Conserved Protein Domain Family
PHA02624

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PHA02624: PHA02624 
large T antigen; Provisional
Statistics
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PSSM-Id: 222912
Aligned: 23 rows
Threshold Bit Score: 817.685
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
9627023     1 MDRVLSRADKERLLELLKLPRQLWGDFGRMQQAYKQQSLLLHPDKGGSHALMQELNSLWGTFKTEVYNLRMnlggtgfqg 80 
90403566    1 ------MSTLQKLIDLLGLPPSA--TEADVRSAYRKKALEFHPDKGGDPERMKELNRLMDEFRH---------------- 56 
90403559    1 MANNM-RADIAELRQLLDLPKTA--SYEKIKAAYRRKALMYHPDKGGDEEKMKRLNQLMDVARKYDFS------------ 65 
9628284     1 MDRILTKEEKQALISLLDLEPQYWGDYGRMQKCYKKKCLQLHPDKGGNEELMQQLNTLWTKLKDGLYRVRLllgpsqdpn 80 
9626487     1 --MELTSEEYEELRGLLGTPD--IGNADTLKKAFLKACK----------------------------------------- 35 
30315608    1 ------MASLRRLTELLCLPVTA--TAADIKTAYRRTALKYHPDKGGDEEKMKELNTLMEEFRE---------------- 56 
30315611    1 MDQTLSKEERNELMDLLQITRAAWGNLSMMKKAYKNVSKLYHPDKGGDSAKMQRLNELFQRVQVTLMEIRSqcgssssqg 80 
262340526   1 MDRFLSREESNELMELLNIPKHCYGNFALMKINHRKMSLKYHPDKGGDPEKMARLNALWQKLQEGIYNARQeyptsf--- 77 
302317582   1 MDKFLSREESLELMDLLQIPRHCYGNFALMKINHKKMSLKYHPDKGGDPEKMSRLNQLWQKLQEGIYNARQefptsf--- 77 
303291526   1 MDKLLGRDEVKELMELIGLNMACWGNLPLIQHKVRLASKKYHPDKGGDPQKMQRLNVLKDKLQATLRDQRSgsp------ 74 
9627023    81 sppr---taergteesghsPLH--DDYWSFSYGSKYFTREWNDFFRKWdpsyqsppktaesseQPDLFCYEEPLLSPnps 155
90403566   57 ---------------------------------------------------------------SQSLFCDETLDSDSddg 73 
90403559   66 ---------------------------------------------------------------AETLQCEETLYSSDeed 82 
9628284    81 ast----stsrpgefynpdTGGywSYSYGSAGYSDQQKKYWEEFFSKWd-------------vNEDLTCQEELSSSEdef 143
9626487    36 ----------------------------VPEYGTSQWEQWWEEFNQGFd--------------EQDLHCDEELEPSDnee 73 
30315608   57 ---------------------------------------------------------------TEGLRADETLEDSDpe- 72 
30315611   81 yfsedfyfgpttfqyspmdRDA--VREDLPNPGEGSWGKWWREFVNRQc--------------CDDLFCSETMSSSSded 144
262340526  78 --------------gskhdVPTq-DGRDIPPYGHPTWASWWESFNRDWdnlf-------edlqDPDLFCDESTLPSDesr 135
302317582  78 --------------ssqhdVPTq-DGRDIPPYGHPSWASWWESFNQEWdnlf-------dtmqDPDLFCHESTIPSDesr 135
303291526  75 ----------------mwhYSSd-EVRPPPPYGSPAWDQWWQDFNKGW---------------DEDLYCTEELSSSDeee 122
9627023   156 sptdtpahtagrrrnpcvaepddsispdpprtpvsrkrprpagatggggggvhanggsvfghptggtstpahpppyhsqg 235
90403566   74 dspgpsqrtstp-------------------------------------------------------------------- 85 
90403559   83 vspgpsqrpedtgyesfs-------------------------------------------------------------- 100
9628284   144 tpwhpnpppspvsissdssssscdeeyprnssrkrkrvhangspnt-----------------piqpnkrahtpgggrtt 206
