6LHS_A 179 PLVFE----------------------------------------AVWHLHNEGIVCLDEILESCKDTISAVDWLFSEMc 218 XP_002074682 21 CDLQIpgttesqeefilllnylsakerllvakyfcqlpanvgsfrVLGQLQQLRILTATEYVLSKQQSDQLQVDLIIFL- 99 Drosophila wi... XP_002050419 20 CETRQtnqraardlddllkclnake-klllakyfcqlplsvgsfrVLGQLQQLRVLTATEYICSIENEEQLQLILIEFL- 97 Drosophila vi... XP_002005059 20 CDSAQtskratedlvdllkslnake-klllskyfcqlplsvgsfrVLRQLQKLRILTATEYICSIENDEQLQLILIEFL- 97 Drosophila mo... ACH92387 28 CGIQQlgalekyefaellkilngte-kflaskffcqlpanvgsfrVLRQLQELRILTATQYIFSKEDSDQLQVDLIIFL- 105 fruit fly XP_001960500 28 CGIQQqsatfdfqfeellkilnaqe-kfllsryfsqmptnvgsyrVLLQLQNLQILTASEYILRREHSDQLLVDLVIFL- 105 Drosophila an... Q16VS9 14 NHRIEklhvpyenefrmqikylhvkekailrqfifeqewnlgsskVLSMLQEAGIVTASEYVLRLRSSSAIQQVMNDLL- 92 yellow fever ... Q5TWN0 8 RHRIGmlnlpyeeeyraqlkhlgykekdilreafqrqewnvgsarVLSLLQEANILTASEYILSLDSIELMQQILNDFL- 86 Anopheles gam... EHA98935 224 SLLLE----------------------------------------AVWCLHVHSVVSLRELLESHPEAQAVTAWLFGNLc 263 naked mole-rat ELK02893 176 SLLLE----------------------------------------AVWHLHKQNVVSLPELLESHADMQAVVAWLFRNLh 215 black flying fox
6LHS_A 219 slclyi---dnsslagDLAEKMISDFQA--------------LLVENSfrrssaterileqhKTEEICLSILDKLLSWLL 281 XP_002074682 100 ----------------ESQHELLSNLFL--------------SAAFDS--------------EYGMILTSILIDALRNLF 135 Drosophila wi... XP_002050419 98 ----------------QNEYKLLSNLFI--------------SAHYDS--------------VNMLRLNNILENALRNLF 133 Drosophila vi... XP_002005059 98 ----------------QNENELLINLFI--------------SAHYDS--------------VKMLRLNNILENSLRNLF 133 Drosophila mo... ACH92387 106 ----------------ESEFELLANVFF--------------SAAYDA--------------ESALKLTLILTSALGNLY 141 fruit fly XP_001960500 106 ----------------ESEFDLLEDLFM--------------TAAYNA--------------TCRLKLTAILESALGHLY 141 Drosophila an... Q16VS9 93 ----------------EVEHILLADIIS--------------NAHLDT--------------SYSTTLREVLHDSFNSVL 128 yellow fever ... Q5TWN0 87 ----------------EAEYSLLAHIVR--------------YAYQEN--------------VQSQSLTNVLKESFRTLL 122 Anopheles gam... EHA98935 264 llceqm---eascqsgDTTRAMLSDFVQllvlrafqensnvgRTMEPE--------------KMPQVALAVLQKMLSFAL 326 naked mole-rat ELK02893 216 glceqseqmdtscpqaDIARAVLSDFVQllvlkgfqtnsglrGEAEPE--------------RTPQVAVAVLQRMLASAL 281 black flying fox
6LHS_A 282 DAVSVEKSDKSS---AeqhwlsafevhRYRARVVPESI-EQFFIHTLTQVLTFKPKLK-VSDAIQCQANWSFVKTSTlLT 356 XP_002074682 136 MGLARDPKISNLsyvT-----------ALCQSLPSDAL-GVCVHMHLGVLLELHESTE-IGEAFANFSAWINEGVDEl-- 200 Drosophila wi... XP_002050419 134 SALAENPKIGNLnyvE-----------HLCKFLPDDVLvNVCMQMHLNILLELHEAAD-VSLAFQHFSAWINEGVDEl-- 199 Drosophila vi... XP_002005059 134 TALAVNPKISDLsyiA-----------PLCKSLPDDVLlNVCIQMHLNCLLELHVAAD-ISLAFKHLSAWINEGVDEl-- 199 Drosophila mo... ACH92387 142 SGLVGNPKICSLayvE-----------FLCKTLPDEAL-NVCMNMHLSTLLDLHRSEN-VDEAFASFSAWINEGVDEl-- 206 fruit fly XP_001960500 142 AGLVSNPKISELayvD-----------FLPKSLPDDAL-AVCINMHLNTVLQLHQVEE-INEAFANFSAWINEGVDEl-- 206 Drosophila an... Q16VS9 129 DDLIAEPNVVPCnylE-----------RLKSHLPDPDL-TRLRTQHLQLLLGKEKLHA-LSEAVGLQEQWRAECEDR-RS 194 yellow fever ... Q5TWN0 123 NDLNDNPNVIPNnylQ-----------AIGTRLRTHEQ-KLVINEHLQLLLGSERGPLdLDAAIGRQHQWREEMQTIlTG 190 Anopheles gam... EHA98935 327 DSLAAGLQEESPaykAvrwwfdvfsahSC-CVIAPDPL-KKFFRHTLVQTLTHSPVLK-VSDAVQMQSRWSFSRTHPlLI 403 naked mole-rat ELK02893 282 EALAAGVQEESSahrAarcwfsvlsghTC-SMISTDSP-KSFFRHTLTQIFTHKPVLK-VSDAIQMQREWSFARTHPlLT 358 black flying fox
6LHS_A 357 DLYRKLFVALSAEKLiAHIQLVLDTQE----VNWHHVLTCVSCLVICLPEA---QQLIKDLLCRLLTHAFESYELEGMIT 429 XP_002074682 201 TFIRTIASKLLPKHQlEALNYLFKQSVeenfKNWKFYIILLQAIASCGQTEt--QTFIKKYLKSRLIHTATIGCFSSFLH 278 Drosophila wi... XP_002050419 200 IFVKHITGKLFGSHQqEALSHLFKLSTssnfKHWKFYIILLQSMASSGNADt--IAFIKKYLKNRVLQVASLGCQLSLLH 277 Drosophila vi... XP_002005059 200 IFIKRLADTLLGRHQeQALSHLFKVSTstsfKYWKFYIILVQSIASGANADt--AAFIKKYLKNRLLHAATFRCQLTLLH 277 Drosophila mo... ACH92387 207 TFVKHLCDKMFASHQqAALQYLFKQSNtenfNQWKFYLILVQTIASAANPEt--TAYIKKYLKNRLLQTASTASLGSLLH 284 fruit fly XP_001960500 207 TFVKHLSEKLFASHQqDALQFIFKYSNqenfVDWKFYLILVQSIASIAKSEt--QAYIKKYLKGRVLHTANTGCLKSFLH 284 Drosophila an... Q16VS9 195 TTLGRIMLEVVQDQA-NAIETLFASAKtk-sLSWKYYLALLHMVAVAIEGDkveIVRVKGILKDLFNRVVDAGDFETFMI 272 yellow fever ... Q5TWN0 191 TVFERLLIELIRDKA-NLLEVLKELLKrscpFSLKHALYLLSQAARATTDEp-dERLLKSFIKDLFRTVVETGLMSQLQL 268 Anopheles gam... EHA98935 404 SLYCRLFMMLSPEEAiSCVQEVLEEQE----VNWQRVLSCVSVLVTCFPEA---QQLVRDWVARLMAGAFESFHLDSMVT 476 naked mole-rat ELK02893 359 SLYRRLFVVVSPEELvGHVQEVLETHE----VNWQHVLSCVSALVICFPEA---RQLVTDWVARWLARAFENFDLDSMVT 431 black flying fox
6LHS_A 430 AFLIVRQAALEGPAA---FVSYTEWFKCTFGAANsYHGNSKKSLVFLLKFLSDIVPFEA-PQYLKVHVLHPPFVPTKYRP 505 XP_002074682 279 FLLTARAISANTMDVqqnLENYALWYKQNIGEMS-Y-ALNMDKFHVVLNMLNDSLHLEQeVAYLEIHVAIAIAPGGK--- 353 Drosophila wi... XP_002050419 278 LLLTARAAAATTMNIqqnLDNYAQWYKQNIGEMT-Y-VLSSEQFQVILNILEDSIHYEQeIDYVEIHAAIAISPGGK--- 352 Drosophila vi... XP_002005059 278 LLLTARAAAANTMNIqqnLDNYAKWYKQNIGEMS-Y-VLSTEQFKVVLNMLEDSIHYEQeIDYVEIHAAIAISPGGK--- 352 Drosophila mo... ACH92387 285 LLLTARAACASTMDVranLDNYAKWYKQNIGEMT-Y-ILGTEKFQTILRLLEESLPYEKeLQYLEIHVSIAISPGGR--- 359 fruit fly XP_001960500 285 LLLTARAASATTMDIqsnLDNYAKWYKQNIGEMT-Y-LMTTEKFHLMLGLLEQSLFYEKeLAYLEVHASIAISPGGR--- 359 Drosophila an... Q16VS9 273 LMVSAREICMSNERV---LGSYSGWYKATIGEMS-Y-RIKKEQFAHVVELMTRLIGLEKdPEVLKVHINISVSTPPKCME 347 yellow fever ... Q5TWN0 269 VLLFAREICSANTAV---LGTYPAWYKQTVGEMT-Y-SVKRDQFIGTMELLTALIPAERnLELLGVHATIAISAPVKCND 343 Anopheles gam... EHA98935 477 AFLVVRQAALEGPAA---FPPYADWFKASFGSSRgYHSCSKKALVFLFKFLSDLVPWEA-PWYLQVHILYPPLVPSKYRC 552 naked mole-rat ELK02893 432 VFLLVRQAALEGPSL---FLSYADWFQASFGSARgLHGCSKKALVFLFKFLSDLVPFEA-PHYLQVHILHPPLVPSKYRF 507 black flying fox
6LHS_A 506 LLMEYISLAKTRLTDMK 522 XP_002074682 354 LVQAYKTKCRTHLSQLK 370 Drosophila willistoni XP_002050419 353 LVQSYKTKCKAHLARLK 369 Drosophila virilis XP_002005059 353 LVQSYKTKCKTHLARLK 369 Drosophila mojavensis ACH92387 360 LVQAYKTKCRAHAAQLK 376 fruit fly XP_001960500 360 LVQAFKTKCRSQVSFLK 376 Drosophila ananassae Q16VS9 348 LIVNYKQLCRAHLAKLL 364 yellow fever mosquito Q5TWN0 344 YVLNYKQLCRAHIAQLK 360 Anopheles gambiae str. PEST EHA98935 553 VLTDYISLARTRLADLK 569 naked mole-rat ELK02893 508 LLTDYVSLARTRLADLK 524 black flying fox
Jiyao W et al.(2023). "The conserved domain database in 2023.",