Conserved Protein Domain Family
FAM131
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pfam15010: FAM131 (this model, PSSM-Id:405666 is obsolete and has been replaced by 464442)
Putative cell signalling
The precise function of this protein family is unknown, however studies have shown it undergoes Protein N-myristoylation; a type of lipid modification in eukaryotic and viral proteins. Protein N-myristoylation is usually an irreversible co-translational protein modification which is useful in cell signal transduction pathways. This indicates that FAM131 may have some sort of role in cell signalling due to its ability to be myristoylated. This family of proteins is found in eukaryotes and are typically between 257 and 361 amino acids in length.
Links
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Statistics
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PSSM-Id: 405666
Aligned: 12 rows
Threshold Bit Score: 254.825
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_023207242  21 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWCK-----PIDTPAALESDFNSYSDLTE 95  southern platyfish
Q3TY60        39 ILPKLKRNSNAYGIGALAKSSFSGISRSMKDHVTKPTAMGQGRVAHMIEWQGWGKaptiqPQHSHEAVRRDTDAYSDLSD 118 house mouse
XP_015216920  42 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWCK-----PTDSPAALESDFNSYSDLTE 116 spotted gar
Q8BWU3        86 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSK-----PSDSPAALESAFSSYSDLSE 160 house mouse
XP_001520919   7 RALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSKPSDSPI-----ALESAFSSYSDLSEGEQEAR 81  platypus
XP_007486246  90 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSK-----PRDSASALESAFSSYSDLSE 164 gray short-tail...
XP_017202443 243 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSK-----PNDSPAALESAF-------- 309 rabbit
XP_010591120   1 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWSK-----PSDSPAALESAFSSYSDLSE 75  African savanna...
XP_005461052  66 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWCK-----PIDTTAALESDFNSYSDLTE 140 Nile tilapia
TNN01273       1 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWCK-----PIDTP-ALESDFNSYSDLSE 74  Takifugu bimacu...
XP_006001413  39 ILPKLKRNSNAYGIGALAKSSLTGISRSVKDRITKPTAMAQGKVAHMIEWQGWSKqqhpyRQPIHETVRMDVDAYSDLSD 118 coelacanth
XP_016851166  47 MLPKSRRALTIQEIAALARSSLHGISQVVKDHVTKPTAMAQGRVAHLIEWKGWCK-----PMDSPVALESTFNSYSDLTE 121 green anole

XP_023207242  96 GEQEARFA------------AGVAEQFAIAEAKLRAWSSVDGDESNDDSYDEDFLPASEPt----TQSTE-LSSYP--PY 156 southern platyfish
Q3TY60       119 GEKEARFL------------AGVMEQFAISEATLMAWSSMDGEDMSVNSTQEPLDCNYSDnyqelMESQDaLAQAPmdGW 186 house mouse
XP_015216920 117 GEQEARFA------------AGVAEQFAIAEAKLRAWSSIDGEDSNDDSYDEDFGPASEPsq--tLQNSDtVSSYP--SY 180 spotted gar
Q8BWU3       161 GEQEARFA------------AGVAEQFAIAEAKLRAWSSVDGDDSTDDSYDEDFTGGIDT---------DmAG--PlgSH 217 house mouse
XP_001520919  82 FAAGVAEQ------------FAIAEAKLRAWSSMDGEDSADESYDEDFAGEADSLPPTDT-----AGQPPpGPHLQdlLL 144 platypus
XP_007486246 165 GEQEARFA------------AGVAEQFAIAEAKLRAWSSVDGEDSTDESYDEDFAAGADS-----PQPPDiAGQl--gPH 225 gray short-tail...
XP_017202443 310 ----SSYSdlsegeqearfaAGVAEQFAIAEAKLRAWSSVDGEDSTDDSYDEDFAGGTDT---------DlAGQLPfgPH 376 rabbit
XP_010591120  76 GEQEARFA------------AGVAEQFAIAEASxRAWSSVDGeDSTDESYDEDFAGGTDT---------DvSGQLPlgAH 134 African savanna...
XP_005461052 141 GEQEARFA------------AGVAEQFAIAEAKLRAWSSVDGDESNDDSYDEDYLPANEPt----TQSTD-VPSYP--PY 201 Nile tilapia
TNN01273      75 GEQEARFA------------AGVAEQFAIAEAKLRAWSSVDGDESNDDSYDEDFLPANEPs----TQSTD-VPSYP--PY 135 Takifugu bimacu...
XP_006001413 119 GEKEARFA------------AGVMEQFAISEATLIAWSSMEAEEMSMGSTVDNMANSTELn----MENQEnQAQNMyeVW 182 coelacanth
XP_016851166 122 GEQEARFA------------AGVAEQFAIAEAKLRAWSSVDGDDSNDESYDEDYATPSDT--------TQpADAVP---- 177 green anole

XP_023207242 157 LKD---------LIhsqlcqhlgmqrpcsesrggisegggsREPSSTAgSPDTLCSSLCSLdeqhpllrdl-rthrgnha 226 southern platyfish
Q3TY60       187 PHS---------YV---------------------------SQGMYCLgSSDAWEASDQSLi------------------ 212 house mouse
XP_015216920 181 LRD---------FLhshvcqqrss--------rqgsseqenSDTSPTV-SPDTLCSSLCSLedhpl----------lkdl 232 spotted gar
Q8BWU3       218 LQD----------Lftgrrfsrp---------vrqgsvepeSDCSQTV-SPDTLCSSLCSLedg---------------l 262 house mouse
XP_001520919 145 LGR---------RCprpvrqgsc---------epesdssqtVSPETLC-SSLCSLEDGLLGspa---------------r 190 platypus
XP_007486246 226 LQD----------Lltgrrysrp---------lrqgscdpeSDSSQTV-SPETLCSSLCSLedg---------------l 270 gray short-tail...
XP_017202443 377 LQD----------Lftgrrfsrp---------vrqgsvepeSDCSQTV-SPDTLCSSLCSLedg---------------l 421 rabbit
XP_010591120 135 LQD----------Lfggrcfsrp---------lrqgsvepeSDCSQTV-SPDTVCSSLCSLedg---------------l 179 African savanna...
XP_005461052 202 LKD---------LIhsqlcqhlgfrspccesrgggvegggsGEPSPTAgSPDTLCSSLCSLd------------------ 254 Nile tilapia
TNN01273     136 LKD---------LInsqlcqhlglrgpc-cegggggeggssgePSPVAgSPDTLCSSLCSLdenhpllrdmgsqqrgthh 205 Takifugu bimacu...
XP_006001413 183 PHS---------YV---------------------------SQGMYCLsSSDAWEQSDQSLi------------------ 208 coelacanth
XP_016851166 178 --QiapstllkgFLhsrlcqlna----------rqgscdpeSDSSQTTiSPETLCSSLCSLedsll-----------lke 234 green anole

XP_023207242 227 qN------------------NAAelAAKILSalhggEE-LLARLqrvghsgpGGGdcgfhslsgggrgsrsyggqDSPCY 287 southern platyfish
Q3TY60       213 -A------------------SPA--TGSYLGpa--fDD-SQPSLhd----mgPSQ--------------------PASGY 244 house mouse
XP_015216920 233 gS------------------SPVdlAAKILGalqggEE-LLSRLq-------rGResafrs--------lghlvcEDSSY 278 spotted gar
Q8BWU3       263 lG------------------SPArmTSQLLG-----EElLLARLp-------PSResafrs--------lgpleaQDSLY 304 house mouse
XP_001520919 191 lA------------------TKLlgQELLLS-----KLaPSGESa-------FRSlgpler--------rdslysMSYTE 232 platypus
XP_007486246 271 lG------------------SPAhlSPSLLT-----EElLLSKLp-------PSResafqs--------lgplerRDSFY 312 gray short-tail...
XP_017202443 422 lG------------------SPArlASQLLG-----DElLLAKLp-------PSResafrs--------lgpleaQDSLY 463 rabbit
XP_010591120 180 lG------------------SPArlASQLLG-----EElLLPKLp-------PSResafrs--------lgpleaQDSPY 221 African savanna...
XP_005461052 255 -EqhpllrdlgghrgthshsNAAelAAKILSalhgrEElLLARLqrvgqsgpGGGdcgfqslgvvgrgirpcggqDSPCY 333 Nile tilapia
TNN01273     206 hG------------------NASelAAKILSalqggEE-LLARLqragqggtgsgdfhs--lggagrgvrpcggqDSPCY 264 Takifugu bimacu...
XP_006001413 209 -A------------------SPA--TGSYCGqn--yEE--QPQGqregistpPTQqqlqp----------hfishTPPLV 253 coelacanth
XP_016851166 235 lS------------------SPSelAIKLLGslsgrEEaLLSKLp-------ATQtagecafr-----slaqlecQDSLY 284 green anole

