4KYS


Conserved Protein Domain Family
thiaminase_BcmE
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TIGR04541: thiaminase_BcmE 
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thiamine pyridinylase
Members of this family are thiamine pyridinylase (EC 2.5.1.2), also called thiaminase I. Most examples of this secreted, thiamine-degrading enzyme are encoded with a cluster for biosynthesis of the thiamine antivitamin bacimethrin. [Cellular processes, Biosynthesis of natural products]
Links
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Statistics
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PSSM-Id: 275334
Aligned: 4 rows
Threshold Bit Score: 620.404
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4KYS_A        34 LSLLFSFIMIFTLVSGlnvkafsGDEPKQTLNVALYEYVPDPIRFKKAVETEWNKKEPNIKLNFVD---WD-CYSEDPPK 109 Clostridium bot...
Q2T5P7         8 LTILLGFLFAAPSHAG-------DAAAVQQLTVALYPWVPRVDQFRRAIESEWKKVQPAVALRFLSadaWDgGYKNDPPA 80  Burkholderia th...
WP_011948479  11 LSLLFSFIMIFTLVSGlnvkafsGDEPKQTLNVALYEYVPDPIRFKKAVETEWNKKEPNIKLNFVD---WD-CYSEDPPK 86  Clostridium bot...
P45741        12 LMVMLALLLVVVSPAGaga-ahsDASSDITLKVAIYPYVPDPARFQAAVLDQWQRQEPGVKLEFTD---WD-SYSADPPD 86  Paenibacillus t...

4KYS_A       110 DLDVFVFDAVYLSHFVKEGYLSEIPEKDIKNKEDILPFAMEGCTIKGSAYAIPQIISTNLLFSRKGDYDIQKVNSVYDLY 189 Clostridium bot...
Q2T5P7        81 NADVYVYDAIFFDYFRSQNWLEPLTASEIRNIDDFLPYAIRGVKSGDLYYSIPQLGCANVLFYRKDDAALAAATTLTQVR 160 Burkholderia th...
WP_011948479  87 DLDVFVFDAVYLSHFVKEGYLSEIPEKDIKNKEDILPFAMEGCTIKGSAYAIPQIICTNLLFSRKGDYDIQKVNSVYDLY 166 Clostridium bot...
P45741        87 DLDVFVLDSIFLSHFVDAGYLLPFGSQDIDQAEDVLPFALQGAKRNGEVYGLPQILCTNLLFYRKGDLKIGQVDNIYELY 166 Paenibacillus t...

4KYS_A       190 DKLGKFTSEDIILPNNKGLLIDMSGGTSKACMYLDSLIDTTQEYTkFCSLPNLNELNKDAIESLVLLQSMAGksqanyWP 269 Clostridium bot...
Q2T5P7       161 SALGQCTFTSEIAPDKRGLMVDMSGRTTNAALYLDAEHSRTGAYP-LPLPWSANDLNGGALGSLRALMAMSS------WP 233 Burkholderia th...
WP_011948479 167 DKLGKFTSEDIILPNNKGLLIDMSGGTSKACMYLDSLIDTTQEYTkFCSLPNLNELNKDAIESLVLLQSMAGksqanyWP 246 Clostridium bot...
P45741       167 KKIGTSHSEQIPPPQNKGLLINMAGGTTKASMYLEALIDVTGQYTeYDLLPPLDPLNDKVIRGLRLLINMAGekpsqyVP 246 Paenibacillus t...

4KYS_A       270 ENN----DSYIRAKWFINGKGRAYIGYTEAMSQMKEFA-NDIDFKTISLSKNSNIPIFYGDVVGINSSITNSykkEKAIE 344 Clostridium bot...
Q2T5P7       234 NATaelpGQYDRSAWFSDGDGRAVIGYSESMSAMSEAArRNLDFKFLPLSDEPQPPLFYADVIGVNTTTNARgtrALAVQ 313 Burkholderia th...
WP_011948479 247 ENN----DSYIRAKWFINGKGRAYIGYTEAMSQMKEFA-NDIDFKTISLSKNSNIPIFYGDVVGINSSITNSykkEKAIE 321 Clostridium bot...
P45741       247 EDG----DAYVRASWFAQGSGRAFIGYSESMMRMGDYA-EQVRFKPISSSAGQDIPLFYSDVVSVNSKTAHP---ELAKK 318 Paenibacillus t...

4KYS_A       345 LANIITDKNTMVKAVSPDENNkYPQYLLPARRSVYHNLGNKYPIYGKLYKIADNSNNKLFRTGPEIREWLK 415 Clostridium botulinum A ...
Q2T5P7       314 LANVIAASSTMVQSVGPDGSG-VPQYLFSARRSVLQTLAQRYPLYRKMVALLDAREPVMFKIDAQSRNWLA 383 Burkholderia thailandens...
WP_011948479 322 LANIITDKNTMVKAVSPDENNkYPQYLLPARRSVYHNLGNKYPIYGKLYKIADNSNNKLFRTGPEIREWLK 392 Clostridium botulinum
P45741       319 LANVMASADTVEQALRPQADGqYPQYLLPARHQVYEALMQDYPIYSELAQIVNKPSNRVFRLGPEVRTWLK 389 Paenibacillus thiaminoly...
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