4FVM_A 435 NAWAQTLGGTRAGRNEYILLHEFSRNGFIVPd-------KEGNrSRAQkqrqneena-------------dapvnskkAk 494 Saccharomyces cerev... Q6TVU5 494 LPQSVVFEYRASTCIKGPLMKLLLENRTVMV--------RADTkSKFF-------------------------------- 533 Orf virus P06856 488 LPQSMVFEYRASTVIKGPLLKLLLETKTILV--------RSETkQKFP-------------------------------- 527 Vaccinia virus WR Q9Q8R2 489 LPQSMVFEYRASTLIKGPLLKLLLEKKIIMT--------RSEKkNKYP-------------------------------- 528 Myxoma virus Q98207 485 LPQCLALEYRASTLIKGPLLRLMLRERVVYV--------RTQEpARYT-------------------------------- 524 Molluscum contagios... P21402 474 LPQSLALEYRASTLIKGPLLKLLLEERVIYT--------RKITkVRYP-------------------------------- 513 Fowlpox virus strai... 5EXR_G 440 NIMSRTLMGGRSERNEFLLLHAFYENNYIVPdkqi-frkPQQKlGDEDeeidgdtn--------------kykkgrkkAa 504 human P26019 796 NTMTRTLQGGRSERNEFLLLHAFHEKNYIVPdkk--pvsKRSGaGDTDatlsgada---------------tmqtkkkAa 858 fruit fly O48653 825 NLWGKTLQGSRAQRVEYLLLHAFHARKFIVPdkfarskeFNSTkRKMNpdteaarpdeadpsiddeghhvdqgktkkgPs 904 Japanese rice Q57UW4 676 NLWSRTLYGARSERIEYLLLHAFHNLKFVTPdk----kkRDLKrGREDddde----------------------gkrkTk 729 Trypanosoma brucei
4FVM_A 495 YQGGLVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTTVDRNKEDID--ELPS--------------------VPP-- 550 Saccharomyces cerev... Q6TVU5 534 YEGGRVMVPKQKMHDKHVLIFDYNSLYPNVCIYANLSPETLVGVVVSDN--RLDAevaavdvrrmfpapryiavpCEPrs 611 Orf virus P06856 528 YEGGKVFAPKQKMFSNNVLIFDYNSLYPNVCIFGNLSPETLVGVVVSTN--RLEEeinnqlllqkypppryitvhCEPrl 605 Vaccinia virus WR Q9Q8R2 529 YEGGKVFAPKQKMFINNVLIFDYNSLYPNVCLFGNLSPETLVCVFVANN--KLEAeinkqeiqkmypgpryisvqCEPrs 606 Myxoma virus Q98207 525 YGGGKVFLPRQKLFDTNVMVFDYNSLYPNVCIFGNLSPETLVGVVANAH--RLDAeinmqelrrrfpepaflhvlCEAra 602 Molluscum contagios... P21402 514 YIGGKVFLPSQKTFENNVMIFDYNSLYPNVCIYGNLSPEKLVCILLNSN--KLESeinmrtikskypypeyvcvsCESrl 591 Fowlpox virus strai... 5EXR_G 505 YAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQ--KVTEdgeq------------eqipELPd- 569 human P26019 859 YAGGLVLEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTTVQQPVDADElpTLPD------------------------- 913 fruit fly O48653 905 YAGGLVLEPKKGLYDKYVLLLDFNSLYPSIIQEYNICFTTVDRSADGNVp-NLP-------------------------- 957 Japanese rice Q57UW4 730 YQGGMVLEPKSGLYSEYILLLDFNSLYPSLIQEFNVCYTTIDRDENTVSa-EVPPpesl------------iclsCRAag 796 Trypanosoma brucei
4FVM_A 551 ----------SEVDQGVLPRLLANLVDRRREVKKVMK-TETDPhKRVQCDIRQQALKLTANSMYGCLGYVNSRFYAKPLA 619 Saccharomyces cerev... Q6TVU5 612 pelvaevaifDREAKGIIPMLLRSFLDARAKYKKLMK-AAETAvDREIYNSMQYTYKITANSVYGLMGFRNSALFSYASA 690 Orf virus P06856 606 pnliseiaifDRSIEGTIPRLLRTFLAERARYKKMLK-QATSStEKAIYDSMQYTYKIVANSVYGLMGFRNSALYSYASA 684 Vaccinia virus WR Q9Q8R2 607 edlvseiavfDRSVEGIIPKLLKTFLTERLKYKKMIK-ETNDVvEKAIYDSMQYTYKIIANSVYGLMGFKNSALYSYASA 685 Myxoma virus Q98207 603 rdgyseiavfDRRRQGIIPKLLGTFMEQRARYKALMR-AASSGlERTLYDSMQYVYKVVANSVYGLMGFYNSSLYSYSSA 681 Molluscum contagios... P21402 592 sdyyseiivyDRREKGIIPKLLEMFIGKRKEYKNLLK-TASTTiESTLYDSLQYIYKIIANSVYGLMGFSNSTLYSYSSA 670 Fowlpox virus strai... 5EXR_G 570 ----------PSLEMGILPREIRKLVERRKQVKQLMKqQDLNPdLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLA 639 human P26019 914 ----------SKTEPGILPLQLKRLVESRKEVKKLMAaPDLSPeLQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLA 983 fruit fly O48653 958 ----------ASKTTGVLPELLKSLVERRRMVKSWLK-TASGL-KRQQFDIQQQALKLTANSMYGCLGFSNSRFYAKPLA 1025 Japanese rice Q57UW4 797 l-------psPCLHKCILPKVIRGLVDSRREIKRMMK-SERDPgNLAMLEIRQLALKLTANSMYGCLGFEYSRFYAQPLA 868 Trypanosoma brucei
4FVM_A 620 MLVTNKGREILMNTRQLAES-------------------------------------------M-NLLVVYGDTDSVMID 655 Saccharomyces cerev... Q6TVU5 691 KSCTAIGRTMIAYLERTLDgasvcgtrlslaaapdnpllrdeafagraaeleidaavagertervGFRSVYGDTDSVFLE 770 Orf virus P06856 685 KSCTSIGRRMILYLESVLNgaelsngmlrfanplsnpfy------mddrdinpivktslpidyrfRFRSVYGDTDSVFTE 758 Vaccinia virus WR Q9Q8R2 686 KSCTAIGRQMIHYLNSVLNgcklssgkfqlaaypinpff------qddrsvdlyastnlpteynyDFKGVYGDTDSVFLE 759 Myxoma virus Q98207 682 KCCTTIGRVMITYLDRVVDgatlcagvlrlaaeprnplla----sapprardvdvsaalghelelRFRSVYGDTDSIFLE 757 Molluscum contagios... P21402 671 KTCTTIGRNMITYLDSIMNgavwendkliladfprnif--------sgetmfnkelevpnmnesfKFRSVYGDTDSIFSE 742 Fowlpox virus strai... 5EXR_G 640 ALVTYKGREILMHTKEMVQK-------------------------------------------M-NLEVIYGDTDSIMIN 675 human P26019 984 ALVTHKGREILTNTQQLVQK-------------------------------------------M-NYDVVYGDTDSLMIN 1019 fruit fly O48653 1026 ELITLQGREILQNTVDLVQN-------------------------------------------NlNLEVIYGDTDSIMIH 1062 Japanese rice Q57UW4 869 ELVTRQGRLALQNTVELIPQis------------------------------------------pSIRVIYGDTDSVMIQ 906 Trypanosoma brucei
4FVM_A 656 TGC-DNYADAIKIGLGFKRLVNE-RYRL-LEIDIDNVFKKLLLHAKKKYAALTVNldkngNgt-tV-LEVKGLDMKRREF 730 Saccharomyces cerev... Q6TVU5 771 VGA-SDIAFSRRVGRCLERVINEhVLFAnFKVEFEAVYCNLIMQSKKKYTTIKFAvsdggG----SeRVSKGTSETRRDV 845 Orf virus P06856 759 IDS-QDVDKSIEIAKELERLINNrVLFNnFKIEFEAVYKNLIMQSKKKYTTMKYSassnsKsvpeR--INKGTSETRRDV 835 Vaccinia virus WR Q9Q8R2 760 INT-NDVLTSIKIAKELERVINTkVLFDnFKIEFEAVYKNLIMQSKKKYTTLKYVpsstqNsipvR--INKGTSETRRDV 836 Myxoma virus Q98207 758 LNL-REVQTTLAVARTLERVLNEhVLFEnFRVEFEAIYQNLILQSKKKYSTTKYAadhraGdapeH--VSKGTSETRRDV 834 Molluscum contagios... P21402 743 IST-KDIEKTAKIAKHLEHIINTkILHAnFKIEFEAIYTQLILQSKKKYTTIKYLanykpGdkpiR--VNKGTSETRRDV 819 Fowlpox virus strai... 5EXR_G 676 TNS-TNLEEVFKLGNKVKSEVNK-LYKL-LEIDIDGVFKSLLLLKKKKYAALVVEptsdgNyv-tK-QELKGLDIVRRDW 750 human P26019 1020 TNI-TDYDQVYKIGHNIKQSVNK-LYKQ-LELDIDGVFGCLLLLKKKKYAAIKLSkdskgNlr-rE-QEHKGLDIVRRDW 1094 fruit fly O48653 1063 TGL-DDISRAKGIAGKVIQEVNK-KYRC-LEIDLDGIYKRMLLLKKKKYAAIKVAldgslR----EnIERKGLDMVRRDW 1135 Japanese rice Q57UW4 907 TGIkDDIGKVRNLGFEIKGKVNQ-RYQS-LELDIDGVFRAMLLLRKKKYAALSVVdwqgeGkvykR--EVKGLDMVRRDW 982 Trypanosoma brucei
4FVM_A 731 CPLSRDVSIHVLNTILSD------KDPEEALQEVYDYLEDIR-IKVETNNI-RIDKYKINMKLSKDPKAYpGGKNMPAVQ 802 Saccharomyces cerev... Q6TVU5 846 APFHKLMIRKYKDMLCRAla--eeGSGNVGVEILRSLEDELT-FEFEARSM-PLDWFLLSRTHHK---NF-KSPDNPNVA 917 Orf virus P06856 836 SKFHKNMIKTYKTRLSEMlsegrmNSNQVCIDILRSLETDLR-SEFDSRSS-PLELFMLSRMHHS---NY-KSADNPNMY 909 Vaccinia virus WR Q9Q8R2 837 SKFHKYMIKIYKTRILEMlsdgtsSSLQVCINILKSLESDLL-IEFETRKA-PLDLFLLSRTHHC---NY-KSIDNPNMY 910 Myxoma virus Q98207 835 SRFHKLMISRYKAQLVALlaearlSSRQVCIEMLRSLEVDLF-AEFAARAQ-PLEMFLLSRMHHR---NY-KAPDNPNVE 908 Molluscum contagios... P21402 820 ALFHKHMIQRYKDMLMKLlm--esKGQQEITRLILQSLETDMiSEFTHNR--EFEKYLLSRKHHN---NY-KSATHSNFE 891 Fowlpox virus strai... 5EXR_G 751 CDLAKDTGNFVIGQILSD------QSRDTIVENIQKRLIEIG-ENVLNGSV-PVSQFEINKALTKDPQDYpDKKSLPHVH 822 human P26019 1095 SQLAVMVGKAVLDEVLSE------KPLEEKLDAVHAQLEKIK-TQIAEGVV-PLPLFVITKQLTRTPQEYaNSASLPHVQ 1166 fruit fly O48653 1136 SLLSKEIGDFCLNQILSG------GSCDDVIESIHSSLVQVQ-EQMRGGQT-ELEKYIITKSLTKAPEDYpDAKNQPHVQ 1207 Japanese rice Q57UW4 983 CPLSQHVSDAVLKRILNA------EGGEDILDFVIKYMKGVA-QDVRSGNVyPLEEFVISKSLTKEPESY-HGTGYPHAV 1054 Trypanosoma brucei
4FVM_A 803 VALRMRKA-GRVVKAGSVITFVITKQDEidnaadtpALSVAERAHALnEVMIK---SNnLIPDPQYYLEkQIFAPVERLL 878 Saccharomyces cerev... Q6TVU5 918 LVTRYNAAnAEAIEIGERYFFAYVCE-EgpwrrriaNVKSYERVVDK-TFKLD---KN-ERIMYEVYFK-RLCTEIVNLL 990 Orf virus P06856 910 LVTEYNKNnPETIELGERYYFAYICPANvpwtkklvNIKTYETIIDR-SFKLG---SD-QRIFYEVYFK-RLTSEIVNLL 983 Vaccinia virus WR Q9Q8R2 911 LVNEYNKNnPERIEIGERYYFAYLCDAKdawqkklvNIKTYERIIDK-GFTLG---ST-DRIFYEVYFK-RLATEVVNLL 984 Myxoma virus Q98207 909 LVNRYNREnLEPIELGERYYYAYVCASElpwqlavaNVRNHERIVDA-SYVLP---ER-ERVFYEIYFR-RLATELVNLL 982 Molluscum contagios... P21402 892 LVKRYNLEnTEKIEIGERYYYIYICDISlpwqkklcNILSYEVIADS-KFYLP---KD-KRIFYEIYFK-RIASEVVNLL 965 Fowlpox virus strai... 5EXR_G 823 VALWINSQgGRKVKAGDTVSYVICQDGS--------NLTASQRAYAPeQLQKQ---DN-LTIDTQYYLAqQIHPVVARIC 890 human P26019 1167 VALRMNRErNRRYKKGDMVDYVICLDGT--------TNAAMQRAYHL-DELKTsedKK-LQLDTNYYLGhQIHPVVTRMV 1236 fruit fly O48653 1208 VALRLKQNgYSGCSAGDTVPYIICSQQDses---thSGGIAQRARHPeELKRN---PDkWMIDIDYYLSqQIHPVVSRLC 1281 Japanese rice Q57UW4 1055 VALRMKQRk-EGVRVGDLIPYVICEG----------DEHIDDKAYHIdEVRRS---DG-LSVDVEWYLSsQLYPPVMRLC 1119 Trypanosoma brucei
4FVM_A 879 ERI 881 Saccharomyces cerevisiae S288C Q6TVU5 991 Dnk 993 Orf virus P06856 984 Dnk 986 Vaccinia virus WR Q9Q8R2 985 Dnk 987 Myxoma virus Q98207 983 Dnk 985 Molluscum contagiosum virus subtype 1 P21402 966 Tdk 968 Fowlpox virus strain NVSL 5EXR_G 891 EPI 893 human P26019 1237 EVL 1239 fruit fly O48653 1282 ASI 1284 Japanese rice Q57UW4 1120 EHI 1122 Trypanosoma brucei
Jiyao W et al.(2023). "The conserved domain database in 2023.",