15606774 109 SKIRKAKERILRELEYARRYgdwwtaetlelelRQLEATEQSIRRQLEQVEKSLstVFAPEDVKAFLENKLSIDGLIRKA 188 Aquifex aeolicus 15594714 1 MYDRRALNCLFFNTFLFFMEs------------RHLVFTEEHIFYGLIKSDKVK--ELLNLCAIDFYKLNKQLEEFFSKL 66 Lyme disease spir... 15595179 1 -------MVEIDSKEIARKN-------------KNKEVSIWHLLMSIITTPKKs--EIKFIDSKTLKNIKQEVISEIDKL 58 Lyme disease spir... 19552964 1 ----------------------------------------------------------MNSRGLPHTTNHYKKEPPTVPF 22 Corynebacterium g... 19552991 -------------------------------------------------------------------------------- Corynebacterium g... 19074942 5 KYTERAQNALKMCVDEALAN-------------NNNTIEPEHLLKAILSDQTSv--LHNVLSPTERNNVKNALIKRIGGF 69 Encephalitozoon c... 18202342 -------------------------------------------------------------------------------- Mycobacterium tub... 15678312 -------------------------------------------------------------------------------- Methanothermobact... 15597921 -------------------------------------------------------------------------------- Pseudomonas aerug... 12230885 -------------------------------------------------------------------------------- Pseudomonas aerug...
15606774 189 LEKSPLieqvkelgISPdriidkvaekvfgkkptfdySQYLTQVLEKAQDKAVSE--GEAQVQPSHISAALIEAK-DTIG 265 Aquifex aeolicus 15594714 67 PLRGNYipdyvssmDYLyddi------------isvlFFYKKPYKIQEKDLLWVLvkKRKNSILDALLSSGFNLTiFDKL 134 Lyme disease spir... 15595179 59 EKILIEk------nEII--------------------IPKINKEIFALIKEAKKEfkSKPLIGAKEIFYQILKNK-KLLK 111 Lyme disease spir... 19552964 23 HDFTD--------------------------------PDSDPRQNAPANPTAQPP-----SAPTSHSSQQGLPPG----- 60 Corynebacterium g... 19552991 -------------------------------------------------------------------------------- Corynebacterium g... 19074942 70 AKQYNCt------------------------------EPRVGETLAKVLMAAESKg-EGEYVSVNALVLSLLEVE----- 113 Encephalitozoon c... 18202342 -------------------------------------------------------------------------------- Mycobacterium tub... 15678312 -------------------------------------------------------------------------------- Methanothermobact... 15597921 -------------------------------------------------------------------------------- Pseudomonas aerug... 12230885 -------------------------------------------------------------------------------- Pseudomonas aerug...
15606774 266 GKLINQVLGGEK------EMKKDVTQ-------------ELKEEEKS---------PLERFGVNLNELARQGKLDPVIGR 317 Aquifex aeolicus 15594714 135 IEAHDYLAVNTKsasgdsELIAEYIHnnapkrkggfhifDDKRDELDqnnifleskDSIGNFLTNVIDTLDLKYNPLIGR 214 Lyme disease spir... 15595179 112 KHKLSKSSFNFKd----qNILEYMEKnkir------lieTYKEFDEEirle-nehfEIGKYVKNLTALAKAKKLDPLVGR 180 Lyme disease spir... 19552964 61 -AIMIPFPGQPQ---------QQ-----------------S---------------APNDETRFIDLNERHKDDEPALFR 98 Corynebacterium g... 19552991 1 ----MTQVVAGTlv--geSINREID-------------------E------------DKYPYLSSYAAPVAVPVREIIGR 43 Corynebacterium g... 19074942 114 --SIRELIANSEdi--rkKVEEQTKnk----------rfDSRNADDGt-------dVMSRFAVDMVEQARQNVFDPVIGR 172 Encephalitozoon c... 18202342 -------------------------------------------------------------------------------- Mycobacterium tub... 15678312 1 -------------------------------------------------------mAVWQDNLKRLLNQKEVLIIHGNIR 25 Methanothermobact... 15597921 1 ---------------------------------------------------------MALGAICCGHDTRCERLSMPGTA 23 Pseudomonas aerug... 12230885 -------------------------------------------------------------------------------- Pseudomonas aerug...
