5A1S


Conserved Protein Domain Family
2HCT
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pfam03390: 2HCT (this model, PSSM-Id:397455 is obsolete and has been replaced by 427276)
2-hydroxycarboxylate transporter family
The 2-hydroxycarboxylate transporter family is a family of secondary transporters found exclusively in the bacterial kingdom. They function in the metabolism of the di- and tricarboxylates malate and citrate, mostly in fermentative pathways involving decarboxylation of malate or oxaloacetate.
Links
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Statistics
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PSSM-Id: 397455
Aligned: 73 rows
Threshold Bit Score: 298.247
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5A1S_A                        23 IFGMPLPLYAFALITLLLSHFYNAIP--------------TDLVGGFALMFVMGAIFGEIGKRLPIFNKyIGGAPVMIFL 88 
Q15WU4                         1 -----mgLFVLIAITSVAILQLDELKt-------------VGVVGAFAVLWTIGLFFYALGERVKLLKSvLGGGLVVAYF 62  Pseudoalteromonas atlantica T6c...
jgi:Hbal_1529                 25 lAGIAIVPFGIMAILSAIFLISGHIQe-------------AGLPGAFALMWSVGFVLYSIGEKLPIWKEyAGGGLIMAFL 91  Hirschia baltica ATCC 49814...
KuoIPMB:SCULI_v1c01670       225 IWTIPMWMYLTFAGILTASILTDTVE--------------ANMIYGPAILLIIAIISGAIFSKIPIWKKyFGGAVMGSMF 290 Spiroplasma culicicola AES-1...
jgi:B1NLA3E_22100             28 mYGLPLWAWFAGALIFAFGTMTKSFP--------------ISFAGDVLVLIVVGFFFGKVGDTLPIWKDyLGGGSLLAFL 93  Bacillus sp. 1NLA3E...
WP_021869382                   9 vcgltAKYFVPLFLVVIICTYGGFMPtvkig-----ettgVGMVGTLAFLMSVGGLFFWLGNSIPIVNSyLGGSVLFCMF 83  Clostridium sp. AM22-11AC...
CCY44239                       9 VCGLPAKYFIPFFIIVMATVYLGFMPvvkiysndagkymaTSFIMTIAYLMAVGGLFFWLGNTIPIVNNyLGGACLLPLI 88  Clostridium sp. CAG:7...
CCY43253                     126 vCGLSFKHFVLFFAVVFVSAYLGFMPtvtiysnsagaftaTTFVGSVAFLMAVGGVFFWLGNTIPILNNyLGGACLLPLL 205 Clostridium sp. CAG:7...
csisp-ryc-ciber-uv:acin_1093  10 vCGMGPKPFFILFAVVLIAVYGNFMPlakiysnasgnfvvSSYVLTVAFLMAMGGLFFWLGNTIPIVNNyLGGACLLPLI 89  Acidaminococcus intestini RyC-MR95...
zhongguo:AS9A_3877            78 ISGMPAEYFLVLFAVIVVASLTGTLP--------------TSLIAGFAAAIAFAGILMWIGQKVPYLRD-FGLPVILCLF 142 Hoyosella subflava DQS3-9A1...

5A1S_A                        89 VAAYFVYAGIFTQ---KEIDAISNVMDKSNFLNLFIAVLITGAILSVNRKLLLKSLLGYIPTILAGIVGASLFGIVIGLC 165
Q15WU4                        63 GAALTANSGAINT---GDIKYVQSFIIENRFLYFVLAALLISSIISVKTEVLKAALMSYAPIILGGLSLAAIFGVLAGMM 139 Pseudoalteromonas atlantica T6c...
jgi:Hbal_1529                 92 GSAVLVHFGVIPK---EESEFLTASVIDNRFLYLLLVGLVAGTILSVDRKSLMRSVVGLVPVIFFAISGAVVLGVLIGWF 168 Hirschia baltica ATCC 49814...
