Conserved Protein Domain Family
MIIP

?
pfam15734: MIIP (this model, PSSM-Id:406221 is obsolete and has been replaced by 434892)
Migration and invasion-inhibitory
This family of proteins binds to insulin-like growth factor binding protein 2 (IGFBP-2) and inhibits the invasion of glioma cells.
Statistics
?
PSSM-Id: 406221
Aligned: 17 rows
Threshold Bit Score: 290.519
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_002604887   42 SQKR-PRDTYKVPVDKTGDVLGVKDVENLPKEarsp-dhkkTRVGDSTGVGWGSAVARQPARLrvrTPKKVTFVDEVSRp 119  Florida lancelet
ELW68633      859 SSLD-SSISSNSETPSYQETCSTSSRTYCPRDpl------dAFQTDPRDMTRPG--LSRAASL---PPAKSQHQQYLGR- 925  Chinese tree ...
XP_021589224   76 SGLN-SCNIYDSETPLSPETSSISWQASCSKDrchkwdpldTHGDDPCDVAWLDRVSPRVASQ---PPVKGQHLEPLGQ- 150  thirteen-line...
Q6AYH0         42 SNLDySSSSNNLEMPLSQET-SASSVAPNSQDkrhvwdpldSHRGDTYDVAWYGKVNSRVDSL---PPATCQHQEPQEG- 116  Norway rat
7_pfamImport    1 GRED---EAEDRREPAGVLTGGHRGAALARPTvrf---------adTCARQTGASHDSTPALSstcRRGTADHAAPSGL- 67  
EHB16611       39 SGVDsSSSSCDSEMPLTPETSSASPSTSCSQDqwcawappdTHRGHPCDTAW---ARSRVSSL---PPAKCQRPGALGP- 111  naked mole-rat
XP_016778843   39 SSLE-SSSSYNSETPSTPETSSTSLSTSCPQGrssvw-----gppdACQGDLRDVARSGVASL---PPAKCQHQESLGR- 108  chimpanzee
XP_003793334   37 SSLD-SSNNDNTEMSRSQKTPSASSRASCPRGkchpkgppdAHQSDPFDVA-----SCKVAAL---QPAKCQHQESLGQ- 106  small-eared g...
XP_017193069   39 SSLD-PSSSYNSKVSLSPETSSSSSRACSPPDvqq---------adPSDVASLGRVSSRVTSL---PPARRQHQASLGQ- 104  rabbit
XP_025333006   42 SALG--ASSWDSQTPSSQEMSPVAFRASRLQD---------AQQDAPCGTSWPGGASSGVTSL---PSARDRHPASLGS- 106  dingo
XP_002604887  120 ggqlqdtvqgverlPRFHSTPLredggkvLtaATQDVEDDTFPTGESTRHlLSEHLAGQESSlRVDHEPHtPHLydEGnn 199  Florida lancelet
ELW68633      926 --------------PRPHSAPL-------P--TTSDLNDPEPVAGLNDLGlQKAQVLRSLEA-RQSKPSK-PRV--TFce 978  Chinese tree ...
XP_021589224  151 --------------PRFYS----------L--TTIDPKEPAPLSGLCDRVp------RSILA-EQSEQSK-SRV--T--- 191  thirteen-line...
Q6AYH0        117 --------------LRPSSVPL-------L--ATEGLKRPVSLGGPKGLGpDKAQVPRSLPL-RLGKLSK-PKV--TF-- 167  Norway rat
7_pfamImport   68 --------------SRDRDRHP-------F--THSRLQRVDPSATKSCLVnHSKEQMGLKEPgHSAQSEVcSRV--TFlp 122 
EHB16611      112 --------------PRPHSVPL-------L--ASSDLWEP--STGPDDPGpRDAQVPKSMLA-RRSRPSK-PRV--TF-- 160  naked mole-rat
XP_016778843  109 --------------PRPHSAPS-------L--GTSSLRDPEPSGRLGDLGpQEAQALRSILA-QQSKLSK-PRV--TF-- 159  chimpanzee
XP_003793334  107 --------------PRSHSSPH-------LkaATSDLKDPEPSAGPGDLGpQEEQSLKSVLA-QGSKQSK-PKV--TFce 161  small-eared g...
