Conserved Protein Domain Family
DEXHc_TDRD9
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cd17988: DEXHc_TDRD9 
DEXH-box helicase domain of tudor domain containing 9
Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350746
Aligned: 4 rows
Threshold Bit Score: 312.128
Created: 18-Jul-2017
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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ATP bindingDEAD box
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of human RNA helicase A (DHX9) with bound Mn.ADP
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      #                        #######                                  #             
Q8NDG6     132 LPISRYKEEVVSLIEsNSVVIIHGATGSGKSTQLPQYILDHYvqrsaycSIVVTQPRKIGASSIARWISKErawtlggVV 211  human
EFZ09194    51 LPILSLKDKILSIIEtNSVVIIQGPTGCGKTTQIPQFILDSYikkklncNIIVTQPRRIAAISIAKRVSEEggwrlgsLV 130  red fire ant
Q9VF26     115 LSIYAKREEILAAINaHPVVIIKGETGCGKTTQVPQYILDEAyksgkycNIVVTQPRRIAAISIANRVCQErewqqntVC 194  fruit fly
B8A4F4      89 LPITKNRQELVSLIEnNSVVIIRGATGSGKTTQLPQFILDHYaernipcNLVVTQPRKIGATSIARWVARErkctlgsLV 168  zebrafish

Feature 1                                                 ##                                   
Q8NDG6     212 GYQVGLEKIATed-tRLIYMTTGVLLQKIvsakslmefTHIIIDEVHERTeemDFLLLVVRKLLRtnsrfVKVVLMSATi 290  human
EFZ09194   131 GYHVGMRRESSke-tRLTYCTTEILLQHLinlkhmldyTHIILDEIHERDqhlDFLLLVIKRLLQtnsgqVKIILMSATi 209  red fire ant
Q9VF26     195 SFQVGLHRPNSledtRLLYCTTGVLLNNLinnktlthyTHIVLDEVHERDqnmDFLLIVVRRLLAtnsrhVKIILMSATi 274  fruit fly
B8A4F4     169 GYQVGLEKMATeh-tKLIYVTTGVLLQKLvssktlteySHIFIDEVHERSeelDFLLLVVRKLLRsnsryVKVILMSATi 247  zebrafish

Feature 1                               
Q8NDG6     291 sCKEFADYFavpvqnkmnpaYIFEV 315  human
EFZ09194   210 sVTKFARYFsmk-----venELVPA 229  red fire ant
Q9VF26     275 dAKELSDYFtttn----sipPVITT 295  fruit fly
B8A4F4     248 nCIEFAEYFgspirnqmnpaYVFEV 272  zebrafish

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