1PKM,1LIU,1PKL,1A3W,1PKY


Conserved Protein Domain Family
Pyruvate_Kinase

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cd00288: Pyruvate_Kinase 
Click on image for an interactive view with Cn3D
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Statistics
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PSSM-Id: 238178
Aligned: 15 rows
Threshold Bit Score: 674.413
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitedomain
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    # #                                     #        
1PKM       41 ARNTGIICTIGPASRSVEILKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFAsdpiryrPVAVALDTKGPEIRT 120 cat
1A3W_A     18 LRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKSEELYPg-----rPLAIALDTKGPEIRT 92  baker's yeast
1PKY_D      1 MKKTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGk------TAAILLDTKGPEIRT 74  Escherichia coli
125607     32 FRRTSIICTIGPKTNSVEKINALRRAGLNVVRMNFSHGSYEYHQSVIDHAREAEKQAAg-----rPVAIALDTKGPEIRT 106 Emericella nidulans
400142     41 FRRTSIICTIGPKTNSVEALNKLRDAGLNVARMNFSHGSYEYHQSVIDNVRASVAAHPg-----rPVAIALDTKGPEIRT 115 Hypocrea jecorina
1170699    29 YRKSSIIGTIGPNTNSAEMISKLRQAGLNIVRMNFSHGSYEYHQSVIENARESEQRFRg-----rPLAIALDTKGPEIRT 103 Yarrowia lipolytica
125606     19 IPKTKIVCTLGPSSRTVPMLEKLLRAGMNVARFNFSHGTHEYHQETLDNLKIAMQNTQi------LCAVMLDTKGPEIRT 92  potato
585371      2 KRKTKIVCTIGPASESVDKLVQLMEAGMNVARLNFSHGDHEEHGRRIANIREAAKRTGr------TVAILLDTKGPEIRT 75  Geobacillus stearo...
P43924      5 LRRTKIVCTMGPSTDRDNNLEKIIAAGANVVRMNFSHGTPDDHIGRAERVRSIAKKLGk------TVAILGDLQGPKIRV 78  Haemophilus influe...
1346399     1 MKKTKIVSTLGPASDDIETITKLAEAGANVFRFNFSHGNHEEHLARMNMVREVEKKTGk------LLGIALDTKGAEIRT 74  Lactobacillus delb...
Feature 1                                                                                     
1PKM      121 GLIKGsgtaEVELKKGATLKITLDnaymeKCDENVLWLDYKNICKVVEVGSKVYVDDGLISLLVKEKGAD--FLVTEVEN 198 cat
1A3W_A     93 GTTTNd--vDYPIPPNHEMIFTTDdkyakACDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLEVVDDk-TLKVKALN 169 baker's yeast
1PKY_D     75 MKLEGg--nDVSLKAGQTFTFTTDks--vIGNSEMVAVTYEGFTTDLSVGNTVLVDDGLIGMEVTAIEGN--KVICKVLN 148 Escherichia coli
125607    107 GNTVGd--kDIPIKAGHEMNISTDeqyatASDDQNMYVDYKNITKVISAGKLIYVDDGILSFEVLEVVDDk-TLRVRCLN 183 Emericella nidulans
400142    116 GNTAGd--vDIPISAGTVMNFTTDekyatACDTQNMYVDYKNITKVIQPGRVIYVDDGVLAFDVLSIKDDq-TVEVRARN 192 Hypocrea jecorina
1170699   104 GVTKDd--kDWDVKAGHVMLFSTNpkykdQCDDKIMYIDYTNIVKQIDIGKIIFVDDGVLSFKVLEKIDGe-TLKVETLN 180 Yarrowia lipolytica
125606     93 GFLTDg--kPIQLKEGQEITVSTDyt--iKGNEEMISMSYKKLVMDLKPGNTILCADGTITLTVLSCDPPsgTVRCRCEN 168 potato
585371     76 HNMENg---AIELKEGSKLVISMSe---vLGTPEKISVTYPSLIDDVSVGAKILLDDGLISLEVNAVDKQagEIVTTVLN 149 Geobacillus stearo...
P43924     79 STFKDg---KIFLNVGDKFILDAElp-kgEGTQESVGLDYKTLPQDVVPGDILLLDDGRVQLKVLSTDGA--KVFTEVTV 152 Haemophilus influe...
1346399    75 TDQEGg---KFTINTGDEIRVSMDat--kAGNKDMIHVTYPGLFDDTHVGGTVLIDDGAVGLTIKAKDEEkrELVCEAQN 149 Lactobacillus delb...