15606774 318 EREINQVIEILLRRTKNNPVLVG-DPGVGKTAIVEGLAQRIVNKEVPPE--LQDKEIWSIDMASLLAGSKYRGEFEERLK 394 Aquifex aeolicus 15594714 215 SQELSRLIQVILRKHKSNPILFG-EPGVGKTVLIQGLAYKIKIENVPKD--LIGYEIYSLDIGRLVSGTKYRGDLESRVN 291 Lyme disease spir... 15595179 181 EAEIKTLTNILLRRNKNSAMLIG-EPGVGKTAIVEGLASSIVQKKISSK--LQDKTILMLKVSNLVSGTKYRGEFEDRLN 257 Lyme disease spir... 19552964 99 DDVIDQTLAILISKNKPNALLVG-PAGTGKSRIAEDIARRLANDDVSIPdqLVGHRILDVSIAELVAGAGVVGQLEERIL 177 Corynebacterium g... 19552991 44 EEEVNKIMAALMRPEISNVMLVG-PAGSGKTTLVQQALVKDPERNYIEV---DVAKMVADLSTPAQMAARIKGVFEDAIA 119 Corynebacterium g... 19074942 173 DEEIRRVLEILSKKTKSNAILVG-KPGVGKTAIVNGIAQLIANGEAPT---LRGARIYNVDVGSMVAGTSHRGDFEERLK 248 Encephalitozoon c... 18202342 -------------------------------------------------------------------------------- Mycobacterium tub... 15678312 26 DTAYLTEEGNLVRGLTDLINRTGrELGYDKTVSWGSFFDHEGRGHSPMWs-LERITPLNGDQPEIRETESQDRVSDVLHR 104 Methanothermobact... 15597921 24 LFEKPRWLRDLLRFLPLKSQFVL---SGN---IRDLQACEVVPGTVTAQ---SFNQTLCDALLDAGYAQVLAWDPLAGFR 94 Pseudomonas aerug... 12230885 -------------------------------------------------------------------------------- Pseudomonas aerug...
15606774 395 ALLDEVK-EKgNVILFIDEIHTVVGAG---AaEgAVDAANIMKPALARGEIRVIGATTVDEYRKYIEKDPALERRFQPVF 470 Aquifex aeolicus 15594714 292 RVLDFLSsRK-KVMLFIDEIHMIVGAGat--sFgSMDISNLLKPILTLGKIKFIGATTEYEYRKFFLKDKALMRRFQSIE 368 Lyme disease spir... 15595179 258 NIIKYIEkNK-NTIIFIDEIHTLIGAGnseG---ALDASNILKPSLSRAEIQIIGATTYNEYRKYISKDKAFARRFQTIT 333 Lyme disease spir... 19552964 178 DLIKYATdPSnKVIIFIDEIHQIAGDQsshS-GsQAKVAQILKPYLARGDLRVIGATTTQEAR-DFDHDPALKRRFSRVN 255 Corynebacterium g... 19552991 120 YRKHEGH----ELVLFVDEFHQIVQLSna-----aVEAIKPILAMSGVLGVRVIAATTLEEFHEHIRPNQALTERLQEIR 190 Corynebacterium g... 19074942 249 TLVKEAEtTP-GVILFIDEIHIVLGAGktdG---AMDAANMLKPGLAAGTIKCIGATTHDEYRKYIENDPAFERRFVQVV 324 Encephalitozoon c... 18202342 -------------------------------------------------------------------------------- Mycobacterium tub... 15678312 105 WLEDEITsIDeKKIFIINYIDKITGYAp---------DGMYSEPTAELVTLIQKIIENISENNRLIMIALRDTMIPVEYY 175 Methanothermobact... 15597921 95 VLGRPGSeAGaTPQVLLDLGLTPVDGAapaG----IDLLGATLQRLVNRSGEPIALIVDFASR-LAVRNDALSAAEHQLF 169 Pseudomonas aerug... 12230885 -------------------------------------------------------------------------------- Pseudomonas aerug...
15606774 471 VDEPTEEQTIEILKGLRPRLEQFHK--VKISDEAIEAAVKLTKRYVT-FRRLPDKAIDALDQAAARKKLKVIgTPPEIQE 547 Aquifex aeolicus 15594714 369 LKEPNFEDAYNILQEIKKDYERYHN--VEYTDEAIQACILMSQKYIK-DRFLPDKAFDILDELGSKFKLEN--------- 436 Lyme disease spir... 15595179 334 VKEPDEKDTLKIIENIAKNFEDYHG--VIYEKSALLNIVKLSSKYLI-NKRFPDKAIDIIDIAGAIKKEE---------- 400 Lyme disease spir... 19552964 256 VDEFDRDQTLTILHAARDGYLKHFNnaVTVSDDVLGYVYTYSQQFNPgNTAQPDAALTLFDKALASLTME---------- 325 Corynebacterium g... 19552991 191 LTPTDQKTTVAILRGMADRYGVSDQ---FYDDHVFEQIYSTTERFMP-SSVQPRKSIRVLDAMVGWHRLS---------- 256 Corynebacterium g... 19074942 325 VNEPSIEDSITMLRGLKGRLEAYHG--VKIADSAIVYAVNSSKKYIS-NRRLPDVAIDLLDTACASVMIALEsEPQEILN 401 Encephalitozoon c... 18202342 -------------------------------------------------------------------------------- Mycobacterium tub... 15678312 176 TNSPRVAVMEIPLPDRAERHLYYST---TLASASIPSDQIDLLSNITeGLYMKDLENILSDVLEEIDENQ---------- 242 Methanothermobact... 15597921 170 TQALVLSHQARSRPAGEQRKPFFNS-----VLWVVEKEGDLPDWLLVdNPRLRHIPVSKPDQPARRALAPALlRGLGGAG 244 Pseudomonas aerug... 12230885 -------------------------------------------------------------------------------- Pseudomonas aerug...
15606774 548 IERKIKALEEQIIEANLKGDy-------------------------------EKEAQLKIEKAKLEKekqellgkvggve 596 Aquifex aeolicus 15594714 437 ------------------------------------------------------IKRIITk------------------- 443 Lyme disease spir... 15595179 401 ----------------------------------------------------LTKDNIIT-------------------- 408 Lyme disease spir... 19552964 326 -----------------------------------------------------KQRLINNHVIAPSl------------- 339 Corynebacterium g... 19552991 257 -------------------------------------------------------GKPMDMD------------------ 263 Corynebacterium g... 19074942 402 QKSKAWGLDIAKTSLEFDLSqkkdeqtlkklkevveelekvkaslqpmeeayLRDKKHIIEAKKLKKkledtklrlaqae 481 Encephalitozoon c... 18202342 1 -----------------------------------------------------------------------mpeptptay 9 Mycobacterium tub... 15678312 243 ------E---------------------------------------------VSSSMLRKIVNRYR-------------- 257 Methanothermobact... 15597921 245 VAEEALQQAAATFVENTEG----------------------------------LLLLDLNAIVQLAR------------- 277 Pseudomonas aerug... 12230885 -------------------------------------------------------------------------------- Pseudomonas aerug...
15606774 597 akiaelkkkieeldekikeaaekgdyekeaelkiekAKLEKELKKLEQeKske---lvVTWDDVAEVVSEWTGIPVS-RL 672 Aquifex aeolicus 15594714 444 -------------------------------------------------------------DDVCDLIKSIVGSNIF-NF 461 Lyme disease spir... 15595179 409 -------------------------------------------------S-----------DDIQKAINEILSIKTA-NN 427 Lyme disease spir... 19552964 340 ------------------------------------KFP------------------------VSERHIHNTARKLA-FG 358 Corynebacterium g... 19552991 264 --------------------------------------------------------------LLGDVLHDAIGVDIA--- 278 Corynebacterium g... 19074942 482 -----------------------rdrntyvaydlktNVIPVIESELKRlEles--vvvILPSHVAEIISRWTGIDVK-RL 535 Encephalitozoon c... 18202342 10 pvrldelinaikrvhsdvldqlsdavlaaehlgeiadhlighfvdqarrsgaswsdigksmgvtkqaaqkrfvpraeatt 89 Mycobacterium tub... 15678312 258 ---------------------------------------------------------------IGTEEDPWSRIPLT--G 272 Methanothermobact... 15597921 278 -----------------------------------------VEG--------------LAMERIADAVRRYKVGVTEdPW 302 Pseudomonas aerug... 12230885 1 --------------------------------------MPFLSDMLDQsRrqqdeeqaLARENLAEASLLQAHLSHRsAL 42 Pseudomonas aerug...
