Conserved Protein Domain Family
MetH1

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COG0646: MetH1 
Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
Methionine synthase I (cobalamin-dependent), methyltransferase domain is part of the Pathway/BioSystem: Methionine biosynthesis
Statistics
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PSSM-Id: 440411
Aligned: 650 rows
Threshold Bit Score: 403.844
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012420988    1 Msras---------rteRLDYLKDQLRKRVVILDGAMGTNIQKFRLGEGDYRGErfadaecypndlKNNNDLLVLTRPDI 71  
NP_603070       1 -------------------------MEERILVLDGAMGTVLQKYELTLEDFNGa------------KGCYEILNETRPDI 43  
NP_809093       1 -----------------MKKTISQIVSERILILDGAMGTMIQQYNLKEEDFRGErfahi---pgqlKGNNDLLCLTRPDV 60  
WP_014545890    1 M-------------------TLREAFESKMMLLDGGMGSVIQTYGIK-------------------GANNDMLSIEKPEI 42  
WP_013388845    1 ---------------------MRELLKEKILILDGAMGTAIQNYSLEESDFRGElfshi---kgslRGCNELLNLTKPEV 56  
WP_013445255    1 -------------------MNLRTILENRILILDGAMGTMIQRHKLNEADYRGTrfanc---eilqKGNNDLLVLTQPDI 58  
WP_014270523    1 Md---------------RQQYLLKLLSERVLVLDGAMGTMIQNQGLRDEDFYLEdi--------kaVGCNELLSLTRGDV 57  
WP_015043771    1 Mqrsg---------etmKQQIFNELLARKILILDGAMGTMLQQKDLSAEDFGGPe----------qEGCNEILTLTRPYI 61  
WP_096686647    1 MgtcipsiscilknskvTDSILNRILGERILILDGAMGTMIQEYDFSEKDYRGDkykdi---enpiKGNNDILSITQPDV 77  
WP_128149236    1 -------------------MKIEDLIKDKILILDGAMGTMIQQHKLKEEDYRGKefknw---hkdiKGNNDLLSITQPEI 58  
WP_012420988   72 ILDIHRRFLDTGrTDILETCTFGATSIGQHDYfwhrpeegshkdqqyfqevvdapELKALVRELNLAAAALARQACDEAE 151 
NP_603070      44 IFEVHKKYIEAG-ADIIETNSFNCNAISLKDY-----------------------HLEDKVYDLAKKSAEIARDAVKKS- 98  
NP_809093      61 IQDIHRKYLEAG-ADIIETNTFSSTTVSMADY-----------------------HVEEYVREINLAATRLARELADEYT 116 
WP_014545890   43 ILDIQRRYVDAG-VDCLTTNTFSSQRVSQHEY-----------------------HQEHRIAEMNRASVKIAKQAAEEGF 98  
WP_013388845   57 LEEIHLSYLEAG-ADIIETNTFNSNRISMREY-----------------------GLEEKSYDLSKAGAELAVKAARKYE 112 
WP_013445255   59 IYGIHNQYLEAG-ADIIETNTFNAQRISMEDY-----------------------GMCDLVREINIEAAKLARKAADEFT 114 
WP_014270523   58 IFDIHTQYLQAG-SDIITTNTFCANSFNLEEY-----------------------GLSSEVETLNRAACEIAREAAADFE 113 
WP_015043771   62 VRDIHEAYLKAG-ADIIETNTFGGTNIVLGEY-----------------------HLGDRDMEINEAAARLAREAADKWS 117 
WP_096686647   78 ISEIHEKYLIAG-ADILETNTFSGTSIAQSDY-----------------------NLENEVYRINYESAVLAKKAAQKYS 133 