Feature 1                                                  #                          # #     
1PKM      199 GGSLGSKKGVNLPGAAVDLPAVSEKDIQDLK-FGVEQdVDMVFASFIRKASDVHEVRKVLGEk-GKNIKIISKIENHEGV 276 cat
1A3W_A    170 AGKICSHKGVNLPGTDVDLPALSEKDKEDLR-FGVKNgVHMVFASFIRTANDVLTIREVLGEq-GKDVKIIVKIENQQGV 247 baker's yeast
1PKY_D    149 NGDLGENKGVNLPGVSIALPALAEKDKQDLI-FGCEQgVDFVAASFIRKRSDVIEIREHLKAhgGENIHIISKIENQEGL 227 Escherichia coli
125607    184 NGNISSRKGVNLPGTDVDLPALSEKDISDLK-FGVKNkVDMVFASFIRRGSDIRHIREVLGEe-GREIQIIAKIENQQGV 261 Emericella nidulans
400142    193 NGFISSRKGVNLPNTDVDLPALSEKDKADLR-FGVKNnVDMVFASFIRRAQDIKDIRDVLGPe-GKQIQIIAKIENRQGL 270 Hypocrea jecorina
1170699   181 NGKISSRKGVNLPGTDVDLPALSEKDKADLK-FGVEHgVDMIFASFVRTANDVQAIRDVLGEk-GKGIQVISKIENQQGV 258 Yarrowia lipolytica
125606    169 TATLGERKNVNLPGVVVDLPTLTEKDKEDILeWGVPNnIDMIALSFVRKGSDLVNVRKVLGPh-AKRIQLMSKVENQEGV 247 potato
585371    150 GGVLKNKKGVNVPGVKVNLPGITEKDRADIL-FGIRQgIDFIAASFVRRASDVLEIRELLEAhdALHIQIIAKIENEEGV 228 Geobacillus stearo...
P43924    153 GGPLSNNKGINKLGGGLSADALTEKDKADII-TAARIgVDFLAVSFPRSSADLNYARELAQQa-GLNAKIVAKVERAETV 230 Haemophilus influe...
1346399   150 TGVIGSKKGVNAPGVEIRLPGITEKDTDDIR-FGLKHgINFIFASFVRKAQDVLDIRALCEEanASYVKIFPKIESQEGI 228 Lactobacillus delb...
Feature 1                          #                               #                          
1PKM      277 RRFD---EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLD 353 cat
1A3W_A    248 NNFD---EILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSDVGNAILD 324 baker's yeast
1PKY_D    228 NNFD---EILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATMMLDSMIKNPRPTRAEAGDVANAILD 304 Escherichia coli
125607    262 NNFD---EILEETDGVMVARGDLGIEIPAPKVFIAQKMMIAKCNIKGKPVICATQMLESMTYNPRPTRAEVSDVANAVLD 338 Emericella nidulans
400142    271 NNFA---EILEETDGVMVARGDLGIEIPAAEVFAAQKKMIAMCNIAGKPVICATQMLESMIKNPRPTRAEISDVGNAVTD 347 Hypocrea jecorina
1170699   259 NNFD---EILKETDGVMVARGDLGIEIPAPQVFIAQKQLIAKCNLAGKPVICATQMLDSMTYNPRPTRAEVSDVGNAVLD 335 Yarrowia lipolytica
125606    248 INFD---EILRETDSFMVARGDLGMEIPVEKIFLAQKMMIYKCNLAGKAVVTATQMLESMIKSPAPTRAEATDVANAVLD 324 potato
585371    229 ANID---EILEAADGLMVARGDLGVEIPAEEVPLIQKLLIKKCNMLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFD 305 Geobacillus stearo...
P43924    231 ANDEamdDIILASDVIMVARGDLGVEIGDPELVGVQKKLIRRSRQLNRAVITATQMMESMISNPMPTRAEVMDVANAVLD 310 Haemophilus influe...
1346399   229 DNID---EILQVSDGLMVARGDMGVEIPFINVPFVQKTLIKKCNALGKPVITATQMLDSMQENPRPTRAEVTDVANAVLD 305 Lactobacillus delb...
