4WGH,5DAN


Conserved Protein Domain Family
AKR_AKR3F1-like
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cd19072: AKR_AKR3F1-like 
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Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins
Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Links
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Statistics
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PSSM-Id: 381298
Aligned: 30 rows
Threshold Bit Score: 273.336
Created: 11-May-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:4WGH: Klebsiella pneumoniae aldo/keto reductase in complex with cofactor NADP; contacts at 4A.
    - View structure with Cn3D
  • Structure:5DAN: Thermotoga maritima aldo keto reductase Tm1743 in complex with cofactor NADP+, contacts at 4A.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ###                                 #    #                         #   
4WGH_A     33 QAAVPAIGLGTWyxge------haaqRQQEVAALRAGIDHGlTVIDTAEXYAdggAEEVVGQAIRg-lRDRVVLVSKVYP 105 Klebsiella pneumoniae
5DAN_A     10 GEEIPALGLGTWgiggfe--tpdysrDEEMVELLKTAIKMGyTHIDTAEYYGgghTEELIGKAIKdfrREDLFIVSKVWP 87  Thermotoga maritim...
PIY18191  279 AIELPVLGIGTSgvggywngmhpyidDVGDVDQLRHAIGKGvFYIDCCLMYGdghAVELVAKAIKnvpRDNLFLNGKLTR 358 Candidatus Dojkaba...
KKR05795   14 KKNIPKLGIGTWgiggymt-kspysdYVNEITQIKYQLSKGlSLVDCWIAQGeggSLELIRQAIEdfdREKITLLCKFDI 92  candidate division...
PKP52397   12 CFTIPVLGLGTWemggrs--sadkseDNKWIHAIEFAIESGiRHIDTAAIYGaghAERLVGQAIKnfdRKNLIITTKVSG 89  Bacteroidetes bact...
AVM43844   11 GFAMPLLGMGSWmlgggae-rdpasdGEKEAAALRSGLELGfRHIDTAEMYAggfSEEIVGRAIRgwkRSDLFLTSKVWK 89  Victivallales bact...
OJJ26611   11 NFSMPVFGMGTWmlggkle-pspdrcERSDTDSIVRAIDAGlTHIDTAEIYAggyAEEAIAKAISgydRSTLFLVSKVSS 89  Roseofilum reptota...
KKU20135   10 GNEMPRLGLGTWtvgggmt-hdpnndDKGQSEQIQKAIEAGfSWIRTAHNYAenyCEKLVGQAIKkydRSKLFLSSAANE 88  Candidatus Sacchar...
CAJ72768    9 NIKIPVIGLGTWtigggd--eadttyDKENISAIKTAIKLGiTHIDNAEAYAqghSEELVGRAIVgldRKSLFITSKVSP 86  Candidatus Kueneni...
KKK43813   10 GEQIPVLGQGTMgikgg----kskeyYEKWRVSLRKGIDLGmTHIDTAELYNfgnSEKIIGDVIKeydRDDLFITSKLFP 85  archeaon Loki

Feature 1                                      #                              ##              
4WGH_A    106 WHag----kaAXHRACENSLRRLqtDYLDXYLLHWRGd--iPLQETVEAXEKLVAEGKIRRWGVSNLdTEDXQALWRtad 179 Klebsiella pneumoniae
5DAN_A     88 THlr----rdDLLRSLENTLKRLdtDYVDLYLIHWPNpe-iPLEETLSAMAEGVRQGLIRYIGVSNFdRRLLEEAISks- 161 Thermotoga maritim...
PIY18191  359 IGgklvgsirEVEEQCNRYLQILgtDYLDQFQIHSPKsiaiSQEDVIGKIGELISAGKVRHFGVSNYnKVELIAAGNii- 437 Candidatus Dojkaba...
KKR05795   93 HKykd---ivELETVFNKYLKQLntDYIDVFQIHKPVftniSERELNIFLMEKIKHGKVGSFAVSNAkKEDLINLKKki- 168 candidate division...
PKP52397   90 DTlq----fhQVLRSADDSRKRMgiDQIDLFLLHWPNps-vPLGQTMSAVNKLLEDRSVKYFGLSNFpVALINEVGFyt- 163 Bacteroidetes bact...
AVM43844   90 THla----ydEVLRACERSLRRLgtDYLDLYLIHQVDda-yPLEETIRALDRLADEKLVRHIGVSNFaVARLERARAca- 163 Victivallales bact...
OJJ26611   90 AHlr----ynDLIESAKQSLARLktDYLDLYLIHEPNpn-iPMEETMNAMAYLKDNGYILNIGVSNFsTERVKAAQKli- 163 Roseofilum reptota...
KKU20135   89 RFapn---kqALIDVAKLTLDNLqtDYLDLFMIGAIGp--tPVQEIVDGLLELQESGLVKNIGVSNYrKPELEYAFNys- 162 Candidatus Sacchar...
CAJ72768   87 EHls----ydNLLASAKGSLQRLntDYIDLYLIHAPNpd-iPIQETMKAMDFLVEQKLVRCIGVSNFsVDQIKEAQKyt- 160 Candidatus Kueneni...
KKK43813   86 LHlg----ynAMIKACNKSLERLdiKYLDLYLVHFPSflfsKIEKHMKLMEQLLNEGKIRYIGVSNFsVDQFKRGQEhlk 161 archeaon Loki