XP_023207242 288 SMSYSETYL-----------------------------------SPGEDDDTP----CKDYEGTVCQKEVdgqgvd--yp 326 southern platyfish
Q3TY60       245 SAQEPPPLLgvdtdwasevggve--------largpveeekrplAPEEEEDAG----CRDLESLSPREDPems------- 305 house mouse
XP_015216920 279 SVSYTESCF-----------------------------------SPEDEEDLA----CKDYDS-VCKDECdy-------- 310 spotted gar
Q8BWU3       305 NSPLSESCL-----------------------------------SPAEEEPDS----CKDCQLLCPLPTGsw-------- 337 house mouse
XP_001520919 233 SCLTAAEDE-----------------------------------AASCKDCPL----LPPPSAGGWALPRka-------- 265 platypus
XP_007486246 313 SVSYTESCL-----------------------------------SPAEDEPIA----CKDCQLLGPAPGGswe------- 346 gray short-tail...
XP_017202443 464 NSPLTESCL-----------------------------------SPAEEEPDP----YKDCQPLCPPPAGsw-------- 496 rabbit
XP_010591120 222 NLPLVESCP-----------------------------------SPAEEESAP----CKDCRALCPLPAGsw-------- 254 African savanna...
XP_005461052 334 SMSYSDTYL-----------------------------------SPGEDDDTP----CKDYDGTVCQVEAerngve--yp 372 Nile tilapia
TNN01273     265 SVSYSETYL-----------------------------------SPGED-DSP----SKDYGSTVCQ--Veadgneveyp 302 Takifugu bimacu...
XP_006001413 254 DIWQGQSNMshayalqevgryvgvpcqdrgepqvddapllskkgSP-EEDDVL----CKDFDSLSPREEPmeq------- 321 coelacanth
XP_016851166 285 SMSFTESCL-----------------------------------SPTEEEEEEegvlCKDCEAhed-------------- 315 green anole

XP_023207242 327 pdynPHRRVSDVASSGVVSLDE 348 southern platyfish
Q3TY60       306 --taLSRKVSDVTSSGVQSFDE 325 house mouse
XP_015216920 311 ---pGRRKVSDVASSGVVSLDE 329 spotted gar
Q8BWU3       338 ---eRQQQVSDVASSGVVSLDE 356 house mouse
XP_001520919 266 ---sDVASSGVVSLDEDEPEEQ 284 platypus
XP_007486246 347 --grRRRKVSDVASSGVVSLEE 366 gray short-tailed opossum
XP_017202443 497 ---eRQRQASDVASSGVVSLDE 515 rabbit
XP_010591120 255 ---eWQRPTSAVASSGVVSL-E 272 African savanna elephant
XP_005461052 373 pnydPRRRVSDVASSGVVSLDE 394 Nile tilapia
TNN01273     303 pdydPRRRVSDVASSGVVSlde 324 Takifugu bimaculatus
XP_006001413 322 -ggmVRRKVSDVTSSGVQSFDE 342 coelacanth
XP_016851166 316 -schVRRKASDVASSGVVSLDd 336 green anole
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