7D7S


Conserved Protein Domain Family
F-protein

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pfam00469: F-protein 
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Negative factor, (F-Protein) or Nef
Nef protein accelerates virulent progression of AIDS by its interaction with cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src kinase family.
Statistics
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PSSM-Id: 425700
Aligned: 21 rows
Threshold Bit Score: 274.276
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7D7S_A   2 GGKWSKRSMGGWSAIRERMRRAePRAEPAAD---------------GVGAVSRDLEKHGAITSSN--------------- 51 
P20868   2 GASGSKKRSEPSRGLRERLLQT-PGEASGGHwdklggeylqsqegsGRGQKSPSCEGRRYQQGDFmntpwrap-aegekg 79  Human immunodeficienc...
P12447   2 GASGSKKRSRPSRGLQERLLRA-RGGACGGLwdeseggysqfhegsGREQKLPSCEGQRYQQGDFmntpwrtpatekeke 80  Human immunodeficienc...
P04600   2 GASGSKKHSRPPRGLQERLLRA-RAGACGGYwnesggeysrfqegsDREQKSPSCEGRQYQQGDFmntpwkdpaaerekn 80  Human immunodeficienc...
P05862   2 GGAISKKRSKPPRDLRQRLLRA-RGENYGRLfkgvedgssqslgglDKGLSSLSCEGQKYNQGEYmntpwrnpaeerkkl 80  Simian immunodeficien...
P12482   2 GGAISKKQYKRGGNLRERLLQA-RGETYGRLwegleegysqslgasGKGLSSLSCEPQKYSEGQYmntpwrnpaterakl 80  Simian immunodeficien...
P15829   2 GSAGSKKRSERQQGLREKLLRV-PERPYGRLsgerreqssrspgesDKDLNSPSCEGQNARGAEG--------------- 65  Human immunodeficienc...
Q02840   2 GSSNSKRQQQGLLKLWRGLRGK-PGADWVLLsdpligqsstvqeecGKALKKSWGKGK--MTPDG--------------- 63  Simian immunodeficien...
P18092   2 GASGSKKLSKHSRGLRERLLRA-RGDGYGKQrdasggeysqfqeesGREQNSPSCEGQQYQQGEYmnspwrnpaterqkd 80  Human immunodeficienc...
P18038   2 GASGSKKHSKHSQRLRERLLRA-HGGGYVQQcnasggeysqsqegsGKGQKSPSCEGQQYRQGDFmntpwrtpaiegqkk 80  Human immunodeficienc...
7D7S_A  52 -TAATNADcaWLEAQEEEEVG-FPVRPQVPLRPMTYKAALDISHFLKEKGGLEGLIWSQRRQEILDLWIYHTQGYFPDWQ 129
P20868  80 sYKQQNMD--DVDSDDDDLVG-VPVTPRVPLREMTYRLARDMSHLIKEKGGLEGLYYSDRRRRVLDIYLEKEEGIIGDWQ 156 Human immunodeficienc...
P12447  81 sYRQQNMD--DVDSDDDDLVG-VSDTSRVPLRAMTYRMAVDMSDLIKDKGGLEGMYYSERRHRILDIYLEKEEGIIPDWQ 157 Human immunodeficienc...
P04600  81 lYRQQNMD--DVDSDDDDQVR-VSVTPKVPLRPMTHRLAIDMSHLIKTRGGLEGMFYSERRHKILNIYLEKEEGIIADWQ 157 Human immunodeficienc...
P05862  81 pYRKQNID--DIDEEDDDLVG-IPVEARVPLRTMSYKLAIDMSHFIKEKGGLEGIYYSARRHRILDIYLEKEEGIIPDWQ 157 Simian immunodeficien...
P12482  81 gYRQQNMD--DVDDEDDDLIG-VSVHPRVPLRAMTYKLAIDMSHFIKEKGGLEGIYYNERRHRILDMYLEKEEGIIPDWQ 157 Simian immunodeficien...
P15829  66 -GGQQDAD----ESDEDDEVGaICKTPIVPLRPMTYKLAVDMSHFIKEQGGLEGMYYSERRHRILDTYFENEEGIVSGWQ 140 Human immunodeficienc...
Q02840  64 -RRLQEGDtfDEWDDDEEEVG-FPVQPRVPLRQMTYKLAVDFSHFLKSKGGLDGIYYSERREKILNLYALNEWGIIDDWQ 141 Simian immunodeficien...
P18092  81 lYRQQNMD--DVDSDDDDLIG-VPVTPRVPRREMTYKLAIDMSHFIKEKGGLQGMFYSRRRHRILDIYLEKEEGIIPDWQ 157 Human immunodeficienc...
P18038  81 lYKQQNMD--DIDSSDDDLVG-VPVTPRVPLRAMTYKLAVDMSHFIKKR-GLDGMFYSRDRHRILDLYLEKEEGIIPDWQ 156 Human immunodeficienc...
7D7S_A 130 NYTPGPGIRYPLTFGWCFKLVPVEPEKVEEanEGENNSLLHPMSLHGMED--AEKEVLVWRFDSKLAFHHMARELHPEYY 207
P20868 157 NYTHGPGVRYPKFFGWLWKLVPVDVPQEGD--DSETHCLVHPAQTSRFDD--PHGETLVWRFDPTLAFSYEAFIRYPEEF 232 Human immunodeficienc...
P12447 158 NYTHGLGVRYPMFFGWLWKLVPVTVPQEGE--DTETLCLMHSAQVSRFDD--PHGETLVWKFDPMLAHEYTTFILYPEEF 233 Human immunodeficienc...
P04600 158 NYTHGPGVRYPMFFGWLWKLVPVDVPQEGE--DTETHCLVHPAQTSKFDD--PHGETLVWEFDPLLAYSYEAFIRYPEEF 233 Human immunodeficienc...
P05862 158 IHS-GPGIRYLKMFGWLWKLIPVNVSDEAQ--EDEEHYLVHPAQTSQWDD--PWGEVLAWKFDPTLAYTYEAYIRYPEEF 232 Simian immunodeficien...
P12482 158 NYTSGPGIRYPMHYGWLWKLVPVDVSDEAQ--EDETHCLVHPAQTYQWDD--PWGEVLAWKFDPELAYSYKAFIKYPEEF 233 Simian immunodeficien...
P15829 141 NYTHGPGIRYPKYFGWLWKLVPVEVPAATRe-EEETHCLMHPAQISSWDD--IHGETLIWQFDSLLAYDYVAFNRFPEEF 217 Human immunodeficienc...
Q02840 142 AYSPGPGIRYPRVFGFCFKLVPVDLHEEAR--NCERHCLMHPAQMGEDPDgiDHGEVLVWKFDPKLAVEYRP--DMFKDM 217 Simian immunodeficien...
P18092 158 NYTHGPGVRYPMYFGWLWKLVSVELSQEAE--EDEANCLVHPAQTSRHDD--EHGETLVWQFDSMLAYNYKAFTLYPEEF 233 Human immunodeficienc...
P18038 157 NYTHGPGVRYPMCFGWLWKLVPVDVSQEAE--DDETNYLTHPAQTSRHDD--EHGETLLWRFDPTLAYDYKAFILHPEEF 232 Human immunodeficienc...
7D7S_A 208 KD 209
P20868 233 GY 234 Human immunodeficiency virus type 2 (ISOLATE ST)
P12447 234 GH 235 Human immunodeficiency virus type 2 (ISOLATE SBLISY)
P04600 234 GH 235 Human immunodeficiency virus type 2 (ISOLATE ROD)
P05862 233 GS 234 Simian immunodeficiency virus (MM142-83 ISOLATE)
P12482 234 GS 235 Simian immunodeficiency virus (F236/SMH4 ISOLATE) (SOOTY MANGABEY)
P15829 218 GY 219 Human immunodeficiency virus type 2 (ISOLATE D205,7)
Q02840 218 HE 219 Simian immunodeficiency virus (isolate AGM / clone GRI-1)
P18092 234 GH 235 Human immunodeficiency virus type 2 (ISOLATE BEN)
P18038 233 GH 234 Human immunodeficiency virus type 2 (ISOLATE GHANA-1)
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