Feature 1            #                                  #######                        #      
4WGH_A    180 geHCATNQVLYHLASRg-------iEYDLLPWCQQHsLPVXAYCPLAQAgrlrdglfqHSDIINXANARGiTVAQLLLAW 252 Klebsiella pneumoniae
5DAN_A    162 qePIVCDQVKYNIEDRdp------eRDGLLEFCQKNgVTLVAYSPLRRTlls---ektKRTLEEIAKNHGaTIYQIMLAW 232 Thermotoga maritim...
PIY18191  438 kePIISNEIPFGVYTRny------eQDGTLEHMYKQnIATISYFTIRKGgllvefddeKNMLNVLAKKYQkTPSQIAINW 511 Candidatus Dojkaba...
KKR05795  169 diPVEANEILYNIFDRey------eVNGTIEYCNKNnIKILAYRPLNRGmtni--ahtSPSFAEIVNRYTlTPNQIALNW 240 candidate division...
PKP52397  164 daPIITNQLEYNLMNRnqgsynqnvETEIIPYCLKKgVSITAWRPVMKGdas---aiiYPLLQSLAEKYDkTVFQIALNW 240 Bacteroidetes bact...
AVM43844  164 ghPIAANQVHYNLAVRea------eLSGLTDYCVEHdIMLIAWRPLQKGmld---aeaPELLREIARRHGrTPAQIALAW 234 Victivallales bact...
OJJ26611  164 daPIVANQVHYNLKFRep------eILGLLEYCQATnMMLIAWRPIQKGlls---tggIPILDEMCEKYAkSPAQIAINW 234 Roseofilum reptota...
KKU20135  163 gkKIVYDEMHYNLVIRep------eLCGSFDFCRKNgIVLSAYRPLQLGqls---kpgIVVLDEMAKKYGkTQSQISLGW 233 Candidatus Sacchar...
CAJ72768  161 knKIVANQIEYNLLVRdkgrvtenmESEIIPYCQENnIFIIAWRPLAKGkla---kpgFKILDELADKYHkTQAQIAINW 237 Candidatus Kueneni...
KKK43813  162 kaEIVANQLRANIMKQk-------hIHNSLPYYKKEgIILTAYSPLGHRgytnlnvdmGSKLKHVANSHNaTIQQIALAW 234 archeaon Loki

Feature 1              ######  #  ##                 
4WGH_A    253 VIRhpGVLAIPKAASIEHVVQNAAAlDIVLSGEELAQLD 291 Klebsiella pneumoniae
5DAN_A    233 LLAkpNVVAIPKAGRVEHLRENLKAtEIKLSEEEMKLLD 271 Thermotoga maritima MSB8
PIY18191  512 VVNhpRTMALIKATNGTHVNENVGAvGWKMEEEDYQRIN 550 Candidatus Dojkabacteria bacterium CG_4_10_14_3_um_filter_D...
KKR05795  241 LLQkeNVLALVKSSNRAHINENMDCmSITLTLKDLNDLD 279 candidate division WS6 bacterium GW2011_GWF2_39_15
PKP52397  241 LISkpSMLAIPKMTSEAHIMQNIDAtQFEIDQDDMLLLD 279 Bacteroidetes bacterium HGW-Bacteroidetes-1
AVM43844  235 LAAqpNTVTISTMRDRRHQLLNCEAlEFTLPAEELQRLS 273 Victivallales bacterium CCUG 44730
OJJ26611  235 LISqpNVVTLSTMRTLEHLEENLGAlGWEMEAEDIEKLR 273 Roseofilum reptotaenium AO1-A
KKU20135  234 LIQkeGVIVVVKVLDDKHVTQDLDIfDWSIEEKDMQRLD 272 Candidatus Saccharibacteria bacterium GW2011_GWA2_46_10
CAJ72768  238 LISkkGIVVISKSTKVEHLEKNLGAiGWKLRQEDTDRLN 276 Candidatus Kuenenia stuttgartiensis
KKK43813  235 LINhdNVIAIPKAFQIEHVEANAAAtDIKLTEAELKQFY 273 archeaon Loki

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