WP_128149236   59 IKDIHLEYFEAG-ADIVETNTFNANRISMADY-----------------------DMQDWVNELNISSVKAAKEARDEYY 114 
WP_012420988  152 aa-dGKPRLVAGSIGPMPVTCSlspdvndPgFRAVNFRQLRQAYRDQVLALLEGGVDMLLVETIFDTLNAKAALFAIEEI 230 
NP_603070      99 ----GKKVYVFGSVGPTNKGLSfsv-gdvPfKRAVSFDEMKEVIKVQVAGLIDGGVDGILLETVFDGLTAKVALLAIEEV 173 
NP_809093     117 akspDKPRFVAGSVGPTNKTCSmspdvnnPaFRALSYDELAASYQQQMEAMLEGGVDAILIETIFDTLNAKAAIFAAGQA 196 
WP_014545890   99 kk-yGRKVYILGDVGPTSKMLSmsedvndPaSRAITFDELEDAYLEQISVLMEEGVDAILIETIFDTLNAKAALSAYSKA 177 
WP_013388845  113 yd-nKKRIFVAGSMGPTSKSASipt-ggdPfGREVSYSELKAAYKEQALGLFDGGVDAFLIETIFDGLNAKAAVIAIEEV 190 
WP_013445255  115 aknlAKPRFVAGAVGPTNKTASmspdvnnPaFRAVSFDDLVAAYKEQILALIEGGVDALLIETIFDTLNAKAAIFAAEEA 194 
WP_014270523  114 rt-qEKYAFIAGTLGPTNRSLAfssdvddPsFRKSDFKGFEEMYLQQAGVLLDGGVDLLLIETVFDTLAAKAAIRSCFKA 192 
WP_015043771  118 t--aEKPRFVAGSMGPTTKMLAf--------GGGITFTDLEEAYCRQTLGLIKGGVDLLIVETCQDTLNIKAAGLGIQRA 187 
WP_096686647  134 se--eKPRFVAGAIGPTNKTASispdidnPsFRSITFDELAISYQQQCEALIDGRVDIFLIETVFDTLNAKAAMFACQEA 211 
WP_128149236  115 dkhtFRPLYIAGSIGPTSKTASispdvndPaYREVDFDFLAQIYKEQAIALIDAGSDLLLVETIFDTLNAKAAFFGIEEA 194 
WP_012420988  231 FEE-------QpE------SSVPVMVSVTLtDKAGRTLSGQTIEAFWNSIRHVRPFSVGINCALGPDLMRPFAEELSGLA 297 
NP_603070     174 FEE-------K-N------IKLPVSISATV-NKQGKLSTGQSIESLMVDLDRDFVISFGFNCSFGAKNLVPLVIKIKELT 238 
NP_809093     197 MKV-------T-G------IEVPVMLSVTVsDIGGRTLSGQTLEAFLASVQHANIFSVGLNCSFGARQLKPFLEQLASRA 262 
WP_014545890  178 NDArieaakaA-GtpeaeiKPIEVMLSMTVsDASGRTLSGQTVEAFAVSVMHMHPLSIGLNCGLGADGMVPYLRRMGAIA 256 
WP_013388845  191 LEE-------K-G------EKLPIMISGTV-DVNGKLLSGQSIESLIVAIDRDSIISYGLNCSFGAKELIPLIKKLGKLT 255 
WP_013445255  195 MSE-------L-G------KRVEIMLSATVaDTSGRTLSGQTIRAFLASIGHANILSVGLNCSFGAKDLKPYLHEINEHS 260 
WP_014270523  193 MEE-------K-E------RKVPVMVSVTFsDLSGRTLSGQTLEAFVSSLAPFPIFSLGLNCSTGPEQMVPLIEKLSAIS 258 
WP_015043771  188 FAE-------F-G------REVPLVVSVTI-EPSGTMLAGQNIEALYISIQHLKPAAIGMNCGTGAELMNDHLRTLEGLA 252 
WP_096686647  212 MKK-------K-N------VHIPIMLSGTItDISGRTLSGQTTEAFLISVSHVPLLSIGLNCALGAEQILPYLQILSDKS 277 
WP_128149236  195 FDS-------T-G------KSLPLMASGTItDAAGRTLSGQTTEAFLVSLSHLPLLSIGLNCALGADQLYQYLEILAKYS 260 
WP_012420988  298 DCHMSIYANAGLPNPLSPtgYDLLPADMARFMKEYAEQGLLNIVGGCCGTTPEHIGAIAAAVEG--MPPRVPAPQTPALR 375 
NP_603070     239 TKFVSLHANAGLPNQNGE--YEETAQKMRDDLLPLIENQAINILGGCCGTDYEHIKLIAELVKGqkprilpkr------- 309 
NP_809093     263 PYYISAYPNAGLPNSLGK--YDQTPADMAHEVKEYIQEGLVNIIGGCCGTTDAYIAEYQTLIAGa-KPHVPAPKPDCMWL 339 
