Conserved Protein Domain Family
PRAP
?
pfam15314: PRAP (this model, PSSM-Id:405902 is obsolete and has been replaced by 434624)
Proline-rich acidic protein 1, pregnancy-specific uterine
PRAP, or proline-rich acidic protein 1, is a family of eukaryotic proteins. PRAP is abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. It is significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. In the mouse it is expressed in the epithelial cells of the mouse and rat gastrointestinal tracts, and pregnant mouse uterus. This article describes the isolation, distribution, and functional characterization of the human homolog. PRAP was abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. PRAP plays an important role in maintaining normal growth suppression.
Links
?
Statistics
?
PSSM-Id: 405902
Aligned: 15 rows
Threshold Bit Score: 53.9555
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_019664964  98 PEPDRDDLYHPPPgegEEAQEEAGLWSRALSPPRGLQGPEEDRDHIYH 145 giant panda
XP_023492214  98 PEPDYDSLYHPPP---EEAQEEAGPRSQVLLSRQVLRGPEEDRDHIYH 142 horse
XP_008977210 105 PEPDYDGLYHPSP---EEDQGAEEPQLWVVPNRQVLQGPEKDQDHIYH 149 white-tufted-ear marmoset
Q96NZ9       105 PEPDHDSLYHPPP---EEDQGEERPRLWVMPNHQVLLGPEEDQDHIYH 149 human
XP_023417278 162 PEPDLDSLYHPAS---QEIQVKEEPLLRAMLSRQVLRGPEKDLDHIYH 206 domestic guinea pig
EHB00969      93 PETDHDSLYHPES---EEIQVEEEPFSWAVLSRQVLQGPEEDLDHIYH 137 naked mole-rat
XP_005320900  95 PELDLDSLYHPPV---EEVQGKERPWSPVLLPRQVLEGPEEDLDHIYH 139 thirteen-lined ground squirrel
Q9ES75       100 PELDLDSIYHPMS---EDVQNEEVPQSRPILYRQVLHGPEEDLDHISH 144 Norway rat
XP_023354124 111 PEEDRDYFYHPRS---VEDDIEESKMLK-VSHYAVLQGPEEERDKAFH 154 Tasmanian devil
ELW67312     250 PEPDHDHLYHPLP---EEAQGEERHWLWAMLFHQVLQGPEKDQDHIYH 294 Chinese tree shrew
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap