Conserved Protein Domain Family
IER
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pfam05760: IER (this model, PSSM-Id:399051 is obsolete and has been replaced by 461732)
Immediate early response protein (IER)
This family consists of several eukaryotic immediate early response (IER) 2 and 5 proteins. The role of IER5 is unclear although it play an important role in mediating the cellular response to mitogenic signals. Again, little is known about the function of IER2 although it is thought to play a role in mediating the cellular responses to a variety of extracellular signals.
Links
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Statistics
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PSSM-Id: 399051
Aligned: 18 rows
Threshold Bit Score: 234.002
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q99J55         1 MECALDAQSLISISLRKIHSSRTQRGGIKLHKNLLVSYVLRNARQLYLSERYAELYRRQQQQQQqqpphhqhq------- 73  house mouse
CAF96710       1 MECAVDAQSLISISLMKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYIKEKYAEIYRMQQYEEV---------------- 64  spotted green p...
XP_011615873   5 aECAVDAESLISISLMKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYIKEKYAEVYRIQQYEEV---------------- 68  torafugu
XP_006635330   1 MEYKVEAHRIMSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSEYYQGVCLNAQHMDTapqwgegaivdstqdk 80  spotted gar
XP_003785699   1 MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYLAGPAGTPapppqqpgepaa---- 76  small-eared galago
Q5VY09         1 MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYLAGPAGTPapppqqqpgepaa--- 77  human
XP_005806983   1 meCAFDAQNLISISLRKIQSSRTQRGGIKLHKNLLVTYVLRNARQFYMSKNSLQTQRTPPYEDAaavhr----------- 69  southern platyfish
XP_004072580   1 meCAFEAQNLISISLRKIQSSRTQRGGIKLHKNLLVTYVLRNARQFYMNKNVSQAQRSPPYEDAaavre----------- 69  Japanese medaka
XP_003445593   1 MECAFEAQNLISISLRKIQSSRTQRGGIKLHKNLLVTYVLRNARQFYMSKNLSQMQRTNPYEDVtvvre----------- 69  Nile tilapia
XP_022612745   1 MECAFDAQNLISISLRKIQSSRTQRGGIKLHKNLLVTYVLRNARQFYMSKNLSQTQRTHHYEDVatvre----------- 69  greater amberjack

Q99J55        74 ------hlayaapgMPASA-------ADFGPLQLgggg---daeAREPVARHQLHQLHQLHQLHLqqql-hqhQHpaprg 136 house mouse
CAF96710      65 --------------MAVCNe-----iQELDPLELeag-----daDDGDQARGVCCGEESSPCGS---------AChr--- 108 spotted green p...
XP_011615873  69 --------------MAVCNe-----iEELNPLETaae-----dmDNGDQARGGCCSEESSLCGS---------AChr--- 112 torafugu
XP_006635330  81 agsdpagsaqgspdSGSTLppe-----ssHPLPAat-------------------------------------------- 111 spotted gar
XP_003785699  77 --vppagwgeppppAARAAwretepqPQPQPQPErtavldaqwvGGAEPATSVTRVGDALQGREAdaaeaawgSVegprg 154 small-eared galago
Q5VY09        78 --gppagwgeppppAARASwpe------tePQPErssvsdaprvGDEVPVATVTGVGDVFQGGEAdateaawsRVegprq 149 human
XP_005806983  70 ----------rqeyIELTGs-----fTEL--------------------ADDFYCNFTGTESDTW--------HCga--- 103 southern platyfish
XP_004072580  70 ----------kqeyLELTGs-----fTEL--------------------ADDFYCNFTGAESDSW--------HCga--- 103 Japanese medaka
XP_003445593  70 ----------rqeyLEWTGs-----fTEL--------------------ADDFYCNFTGVESDTW--------HC----- 101 Nile tilapia
XP_022612745  70 ----------rqeyLELTGs-----fTEL--------------------ADDFYCNFTGVESDTW--------HC----- 101 greater amberjack

Q99J55       137 ctAAApva------vaGAPAGCAGALSELPGCAalqpphgaPHRGQHL--EPlQPGpaplpppapaalcprdprvpaacs 208 house mouse
CAF96710     109 -dAA-----------------HARAASALPGCP----------RLEDAnkEP-ESAyyrs-------------------- 139 spotted green p...
XP_011615873 113 -dAA-----------------HARALSALPCCP----------RLEDVskEP-ENPyyrs-------------------- 143 torafugu
XP_006635330 112 ---------------aLESPAAGRQPETAEPGEqsapsapsSP--ACCcrPTgEPLg----------------------- 151 spotted gar
XP_003785699 155 aaAAGagdpvrgsdvfPEGP--ARRPSACPPGGedqrgaaaASPGADCccAP-RPVv----------------------- 208 small-eared galago
Q5VY09       150 aaAREaegtaggwgvfPEVSRAARRPCGCPLGGedppgtpaATPRAACccAP-QPAe----------------------- 205 human
XP_005806983 104 hqSSAq----------PSELAHQDASACAMASPsd-----sELMVSEAcwSCtDKSs----------------------- 145 southern platyfish
XP_004072580 104 hqHNGq----------LTEVQHQDASSCVLVSPnd-----sDLMLSEAcwSC-ADKs----------------------- 144 Japanese medaka
XP_003445593 102 --GAHqpn------gqPAEVAHQGASACAMDSPsd-----sDLMVSDAcwSCaDKSs----------------------- 145 Nile tilapia
XP_022612745 102 --GAHqpn------gqPAEVAHQDASACAMVSPnd-----sDLMVSEAcwSCaDKSs----------------------- 145 greater amberjack

Q99J55       209 apsvlpgaapstvaassppastapssstgfyrGAYPAPs-----------------------------dFGVHCsSQTTV 259 house mouse
CAF96710     140 -----------------------------ccaQPYPAShcaqv----------------------taggGSAQC-TKTTV 167 spotted green p...
XP_011615873 144 -----------------------------cfmQPYPLSncaq-----------------------fvtnGSAQC-TKTTV 170 torafugu
XP_006635330 152 --------------------------------EPVPAPadlpcapvapfparshgaetppykeatppeeGAGGC-GEAEV 198 spotted gar
XP_003785699 209 --------------------------------DESPAPpavc-----------------------prkrGAAGV-G---- 228 small-eared galago
Q5VY09       206 --------------------------------DEPPAPpavc-----------------------prkrCAAGV-G---- 225 human
XP_005806983 146 --------------------------------WELPIL--------------------------------NAQA-NQKTV 160 southern platyfish
XP_004072580 145 --------------------------------WELPVP--------------------------------NTQA-NQKTV 159 Japanese medaka
XP_003445593 146 --------------------------------WELSIP--------------------------------NTQA-NQKTV 160 Nile tilapia
XP_022612745 146 --------------------------------WELPIP--------------------------------NTQA-NQKTV 160 greater amberjack

