3X05,1BO1,3WZZ,3X0B


Conserved Protein Domain Family
PIPKc_PIP5K2B
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cd17310: PIPKc_PIP5K2B 
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Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP5K2B) and similar proteins
PIP5K2B (EC 2.7.1.149), also known as 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta, or diphosphoinositide kinase 2-beta, or phosphatidylinositol 5-phosphate 4-kinase type II beta, or PI(5)P 4-kinase type II beta, or PIP4KII-beta, or PtdIns(5)P-4-kinase isoform 2-beta, or PIP5KIIbeta, or PIP4K2B, participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. It directly regulates the levels of two important phosphoinositide second messengers, PtdIns5P and phosphatidylinositol-(4,5)-bisphosphate (PtdIns(4,5)P2), one of the key metabolic crossroads in phosphoinositide signaling. It regulates the levels of nuclear PtdIns5P, which in turn modulates the acetylation of the tumour suppressor p53. It also interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha. Moreover, PIP5K2B is a molecular sensor that transduces changes in GTP into changes in the levels of the phosphoinositide PtdIns5P to modulate tumour cell growth.
Links
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Statistics
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PSSM-Id: 340447
Aligned: 10 rows
Threshold Bit Score: 606.661
Created: 8-Mar-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic core residues [active site], 3 residue positions
Conserved feature residue pattern:K D DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Lys proposed to bind the alpha-phosphate of ATP; mutation of this residue in PIPKI-alpha and PIPKII-alpha destroys enzyme activity.
  • Comment:1st Asp functions as a weak base
  • Comment:2nd Asp binds catalytic Mg2+ or Mn2+
  • Citation:PMID 9753329
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
3X05_A         7 GQKVKLFRasePILSVLMWGVNHTINELSNVPvpvmlmpDDFKAYSKIKVDNHLFNKenlPSRFKFKEYCPMVFRNLRER 86  human
1BO1_A        30 CQKVKLFRasePILSVLMWGVNHTINELSNVPvpvmlmpDDFKAYSKIKVDNHLFNKenlPSRFKFKEYCPMVFRNLRER 109 human
3WZZ_A         7 GQKVKLFRasePILSVLMWGVNHTINELSNVPvpvmlmpDDFKAYSKIKVDNHLFNKenlPSRFKFKEYCPMVFRNLRER 86  human
3X0B_A         7 GQKVKLFRasePILSVLMWGVNHTINELSNVPvpvmlmpDDFKAYSKIKVDNHLFNKenlPSRFKFKEYCPMVFRNLRER 86  human
XP_015155004  36 CQKVKLFRasePLLSVLMWGANHTINELSNVPvpvmlmpDDFKAYSKIKVDNHLFNKenlPSRFKFKEYCPLVFRNLRER 115 chicken
NP_001090598  31 CQKVKLFRasePLLSVLMWGVNHTVNELSNVPapvmlmpDDFKAYSKIKVDNHLFNKenlPSRFKFKEYCPMVFRNLRER 110 African clawed ...
XP_007909100  22 AQKVKLFRasePLLSVLMWGINHTINELSHVQipvmlmpDDFKAYSKIKVDNHLFNKenlPSRFKFKEYCPMVFRNLRER 101 elephant shark
P78356        30 CQKVKLFRasePILSVLMWGVNHTINELSNVPvpvmlmpDDFKAYSKIKVDNHLFNKenlPSRFKFKEYCPMVFRNLRER 109 human
NP_001158866  25 GQKVKLFRasePILSVLMWGVNHTINELSNVPvpvmlmpDDFKAYSKIKVDNHLFNKenlPSRFKFKEYCPMVFRNLRER 104 Atlantic salmon
XP_014353107  48 CQKVKLFRasePILSVLMWGVNHTVNELGNVPvpvmlmpDDFKAYSKIKVDNHLFNKenlPSRFKFKEYCPMVFRNLRER 127 coelacanth

