4LEP,4W6V,4IKV,4IKX,4APS,4XNI,5MMT,4Q65


Conserved Protein Domain Family
MFS_DtpA_like

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cd17346: MFS_DtpA_like 
Click on image for an interactive view with Cn3D
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters
The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Statistics
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PSSM-Id: 340904
Aligned: 53 rows
Threshold Bit Score: 235.162
Created: 4-Feb-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
chemical
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:chemical substrate binding pocket [chemical binding site]
Evidence:
  • Structure:4LEP; Shewanella oneidensis proton dependent oligopeptide transporter in complex with the peptidomimetic alafosfalin; contacts at 5A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      #   #                                                             
4LEP_A        11 THSFMTVSLIELWERFGYYGMQALIVYFMVQRlg-----fdDSRANLVWSACAALIYVSPAIGGWVGDKIlGTKRTMLLG 85  Shewanella onei...
P77304        20 PKAFYLIFSIELWERFGYYGLQGIMAVYLVKQlg-----msEADSITLFSSFSALVYGLVAIGGWLGDKVlGTKRVIMLG 94  Escherichia col...
Q7NRM5        12 PKPFYLIFSIEFWERFGFYGLQGILAVYLVKAlg-----lrEADSFTLFSSFIALVYGLIAVGGWLGDKVlGTKRTILLG 86  Chromobacterium...
P36837        13 PRPFFMIFFVELWERFGYYGVQGVLAVFFVKQlg-----fsQEQAFVTFGAFAALVYGLISIGGYVGDHLlGTKRTIVLG 87  Escherichia col...
WP_033170234  10 KKAFNMLFFIEFWERFGYYGLQAVLAGFFVKSlg-----meDAESFVVFGAFSAMVYGYVSLGGFLGDKIlGTQRTITLG 84  Selenomonas sp....
YP_169991      7 QNSFFLLCFFEFFERFGYYGFSYTAILFFMSKygf---dftEKQAVLLFGGFASLSYVFNAIGGYVADKVfGIKRTMFLG 83  Francisella tul...
YP_169669     39 SKQSFTIVAITFWGQFATYSFNAILILYLTRSvldygigfsESHAYSFQGIYKAMNYAIIMFGGYIADRYlGLRRSIFWG 118 Francisella tul...
YP_169597     10 TKYFISLFWLQLFERFSFFGFFYILIFFCINKln-----ltESYASTFAGSFTALCYVLSSLGGFISDKAlGVRRTLIAG 84  Francisella tul...
YP_205979      9 PTIAKVLILRQFLWGAAFYGAFVLLTKFFLDDln-----ysEADTIMMMGAFGAVGPVFSAVGGFLADKFiGAFRAVYIG 83  Aliivibrio fisc...
YP_206031      3 NKLNKSMMFCQMMFGLSFYGVMVILTRFFLEEln-----ysEADTMMVVGAFSSIGPLFAIAGGFIADKFlGAYRSLTIS 77  Aliivibrio fisc...
Feature 1                                               #                          #  ##  #      
4LEP_A        86 AGILSVGYALMTVpte----ntWFMFSALGVIVVGNGLFKPNAGNLVRKIyegdd-skidsAFTIYYMAVNVGSTFSMLL 160 Shewanella onei...
P77304        95 AIVLAIGYALVAWsgh----daGIVYMGMAAIAVGNGLFKANPSSLLSTCyeknd-prldgAFTMYYMSVNIGSFFSMIA 169 Escherichia col...
Q7NRM5        87 ALVLTAGYAMVTAsse----hiSLLYLGMGTIAVGNGLFKANPSSLLSKCyeend-prldgAFTMYYMAINIGSLLSMLA 161 Chromobacterium...
P36837        88 ALVLAIGYFMTGMsll----kpDLIFIALGTIAVGNGLFKANPASLLSKCyppkd-prldgAFTLFYMSINIGSLIALSL 162 Escherichia col...
WP_033170234  85 AVVLMIGYAMMALaga----dkTMVFLALGAIACGNGIFKANPSSLLSKLyegde-kdldsAFTMYYMAVNIGSFLSMLL 159 Selenomonas sp....
YP_169991     84 AVFLLVGYFSLALspyf-vnidNYVYISLACIIVGSSLFKPAPTNLISRIytdkl--kldsVYTYFYMSINMGSLSASLL 160 Francisella tul...
YP_169669    119 SLLLAFAYLAVFLsgfmvhfsdEFFIFAFALVPVCGSLQLGTASAMVSKIysdnp-vhaksGMTMFYISINLGSLLAYLV 197 Francisella tul...
YP_169597     85 GICLILGYSLLSTsdm---lmnFSIYVGLAMIIVGACLFVPMTLNSMSRLyagdp-akldsIYAYFNMTNNIGALSGAIL 160 Francisella tul...
YP_205979     84 YATYLAGFLLLGIgasq--lnvPMSILAIALIGFARGLSATCPTVLFGNSysetnreafqqGLTVNYSINNLGSFSAKYL 161 Aliivibrio fisc...
YP_206031     78 YFGFATGYALLVLgsyt--tnvPMALCGIALASYGRGLMSPSYPSLYKRTfdtqe--hfenCYPVNYSVNNVGALLGQYL 153 Aliivibrio fisc...
Feature 1                                                                                        
4LEP_A       161 TPWIkdyvnaqygneFGWHAAFAVCCVGILVGLGNYALMHKSLAnygsepdtrpvnkkslaivlalaalsvvasaii-le 239 Shewanella onei...
P77304       170 TPWLaa--------kYGWSVAFALSVVGLLITIVNFAFCQRWVKqygskpdfepinyrnllltiigvvaliaiatwl-lh 240 Escherichia col...
Q7NRM5       162 TPWLad--------qFGYAHAFALSVVGMLITVANFILMQGWVKnygsdadfrtprlstwlavlagvvaacaaaall-lk 232 Chromobacterium...
P36837       163 APVIad--------rFGYSVTYNLCGAGLIIALLVYIACRGMVKdigsepdfrpmsfskllyvllgsvvmifvcawl-mh 233 Escherichia col...
WP_033170234 160 VPIIga--------qYGLSLGFMICAMGLILAIGGFLGFRYLVRgidspagaepltmkkivltligvvvmtvfsswl-ls 230 Selenomonas sp....
YP_169991    161 IPVLat--------kYGYTAAYGVCSVGFAIGILNSLLSYASIKdignevdfrnmgyprtilivsvfiiviiglsvilqt 232 Francisella tul...
YP_169669    198 APSLig-------yqFGALAVLSVVFIGKLLAIINFSYRYKIYDnvvdeidkkpmtsiakkvvlgylaivyvftvicyhy 270 Francisella tul...
YP_169597    161 IPYLssads-yglenRHYGIALGVCACGVLLALGNIFMNKKLFStiaapvgkktlsfqqlvlaiigiiffvsvvtgl-ly 238 Francisella tul...
YP_205979    162 FPFLia--------yLAYQGVFFVSAILMALNLLMFYKFRKELVsvgndldktplplktwvmffagsaamlglifwi-fs 232 Aliivibrio fisc...
YP_206031    154 FPMFvl--------vLGFHGSFLLSCVLALLAFATLVIFRKPLLtvgahidqkpvsmqnwisflitsvamialvffm-fs 224 Aliivibrio fisc...
Feature 1                                                           #                            
4LEP_A       240 yedvarvfvyaagvavlgiffhlirtsepsERAGLIAALILTVQTVFFFIFYQQMSTSLALFAlrnvdwdfqvfgthlwt 319 Shewanella onei...
P77304       241 nqevarmalgvvafgivvifgkeafamkgaARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAirnveh-----silgla 315 Escherichia col...
Q7NRM5       233 heiianvvlavlsigvvglyvketlllkgaERKKMIVAAILMLQATVFFVLYNQMPLSLNFFAihnteh-----mlfgip 307 Chromobacterium...
P36837       234 nvevanlvlivlsivvtiiffrqafkldktGRNKMFVAFVLMLEAVVFYILYAQMPTSLNFFAinnvhh-----eilgfs 308 Escherichia col...
WP_033170234 231 hlsvahwllfvigvlvygvffkmiiqakgaERSHMAAAMILIVEAIIFFTLYQQMPTSLNFFAiknvehs----vlgiai 306 Selenomonas sp....
YP_169991    233 ndtinyilwfgaglifgvfafqiyvekdpsSRKKIVAAIILLVYAVLFFIIYQQKSTSFFLFNvhhvnln----lfgysv 308 Francisella tul...
YP_169669    271 pdyanvvvavismfclllfllrtifflkddVHIKQIVGLILIVVAVVFFVIYNQMESTLVMAAknnsdl-----lmfgfk 345 Francisella tul...
YP_169597    239 fssliiivlvlavvmivgyfinitfqqdkeYRLKMLLLLVFIFYATIFFMTYAQKTTSFFLFNvhhvdln----vlgikl 314 Francisella tul...
YP_205979    233 nletgkyilytlgfgaigyfiyeitqatraYQYKMVAVLITVCILIVFYFFYGQMFTSMNMYAinlmddt----llgfip 308 Aliivibrio fisc...
YP_206031    225 nmdigqnivygiglaaigyfvilmlkskksDALKMGTILIMTALTTAFFVYYGQMMTSMTMVTintmrgd----lfdlip 300 Aliivibrio fisc...
Feature 1                 ##  #                                                                  
4LEP_A       320 WSPAQFQALNPIWIMVLSPVLAWSyswagrnnkdfSIAAKFALGFAVVAIGFFIYGFAGQFavng--ktsSWVMIWGYAS 397 Shewanella onei...
P77304       316 VEPEQYQALNPFWIIIGSPILAAIynkm---gdtlPMPTKFAIGMVMCSGAFLILPLGAKFasda-givsVSWLVASYGL 391 Escherichia col...
Q7NRM5       308 VQPEQFQSLNPFWIMLASPLLALCynkl---gnrlPMPHKFAIGMVLCAGAFLVLPLGAKYanaq-glvsSNWMVLSYLL 383 Chromobacterium...
P36837       309 INPVSFQALNPFWVVLASPILAGIythlgnkgkdlSMPMKFTLGMFMCSLGFLTAAAAGMWfadaqgltsPWFIVLVYLF 388 Escherichia col...
WP_033170234 307 PNAEVFQTLNPFWIMLASPVLAWAyshfgsegkdlSMPAKFALGMLLTAASFLVVGFSANFanea-givsAWWLIGSYFL 385 Selenomonas sp....
YP_169991    309 NPQSIPGVLNTAGVIILSPILALIytklg--kkdfSLPFKFALGILLCGLAYGSMFLACLIndptakvsiLWEVLAITIF 386 Francisella tul...
YP_169669    346 VNAASYQIVNPILIIFGGMLLIRIypmf----prfYIPYQFAVGVLLAAAGLFIMYYGFSIdnng--ivsGNYITLSYVL 419 Francisella tul...
YP_169597    315 NSQTVPGLLNTSGILIFSPILAMYfnkm---gdrlRSTSKFALCLLFAGICYAFLYFVCVFndpsskvsfWWEVVAVGVF 391 Francisella tul...
YP_205979    309 IHPESNMAFNPLWCFVLGGPMIQLyawldrkgyspTIPTKIAGAFMLSTIAFGLLGLSAGSigen-gkisADWILLVHFF 387 Aliivibrio fisc...
YP_206031    301 IAPEASMAMNPLWCIVAGPVIAMIfsalekrdihfSTATKIGFAFILTAIAFGILTMAVMGvged-aiirPEVFLLIHFF 379 Aliivibrio fisc...
Feature 1            #                                                                           
4LEP_A       398 YSLGELLVSGLGLAMIARyvparmggFMMGAYFVASGISQYLGGVVANfasvpqdlv--------dplqtlpvYTNLFNK 469 Shewanella onei...
P77304       392 QSIGELMISGLGLAMVAQlvpqrlmgFIMGSWFLTTAGANLIGGYVAGmmavpdnvt--------dplmslevYGRVFLQ 463 Escherichia col...
Q7NRM5       384 QSVGELLISGLGLAMVAQlvpqrlmgFIMGAWFLTSAASSVIAGWVAGltaapdnvt--------nplatleiYSRVFTQ 455 Chromobacterium...
P36837       389 QSLGELFISALGLAMIAAlvpqhlmgFILGMWFLTQAAAFLLGGYVATftavpdnit--------dpletlpvYTNVFGK 460 Escherichia col...
WP_033170234 386 SSIGELLISGLGLSMISKlvpqkligFLMGAWFLTTSIAAILGGWVATlttvskdvv--------dplqtlpvYSEVFTQ 457 Selenomonas sp....
YP_169991    387 FSAGELLISALGLSLMAKllpqritgFAMGTWFITSAIGIKIGTTIAQavtsgiqydeskgfdtqmtissfhkYQDLFGY 466 Francisella tul...
YP_169669    420 ISISELFVSAIGLSMIGIycdsktigFAMEAWYISSSMANSITGLLNQvvalpkdgv--------salesanmYKTYFFD 491 Francisella tul...
YP_169597    392 FSWAEIMATAVGLSLITQlvptkvrgFCMGMWFLTWAVGIKLGVYVASlyaskdlehs------ksslligqtKIDSYLG 465 Francisella tul...
YP_205979    388 QSGAELIVGALGAGFIFEmvprylaaFSIGLRAVAISLSGILAAVIATkialpkdiv-------ftpevvetvYTSYFYM 460 Aliivibrio fisc...
YP_206031    380 QAFAEVIVGSLVVAFILSvapkhiegFSVSLFSVAMALSGIIGAVFSTsiaqekghv-------itqefvqtvYGSYFQL 452 Aliivibrio fisc...
Feature 1                          
4LEP_A       470 LGVAAVVCTIIALAVLPL 487 Shewanella oneidensis MR-1
P77304       464 IGVATAVIAVLMLLTAPK 481 Escherichia coli K12
Q7NRM5       456 IGVVTGVIAVVTIIIAPW 473 Chromobacterium violaceum
P36837       461 IGLVTLGVAVVMLLMVPW 478 Escherichia coli K12
WP_033170234 458 IGLVTLGVTIIMALTVPM 475 Selenomonas sp. ND2010
YP_169991    467 VSLVAIIFAVIAFVIGKK 484 Francisella tularensis
YP_169669    492 TSLSVMLIGILVLILAYF 509 Francisella tularensis
YP_169597    466 YENLFMWITIVTVAAAFH 483 Francisella tularensis
YP_205979    461 LAQVAAFMAILTLGLSKV 478 Aliivibrio fischeri
YP_206031    453 LTVLAVVMVAIAFIASFI 470 Aliivibrio fischeri

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