6CM9


Conserved Protein Domain Family
F-protein
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pfam00469: F-protein (this model, PSSM-Id:366118 is obsolete and has been replaced by 425700)
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Negative factor, (F-Protein) or Nef
Nef protein accelerates virulent progression of AIDS by its interaction with cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src kinase family.
Links
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Statistics
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PSSM-Id: 366118
Aligned: 21 rows
Threshold Bit Score: 278.126
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6CM9_L  60 GGKWSKSSVIGWPAVRERMRRA---EPAAD---------------GVGAVSRDLEKH-GAITSSNTAANNAAcaWLEAQE 120
P27970   2 GLGSSKPQHKKQLTIWRALHATrhtRYGLLadpligqsstlqeecDKGLRKSLIRKRnGNMTPEGRRLQDGDqwDEWSDE 81  Simian immunodeficien...
P24741   2 GGKWSKKSRVEWPEVRKRMRET---PAAAKgv---------------gAVSQDLDKY-GAVTSSNTSSTNAScaWLEAQE 62  Human immunodeficienc...
P05859   2 GNKWSK----GWPAVRERIRQTppaPPAAEgv---------------gAASQDLAKH-GAISSSNTATNNPDcaWLEAQE 61  Human immunodeficienc...
P04604   2 GGKWSKSSIVGWPAIRERIRRT---NPAADgv---------------gAVSRDLEKH-GAITSSNTASTNADcaWLEAQE 62  Human immunodeficienc...
P04603   2 GGKWSKSSIVGWPKIRERIRRT---PPTETgvg----------avSQDAVSQDLDKC-GAAASSSPAANNASc---EPPE 64  Human immunodeficienc...
P20867   2 GGKWSKHSVPGWSTVRERMRRA---EPATDrvrqtep-----aavgvgAVSRDLEKH-GAITSSNTAATNADcaWLEAYE 72  Human immunodeficienc...
P05857   2 GGKWSKRSVVGWPTVRERMRKT---EPAADgv---------------gAASRDLEKH-GAITSSNTPANNADcaWLEAQE 62  Human immunodeficienc...
P04324   2 GGKWSKSSVVGWPAVRERMRRA---EPAADgv---------------gAASRDLEKH-GAITSSNTAANNAAcaWLEAQE 62  Human immunodeficienc...
P17664   2 GTKWSKSSLVGWPEVRRRIREA---PTAAEgv---------------gEVSKDLERH-GAITSRNTPETNQTlaWLEEMD 62  SIVcpz GAB1

6CM9_L 121 E-EEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGW 199
P27970  82 E-DEVGFPVRPRVPLRQITYKLAVDFSHFLKEKGGLDGIYYSDRRNKILNLYALNEWGIIDDWNAWSKGPGIRYPRCFGF 160 Simian immunodeficien...
P24741  63 E-GDVGFPVRPQVPLRPMTYKAAFDLSFFLKEKGGLDGLIHSQKRQEILDLWVYHTQGFFPDWQNYTPGPGIRYPLTFGW 141 Human immunodeficienc...
P05859  62 EsEEVGFPVRPQVPLRPMTFKGAFDLSFFLKEKGGLDGLIYSKKRQEILDLWVYHTQGFFPDWHNYTPGPGTRYPLCFGW 141 Human immunodeficienc...
P04604  63 EsDEVGFPVRPQVPLRPMTYKEALDLSHFLKEKGGLEGLIWSKKRQEILDLWVYNTQGIFPDWQNYTPGPGIRYPLTFGW 142 Human immunodeficienc...
P04603  65 EeEEVGFPVRPQVPLRPMTYKGAFDLSHFLKEKGGLDGLVWSPKRQEILDLWVYHTQGYFPDWQNYTPGPGIRFPLTFGW 144 Human immunodeficienc...
P20867  73 D-EEVGFPVRPQVPLRPMTYKAAIDLSHFLKEKGGLEGLIYSQKRQDILDLWIYHTQGYFPDWQNYTAGPGVRFPLTFGW 151 Human immunodeficienc...
P05857  63 E-EEVGFPVRPQVPLRPMTYKAAVDLSHFLKEQGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGIRYPLCFGW 141 Human immunodeficienc...
P04324  63 E-EKVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGIRYPLTFGW 141 Human immunodeficienc...
P17664  63 N-EEVGFPVRPQVPTRPMTYKAAFDLSHFLKEKGGLEGLVYSRRRQEILDLWVYHTQGFFPDWQNYTTGPGTRFPLCFGW 141 SIVcpz GAB1

6CM9_L 200 CYKLVPVEPDKVEEanKGENTSLLHPVSLHGMDD--PEREVLEWRFDSRLAFHHVARELHPEYFKN 263
P27970 161 CFKLVPVALHEEAE--TCERHCLVHPAQLHEDPDgiNHGEILAWKFDPMLAVQYDPSREYFTDLYS 224 Simian immunodeficiency virus (AGM1...
P24741 142 CYKLVPVDPAEVEEatGGENNSLLHPICQHGVDD--EEKEVLMWKFDSTLALKHRAYELHPEFYKD 205 Human immunodeficiency virus type 1...
P05859 142 CFKLVPVDPREVEEanTGENNCLLHPMSQHGMDD--DEREVLMWKFDSSLARKHLAREMHPEFYKD 205 Human immunodeficiency virus type 1...
P04604 143 CYELVPVDPQEVEEdtEGETNSLLHPICQHGMED--PERQVLKWRFNSRLAFEHKAREMHPEFYKN 206 Human immunodeficiency virus type 1...
P04603 145 CFKLVPMSPEEVEEanEGENNCLLHPISQHGMED--AEREVLKWKFDSSLALRHRAREQHPEYYKD 208 Human immunodeficiency virus type 1...
P20867 152 CFKLVPVDPEKVEEanEGENNCLLHPMSQHGMDD--PEKEVLVWKFDSKLALHHVARELHPEYYKD 215 Human immunodeficiency virus type 1...
P05857 142 CFKLVPVKPEKIEEanEGENNSLLHPMSLHGMED--PEREVLEWRFDNRLAFHHMARDLHPEYYKD 205 Human immunodeficiency virus type 1...
P04324 142 CYKLVPVEPEKLEEanKGENTSLLHPVSLHGMDD--PEREVLEWRFDSRLAFHHVARELHPEYFKN 205 Human immunodeficiency virus type 1...
P17664 142 CFKLVPLTEEQVEQanEGDNNCLLHPICQHGMED--EDKEVLVWRFDSRLALRHIAREQHPEYYKD 205 SIVcpz GAB1
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