KuoIPMB:SCULI_v1c01670       291 VGAFLVYFGVFYKgdnGVYDSVAMWFKNQDFLSLYISVLLVGAVLLIPRKMIIKATGGFFILIIAGTALGLLFGLLGSLI 370 Spiroplasma culicicola AES-1...
jgi:B1NLA3E_22100             94 GASYLVSTGVISE---DVAGGVRTLFDDMGMLDFFIAVIITSSILSINRKFLAKAIGGFIPLVLVGTAVAFIMAIVGGWI 170 Bacillus sp. 1NLA3E...
WP_021869382                  84 GPALLNYFGLLPE---TTVKGVSILMK-YGFQDVYIAALLCGSVLYMDRKILLGAISRYLPAILGSQVFALGFCFLGGLI 159 Clostridium sp. AM22-11AC...
CCY44239                      89 GASFLNYVGLVPQ---ELVNGVKVLMG-GGFQDAYIAMLLVGSILVMDRKVLLGATARYMPTILGSQVFALGFCMLAGLV 164 Clostridium sp. CAG:7...
CCY43253                     206 GASLMNYLGLVPE---PLANGVRMVMK-GGFQDMYVAMLLIGSVLVMDRKLILSATARYLPTIIGSQVFALGFCMIGGAI 281 Clostridium sp. CAG:7...
csisp-ryc-ciber-uv:acin_1093  90 GASWLNYVGLIPK---PLENGIRTVMR-GGFQDMYIAALLIGSVLVMDRKILLKATARYLPAIIGSQVVALVSCYIGGKL 165 Acidaminococcus intestini RyC-MR95...
zhongguo:AS9A_3877           143 VPATLVYLGVMPE---STIALFDAFVDEQGAMDFILIVIIVGAILGMPRKLIVKAGVRFIVPVIGTIAATLLLIGLVGAA 219 Hoyosella subflava DQS3-9A1...

5A1S_A                       166 FGIPVDRIMMLYVLPIMGGGNGAGAVPLSEIYHSVTGRSREEYYSTAIAILTIANIFAIIFAA----LLDMVGKKYTw-- 239
Q15WU4                       140 AGVPTERVLIMYFLPIMGGGTGAGAIPMSEVYAEATGNSAADYFNYAIGVLTLGNIVAIITAS----SLNMLGNKLTf-- 213 Pseudoalteromonas atlantica T6c...
jgi:Hbal_1529                169 FQVEPARIVTHYVLPIMGGGNGAGAIPMSEIYADATGENGAKYYGFAISVLTIANMVAILMAS----VLNKIGQAFPa-- 242 Hirschia baltica ATCC 49814...
KuoIPMB:SCULI_v1c01670       371 TGMDMKELILYYALPILADGNGGGIQPIGAIAGKF-GYSEELWISRALAISTLASIMSVVAAA----IVNGIGKSKPs-- 443 Spiroplasma culicicola AES-1...
jgi:B1NLA3E_22100            171 VGVNYKDVIVNYALPIMGGGNGAGAIPMSQIWGEVTGKDPKIWYSSAITILTIANIFAIMVGA----LLNGLGKKVPk-- 244 Bacillus sp. 1NLA3E...
WP_021869382                 160 TGYGPLNAIFDIGAPTMSGGSGGALVTIPILYTDLSGTDWMSMSGMFLCYVSLSNVVAVLMCAlskpILRKLGMVSPd-- 237 Clostridium sp. AM22-11AC...
CCY44239                     165 TGYGIPEALFDIGAPCMSGGSGGAMTTLPTLYSSLSGTDMTPMAGKFLCYASIANVLAVVLAA----IAGSVTAKMKg-- 238 Clostridium sp. CAG:7...
