1FTP,2FLJ,5GGE,1FTP


Conserved Protein Domain Family
FABP_pancrustacea
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cd19852: FABP_pancrustacea 
fatty acid-binding protein similar to Locusta migratoria FABP (Lm-FABP)
This subfamily includes fatty acid-binding protein found mainly in insects such as the migratory locust (Locusta migratoria) FABP (Lm-FABP) and the desert locust (Schistocerca gregaria) FABP (Sg-FABP), having flight muscle tissues that contain unusually high levels FABP, similar to migratory birds. Both Sg- and Lm-FABP are closely related to the mammalian i-LBP subfamily IV, especially to the heart and adipocyte FABP forms. This subgroup belongs to the intracellular fatty-acid binding protein (FABP) family, members of which are small proteins that bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.
Links
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Statistics
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PSSM-Id: 381252
Aligned: 7 rows
Threshold Bit Score: 176.626
Created: 16-Oct-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
ligand binding
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding cavity [chemical binding site]
Evidence:
  • Comment:ligand is bound within the beta-barrel in a central internal water-filled cavity lined with polar and hydrophobic amino acids
  • Comment:based on cytosolic fatty acid-binding protein family members with structure
  • Citation:PMID 7683727
  • Structure:2FLJ: Locusta migratoria fatty acid-binding protein binds oleic acid, contacts 4.0A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #            #  ##  #     ##  #    # # #       # # #      # # #       #        
1FTP_B         3 EFAGIkYKLDSQTNFEEYMKAIGvGAIERKAGLalSPVIELEILDgdkFKLTSKtaikNTEFTFKlgEEFDEETLDGRKV 82  desert locust
2FLJ_A         4 EFAGIkYKLDSQTNFEEYMKAIGvGAIERKAGLalSPVIELEVLDgdkFKLTSKtaikNTEFTFKlgEEFDEDTLDGRKV 83  migratory locust
5GGE_A         2 SFVGKkYKLDKSENFDEYMKELGvGLVTRKMGNslSPTVEVTLEGd-tYTLTTTstfkTSAISFKlgVEFDEETLDGRNV 80  fruit fly
1FTP_A         3 EFAGIkYKLDSQTNFEEYMKAIGvGAIERKAGLalSPVIELEILDgdkFKLTSKtaikNTEFTFKlgEEFDEETLDGRKV 82  desert locust
AAC24317       2 EFVGKkYKMISSENFDEFMKAIGvGLITRKAANavTPTVELRQEGd-gYNLVTSstfkTTEMKFKpgEEFDEERADGAKV 80  tobacco hornworm
XP_002426176   3 QFLNIqYKLSKSENFDEYMKALGvGLVTRKMGTamTPVVSLSLKDg-tYTLTTS----TTFKNQVpnEEFEEETLDGRKV 77  human body louse
EFX85386       3 AFLNKkFKLVSSEKFDEYMQELKiGFVMRKLGNsaTPVVELTCEGd-eYTFTTTtmlkTTTIKFKlgEEFEEERGDGAKV 81  common water flea

Feature 1                   # #            # #      # # #        # #  
1FTP_B        83 KSTITQDgpNKLVHEQKGd---hPTIIIREFSKEQCVITIKLgdLVATRIYKA 132 desert locust
2FLJ_A        84 KSIITQDgpNKLVHEQKGd---hPTIIIREFSKEQCVITIKLgdLVATRIYKA 133 migratory locust
5GGE_A        81 KSIITLDg-NKLTQEQKGd---kPTTIVREFTDNELITTLTIgnVKCVRVYKA 129 fruit fly
1FTP_A        83 KSTITQDgpNKLVHEQKGd---hPTIIIREFSKEQCVITIKLgdLVATRIYKA 132 desert locust
AAC24317      81 KSVCTFEg-NTLKQVQKAad-glEVTYIREFGPEEMKAVMTAkdVTCTRVYKV 131 tobacco hornworm
XP_002426176  78 KSIVKFDg-NKMIQTQKDsvgkvISIIEREFSKNTMTTVLTAgdVVSTRVYER 129 human body louse
EFX85386      82 KSTITMDg-NKMTHVMKGd---pESTIVREFNGDELKAVLTVndVVCTRIYKA 130 common water flea

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