9626487       --------------------------------------------------------------------------------    
30315608      --------------------------------------------------------------------------------    
30315611  145 tppaaqpppppapsp----------------------------------------------------------------- 159
262340526 136 spsptpgtstq--------------------------------------------------------------------- 146
302317582 136 spsptpgpstqfs------------------------------------------------------------------- 148
303291526 123 paas---------------------------------------------------------------------------- 126
9627023   236 gsesmggsdssgfaegsfrsdprcesenesysQSCSQSSFNATPPKKA--REDPAPSDFPSSLTGYLSHAIYSNK--TFP 311
90403566   86 -----------------epgtgkdsghgtfepEAESSQASFGTPPKRG-----PPHIDLPASIEACLLTAKSVQS--CPD 141
90403559  101 ------------asftdsgpapeaaggcsgspPPTPGSGSFSTPPKSQ--REICLPADVEACLLAAKSIQS------CPE 160
9628284   207 irgdtdiprtparesqstfgsyfnsteeleeeISQTQQSHHNTTPKKP--PPTVSPDDFPTILRGFLSHAIFSNK--TQN 282
9626487    74 -----------------------------enpAGSQAPGSQATPPKKP-----RTSPDFPEVLKEYVSNALFTNR--TYN 117
30315608   73 ------------------------------peESGYATFENVSVPDID--GAFFKLMKLKKCMQTYFSVNERRKQqsCPD 120
30315611  160 ---------------eeedeiefveetpsscdGSCSQSSYTCTPPKRKk-TEEKKPDDFPVCLYSFLSHAIYSNK--TMN 221
262340526 147 ------------------fseenprrrrsedpPTCSQSSFTATPPKPKksKYDSVPNDFPNVLRPFLSSAVYSNK--TLS 206
302317582 149 -----------------eensrrrraappedsPGCTQSSFSATPPKPKksKYDSVPNDFPDMLRPFLSNAVYSNK--TLS 209
303291526 127 -------------------------asvnpeeGCSQDSKYSATPPKQK--KPNPAPQDFPECLSEFLSHATLGNK--CYT 177
9627023   312 AFLVYSTKEKCKQLYDTIGK--FRPEFK-CLVHY---E-EGGMLFFLTMTKHRVSAVKNYCSKLCR-SFLMCKAVTKPME 383
90403566  142 AHLIITTCNKLQNLRPQLMTn-FTTRGH-IQAVW---DsSYALFVILMERPTRVSTVGNFCKKHCTvSLCIVRGIKKNGV 216
90403559  161 GHLVVTTHQKLQELQSSLLNh-FDTAGH-LVCKW---GtDFAIMLIILTTGTRISTVLNFCKKHCTvSPLCVRGLKKHCL 235
9628284   283 AFIIYSTKEKCEVLYEQIDK--YNPDYK-GIFIM---KqTEAFVMFMTPGKHRVAAVKSYCCKFCTvSFLLCKAVTKPLE 356
9626487   118 CFIIFTTAEKGKELYPCIQAa-YKCTFI-ALYMY---N-GDSVLYIITVGKHRVNAMENLCSKKCTvSFLQAKGVLKPQE 191
30315608  121 CHLLITSITKMPQLKAHLYEh-FGIKGH-IVAHW---T-GIALLVLQLEKPTRISTVHNFCKKYCTiSICSVRGIKKNCV 194
30315611  222 SFLIYTSLEKARQLYKTVEKskIVVDFK-ASFSYqdeEgEGCLLFLITLGKHRVSAVKHFCVSQCTfSFIHCKAVVKRLE 300
262340526 207 SFLIYTTNEKAEFLYKTLDK--FNPDFK-SRHAF---Q-EGSLVFLMTPGKHRVSAIRNLCLTHCTvSFLLCKAVIRQVE 279
302317582 210 SFLIYTTNEKAEYLYKKLDK--FNPEFK-SRHSF---Q-EGSMVFLMTPGKHRVSAIKNLCVTHCTvSFLLCKAVIKQVE 282
303291526 178 CFLCYTTYEKSMLLYEKLGVe-FNALFIgAYNCV---DgSGALVFFISGSRHRVSAILNACKKHCTvSFIMVKAVLKNAE 253
9627023   384 CYQVVTA-APFQLITENKP-GLHQFEFTDEPEEQKAVDWIMVADFALENNLDDPLLIMGYYLDFAKEVPSCIKCSKEEt- 460