Q99J55       260 LDLDTHVVTTVENGYLHQD--CCASAHCPCcgQGAPGPgla-saAgCKRKYYPGQEEEDDEEDAgDlgaeppggtpFAPC 336 house mouse
CAF96710     168 LDLDTHVVTTVENGYLHQDccCCCDA-PQWg-QIAQSP------T-KKRKVEFGGCAPDAEEVS-D----------FTAT 227 spotted green p...
XP_011615873 171 LDLDTHVVTTVENGYVHED--CFCDS-PQCg-QNTQST------T-KKRKVEFSCCVSDAVDVS-D----------FIAT 228 torafugu
XP_006635330 199 KGGESESSETRLNHSAAAS--CCRKRS------AEKAPhaespvKkTKQTSPS--------------------------- 243 spotted gar
XP_003785699 229 -GGP-------------AG--C-------------QAPgat-plKkPRRNLEEq----QPGRg--E-------------- 258 small-eared galago
Q5VY09       226 -GGP-------------AG--C-------------PAPgst-plKkPRRNLEQ-----PPSGg--E-------------- 254 human
XP_005806983 161 LDLDTHVVTTVTNGYFHSD--CCAQPKQPQ--AGAQC-------YtRKRKMDTSYYIVDPEFYLpD----------FVPC 219 southern platyfish
XP_004072580 160 LDLDTHVVTTVSNGYFHSD--CCAQPRQP---QGAQCh--------KKRKMDTSYFIVDPEFYLpD----------FVPV 216 Japanese medaka
XP_003445593 161 LDLDTHVVTTVTNGYFHTD--CCAQPKQP---QGAQC-------YtKKRKIDISYHIVDPEFYLpD----------FAPV 218 Nile tilapia
XP_022612745 161 LDLDTHVVTTVTNGYFHSD--CCAQPKQP---QGAQC-------YaKKRKMDTSYHIVDPEFYLpD----------FGPV 218 greater amberjack

Q99J55       337 --KRARFEDfCPDSSP-------------DASNISNLISIFGS-GFSGLVSRQPDs-SEQPppLN--------------- 384 house mouse
CAF96710     228 r-KRPRRED-GPFSGPdh----------aDASNITNLISIFGS-GFSGLLSRQSD--MEQI------------------- 273 spotted green p...
XP_011615873 229 r-KRLKRDD-CPFSNPdy----------tDASNITNLISIFGS-GFSGLLSRQSD--MEQI------------------- 274 torafugu
XP_006635330 244 ----------EEAEREee----------mDTSNVSSLITIFGS-SFSGLLSK------------Dsapqaeppagdsdsa 290 spotted gar
XP_003785699 259 ------------DDDPed----------mETGNVANLISIFGS-SFSGLLRKSPGggREEEegAEsgpe--------aae 307 small-eared galago
Q5VY09       255 ------------DDDAee----------mETGNVANLISIFGS-SFSGLLRKSPGggREEEegEEsgpe--------aae 303 human
XP_005806983 220 --KRMRSED-DDDDNDddgddlqsdsgqlDSANISNLISVLGSgGLSEFVSWQQMd-LEQI--FG--------------- 278 southern platyfish
XP_004072580 217 pfKRMRSDD-DSHSDSdq----------lDNTNISNLISVLGSgGLSEFVSWQQTd-LEQI--FG--------------- 267 Japanese medaka
XP_003445593 219 pcKRMRSDD-DSHSDSdq----------lDSTNISNLISVLGSgGLSEFVSWQQTd-LEQI--FA--------------- 269 Nile tilapia
XP_022612745 219 pcKRMRTDD-DSYSDSeq----------lDSTNISNLISVLGSgGLSEFVSWQQTd-LEQI--FA--------------- 269 greater amberjack

Q99J55       385 -GQL-CAKQALASLGAWTRAIVAF 406 house mouse
CAF96710     274 -----CSKQVLASLGAWTRAIVAF 292 spotted green pufferfish
XP_011615873 275 -----CSKQVLASLGAWTRAIVAF 293 torafugu
XP_006635330 291 sGQIcCEQ-MLKNMNPWSTAIVAF 313 spotted gar
XP_003785699 308 pGQIcCDKPVLRDMNSWSTAIVAF 331 small-eared galago
Q5VY09       304 pGQIcCDKPVLRDMNPWSTAIVAF 327 human
XP_005806983 279 -TQTiCLKHTLLAGSGWTRAIEAF 301 southern platyfish
XP_004072580 268 -TQTiCLKHTLFTGSGWTRAIEAF 290 Japanese medaka
XP_003445593 270 -TQTiCLKHTLLTGSGWTRAIEAF 292 Nile tilapia
XP_022612745 270 -AQTiCLKHTLLTGSGWTRAIEAF 292 greater amberjack
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