WP_014545890  257 PCYLSCHPNAGLPNQFGG--YDDTPEDMVRLMRVYLDDKLVNMIGGCCGTTPEHIAAMRQMLDAlpADYKRREPAPKYVT 334 
WP_013388845  256 KKNISLYPNAGLPNEKGE--YDETPHMTGSYVKELIENKDINILGGCCGTTPEHIKVMAELAQG--KSPRKTSMENLAGI 331 
WP_013445255  261 PWFVSAYPNAGLPNQFGE--YDETPETMAIQVKEYFDEKLVNIIGGCCGTSPDHIATYSALIENkeVRKPGLASKKLELS 338 
WP_014270523  259 PFFVSAHPNAGFPDKEGH--YTLTPRQLADQMAPVLGKGCLNIVGGCCGTTPEHIQALKEATNR--AKVHVKNERPPVLV 334 
WP_015043771  253 SCAVSCYPNAGLPDEEGG--YQETPEEFAGKMAAYAAKGWLNIAGGCCGTTDRHIEALAAALAK--YAPRQIRAAERSSV 328 
WP_096686647  278 EFNISVHPNAGLPNAFGQ--YDETPEMMGEKIEEFFKRGLINIVGGCCGTTPDHIAEISRISKNytrrif---------- 345 
WP_128149236  261 PFYVSAYPNAGLPNPLGG--YDETPEMMAEKVKLYLDSELVNILGGCCGTTPSHIKLFAEMASNytpraikvs------- 331 
WP_012420988  376 LSGYEAYNHTREKNTLFVGERCNVAGSPKFARLIREGNYEEAVSIARQQVENGALVLDFCFDDGLIDGPQAMVRFLNLVS 455 
NP_603070         --------------------------------------------------------------------------------     
NP_809093     340 SGLELLEVKPEINFVNIGERCNVAGSRKFLRLVNEKKYDEALSIARQQVEDGALVIDVNMDDGLLDARTEMTTFLNLIMS 419 
WP_014545890  335 SPRLRLAGLEPLFREQVRPSNGADSCNADDFVKVGERCNVAGSKKFLRLINEKNYEEALDIARKQVDDGADVIDVNMDDG 414 
WP_013388845  332 VSGNDTVSLHEEFLVVGERNNVSGSRKFARLIREESYDEALDIARTQVEKGAKILDINLDDALLDSVEEMEKFIRLLQND 411 
WP_013445255  339 GLEELEIEDSSLFVNIGERCNVAGSRMFLRLINEKKYEEALSIARKQVEDGAQVIDINMDDAMLESKEEMVTFLNYVAAE 418 
WP_014270523  335 LSGLERLEVRDGSFLVIGERTNVAGSKKFARLIKEENWEEALSVARNQIAQGAQVIDICMDASMLDAPKAMVAFLRQVAS 414 
WP_015043771  329 AGLEAVWPEEENRPLLVGERANVIGSRKFKELIADEYYEEGSEIARNQVKKGAQIVDVCVANPDRDELKDMVSFLPHVVN 408 
WP_096686647      --------------------------------------------------------------------------------     
WP_128149236      --------------------------------------------------------------------------------     
WP_012420988  456 AEPDIARVPFMVDSSKWEVLEAGLQCMQGKGIVNSISLKEGEEEFLKKAALIKKYGAAVVVMAFDEQGQAANYEDRVRIS 535 
NP_603070         --------------------------------------------------------------------------------     
NP_809093     420 EPEIARVPVMIDSSKWEVIEAGLKCLQGKSIVNSISLKEGEEVFLEHARIIKQYGAATVVMAFDEKGQADTAARKIEVCE 499 
WP_014545890  415 LLDATAEMRTFLNLIASDPAVSRVPIMVDSSRFEVIEEGLKCIQGKSIVNSISLKMGEKAFIEHALTVKRLGAAVIVMLF 494 
WP_013388845  412 MILSKLPIMIDSSNFDVIEKGLENLAGKGIVNSISLKDGEHEFLRKAAVVRKFGAALVVMAFDEKGQAVSSERKKEICKR 491 
WP_013445255  419 PEISRVPIMIDSSKWEVIEAGLKCVQGKCIVNSISLKEGEEEFLYKARKIRAYGAAVVVMAFDEQGQADSFDRKTQICSR 498 
