1SNZ,1Z45,1NSX,1L7J,1LUR,3IMH,1YGA


Conserved Protein Domain Family
galactose_mutarotase_like

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cd09019: galactose_mutarotase_like 
Click on image for an interactive view with Cn3D
galactose mutarotase_like
Galactose mutarotase catalyzes the conversion of beta-D-galactose to alpha-D-galactose. Beta-D-galactose is produced by the degradation of lactose, a disaccharide composed of beta-D-glucose and beta-D-galactose. This epimerization reaction is the first step in the four-step Leloir pathway, which converts galactose into metabolically important glucose. This epimerization step is followed by the phosophorylation of alpha-D-galactose by galactokinase, an enzyme which can only act on the alpha anomer. A glutamate and a histidine residue of the galactose mutarotase have been shown to be critical for catalysis, the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. Galactose mutarotase is a member of the aldose-1-epimerase superfamily.
Statistics
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PSSM-Id: 185696
Aligned: 224 rows
Threshold Bit Score: 268.22
Created: 2-Aug-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1NSX_A; Lactococcus lactis galactose mutarotase binds galactose, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                          #          #                 
1SNZ_A       23 KFQLQSd-lLRVDIISWGCTITALEVkdrqgrasDVVLGFaelEGYLQkqpYFGAVIGRVANRIAKGTFKvdgkEYHLAI 101 human
1NSX_A       14 LISLTNkagVTISFTNLGARIVDWQKdg-----kHLILGFdsaKEYLEkdaYPGATVGPTAGRIKDGLVKisgkDYILNQ 88  Lactococcus lactis
3IMH_A       20 EITLENdagMAVKVLNYGATLEKVLLdg-----eNMILSLnspEDYSKernFLGGTVGRIAGRVRAGQWKhgneIHQLPL 94  Lactobacillus ac...
ZP_01169898  23 IFTLVNrqgMEVSCLDYGCIITKILVpdrdgrmeNVVLGFdtlEEYQQhspYFGAVCGRHAGRIAGGEFElngkTYKLAK 102 Bacillus sp. NRR...
NP_693129    14 QFTLINdrdMEVSILNYGGIITRIITpdrneqkrNIVARYknlDDYIEnplYLGAIIGRVAGRIQNGSFSigdkEIQLQA 93  Oceanobacillus i...
NP_978524    18 SFTMMNdqgMKITCIDLGCTITRIDVpdkkgnleNIVLGFdclEEYLKyspYFGAVIGRVAGRIYPSSFNlddvTYHLPN 97  Bacillus cereus ...
10175376     18 AFTMTNdhgMEVTCIEYGCIITELKTpdrhgnleNIVLGFdrmDDYEKhsqYFGAVIGRVAGRIANGEFMldnqSYTLAN 97  Bacillus halodur...
NP_562260    12 SKIILKnnkVSVEILNLGAIVEKINVedrygnkeNIVLAYkdeESYIEnpsSLGSIVGRVAGRIGKGSFKlngiNYELDK 91  Clostridium perf...
ZP_02691587  10 VITLTNennMSVEILNLGGIITKIMVpdkngkleNVVLGYedyQEYGKnqgYLGTLIGRTSGRIGGANFVldgiTYKLPE 89  Epulopiscium sp....
YP_804557    19 RISMFNkngVQVDILNYGATLEHFFVpgrtsekdNIILSLerpEYYDKernYLGGTVGRVIGRIAHGHWQdednTIQFEL 98  Pediococcus pent...
Feature 1              #                                                                        
1SNZ_A      102 NkepNSLHGGvrgFDKVLWTPRVl----sNGVQFSRISPDgeeGYPGELKVWVTYTLdg-gELIVNYRAQAsqATPVNLT 176 human
1NSX_A       89 NegpQTLHGGeesIHTKLWTYEVtdlgaeVQVKFSLVSNDgtnGYPGKIEMSVTHSFdddnKWKIHYEAISdkDTVFNPT 168 Lactococcus lactis
3IMH_A       95 NdgdNHIHGGi-gTDMHVWDFRPscdsehARVDLTLFDPDgnnDYPGNLKLHARYELdnenNLHYLLEAVSdkLTIFNPV 173 Lactobacillus ac...
ZP_01169898 103 NnggNNLHGGvegFDKKLWEAEVtegpdsASVIFRYVSKDgeeGYPGNLEMKVTYTLndrnELEISYEGTSdeDTIVNVT 182 Bacillus sp. NRR...
NP_693129    94 NegyHVLHGGksgFHQILWDVTTiekpdyVGIRLTYTSKEnesDFPGNVNVAITYYLdnqnELTIDYNAISdkQTPITLT 173 Oceanobacillus i...
NP_978524    98 NegeTHLHGGpngFHQVIWESSIsqspneINITFTYMSPDgegGYPGNLKVSVVYTLtnnnELVITYYGISdkNTLLNVT 177 Bacillus cereus ...
10175376     98 NegeNHLHGGekgFDKVVWKGETidsqdeVGVEFSYISRDgeeGYPGTLSMSVRYILnndnELKVMYSGKAdqKTLVNVT 177 Bacillus halodur...
NP_562260    92 NnngNCLHGGykgFSKKIWDYSYsedeekSTAIFTSFSKDgegGFPGNLKVQVTYSLeg-dKLSIEYRASSdkDTVVNLT 170 Clostridium perf...
