pfam05782: ECM1 (this model, PSSM-Id:399061 is obsolete and has been replaced by 461739)
Extracellular matrix protein 1 (ECM1)
This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness.
Jiyao W et al.(2023). "The conserved domain database in 2023.",