WP_014270523  415 DPSVSKVPVMIDSSDWEVIEIALGEIQGKGIVNSISLKEGEEKFLSHARLIASYGCAMVVMLFDEKGQADHYERKIAIAK 494 
WP_015043771  409 KVKAPLMLDTTDPAVLEAGLRLIQGKAIINSINLENGRERFDEVVPLLRKFGAAVVVGLIDEQGMALTRERKLEVAGRSY 488 
WP_096686647      --------------------------------------------------------------------------------     
WP_128149236      --------------------------------------------------------------------------------     
WP_012420988  536 RRAYDLLVNRVQFPPEDIIFDPNVLTVGTGIAEHADYALDFFKAAGWISRNLPHAHISGGISNVSFAFRGNNPVREAMHS 615 
NP_603070         --------------------------------------------------------------------------------     
NP_809093     500 RAYRLLVDKVGFNPHDIIFDPNVLAVATGIEEHNNYAVDFIEATGWIRKNLPGAHVSGGVSNLSFSFRGNNYIREAMHAV 579 
WP_014545890  495 DEEGQATNYERRVQIASRAYDIMVKQLHFDPSDIIYDPNVLTVATGMAEHNAYAIDFIRAVRWIMDNLPGVRISGGLSNL 574 
WP_013388845  492 AYELLTSNNFPAEDIIFDPNVLTVGTGTEEDRMHGVDFIDSVKWIKENLPGAGVSGGVSNLSFAFRGNNILRHTIHKIFL 571 
WP_013445255  499 AYHLLVDKIGFPPQDIIFDPNVLAIATGIEEHNNYGVDFINATRWIKQNLPYAKISGGVSNLSFSFRGNNVVREAIHSVF 578 
WP_014270523  495 RSYDLLVQAGIKPEDIIFDANVLSIATGIDEHDLYAKDFIRASLWIKENLPFAHTSGGISNLSFSFRGNDVLRNAMHAMF 574 
WP_015043771  489 NLLVNEYGLSAADIIFDPLTFPVGTGDVKYLGSAVETIEGLRLIKAKYPECKTILGISNVSFGLPAAGREVLNAVFVYLN 568 
WP_096686647      --------------------------------------------------------------------------------     
WP_128149236      --------------------------------------------------------------------------------     
WP_012420988  616 AFLYHATQQGLDMCIVNAGMLEVYDNIPKDRLELIEDVLLNRRTDATERLTDYAEKLAAEKTGDGKEKKTVQAWREQDVA 695 
NP_603070         --------------------------------------------------------------------------------     
NP_809093     580 FLYHAIQQGMDMGIVNPGTSVLYSDIPADTLEKIEDVVLNRRPDAAERLIELAEALKETMGGTSGQAAVKQDAWREESVQ 659 
WP_014545890  575 SFAFRGNNYLREAMHTTFLHYAIPNGMGMAIMNPSAIIKYKTIPLELRMAITEVIFNTEPEASEELIEIASRMTAAQAKA 654 
WP_013388845  572 EEGEKAGMTMAIVNPGEDPGNITPEVRKAVENLLAGDKNAVDEILNLSFEKSAKKTAEIKPVTVEERLKDYLLKGRSQGI 651 
WP_013445255  579 LYYAIKEGMDMGIVNAGMLQIYQDIEPELLEHVEDIVLNRRPDATERMIELAEKVKNQASGEKVEKVDEWRSRTLQGRLE 658 
WP_014270523  575 LAFAKLDMAIINPGADRNLDSIPPHARAIIGKALLPEDTKAAQARQNLIDLALSGELTKPTQTKEKTKEEAWKSLGPEER 654 
WP_015043771  569 TVAGLDYAIVNSEKLERYATIPHEEKKLAEDLLLNTNDQTLKAFTDFYREKKVTEQKQTSGLSVEERLAGAIVEGSKEGL 648 
WP_096686647      --------------------------------------------------------------------------------     
WP_128149236      --------------------------------------------------------------------------------     
WP_012420988  696 KRLEYSLIKGITEFVDADTEEAFQELGSPLNVIEGPLMAGMKVVGQLFGDGKMFLPQVVKSARVMKQAVAWLTPYIEADS 775 
NP_603070         --------------------------------------------------------------------------------     
NP_809093     660 ERLKYALMKGIGDYLEQDLAEALPLYDKAVDVIEGPLMDGMNYVGELFGAGKMFLPQVVKTARTMKKAVAILQPIIESEK 739 
WP_014545890  655 KETGAKYDPKAIFAVSTGAGSATSDANEKAADAKPTTPEERLQEALLKGTSTTLQPDLMELINRGDSPVGIISGPLMDGM 734 
WP_013388845  652 EDDIKTALEKYSPLQVIQEVLMEGMEEVGALFEKGELFLPQILRSAAVMEKAVEFLTPLIEAGGKEKNVKGKVLMATVEG 731 
WP_013445255  659 HALIKGISEFLEEDLSEALTQFDTAIEIIEGPLMSGMNIVGELFGEGKMFLPQVVKTARTMKKAVAILQPEIEKQKVPGQ 738 
WP_014270523  655 LAEAIFHGENTFLQTDLASLDSMDPIQLVEGPLMYGMKKVGKLFGEGKLFLPQVVRSARTMKLAVDILEPRITAYLTDVN 734 
WP_015043771  649 ENDLYEALTKYRPLEIINGPLMKGMEEVGSLFNRNQLIVAEVLQSAEVMKAAVTILESQMEKAEEAVKGKILLATVKGDV 728 
WP_096686647      --------------------------------------------------------------------------------     
WP_128149236      --------------------------------------------------------------------------------     
WP_012420988  776 KGAAKAGKAVIATVKGDVHDIGKNIVGVVLSCNGFEMIDLGVMVHCDTILDRAEAEQADLVMLSGLITPSLEEMSHVAAE 855 
NP_603070         --------------------------------------------------------------------------------     
NP_809093     740 VEGSSSAGKVLLATVKGDVHDIGKNIVAVVMACNGYDIVDLGVMVPAETIVQRAIEEKVDMIGLSGLITPSLEEMTHVAA 819 
WP_014545890  735 NEVGRRFGEGKMFLPQVVKTARTMKKAVEILQPYIEAGKDANASSRGKIVIATVKGDVHDIGKNIVSVIMACNGYDMVDL 814 
WP_013388845  732 DVHDIGKNIVGTVLKCNGFDVVDLGVMVPKDQILEAILRHDVDMVTLSGLITPSLMEMEKVAEMMAEQNMDIPLLIGGAA 811 
WP_013445255  739 SSSAGKFLIATVKGDVHDIGKNIVAVVLACNNFEVIDLGVMTPTEKIIQTAIDEKVDMVGLSGLITPSLEEMAHVATEMQ 818 
WP_014270523  735 NKIGFQKKKIAVMATVKGDVHDIGKNIVNLILTCNNFEVIDLGVMVPPQKILASALEHKADLVGLSGLITPSLKEMASVV 814 
WP_015043771  729 HDIGKNLVEIILSNNGYKVVNLGVKVSSEQLIEAARKEAPDAIGLSGLLVKSVQQMLLTAQDLQAAGINTPLILGGAALS 808 
WP_096686647      --------------------------------------------------------------------------------     
WP_128149236      --------------------------------------------------------------------------------     
WP_012420988  856 MERRGMTIP 864 
NP_603070         ---------     
NP_809093     820 ELEKAGLDI 828 
WP_014545890  815 GVMVPEDVI 823 
WP_013388845  812 ASELSTAVR 820 
WP_013445255  819 KAGLSIPLL 827 
WP_014270523  815 SLFEANGCT 823 
WP_015043771  809 RKYTEEKIA 817 
WP_096686647      ---------     
WP_128149236      ---------     
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