15606774 673 KEEEMQKLLKLEDELHKRVVDQEHAVKAVAEAIRRARAGLKDPKRPIA-----SFLFLGPTGVGKTELSKALAELLFGDE 747 Aquifex aeolicus 15594714 462 EEYDGELLINLENRIKKELIIHDNLVLDLILNIKLLKFNLLANRSTIG-----IFAFIGASGSGKCKLMDILSEEFK--- 533 Lyme disease spir... 15595179 428 TKEEILELKEIESEINKKVIGQKHAVSELIKEIIKVKLGLNDDSKPLT-----SILLIGSSGCGKTALTDEISKKIIKDQ 502 Lyme disease spir... 19552964 359 SQVPASINTDDARDKLETLFGQDHIIEPVLTAIKREQLGIFPRTKPLS-----WVF-AGSSGVGKTEMARILSRAING-- 430 Corynebacterium g... 19552991 279 ---FKVDGTSIKDKLDEKVMAQSLATTVVARRLQLVVADLHDKSRPLS-----NFLFTGPTGVGKTELVKQLARVLFGDD 350 Corynebacterium g... 19074942 536 TIKENERLMEMSSRIKKRIFGQDHAVDAIVDSILQSRVGLDDDDRPVG-----SFLLLGPTGVGKTELAKAVAMELFDNE 610 Encephalitozoon c... 18202342 90 ldsnqgFRRFTPRARNAVVAAQNAAHGAASSEITPDHLLLGVLTDPAAla--tALLQQQEIDIATLRTAVTLPPAVTEPP 167 Mycobacterium tub... 15678312 273 --PPKGLLDSAENWFLERVVGQDHAVREIVNAIKKARSGVVGLSSGGQskpkaTFFFAGPTGVGKTFLAKKLAEYLFDTE 350 Methanothermobact... 15597921 303 LKIDRQRIRQADEIVRRRVKGQQHAVTHMLDIVKRAMTGVGASRKGNRpr--gVAFLAGPTGVGKTELAKTVTSLLFGDE 380 Pseudomonas aerug... 12230885 43 RSRFRFDPAAVMDCLRAEVLGQDPALQAVEDMLKVVRADIADPRRPLF-----SALFLGPTGVGKTEIVRALARALHGDA 117 Pseudomonas aerug...
15606774 748 -DALIRLDMSEFKEEHSVAKLIGAPPGYVGYEE-GGKLTEAVRRK--P--YSVILLDEIEKAHPRVLDLFLQVLDDGRLT 821 Aquifex aeolicus 15594714 534 -IPKFSLNMGEYNDFNSLDRLIGPVLSNEGYYEsTRFFKFLNKSS-----NSIIFLSDFDKCNKRVLDFFLEGFKTGKLF 607 Lyme disease spir... 15595179 503 -NSVLKLDMSDYKEENSISKLIGTNPGYVGYSD-GGILTNKLRHS--F--ETLILFENIENAHSSVLNLISRMLENGELI 576 Lyme disease spir... 19552964 431 -GDPIIINGPEYISPESITGLIGSSDGYIGSNSkRAKPLDPLISN--P--RQVIVLDEFEKSHPHFQQLFMAALDTGTMA 505 Corynebacterium g... 19552991 351 tGRLIRFDMSEFALESSLDLFRSELTRRVADQG-----------N-----A-IVLLDEVEKADRAIARLLLQVLDDGRLS 413 Corynebacterium g... 19074942 611 -KDMLVIDMSEYGNEMGITKLIGANAGYVGYNQ-GGTLTEPIKGR--P--YNVILLDEVDLAHQTVLNTLYQLLDEGRVT 684 Encephalitozoon c... 18202342 168 -QPIPFSGPARKVLELTFREALRLGHNYIGTEHlLLALLELEDGD--G--PLHRSGVDKSRAEADLITTLASLTGANAAG 242 Mycobacterium tub... 15678312 351 -EAFLRFDMSEFKEEHTVSKLIGSPPGYVGYEQ-GGQLTNAIKNR--P--FSVILFDEIEKAHPKIMDIFLQILDDGRLT 424 Methanothermobact... 15597921 381 -SAYIRFDMSEFSAEHADQRLIGAPPGYVGYDV-GGELTNAIREK--P--FSVVLFDEIEKAHPRILDKFLQILDDGVLT 454 Pseudomonas aerug... 12230885 118 -EGFCRVDMNTLSQEHYAAALTGAPPGYVGAKE-GTTLLEQDKLDgsPgrPGIVLFDELEKASPEVVHALLNVLDNGLLR 195 Pseudomonas aerug...