Feature 1                                                #                                       
3X05_A        87 FgiDDQDYQNSVTrsAPINSDsqgrcgTRFLTTYDrRFVIKTVsSEDVAEMHNILKKYHQFIVECHgntlLPQFLGMYRL 166 human
1BO1_A       110 FgiDDQDYQNSVTrsAPINSDsqgrcgTRFLTTYDrRFVIKTVsSEDVAEMHNILKKYHQFIVECHgntlLPQFLGMYRL 189 human
3WZZ_A        87 FgiDDQDYQNSVTrsAPINSDsqgrcgTRFLTTYDrRFVIKTVsSEDVAEMHNILKKYHQFIVECHgntlLPQFLGMYRL 166 human
3X0B_A        87 FgiDDQDYQNSVTrsAPINSDsqgrcgTRFLTTYDrRFVIKTVsSEDVAEMHNILKKYHQFIVECHgntlLPQFLGMYRL 166 human
XP_015155004 116 FgiDDQDYQNSVTrsAPVNSDsqgrcgARFLTTYDrRFVIKAVsSEDVAEMHNILKKYHQFIVECHgntlLPQFLGMYRL 195 chicken
NP_001090598 111 FgiDDQDYQNSLTrsAPVNSEnqgrfgSRFLTTYDrRFVIKTIsSEDVAEMHNILKKYHQFIVECHgntlLPQFLGMYRL 190 African clawed ...
XP_007909100 102 FsiDDQDYQNSVTrsAPIHSDshnrmgVRFLTTYDkRFVIKTIsSEDVAEMHSVLKKYHQYIVECHgntlLPQFLGMYRL 181 elephant shark
P78356       110 FgiDDQDYQNSVTrsAPINSDsqgrcgTRFLTTYDrRFVIKTVsSEDVAEMHNILKKYHQFIVECHgntlLPQFLGMYRL 189 human
NP_001158866 105 FciDDQDYQNSLTrsAPLNSDsqgrfgNRFLSSYDhRFVIKTVsSEDIAEMHNILKKYHQFIVECHgstlLPQFLGMYRL 184 Atlantic salmon
XP_014353107 128 FsiDDQDYQNSLTrsAPLNSDsqgrfgARFLTTYDrRFIIKTIsSEDVAEMHRILKKYHQFIVEWHgstlLPQFLGMYRL 207 coelacanth

Feature 1                                                                                        
3X05_A       167 TVdGVETYMVVMRNVFshrLTVHRKYDLKGstvareasdkekakdlPTFKDNDFLNEgqklhvgeesKKNFLEKLKRDVE 246 human
1BO1_A       190 TVdGVETYMVVTRNVFshrLTVHRKYDLKGstvareasdkekakdlPTFKDNDFLNEgqklhvgeesKKNFLEKLKRDVE 269 human
3WZZ_A       167 TVdGVETYMVVTRNVFshrLTVHRKYDLKGstvareasdkekakdlPTFKDNDFLNEgqklhvgeesKKNFLEKLKRDVE 246 human
3X0B_A       167 TVdGVETYMVVTRNVFshrLTVHRKYDLKGstvareasdkekakdlPTFKDNDFLNEgqklhvgeesKKNFLEKLKRDVE 246 human
XP_015155004 196 TVdGVETYMVVTRNVFshrLTVHRKYDLKGstvsreasdkekakdlPTFKDNDFLNEgqklhvgeesKKNFLEKLKRDVE 275 chicken
NP_001090598 191 TVdGVETYMIVTRNVFshrLGVHRKYDLKGstvsreasgkekakdlPTFKDNDFLNEgqklhvgeenKKMFLEKLKRDVE 270 African clawed ...
XP_007909100 182 TVdGVETYMTVTRNVFshrLNVHRKYDLKGstvsreasgkekakelPTLKDNDFLNEgqriqigdenKKMFLDKLKRDVE 261 elephant shark
P78356       190 TVdGVETYMVVTRNVFshrLTVHRKYDLKGstvareasdkekakdlPTFKDNDFLNEgqklhvgeesKKNFLEKLKRDVE 269 human
NP_001158866 185 TVdGVETYMVVTRNVFshrLTVHRKYDLKGstvsreasdkekakelPTFKDNDFLNEgqklqigddnKKYFLEKLKRDVE 264 Atlantic salmon
XP_014353107 208 TVdGVETYMVVTRNVFshrLIVHRKYDLKGstvsreasdkekakdlPTFKDNDFLNEgqklyigdenKKLFLEKLKRDVE 287 coelacanth