CCY43253                     282 TGFGAKEGLFYIGAPCMSGGSAGAITTLPSLYSALSGQDMTGMAGQFLCYASIANILAVLMAA----VGGAVTAKMSg-- 355 Clostridium sp. CAG:7...
csisp-ryc-ciber-uv:acin_1093 166 IGFGAAEGLFYIGAPCMSGGSAGAMTTLPLLYSELSGKDMTSLAGQFLCYASIANVLAVVLAA----LGGGITSKISg-- 239 Acidaminococcus intestini RyC-MR95...
zhongguo:AS9A_3877           220 IGYGFGRAMLLIAAPVMAGGLPIGAIPMSEMYAQAVGGTPDDFFPALLSAVLVANIVCIFAAA----IFSGVGKRRGrtw 295 Hoyosella subflava DQS3-9A1...

5A1S_A                       240 --LSGEGELVRKASFKT------EDDEKAGQITHRETAVGMVLSTTCFLLAYVVAKKIlpsiggVs------IHYFAWMV 305
Q15WU4                       214 --LSGKGQLVKGQEDVD-------DELKSAQPTDVNTHAATVLVVSLLLVGVVLSATvg------------lMHLFAWVT 272 Pseudoalteromonas atlantica T6c...
jgi:Hbal_1529                243 --WTGNGKLSDDENFQEl----aPATENSEPTKEMSTLSALFFTVAMLLLAMLLYSLfp------------qVHLFAWAV 304 Hirschia baltica ATCC 49814...
KuoIPMB:SCULI_v1c01670       444 --LSGDGKLMLRDi---------HTVDRTSKANDRNIAASLLMIFMIYILSDLFEKAIf-----TedrigllIPNFAWMI 507 Spiroplasma culicicola AES-1...
jgi:B1NLA3E_22100            245 --WTGNGELIKGQITEK------NGAKEKNTATMEDAGFGLLVAVGFFGLANVIGVGLlpkv------gpfsIHPYAYMV 310 Bacillus sp. 1NLA3E...
WP_021869382                 238 ----ENPAILRKAGTMQte---sTEQLPALSEDPAKVCGGIFICLGIYLLGTILGKLpgt----------kvIAGLAWAI 300 Clostridium sp. AM22-11AC...
CCY44239                     239 --LNGNGEILCSKKAQEskteekEQKRPGTSADYVALGSGIFMSFCLYLLGNILGSLpgf----------gvIPGLAWTI 306 Clostridium sp. CAG:7...
CCY43253                     356 --WNGGGRILVSQSAEEl----kEEKRAGTSADYKKLGSGIFMSLVIYLLGDILGKLpgt----------svIAGLAWSI 419 Clostridium sp. CAG:7...
csisp-ryc-ciber-uv:acin_1093 240 --LNGNGNILIGQEHMit----eGEKRQATTLDYSRLGGGIFICLVVYLMGFILGKLpgt----------gmIAGLAWSI 303 Acidaminococcus intestini RyC-MR95...
zhongguo:AS9A_3877           296 vgFNGNGQLLRVKSNAAd----lKQPAPVTTATFTGLTQGLLIAGAIFIGATMLSALvp------------nIHAYAWAV 359 Hoyosella subflava DQS3-9A1...

5A1S_A                       306 LIVAALNASGLCSPEIKAGAKRLSDFFSKQLLWVLMVGVGVCyTDLQEIIDALTFAN-VVIAAIIVVgavvGAAIGGWLI 384
Q15WU4                       273 VIAVVMNLTGVVSDSMKTALLLLSQWCIKAFLVTILAAFGLS-ADFEVIAQLFDPGS-LFIIVSIVLgaaiGAGVVAHFV 350 Pseudoalteromonas atlantica T6c...
jgi:Hbal_1529                305 LIFVFLNVSDLLPKSLVSALALVNEWGMRTFIVLVLVAVGLM-TDLNDLITAFSIQN-VVISAAIVIgaslGAGLSARLF 382 Hirschia baltica ATCC 49814...