ZP_02691587  90 NnngNCLHGGixgFDKKIWAIENle---nNSVTLSLVSPDgeeGFPGEVHVSVIYTLaednSLSITYTGQTdkKTLLNLT 166 Epulopiscium sp....
YP_804557    99 NddpNHAHGGskgFDTQVFGFTIkenencSILKLHLLDPDnynNYPGNLSIYVTYTLtnenTLIYEIEAISdkKTLCNPA 178 Pediococcus pent...
Feature 1        # #                                                                       #    
1SNZ_A      177 NHSYFNLagqaspnindHEVTIEAdTYLPVDEt-LIPTGEVAPVqgtafdlrkpve------lgkhlqdfhlngFDHNFC 249 human
1NSX_A      169 GNVYFNLngdasesvenHGLRLAAsRFVPLKDqtEIVRGDIVDIkntdldfrqekqlsn-afnsnmeqvqlvkgIDHPFL 247 Lactococcus lactis
3IMH_A      174 NHTYFNLger----aedLNLQMNAdYYLPVDEa-GLPDRGMAEVagtafdfrktkrigd-alnsddsqiklrngLDHPFI 247 Lactobacillus ac...
ZP_01169898 183 NHSYFNLsgdlkreildHELTLKSdRFAELDEa-LIPTGKLVPVngtvfdftegrklkdgntsdnpqnirvgsgYDHPFL 261 Bacillus sp. NRR...
NP_693129   174 NHSYFNLsgdleqtiheHEMTLDSdQFLELDEe-LIPTGEMVDVdmtpfdfrsgrclsiglnndfyqnkivgsgYDHFFL 252 Oceanobacillus i...
NP_978524   178 NHTYFNLsgnlkkdilqHELTIKSdQFLELNRs-LLPTSKLINVentpfdfrsgkriicgvksehpqnkivgrgYDHPFL 256 Bacillus cereus ...
10175376    178 NHSYFNLsgnlkrdileHELTLKSsQFLQLNDq-LLPTGTVLDVvdtpfdfrngrkiidgtkatyeqnvivgngYDHPFK 256 Bacillus halodur...
NP_562260   171 NHSYFNLsgnnkrnvleQKLYIDSdKICELDKd-LIPTGEFLSVektpfdfrklkkige-dinknhlqleigsgYDHPWV 248 Clostridium perf...
ZP_02691587 167 NHSYFNLsgdaktdvlnHELTLKSkLVAEGDEf-LIPTGNLIDVnevaafdfrtpkki--gkdiddpalalasgYDHPFI 243 Epulopiscium sp....
YP_804557   179 NHSYFNLnsgk--dildQYLTLDAdYYLPLDKn-SIPTGEQKSVtntpfdfrkpkllgk-aitsldsqireqlgLNHPFL 254 Pediococcus pent...
Feature 1                                           #                         #                 
1SNZ_A      250 LKgsk---ekhFCARVHHaasgRVLEVYTTQPGVQFYTGNfldgtlkgkngavypkhSGFCLETQNWPDavnqprfpPVL 326 human
1NSX_A      248 LDqlg---ldkEQARLTLd--dTSISVFTDQPSIVIFTANfgdlgtly-hekkqvhhGGITFECQVSPGseqipelgDIS 321 Lactococcus lactis
3IMH_A      248 LNgn------nPAALLSSn--kHRLIVKTNAPALVLYAGNhfnhtgi---vnnigqyDGITFEAQCPPAegn--dlgQIT 314 Lactobacillus ac...
ZP_01169898 262 LAen-----enEEISLYDaesgRRLVVETDQPAVVLYTSNtlegsfsi-rgvtaanhLGVCLETQGLPDavhhpefpSCI 335 Bacillus sp. NRR...
NP_693129   253 FNhe-----kkHVVNMVEprsgRQLFISTNQPGMVMYTSNsvdssqqf-yegeakkyIAVCFETQGSPAslhhdnleTIL 326 Oceanobacillus i...
NP_978524   257 LGen------kQQICLIDhsngRKMIIKTDEPCVVLYTGNmlgdhfqi-rgvpcrkyLGLCLETQRPPNsihnrefaSIL 329 Bacillus cereus ...
10175376    257 LDtn-----lqQEIRLVDeesgRCLEMETTEPCVVLYTGNalqegvpi-rgvrsrkyLALCLETQGFPDaihhpdlpSIV 330 Bacillus halodur...
NP_562260   249 LNkk-----gdFDAILVDeesgRIMKVKTDQKAVVCYSMNfpdelple-ngkvakkhDGICFETQNLPVgyddcfldGII 322 Clostridium perf...
ZP_02691587 244 LEkgeglkkdcVVMTCQEs--gRKMTMDTTYDAVVIYTSNfpnhkkli-ggnsfearDGICFEAQQLPIgrddcnkcDSI 320 Epulopiscium sp....
YP_804557   255 LNrn-----nnIAAVLESldhqRRLSVETTAPSIVVYTGNhfnnsgf---aqnigqyGGVALETQFPPSnde--slsSIV 324 Pediococcus pent...
Feature 1                      
1SNZ_A      327 LRPGEEYDHTTWFKF 341 human
1NSX_A      322 LKAGEKYQATTIYSL 336 Lactococcus lactis
3IMH_A      315 LLPFEKFKRTVDWKF 329 Lactobacillus acidophilus NCFM
ZP_01169898 336 LKAGESFRSVTAFKF 350 Bacillus sp. NRRL B-14911
NP_693129   327 LEANQPYQKTTTFQF 341 Oceanobacillus iheyensis HTE831
NP_978524   330 LEKDKEYHSKTCFSF 344 Bacillus cereus ATCC 10987
10175376    331 LEEGEEYLSTTTYRF 345 Bacillus halodurans C-125
NP_562260   323 LKKDEEYYQKTTFEF 337 Clostridium perfringens str. 13
ZP_02691587 321 LKSDQEYNHTTIYRF 335 Epulopiscium sp. 'N.t. morphotype B'
YP_804557   325 LLPYQKFYSRTSWCI 339 Pediococcus pentosaceus ATCC 25745

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