90403566  217 G-------ALLRAMQEHPAiDVEQAIFPDDGPDEKQFNQALLNGYAISLDCTDALLLLAVYKRLARPVEACPDCAKERet 289
90403559  236 Q-------KLVEIFTNSPNyVVTDNALGKET-LAGPFNYALLNDYACKQNISDALFLLAVYKRMSVNPDECKDCKEDRen 307
9628284   357 LYNCVAKcDDFQILKENKP-GLYHFEFCDEKKEVKQIDWNFLTSFAVENELDDPLVIMGHYLEFSQCESSCKKCAEALp- 434
9626487   192 AYNVCCT---FELISQNIQgGLPSSFFNPVQEEEKSVNWKLISEFACSIKCTDPLLLMALYLEFTTAPEACKVCDNPR-- 266
30315608  195 ------H-ALIKTLLDVPGlDLEECSIDMNVVDEKQFMHAMLYDYAVQIDCTDALLLLAIYKRLAQPTDKCPECQKDKdt 267
30315611  301 LYKTLSK-PRFKLLEENKP-GVSMFEFQEEK--EQCVNWQEICNFANEANISDVLLLLGIYIDFAVEPGKCGKCEKKQ-- 374
262340526 280 CYRCMCS-EPFKLLEESKP-GIFEYEFSEEN-GKPVVNWNLLTEFAVLNRLDDPLIIMAHYLDFAEEPSLCLKCSKKN-- 354
302317582 283 CYRCMCS-EPFKLLEESKP-GIFEYEFNEEN-GKPVVNWNLLTDFAVTNRLDDPLLIMAHYLDFAEEPSICSKCTKKA-- 357
303291526 254 CYKALQD-SKFAVLRESKEgGLHSYDFQEAS-KKDDCDWNFVADFAADMELTDVLLIMGYYMEFATEPSLCPKCLKSV-- 329
9627023   461 ---------rLQIHWKNHRK-HAENADLFLNCKAQKTICQQAAAS-LASRRLKLVECTRSQLLKERLQQSLLRLKEL--- 526
90403566  290 a------krqRTSHLEDHPA-HQKNAALFIGLRDQKRVCQCAVDGvLAEKRFKQATMTRNDRFTERLKETLKGIDTIlh- 361
90403559  308 sslqrlkrrrPGGHLEDHAT-HHMNAKMFLQLREQKRACQEAVDAvLAERRFKTLTMTREEQFNERIECVLASMKEMl-- 384
9628284   435 ---------rMKVHWANHSQ-HLENAELFLHCKQQKSICQQAADNvLARRRLKVLESTRQELLAERLNKLLDQLKDL--- 501
9626487   267 ----------RLEHRRHHTKdHTLNALLFQDSKTQKTICNQACDTvLAKRRLDMKTLTRNELLVQRWQGLFQEMEDLfga 336
30315608  268 v------krkRSTHIDDHPR-HQHNASLFLHIKDQKRLCQCAVDAvLAEKRFRSATMTRDERLKERFRTVLRNIQELld- 339
30315611  375 ----------HKFHYNYHKA-HHANACLFLESRAQKNICQQAVDQvLAAKRLKLVECSRIELLEERFLQVFDEMDDFl-- 441
262340526 355 ----------LKAHFNYHNV-HHKNAKLFKECKTQKTVCQQAADVvMAKQRLKLIECSRKELLEERFKLMFEKLTDEf-- 421
302317582 358 ----------LKAHYNYHSL-HHKNAKLFKECKTQKTACQQAADVvMAKQRLKLIESTRKELLEERFKLMFEKLTDEf-- 424
303291526 330 ------------KAHQHHEK-HWANAKLFKTAKNQKGIAQQAADRvLAARRVLMMESTRKDLMVMSFKKQFKVLAEQf-- 394
9627023   527 -GSSDALLYLAGVAWYQCLLEDFPQTLFKMLKLLTENVPKRRNILFRGPVNSGKTGLAAALISLLGGKSLNINCPADKLA 605
90403566  362 eDTETIDQYVAAILMLNMLVP-RVTDIADILETMVRNPPKKRYYIFRGPVNTGKTTVAAAILNLCTGASLNVNGTPERLQ 440
90403559  385 dSPQETNELCCAIYLLNFLIK-DPKAICEIIKTLVRNPPKRRYFVFRGTVNTGKTTVAAAILNLLTGASLNINGNPDRLQ 463
9628284   502 -SPVDKHLYLAGVAWYQCMFPDFEMMLLDILKLFTENVPKKRNVLFRGPVNSGKTSLAAAIMNLVGGVALNVNCPADKLN 580
9626487   337 rGEEHLAHRMAAVMWLNALHPNMPDVIFNYIKMVVENKPKQRYLLLKGPVNCGKTTVAAGLIGLCGGAYLNINCPPERLA 416
30315608  340 gETEAIDDFVTAILLFNMLFP-DVDVIVDILQTMVKNPPKRRYYIFKGPVNTGKTTVAAAILALCTGASLNVNGTPDRLQ 418
30315611  442 hGEIEILRWMAGVAWYTILLDNCWDVFQNMVQLITTSQRKKRNVLIKGPINSGKTTLASAFMDFFDGKALNINCPADKLS 521
262340526 422 -GQIKILQYMAGVAWYSCLFENIEEVVTKIIRLIVENVPKKRNTLFRGPINSGKTTLAAALMNFLGGKTLNVNCPADKLA 500
