1OBR


Conserved Protein Domain Family
M14_CPT

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cd03859: M14_CPT 
Click on image for an interactive view with Cn3D
Peptidase M14 Carboxypeptidase T subfamily
Peptidase M14-like domain of carboxypeptidase (CP) T (CPT), CPT belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. CPT has moderate similarity to CPA and CPB, and exhibits dual-substrate specificity by cleaving C-terminal hydrophobic amino acid residues like CPA and C-terminal positively charged residues like CPB. CPA and CPB are M14 family peptidases but do not belong to this CPT group. The substrate specificity difference between CPT and CPA and CPB is ascribed to a few amino acid substitutions at the substrate-binding pocket while the spatial organization of the binding site remains the same as in all Zn-CPs. CPT has increased thermal stability in presence of Ca2+ ions, and two disulfide bridges which give an additional stabilization factor.
Statistics
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PSSM-Id: 349432
Aligned: 44 rows
Threshold Bit Score: 264.889
Created: 18-Oct-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteactive site
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:[H] [ED] [H]Click to see conserved feature residue pattern help
Evidence:
  • Comment:Metallocarboxypeptidases share the zinc binding motif HXXE...H, where the zinc ion is penta-coordinated to ND1 atoms of the histidines, OE1 and OE2 atoms of the glutamic acid, and to a water molecule in a slightly distorted tetrahedral manner.
  • Structure:1OBR: Thermoactinomyces vulgaris Carboxypeptidase T; contacts at 3.5A
    View structure with Cn3D
  • Citation:PMID 1521526

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      #  
1OBR_A          6 DSGYHNYNEMVNKINTVASNYPn-iVKKFSIGKSYEGRELWAVKISDNvg-------------tDENEPEVLYTALHHAR 71   Thermoactinom...
OQY26547       93 LGDYTTYQELTDHLTTLAAEYPd-iVHLTTLGQSWQGREIWGVKVSDNpt-------------vEEDEPEALYMGVHHSR 158  Candidatus Cl...
EEY55317       36 VRGSLSVVQVDAFIDEVATNYPl-iTKVEYLGRSVEGRPLRALCLGACni------------seDKKIPQALFTGMHHAR 102  Phytophthora ...
CEM00636       46 VKGYASWSQVVELFDRFIQWYPs-lLKHISIGKSVEGRDLHVWVVGAHpegggsdgvsnatdagAGGVPEVLLTGEHHAR 124  Vitrella bras...
XP_002141468   80 LKGFPTFLEALDILNNFQNKFGnnyIRRKSIGISVEGRSIDAFIIGIFnst-----------diPNNIPSVLVTSMHHSR 148  Cryptosporidi...
XP_001445150   37 PQGRLSMKDVENLFAELENSTNl--VHSQSIGQSYLNKTINSYSLCSNf---------------SKEKPKMLITSLHHSR 99   Paramecium te...
OPL18936       91 MGGYMTWDELSAWMDDLHDTYPsitSAPTSIGDTYQGRPQRVVKISSNtdf----------wydDPALPNVWYDGLIHAR 160  Candidatus Ae...
OLP78426       33 VQGFPSYEEANELLEQFLRSNPn-eLEKRQIGTSFQSRPIYAYVLATPa--------------gRQNKPQALLTALMHAR 97   Symbiodinium ...
OQY27498      114 MGGYFLHDEIVAFVDSLRSEYPdliSQNVVLGQTHDGFDLTAFKVSDNpn-------------iEEDEAEVLFIGMHHAR 180  Candidatus Cl...
EAS01158       52 MNGYFDYNTTMEIYFKASQAFPelvKQPIEIGKSFLNNSMWAIALTLKtd-------------dLNEQQSILIDSLHHGR 118  Tetrahymena t...
Feature 1         #                                                                               
1OBR_A         72 EHLTVEMALYTLDLFTQNYnl----dSRITNLVNn--REIYIVFnINPDGGEYDiss----gsyKSWRKNRQpnsg---- 137  Thermoactinom...