Feature 1                                                                                     
1PKM      354 GADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRGsshstdlMEAMAMGSVEASYKC-LAAALIVLTE 432 cat
1A3W_A    325 GADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNYDDMRNCtpkptstTETVAASAVAAVFEQ-KAKAIIVLST 403 baker's yeast
1PKY_D    305 GTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMNSRLEFNNDNRKlr----iTEAVCRGAVETAEKL-DAPLIVVATQ 379 Escherichia coli
125607    339 GADCVMLSGETAKGNYPCEAVTMMSETCLLAEVAIPHFNVFDELRNLaprptdtVESIAMAAVSASLEL-NAGAIVVLTT 417 Emericella nidulans
400142    348 GADCVMLSGETAKGNYPAESIHEMHEASLKAENTIPYVSHFEEMCTLvkrpvstVESCAMAAVRASLDL-GAGGIIVLST 426 Hypocrea jecorina
1170699   336 GADCVMLSGETAKGTYPIESVKMMHETCLVAEKAIAYAPLFNEMRTLtvrptetVETIAISAVSASFEQ-QARAIIVLST 414 Yarrowia lipolytica
125606    325 GTDCVMLSGESAAGAYPELAVKIMSRICIEAESSLDNEAIFKEMIRCtplpmspLESLASSAVRTANKA-RAKLIVVLTR 403 potato
585371    306 GTDAVMLSGETAAGQYPVEAVKTMHQIALRTEQALEHRDILSQRTKEsqt--tiTDAIGQSVAHTALNL-DVAAIVTPTV 382 Geobacillus stearo...
P43924    311 GTDAVMLSAETAAGQYPSETVAAMASVCLGAEKMPSINVSRHRMDKEfe---tiEESVAMSAMYAANHMkGVAAIVTLSS 387 Haemophilus influe...
1346399   306 GTDATMLSGESANGLYPVQSVQAMHDIDVRTEKELDTRNTLALQRFEeykgsnvTEAIGESVVRTAQEL-GVKTIIAATS 384 Lactobacillus delb...
Feature 1                                                                                     
1PKM      433 SGRSAHQVARYRPRAPIIAVTRN-------------HQTARQAHLYRGIFPVVCkdpvqe----awaedVDLRVNLAMNv 495 cat
1A3W_A    404 SGTTPRLVSKYRPNCPIILVTRC-------------PRAARFSHLYRGVFPFVFekepvs----dwtddVEARINFGIEk 466 baker's yeast
1PKY_D    380 GGKSARAVRKYFPDATILALTTN-------------EKTAHQLVLSKGVVPQLVkeit--------stdDFYRLGKELAl 438 Escherichia coli
125607    418 SGNTARMISKYRPVCPIIMVSRN-------------PAATRYSHLYRGVWPFYFpekkpdfnvkiwqedVDRRLKWGINh 484 Emericella nidulans
400142    427 SGDSARLLSKYRPVCPIFMVTRN-------------PTTSRFSHLYRGVYPFLYpeqkpdfdtvnwqedVDKRIKWAVTr 493 Hypocrea jecorina
1170699   415 SGTSARLCSKYRPNCPILMVTRN-------------AQAARFSHLYRGVYPFIYhkarasn-paewqhdVEERLKWGMDe 480 Yarrowia lipolytica
125606    404 GGSTAKLVAKYRPAVPILSVVVPvlttdsfdwsisdETPARHSLVYRGLIPLLGegsaka----tdsesTEVILEAALKs 479 potato
585371    383 SGKTPQMVAKYRPKAPIIAVTSN-------------EAVSRRLALVWGVYTKEAphv----------ntTDEMLDVAVDa 439 Geobacillus stearo...
P43924    388 TGRTPLLMSRISSGLPIFALSRN-------------QETLNLCALYRGVTPIYHgee----------srTEAGAKAAPQs 444 Haemophilus influe...
1346399   385 SGYTARMISKYRPDATIVALTFD-------------EKIQHSLGIVWGVEPVLAkkp----------snTDEMFEEAARv 441 Lactobacillus delb...
Feature 1                                        
1PKM      496 gkargfFKHGDVVIVLTGwrp-gsGFTNTMRVVPV 529 cat
1A3W_A    467 akefgiLKKGDTYVSIQGfka-gaGHSNTLQVSTV 500 baker's yeast
1PKY_D    439 qs--glAHKGDVVVMVSGalv-psGTTNTASVHVL 470 Escherichia coli
125607    485 glklgiINKGDNIVCVQGwrg-gmGHTNTVRVVPA 518 Emericella nidulans
400142    494 aielktLTAGDTVVVVQGwkg-gmGNTNTLRIVRA 527 Hypocrea jecorina
1170699   481 avalgiLNKGDVVVAIQGwtg-glATPTLSEFSSV 514 Yarrowia lipolytica
125606    480 avtrglCKPGDAVVALHRi-----GSASVIKICVV 509 potato
585371    440 avrsglVKHGDLVVITAGvpvgetGSTNLMKVHVI 474 Geobacillus stearothermophilus
P43924    445 lkekgyLSTGDLVLVTQGgq--gaTQTNVCRTLIV 477 Haemophilus influenzae
1346399   442 akehgfVKDGDLVIIVAGvpfgqsGTTNLMKLQII 476 Lactobacillus delbrueckii subsp. bulgaricus

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