINc---------------gGEdytcndfnYQ 256 Tetrahym...
5DMN_B              262 ------AVSKTWH----HhgehcaqladylpqWQ-----AAG--ARL--IGGCCRTTPADIAALKARS 310 Escherichia coli K-12
WP_014857151        244 ksiscaINPDHYIdlikP--------------LL-----EKKp-LY---AGSCCGSTPAHTKAIKEYI 288 Melioribacter roseus
EKV04507            276 --------IPVWDqefnG--------------LL-----NILlgLKV--IGGCCGTDEEHVETIAKRI 314
WP_011767539        273 --------PIDLGaryrA--------------LR-----PQLpgLAV--IGGCCGTDHRHVEAICAAY 311 Azoarcus olearius
jgi:Cyan7425_0064   273 --------PAELGslyqQ--------------LR-----EHLphLNV--LGGCCGTDDRHIEAICKAC 311
tgen:AM1_0903       273 --------PQELGqqylN--------------LS-----DALpnLNV--LGGCCGTDHRHIEAICKAC 311
ACO48026            269 --------PLELGqlyrK--------------LL-----HEHpqITV--LGGCCGTDLRHVTAIAEAC 307
P74718              306 --------PVELAhsywT--------------LK-----QKVpsANV--FGACCGSDLRHIREIAKVF 344 Synechocystis sp. PC...
jgi:HIMB59_00011980 265 wtfdevISPKDYFnycnR--------------WL-----KKG----IniIGGCCGTGPEHIKYLKENL 309
XP_001032383        257 ------IQPEELPifyqQ--------------LIdldiiEKQdiLF---LGSCCMSTPGHTLQLSKFF 301 Tetrahymena thermoph...
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