pfam03089: RAG2 (this model, PSSM-Id:397280 is obsolete and has been replaced by 427128)
Recombination activating protein 2
V-D-J recombination is the combinatorial process by which the huge range of immunoglobulin and T cell binding specificity is generated from a limited amount of genetic material. This process is synergistically activated by RAG1 and RAG2 in developing lymphocytes. Defects in RAG2 in humans are a cause of severe combined immunodeficiency B cell negative and Omenn syndrome.
Jiyao W et al.(2023). "The conserved domain database in 2023.",