XP_017193069  105 --------------PRARSAPL-------L--PITDSRDPEPSAGQGDLGsQEAQAPRPVLA-QPSK------StvT--- 151  rabbit
XP_025333006  107 --------------PRPCSAPL-------L--PISEPDDSELSAGLPGSVpQEARAQSSVLD-RHSQPPK-SRV--TF-- 157  dingo
XP_002604887  200 rraKETTKVPGSILRTpvkrrtmvgggsnhgnqsamtvgelqaqgreddQPLLGYDWIAGLLDNDASSLDRSEGFFEELR 279  Florida lancelet
ELW68633      979 eqsEEESAVPEKSWRL---------------------------------RPYLGYDWIAGSLDNTSPVSSKPDAFFSKLQ 1025 Chinese tree ...
XP_021589224  192 ---CQEPATPESSWSL---------------------------------QPYLGYDWIVGSMDSSSSITSKPETFFSTLQ 235  thirteen-line...
Q6AYH0        168 ---SQESSVPESSWYS---------------------------------RPCLDYDWTAGSLDSSSPVSSESEAYFSMLQ 211  Norway rat
7_pfamImport  123 -deCEGTSASDRH-RL---------------------------------QPLLGYDWIAGVLDAEDSLIERSDEFFNDLH 167 
EHB16611      161 ---CEESAVPESSWRL---------------------------------RPYLGYDWIAGSLDSSSPVSSKPEAFFSELQ 204  naked mole-rat
XP_016778843  160 ---SEESAVPERSWRL---------------------------------RPYLGYDWIAGSLDTSSSITSQPEAFFSKLQ 203  chimpanzee
XP_003793334  162 --eSKESVLPDRSMHL---------------------------------PPHLGYDWIaGALGNSSSVTSQPETFFSKLQ 206  small-eared g...
XP_017193069  152 ---CEDSEVPESSWRL---------------------------------RPYLGYDWIAGSLDSSSPVTSKPEAFFATLQ 195  rabbit
XP_025333006  158 ---REECAVPDGIWRL---------------------------------RPYLGYDWIAGSLDNSSPVTSKPDAFFSELK 201  dingo
XP_002604887  280 EFRRVNREECEHKAtlevKT---PQFSRhkspLPP--AGASDDT---HDCVHSYRLNSRLFPTPMHSnfagDSECAICKS 351  Florida lancelet
ELW68633     1026 KFRESNEEECVYSR----PR---SQLLG----LHE--GTVVEDD---HECVYCYRVNRRLFLVPVDP----GTPCRLCRT 1085 Chinese tree ...
XP_021589224  236 KFRETNKEECVYST----PE---PQFLG----LCD--GSDVEED---HECVYCYRVNKRLFLVPLDP----GIPCRLCGR 295  thirteen-line...
Q6AYH0        212 RFREDNREDCVCNS----PE---AVFPE----LQE--SSGVEED---HECVYCYRINRRLFPEPLDP----GAPCCLCGI 271  Norway rat
7_pfamImport  168 TFRSLNKDKCVHSKqaefPE---ENHSLlp-lLSD--KNHPEANkhtHQCTFSYRINSRLFPVPLHA----KECCPVCKE 237 
EHB16611      205 EFREAHREECIGRV----HE---PHLQG----LRQ--GEDAEKG---HECVFSYRVNRRLFLVPSDP----GVPCRLCGT 264  naked mole-rat
XP_016778843  204 EFRETNKEECICSH----PE---PQLLG----LREssGSGVEED---HECVYCYRVNRRLFPVPVDP----GTPCRLCRT 265  chimpanzee
XP_003793334  207 EFREANKEECICRY----PE---PQFLG----QPE--SSNVEED---HECVYCYQVNRRLFVVPLDP----GTPCRLCRI 266  small-eared g...
XP_017193069  196 KFREANKKECTASH----SE---PGFLG----LHE--NDGVDGD---HECVYCYRVNRRLFLVPSDP----GTPCRLCGT 255  rabbit
XP_025333006  202 DFREANKEECIHSD----PEprpP---G----VRE--SRGVEEE---HACVYCYHVNRRLFLVPSDP----GVPCRLCKT 261  dingo
XP_002604887  352 TRS--GEETLESPAYVRVSVPRSSLVNSLRVKPHRKRSFDPSDTVGLSGHTLAGWQNSCPST--IPAASNLDLKSSVRFQ 427  Florida lancelet
ELW68633     1086 SRDqqGPKTLKEPAQVRVSIPLSILDPPHRYRVHRRKSFDASDTLALPRHCLLGWDILPPKSerSSAPKSLDLWSSVS-K 1164 Chinese tree ...
XP_021589224  296 PRNpqSPRTLVQSTRVRVSIPLSILDPPHQYRVHRRKSFDASDTPALPRHCLLGWDILPPKSetSTAPKSLDLWSSIS-E 374  thirteen-line...
Q6AYH0        272 PRDeqGPQTLVEPVQVRVSIPLSIMDPPHQYRIHRRKSFDASDTFALPRHCLLGWDILPPKSekTSVPKSLDLWSSVSHG 351  Norway rat
7_pfamImport  238 HKSs-hPHTSAEPALIRVSIPRSTLLPPYKYKAHRRCSFDPSDSLGLPSHCLSGWS--NTGQstLPPPSSLDLRSSLHTK 314 
EHB16611      265 PRDqrGPETLAEPAQVQVSVPPSVLDPPHRYRIHRRKSFDASNTLALPRHCLLGWDIAPPKPerSSAPRSLDLWSSVSSA 344  naked mole-rat
XP_016778843  266 PRDqqGPGTLAQPAQVRVSIPLSILEPPHRYHIHRRKSFDASDTLALPRHCLLGWDIFPPKSekSSAPRNLDLWSSVSAE 345  chimpanzee
XP_003793334  267 PRSqrDPKTLEESAQVRVSIPLSILDPPHQYRIHRRKSFDNSDTLALPRHCLLGWDILPPKSekSSALKSLDLWSAVSSG 346  small-eared g...
XP_017193069  256 LREqqGPETLLEPAQVRVSVPLSILDPPHWYRIRRRKSFDASDTLSLPRHCLLGWDILPPRSekGSAPKSLDLWSSVFAT 335  rabbit
XP_025333006  262 PRDqrGPETLLEPAHVRVSIPLSVLHPPHQYRIHRRKSFDASDTLALPRHCLLGWDIFPPKSekSSAPRSLDLWSCVSSE 341  dingo
XP_002604887  428 PG----ARSMA-PSVSVNT---------------------------SVA--------SRTRSadtrtrellntshamryS 467  Florida lancelet
ELW68633     1165 AQ----HFRLS-ASSPSRL---------------------------ALP--------VRGPP-----------------P 1187 Chinese tree ...
XP_021589224  375 AQ----HQELS--PSSSRL---------------------------ALP--------VRVPP-----------------P 396  thirteen-line...
Q6AYH0        352 AAq---RRNLS-ATNPSYQ---------------------------ALR--------SRVPP------------------ 374  Norway rat
7_pfamImport  315 SStesqDKELE-ELNAPKV---------------------------SGKiadqipevSRLAR-----------------H 349 
EHB16611      345 AQ----HRKLL-AASPSHL---------------------------ALP--------EQAPR-----------------P 367  naked mole-rat
XP_016778843  346 AQ----HQKLSgTSSPFHP---------------------------ASP--------MQVLP-----------------P 369  chimpanzee
XP_003793334  347 AQ----HQKMS-ATRPSFL---------------------------ALP--------ARVPP-----------------P 369  small-eared g...
XP_017193069  336 AQ----HRKLS-AASPSRL---------------------------ALP--------VRGPA-----------------P 358  rabbit
XP_025333006  342 AQ----HRKLP-AASPSHLlphptregdldstiqmgmrgerrvtiqALP--------TRVPS-----------------C 391  dingo
XP_002604887  468 LQVLEQER 475  Florida lancelet
ELW68633     1188 TPIWSEPQ 1195 Chinese tree shrew
XP_021589224  397 TPVWSEPQ 404  thirteen-lined ground squirrel
Q6AYH0        375 -PFWSEPQ 381  Norway rat
7_pfamImport  350 NFQHFSSK 357 
EHB16611      368 TPMWSEPQ 375  naked mole-rat
XP_016778843  370 IPTWSVPQ 377  chimpanzee
XP_003793334  370 PPTWIEPQ 377  small-eared galago
XP_017193069  359 TPIWSHPR 366  rabbit
XP_025333006  392 TPVWSGPQ 399  dingo
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap