Conserved Protein Domain Family
PIPKc_PIP5K1C
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cd17308: PIPKc_PIP5K1C 
Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) and similar proteins
PIP5K1gamma(EC 2.7.1.68), also known as PtdIns(4)P-5-kinase 1 gamma, or PIP5K1gamma, or PIPKIgamma, or PtdInsPKI gamma, is a phosphatidylinositol-4-phosphate 5-kinase that catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), which is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. PIP5K1gamma is required for epidermal growth factor (EGF)-stimulated directional cell migration. It also modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin.
Links
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Statistics
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PSSM-Id: 340445
Aligned: 5 rows
Threshold Bit Score: 680.564
Created: 8-Mar-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Feature 1: catalytic core residues [active site], 3 residue positions
Conserved feature residue pattern:K D DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Lys proposed to bind the alpha-phosphate of ATP; mutation of this residue in PIPKI-alpha and PIPKII-alpha destroys enzyme activity.
  • Comment:1st Asp functions as a weak base
  • Comment:2nd Asp binds catalytic Mg2+ or Mn2+
  • Citation:PMID 9753329
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
O60331        76 SSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDY 155 human
CAG07769      50 SSALQGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFSDFRFKTYAPVAFRYFRELFGIRPDDY 129 spotted green p...
NP_001120474  70 SSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYPDFRFKTYAPVAFRYFRELFGIRPDDY 149 western clawed ...
XP_007906188  46 SSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPGEGSNLTPAHHYPDFRFKTYAPVAFRYFRELFGIRPDDY 125 elephant shark
NP_001305950  76 SSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYADFRFKTYAPVAFRYFRELFGIRPDDY 155 chicken

Feature 1                                        #                                               
O60331       156 LYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRV 235 human
CAG07769     130 LYSLCNESLIELTNPGASGSIFYVTRDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFFGLYCVQCGGKNIRV 209 spotted green p...
NP_001120474 150 LYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRV 229 western clawed ...
XP_007906188 126 LYSLCNEPLIELSNPGASGSVFYLTSDDEFIIKTVINKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRV 205 elephant shark
NP_001305950 156 LYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRV 235 chicken

Feature 1                                                                                        
O60331       236 VVMNNILPRvVKMHLKFDLKGSTYKRRASKKEKEKsfPTYKDLDFMQDmpEGLLLDaDTFSALVKTLQRDCLVLESFKIM 315 human
CAG07769     210 VVMNNILPRsVRMHLKFDLKGSTYKRRASKKEREKskPTFKDLDFLSDvpEGLNLDqDTYGALIKTLQRDCLVLESFKIM 289 spotted green p...
NP_001120474 230 VVMNNILPRvVRMHFKYDLKGSTYKRRASKKEREKrcPTFKDLDFMNEapEGLLLDnDTFNALVKTLQRDCLVLESFKIM 309 western clawed ...
XP_007906188 206 AVMNNVLPRvVKMHMKYDLKGSTYKRRASRKEREKkrPTFKDLDFMLDfsDGLMLDvDMYSALVKTLQRDCLVLESFKIM 285 elephant shark
NP_001305950 236 VVMNNILPRvVKMHLKFDLKGSTYKRRASKKEKEKssPTYKDLDFIQDmpEGLMLDaDTFSALVKTLQRDCLVLESFKIM 315 chicken

Feature 1        #                                                                               
O60331       316 DYSLLLGVHNIdqhererqaqgaqstsdekrpvgqka-lystamesiqggaargeaiesddtmGGIPAVNGRGERLLLHI 394 human
CAG07769     290 DYSLLLGVHNKtqaereqqsagspagggdekrrgpqrslystvmesiqgsstcrdtldhddtmGGIPAVGGRGENLLLFI 369 spotted green p...
NP_001120474 310 DYSLLLGVHNMeqqererqtegaqsqadekrpvgqka-lystamesiqggaahgesidtddtmGGIPAVNGKGERLLLYI 388 western clawed ...
XP_007906188 286 DYSLLLGVHNLdqasrerqaegsqspsdekrpiaqka-lystamesiqggasrgesidtddtmGGIPAINGKGERLLLYI 364 elephant shark
NP_001305950 316 DYSLLLGVHNIdqqererqsegahstsdekrpvgqka-lystamesiqggaargesidtddtmGGIPAVNGKGERLLLHV 394 chicken

Feature 1           #                                                   
O60331       395 GIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSS 449 human
CAG07769     370 GIIDILQSYRLIKKLEHTWKSLIHDGDTVSVHRPGFYAERFLKFCSTVVFRRSCS 424 spotted green pufferfish
NP_001120474 389 GIIDILQSYRLIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMTNTVFRKTSS 443 western clawed frog
XP_007906188 365 GIIDILQSYRLIKKLEHTWKALVHDGDTVSVHRPNFYADRFFKFMSNVVFRKSSC 419 elephant shark
NP_001305950 395 GIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMTNTVFRKNSS 449 chicken

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