Conserved Protein Domain Family
STING_C

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cl17092: STING_C Superfamily (this model, PSSM-Id:418415 is obsolete and has been replaced by 473064)
C-terminal domain of STING
STING (stimulator of interferon genes, also known as MITA, ERIS, MPYS and TMEM173) is a master regulator that mediates cytokine production in response to microbial invasion by directly sensing bacterial secondary messengers such as the cyclic dinucleotide bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) and leading to the activation of IFN regulatory factor 3 (IRF3) through TANK-binding kinase 1 (TBK1) stimulation. STING is also a signaling adaptor in the IFN response to cytosolic DNA. This detection of foreign materials is the first step to a successful immune responses. STING is localized in the ER and comprised of an predicted N-terminal transmembrane region and a C-terminal c-di-GMP binding domain.
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Statistics
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Accession: cl17092
PSSM Id: 418415
Name: STING_C
Created: 13-Sep-2012
Updated: 24-Nov-2020
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