302317582 425 -GQIKILQYMAGVAWYSCLFENIDEVVTKILKLIVENVPKKRNCLFRGPINSGKTTFAAALMNFLGGKTLNVNCPADKLP 503
303291526 395 gGGVEITQLIGAVAWLDCLLPQFTIKIKEMLSYLVENTPKRRNLLFKGPINSGKTTLAAAILDLLGGVALNVNCSSDKIN 474
9627023   606 FELGVAQDQFVVCFEDVKGQIALNKQ--LQPGMGVANLDNLRTTWNGSVKVNLEKKHSNKRSQLFPPCVCTMNEYLLPQT 683
90403566  441 FELGCAIDQYMVLFEDVKGQSRKEGSg-LPTGLGMMNLDNLRDHLEGSVPVNLERKHQNKVSQVFPPGLITMNDYYIPQT 519
90403559  464 FELGCAIDQMMVLFEDVKGEPEADYEpyLPRGMGMINLDNLRDHLEGAVPVNLERKHQNKIAQIFPPGIITMNHYKIPLT 543
9628284   581 FELGVAIDKFAVVFEDVKGQTGDKRH--LQSGLGINNLDNLRDYLDGSVKVNLEKKHVNKRSQIFPPCIVTANEYFFPQT 658
9626487   417 FELGMAIDQFTVVFEDVKGKKSSKSS--LQTGIGFENLDNLRDHLDGAVPVNLERKHQNKVTQIFPPGIVTCNEYDIPLT 494
30315608  419 FELGCAIDQFMVLFEDVKGTPEPDTN--LPSGFGMVNLDNLRDHLEGSVPVNLERKHQNKVSQIFPPGIITMNNYVLPHT 496
30315611  522 FELGCAIDQLCVLLDDVKGQITLNKH--LQPGQGVNNLDNLRDHLDGTIKVNLEKKHVNKRSQIFPPVIMTMNEYLLPRT 599
262340526 501 FELGCAIDQFVVIFEDVKGQVALNKK--LQPGQGVSNLDNLRDHLDGSVEVNLEKKHVNKKSQIFPPCLVTMNEYLLPET 578
302317582 504 FELGCAIDQFVVIFEDVKGQIALNKK--LQPGQGVSNLDNLRDHLDGSVKVNLERKHVNKRSQIFPPCLVTMNEYLLPET 581
303291526 475 FELGCAIDKYMVVIEDVKGTPLPNTD--LPSGVGMANLDNMRDYLDGCVPVNLERKHINKTSQLFPPCIITCNEYAIPTT 552
9627023   684 VWARFHMVLDFTCKPHLAQSLEKCEFLQRERIIQSGDTLALLLIWNFTSDV-FDPDIQGLVKEVRDQFASECSYSLFCDI 762
90403566  520 VLARTRAVVEFHHNDGFARAVANNPDVVEARILTKAETLLALLLINRESEErLSKQVRLDFVTTIDCLKFEVEQRIW-KY 598
90403559  544 VRVRCKNIMDFKRDPTFKKALQANPVVVQKRLLTRPEVLLGLLILADTEVI-DKKQISCKSATCVECLKFEFDERW--RY 620
9628284   659 LYARFHKVYNFEVKDFLAKSLEENSYMGRHRVCQSPLTMLIALLWNVPTEN-FDKSLKEKVETEKKVLSDMCNFTTFAEM 737
9626487   495 VKIRMYQKVELLHNYNLYKSLKNTEEVGKKRYLQSGITWLLLLIYFRSVDD-FTEKLQECVVKWKERIETEVGDMWLLTM 573
30315608  497 IQARARTLVNFKHIKVYAKALRNNISVLEQRLITKPETLLAYLLIRPESEKeISADLRAEFLTVIENLKFEVDERFF-QY 575
30315611  600 IGVRFALHLHLKPKAYLKQSLEKSD-VVAKRILNSGYTILLVLLWYNPVDS-FTPKVQEKVVQWKETLEKYVSITQFGNI 677
262340526 579 IYTRFAYVLNFSPKEHLRSALQAGDYLLTERILQDGVTVALLLVWYCPITM-FTEAIREDVKYWKDILCKYMGHTNFASL 657
302317582 582 IFTRFAYVLNFTPKHNLRSCLQVSDYLLTERILQDGVTIALLLVWYCPITM-FSESIKEDVKYWKDILCKYMGHTNFATL 660
303291526 553 VKARVAKGYYFLHKPGLKKSLDANPILMKKRLLQKGCTLLAALIWWEPVSD-FVEEIQEEVVNWKQTFEQWVSYGMFQTM 631
9627023   763 LCNVQEGDDPLKDICDIAEY 782
90403566  599 LYNLHAGLPYDHED------ 612
90403559  621 YGKLYEGESCFEQTDT---- 636
9628284   738 CLNIQRGADPLEAL------ 751
9626487   574 KENIEQGKNILEK------- 586
30315608  576 NNRLHEGLCVHE-------- 587
30315611  678 QQNIIDGKDPLHGIVIEEQM 697
262340526 658 LLNVEEGKDPLDGIVIEVED 677
302317582 661 LLNVEEGKDPLDSVVIEVED 680
303291526 632 KENILSGKDPFEGVLINDPT 651
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