KuoIPMB:SCULI_v1c01670       508 VICLVLNLCNIVPREMKLGAEKINKFISKQTTWLLMVGVGIIyINLEEFIKALNGEA-IFITMLFVIgatiGPMLLAKPL 586 Spiroplasma culicicola AES-1...
jgi:B1NLA3E_22100            311 VLLIIANALDIIPQRAKDGVKKVNEFMMGKMLFVFLAGVGITyTDFSALVHALSLQT-AVICLFTVFgaviGSWLFAKVV 389 Bacillus sp. 1NLA3E...
WP_021869382                 301 IIAVVVKCTGIMDEKITNYTVNGMNFMLKGLLPAIIAGIGINsISIETMISYFTPAA-LVIIVLAVLgayiGAIIFGQLF 379 Clostridium sp. AM22-11AC...
CCY44239                     307 ILGIIIKFTGLLPDQFADNCVYSMNFALRALLPMLIAGIGINsLKFSTLAEYFSPGA-FVVIFLAVFgamlGAMIFGKLS 385 Clostridium sp. CAG:7...
CCY43253                     420 IIAIVIKCTGILSDDIADNCVYSMNFALKALLPMLVAGIGINsLKITDLTKFFSPGV-FAVIFFGVLgafiGAMIFAKLA 498 Clostridium sp. CAG:7...
csisp-ryc-ciber-uv:acin_1093 304 IIAIIVKCTGIVEDEIMDDAVYAMNFALKALLPMLIAGIGVNsLKFTALTEYFTVPV-FAVIFIGVMgafvGAMFFGRLT 382 Acidaminococcus intestini RyC-MR95...
zhongguo:AS9A_3877           360 LVTIVLKIAKLLPLELETASSHLGDWFVTGLVPPLLIALSTTkITIADVIAVLGDGQfVFLIVAAVVisglAAGLFGLLV 439 Hoyosella subflava DQS3-9A1...

5A1S_A                       385 GFYPIESSITAGLCMANRGGSGDLEVLSACNRMNLISYAQISSRLGGGIVLVIASI 440
Q15WU4                       351 KCYPIEGALAGGLCMANAGGAGDLQVLSAARRLSLYPYAQISSRIGGALMLVLASy 406 Pseudoalteromonas atlan...
jgi:Hbal_1529                383 KFFPIEAAIAAGLCMANRGGSGDLEVLGASKRMALYPFAQISSRIGGGIVLFLAGY 438 Hirschia baltica ATCC 4...
KuoIPMB:SCULI_v1c01670       587 KFNAVESAVSAGLCMTAQGGSGAIAVLGTSERMELMPFGQITCRIAGSVVLIFAAI 642 Spiroplasma culicicola ...
jgi:B1NLA3E_22100            390 GFYEIEAAIAGGLCHVNRGGSGDLEILGASNRMILMSYAQLATRLGGAIILVLASL 445 Bacillus sp. 1NLA3E
WP_021869382                 380 GLWGYEAGITAGLCCCNIGGSGDLAVLTAGDRMSLLAFSSISTRIGGALMVVWIGF 435 Clostridium sp. AM22-11AC
CCY44239                     386 GLWAYEAGVTAGLCCCNIGGSGDLAVLSAANRMNLLAFASISTRIGGALMVIWIGL 441 Clostridium sp. CAG:7
CCY43253                     499 GLFPYEAGVTAGLCCCNIGGSGNLAVLTAADRMNLLAFASISTRIGGALMVVWLGF 554 Clostridium sp. CAG:7
csisp-ryc-ciber-uv:acin_1093 383 GLYPYECGVTAGLCCCNIGGSGDIAVLTAANRMNLLAFASISTRIGGALMVIWLGI 438 Acidaminococcus intesti...
zhongguo:AS9A_3877           440 KMYFIDSAIVPGLIMADTGGSGDLAVLSASERMNLLPFATIATRFGGTLTLLLVSL 495 Hoyosella subflava DQS3...
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