OQY26547      159 ELITVEILLYFLDYLTENYda----sEEVSDLIQe--RQLWFIPmLNPDGHTVVedhhe-gtswGWWRKNTRdnngdgq- 230  Candidatus Cl...
EEY55317      103 ENLVYTIDILTSDYRNGEL-------AALELLAS---RQLWFILvVNPDGYAHNem-------aRVWEHNKMgqrksgap 165  Phytophthora ...
CEM00636      125 EPLSLTTVVYYVGRLLQNYmr---geRYARYVLHn--RVIYTLPfVNPDGYVYIeehp---dkaRVVRKNRRptcsn--- 193  Vitrella bras...
XP_002141468  149 EPESLVTGIYFIGRLLEEAvk----lKDLTSLALlssTIIWYIPfVNPDGYVAIert-----kaYGIRKNQRntcnsy-- 217  Cryptosporidi...
XP_001445150  100 EVASLQMNIYLFLYILWEVkhe--knPYYINMITh--NCIMIVPfVNIDGYNEIeselnkhiyqPQTRKNLNrtincy-- 173  Paramecium te...
OPL18936      161 EPASMRNIRFFMLWLCENYgrngfcgLQATWLLDn--REIWCLPcNNVDGYVYNqqqs--pgggGMHRKNMNwsa----- 231  Candidatus Ae...
OLP78426       98 EPAGLTVLLYFLGHLLEKYsr---gdPDATYILNm--REIWFLPfVNPDGYIANkgl-----rnKVIRKNRRptcrs--- 164  Symbiodinium ...
OQY27498      181 EPMSIVAVLYFTQWLVGNYet----dPMARYIVDe--RQIWVIPiLNIDGYRYNsens--pqggGMWRKNKRdnngdgv- 251  Candidatus Cl...
EAS01158      119 EMLSLSMQIYTFAKLISDYss---ryQDTLNLLTa--SVVWFIPaVNVDGLIKVkdiin-raerDSVRKNFNrtsac--- 189  Tetrahymena t...
Feature 1                                                                                 #       
1OBR_A        138 -----ssyvGTDLNRNYgYKWGcc-gGSSGspsseTYRGRSAFSAPETAAMRDFINSRvvggkqQIKTLITFHTYSELIL 211  Thermoactinom...
OQY26547      231 ---fnqtddGVDLNRNYgYHWGes-yGCSHdpssnVFCGPEAFSEPETQIVRDFCEAH------NFSVALSYHSFGNDLL 300  Candidatus Cl...
EEY55317      166 tcdrsppdaGVDLNRNYdVCFArdskGSSNepcgdDYNGPSAFSEPETRAVRDIVERNt----sDFSVALNYHSYGKYIN 241  Phytophthora ...
CEM00636      194 ----dpalgGVDINRNYdWKWQq---DESKkc-deEYSGEAPFSEPETQAIRDLTSNH------SFKSAMNFHTFGGFWT 259  Vitrella bras...
XP_002141468  218 ----nplykGVDINRNYdFMFKnvvsECDPq----EYSGPYPFSEPETRAIRNLIRKFk-----TFKTAINLHTYGDLWT 284  Cryptosporidi...
XP_001445150  174 ---qqgelaGIDLNRNYgYHFAydniGSSNdpcdeTYRGSAAFSEKETQAIKNVVENY------NIKMAMNLHCFGNLWV 244  Paramecium te...
OPL18936      232 ------ggdGIDLNRNWsVGWGg--pGSSGdpgsqTYRGTAPLSEPEASNIDAFWQDH------PPAQMHSTHTYGNILI 297  Candidatus Ae...
OLP78426      165 -----svdgGVDINRNFaVHWSssfgGCSE-----EHGGSQPFSEPETQAFKKICEEN------AFKTAMNFHAYGSMLT 228  Symbiodinium ...
OQY27498      252 ---fnpsvdGVDLNRNYsVGWAfndiGSSPtpgsqVYRGPFAFSEPETQGVRQLCNAH------EIRVALNFHTFGDMLF 322  Candidatus Cl...