15606774 822 DSHG-RTVDFRNTVIIMTSNIGSQYLLNI---PVDad---------eeTLNREFEKAKEKVLEELKLYMRPEFINRIDE- 887 Aquifex aeolicus 15594714 608 DGLG-KKVSLSESLIVISINAESKELNSIg--------------------FRNKMAGENDFNFILKKRLPNEFLELIDH- 665 Lyme disease spir... 15595179 577 DSKE-DKILFKNTIIIMTTNIGSRMLLGEkniGFNkn----------qQKSLETKSFKEEINQDLEKRFKLSFLDRIQK- 644 Lyme disease spir... 19552964 506 MANG-TTLNFSQAIIIATTNAARDKIGRDsfgFDSdnsg-----vlgsAQAATDPRAQERLKSLMSKDFPVELLNRFQN- 578 Corynebacterium g... 19552991 414 DDYN-REVSFLNTYIVMTTNAGSEIFETIsnyATDdt----------gDGRAIKDFVKNIHTSIKNKGFPPELLGRVDE- 481 Corynebacterium g... 19074942 685 DGKG-AVVDFRNCVVIMTSNLGQEIIMRS-------------------R-GELNDDERKKIEEIVLNRFGAPFVNRIDE- 742 Encephalitozoon c... 18202342 243 ATDA-GATDAG--------------------------------------------------------------------- 252 Mycobacterium tub... 15678312 425 DSRG-QTVFFTESVIIFTSNIGTRTVDSRgntTSEqrkldeiindsdlSDSERERRVREHFTRSVREFFMHEISRRELLn 503 Methanothermobact... 15597921 455 SGRG-DRVYFSEALIVFTSNLGIYRQGENgerVANvlp-------gepFEAVQGKVHGEIERYFKLVLNRPEILNRIGEn 526 Pseudomonas aerug... 12230885 196 VASGeRTYHFRNTLVFMTSNLCAHEIQRYderRQRlpwr-----llpvGGERRRRDIDGMVRARLLKTFSPEFVNRLDS- 269 Pseudomonas aerug...
15606774 888 -----IIVFKPLTM-RELSKIIDLLIANVNKRLA----ERNIKIELTEEAKKELVRRGYD----PAFGARPLKRTIQKYV 953 Aquifex aeolicus 15594714 666 -----VFVFKSIDE-LDFEKIIFNELNYFARILR----DRKFDVFFEKSVVDYIREKIYG----KGYSLKSVRKFIFKEL 731 Lyme disease spir... 15595179 645 -----KIILNILTK-ENVEEICKNYLNTLKTKFH----SKGIEIEIKKDVDKFITTKYYK----KNSGARSVIAAIKGKI 710 Lyme disease spir... 19552964 579 -----IFAFNRIDA-GTYREILDNLYQRRRDAVLl--sHPHYAAQIPADIDSDTLDQLVEttfiSDFGARPAARTIEDHI 650 Corynebacterium g... 19552991 482 -----IVPFQPLSE-TTQDRIISKKLQDVATEVYe---RHGVKLHCSQKVMEFLLVDQVEes-aESGGARGAVRSLQREV 551 Corynebacterium g... 19074942 743 -----VLYFNNLDR-ENMHRILEYQMGYLEKKLR----GRGITFKVSDAVKEDMVTKVLS----SIYGARQLRRFIRSSF 808 Encephalitozoon c... 18202342 -------------------------------------------------------------------------------- Mycobacterium tub... 15678312 504 rigshIIAFNYLKKsDYQVNIIENKLKDISENFRdkfaGRGHRLHLSGELTGYFLEKYGDs--iSEFGGRGLVNALEDEI 581 Methanothermobact... 15597921 527 -----IIVFDFIRA-DVAEQIFTQMVNGTFADLR----EQRLVIELAEAPRQALHDLCLGd---LSNGGRGIRNQLEARL 593 Pseudomonas aerug... 12230885 270 -----VVTFNWIER-DVVARLVELEVQRLNRRLE----KHRCRLEATPEVLAKIARAGFD----RQFGARALRRSVRHHL 335 Pseudomonas aerug...
15606774 954 ETPLADKIIRGEIKd---GMTVVVDYKDG---EFVFIPKEE 988 Aquifex aeolicus 15594714 732 GKLLIDEILFKKIEn---SGKIKIYLD-E---TIKYEFL-- 763 Lyme disease spirochete 15595179 711 EENIITKIAENQNIn---KITIYLEKE-----KIIIE---- 739 Lyme disease spirochete 19552964 651 ASLLM------------------------------------ 655 Corynebacterium glutamicum ATCC 13032 19552991 552 VTEVATFINTYPEVr---DIYVDVDGQMr--nKTNRVSTAR 587 Corynebacterium glutamicum ATCC 13032 19074942 809 KRALTKVLLMRVNEd---PIEVSCTHPSegagGIRISDYVY 846 Encephalitozoon cuniculi 18202342 ----------------------------------------- Mycobacterium tuberculosis 15678312 582 GNIVADQLLLAEERgm-sDINFEVYVDG----DVIRCRRS- 616 Methanothermobacter thermautotrophicus str. Delta H 15597921 594 LNPLSRALFDQDAQp---GERFLISALD----ADGLTLERR 627 Pseudomonas aeruginosa PA01 12230885 336 EVPLAEHLLDHHQPgdgnCTTYLASLEHE---RVRFVRR-- 371 Pseudomonas aeruginosa
Jiyao W et al.(2023). "The conserved domain database in 2023.",