Feature 1                #                                                                       
3X05_A       247 FLAQLkimDYSLLVGIHDVdraeqeemeveeraedeecendgvggnllcsygtppd------spgnllsfprffgpgefd 320 human
1BO1_A       270 FLAQLkimDYSLLVGIHDVdraeqeemeveeraedeecendgvggnllcsygtppd------spgnllsfprffgpgefd 343 human
3WZZ_A       247 FLAQLkimDYSLLVGIHDVdraeqeemeveeraedeecendgvggnllcsygtppd------spgnllsfprffgpgefd 320 human
3X0B_A       247 FLAQLkimDYSLLVGIHDVdraeqeemeveeraedeecendgvggnllcsygtppd------spgnllsfprffgpgefd 320 human
XP_015155004 276 FLAQLkimDYSLLVGIHDVdraeqeemevedraedeecendglggnpissygtppd------spgnllnyprffgpgefd 349 chicken
NP_001090598 271 FLSVLkimDYSLLVGLHDVdraeqeemeveeraeeeecedgsgnpicsygtppds--------pgnllnfprffgpgefd 342 African clawed ...
XP_007909100 262 FLAQMkimDYSLLVGIHDVdraeqeemeveekgddeesendgmgalvgsygtppdspgnmlnfprifgpgefdptvdvya 341 elephant shark
P78356       270 FLAQLkimDYSLLVGIHDVdraeqeemeveeraedeecendgvggnllcsygtppd------spgnllsfprffgpgefd 343 human
NP_001158866 265 FLATLkimDYSLLVGIHDVdraeqeemeveaggeeeeyendgmggaltgsfgtppd------spgnplnfggffspgefd 338 Atlantic salmon
XP_014353107 288 FLAQLkimDYSLLVGIHDVdraeqeemdveergeeeecendgmgtnpvgsygtppd------spgnllnfprffgpgefd 361 coelacanth

Feature 1                                 #                                            
3X05_A       321 psvdvyamkshesspkkeVYFMAIIDILTpYDTKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFNEFMSN 390 human
1BO1_A       344 psvdvyamkshesspkkeVYFMAIIDILTpYDTKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFNEFMSN 413 human
3WZZ_A       321 psvdvyamkshesspkkeVYFMAIIDILTpYDTKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFNEFMSN 390 human
3X0B_A       321 psvdvyamkshesspkkeVYFMAIADILTpYDTKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFNEFMSN 390 human
XP_015155004 350 psvdvyamkshdsapkkeVYFMAIIDILTpYDAKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFNEFMSN 419 chicken
NP_001090598 343 psvdvyamkshdnapkkeVYFMAIIDILTpYDAKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFIEFMSN 412 African clawed frog
XP_007909100 342 iksydltlpnltdapkkeVYFMAIIDILThYDAKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFLEFMMN 411 elephant shark
P78356       344 psvdvyamkshesspkkeVYFMAIIDILTpYDTKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFNEFMSN 413 human
NP_001158866 339 psmdvyaiksndsavkkeVYFMAIIDILThYDAKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFFEFMSN 408 Atlantic salmon
XP_014353107 362 psvdvyaikshdntpkkeVYFMAIIDILTpYDAKKKAAHAAKTVKHGAgaeiSTVNPEQYSKRFIEFMSN 431 coelacanth

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