EAS01158      190 ----qfnfgGVDLNRNYdEHFAldskGSSSyecseDYRGPHAFSEKETQAMKKFVEDRp-----NLKIAFNFHSYGNMWI 260  Tetrahymena t...
Feature 1                                                                                         
1OBR_A        212 YPYGYtytdvp------------------------sdmtqdDFNVFKTMANTMAQtn-----------------gyTPQQ 250  Thermoactinom...
OQY26547      301 YPWSYnnl------------------------------htdQHRLFRTVAEVMVEeng---------------yayGNGW 335  Candidatus Cl...
EEY55317      242 LPFACqaegq---------------------------ptepNNALFVALAREMAHfngf--------------nygQSWK 280  Phytophthora ...
CEM00636      260 HPWNWsgkee---------------------------lpawAAGIYEELGSVLDVev-----------------yeSAPK 295  Vitrella bras...
XP_002141468  285 IPWNCckdmpmaknfsdiynelryeilltspscifrvintiDRQKLESLNYKKYSvslflnmsksfedisrycfssAPNN 364  Cryptosporidi...
XP_001445150  245 IPYSYdneeldk-----------------------dgvpylIYEDFKQKGEFQGRyk------------------iGHAI 283  Paramecium te...
OPL18936      298 YPWGYtdd------------------------------attHAAEYDAQGEIMVQwgt---------------gevHGPA 332  Candidatus Ae...
OLP78426      229 HPFNWatqdl---------------------------mpaeDKRVYQEIARVFGYkk------------------fGPAI 263  Symbiodinium ...
OQY27498      323 FPQYYnsm------------------------------qtpDHQTFMEYSLDMIR---------------------DSQY 351  Candidatus Cl...
EAS01158      261 RPINYladrenk----------------------elqkmirEYHIYQEFDEEAKFseda-------------kkgnAIMV 305  Tetrahymena t...
Feature 1                                                                       
1OBR_A        251 ASDLYitDGDMTDWAYGq----hKIFAFTFEMYPtsynpg---fyppdeVIGRETSRNKEAV 305  Thermoactinomyces vulgaris
OQY26547      336 EVLNYlmTGEACDWLYSe----lGIIAFTPEVGPdeylf-----yplesEIEPLCQENLQAN 388  Candidatus Cloacimonetes bacter...
EEY55317      281 DSNLYtvNGETSDWMWQa----hGIFAMSPEVGPgfqvapvpgfwplpsDVPQLSSELHYSN 338  Phytophthora infestans T30-4
CEM00636      296 SILKYetYGEADDWMLGa----rNIIAQSPEVGPesggf-----yppksEAPGTHRSNYRRI 348  Vitrella brassicaformis CCMP3155
XP_002141468  365 PYIMYeaSGEADDYLLGi----eNVISLSPEIGPeefgf-----ypplnQIIPIAQRYYPQL 417  Cryptosporidium muris RN66
XP_001445150  284 ELVQYtaNGEAADWMLSq-----GVIAISPELGEqaysnffqnfypdkeQTIKLFKTEFPPL 340  Paramecium tetraurelia strain d4-2
OPL18936      333 SQILYysSGNTRDHSYGl----yGTMSWNHETGGdfagf-----wpspeETIKLTRRNLRSY 385  Candidatus Aegiribacteria bacte...
OLP78426      264 KTVGYttSGESDDWMYSa----rHIISMSPEVGPesggf-----wppssQIDGIDTRNFDRA 316  Symbiodinium microadriaticum
OQY27498      352 YYTIGgiNGCSDDWMYAeqtekpKILAYTPEIGDdtdgf-----waptdRILTLAQENLYTQ 408  Candidatus Cloacimonetes bacter...
EAS01158      306 LQGDYlaNGEATDWMLLk----kKIIAMSPEIGDesttf-----fppqqIILKNLQDNYPPV 358  Tetrahymena thermophila SB210

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